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The merit of sintered PDLLA/TCP composites in management of bone fracture internal fixation.

Polyesters based on lactic acid have been reported in terms of safety and biodegradation in human beings for 2 decades. The greatest advantage of such material is its degradation conducted only by hydrolysis, whereby the ester backbones are supposed to be unchained in the aqueous condition. The final degradable products are carbon dioxide and water which can be metabolized and digested in the physiological environment. The goal of this study was aimed at developing a composite sintered with poly-DL-lactide (PDLLA) and tricalcium phosphate (TCP) ceramic particles for orthopedic application. The TCP particles in a range of 30-60 wt% with 5 wt% increments were doped into the PDLLA matrix which was prepared by melting and hot pressing techniques for the reinforcement. The basic mechanical strength, biodegradable behavior, and biological response of the composites were investigated in the study. Various techniques such as pH meter, UV, Fourier-transform infrared, and x-ray diffractometer were used to examine and record the degradable process of the composites soaked in saline for 1-16 weeks. The rabbit femur condyle fracture fixation test was used to evaluate tissue compatibility and the effects of bone fracture fixation on the composites. Histological observation and x-ray photography were used for investigating assistance. The mechanical strength of the composites initially increased with TCP additions up to 50wt%, but thereafter they showed no significant difference (p < 0.05). The composite with 50 wt% TCP addition showed greater mechanical strength and had good agreement with cortical bone in terms of its elastic modulus of 30-40 GPa. The weight loss of the pure PDLLA soaked in the saline started at 4 weeks and reached 95% after 16 weeks. The composites compared with pure PDLLA, however, showed no apparent evidence of degradation after soaked for 12 weeks. The possible mechanisms for the delayed degradation of the composites in saline might have been solution penetration retardation by the ceramic particles and chemical bonds formed between the interface of the TCP particles and the PDLLA matrix. In the histological evaluation of the rabbit femur condyle fracture fixation test, the surface of the composite with 50 wt% TCP addition was attached by the newly generated bone without fibrous tissue around 8 weeks after implantation. The fractured bone was gradually healed and the composite firmly and properly fixed on the fracture area during the implanted period, which provided a breeding environment for normal bone remodeling. The developed composite was thought to be an alternative material for orthopedic application in the future, especially for bone screws and bone plates.

Absorption↗

Practical considerations in anterior cruciate ligament replacement surgery.

The endoscopic method of anterior cruciate ligament (ACL) reconstruction using a patellar tendon graft that is secured with interference screws is a commonly performed procedure. It has many potential pitfalls, the majority of which are secondary to technical errors. Prevention of errors starts with a full knowledge of normal ACL anatomy and any discrepancies with the size and shape of the graft substitute. Accurate tibial and femoral tunnel placement is essential and involves using consistent intra-articular landmarks and achieving specific radiographic criteria. Accurate tunnel placement minimizes graft excursion and impingement against the roof of the intercondylar notch. This will result in maximum knee stability and motion. Much has been written about the principles of graft-tunnel mismatch and interference screw-bone plug divergence. The clinical implications of these potential sources of error remain somewhat controversial and are discussed in this article.

Anterior Cruciate Ligament↗

Three-dimensional motion patterns during active bending in patients with chronic low back pain.

STUDY DESIGN: The three-dimensional motion patterns of chronic low back pain (LBP) patients were studied during active motions. OBJECTIVE: To evaluate whether the motion patterns of coupling and asymmetry in chronic LBP patients differ from those in the normal population according to previous literature. SUMMARY OF BACKGROUND DATA: There exists little data that correlates vertebral motion with LBP symptoms despite extensive research. Several studies have suggested that patterns of motion are sensitive indicators of spinal pathology, including coupled motion patterns and asymmetry of motion. METHODS: In this study, 34 chronic LBP patients enrolled for an external fixation test performed active bending maneuvers, during which the three-dimensional intervertebral motions were measured continuously with an optoelectronic camera via markers attached to the percutaneous transpedicular screws. If a solid connection between each marker carrier and vertebrae was verified, the three-dimensional rotations of the vertebrae were analyzed with special reference to motion asymmetries and patterns of coupled motion. All data were compared to the normal values in the literature since the methodology is not possible in asymptomatic control subjects. RESULTS: Seven patients were removed from the analysis because of a loose screw-bone interface. In the remaining patients, three distinct patterns of motion were observed in each direction of movement. Significant differences in the extension-flexion ratio, the lateral bending asymmetry, and the coupled axial rotation-lateral bending ratio were found between the chronic LBP group and the normal literature values. CONCLUSIONS: Chronic LBP patients exhibited motion patterns altered from those of the normal population. Specific differences were observed in coupled axial rotation during lateral bending movement, in the symmetry between flexion and extension, and in the symmetry be tween right and left lateral bending.

Adult↗

An aid for the removal of compression hip screws.

The compression hip screw has a wide application in fracture management and elective orthopaedics. Due to the design of the sliding screw, bone ingrowth behind the threads can lead to difficulties in metalwork removal, especially in the younger patient. A simple technique is described using the plate to assist nail removal.

Bone Screws↗

The preliminary study and tentative animal study on the sintered PDLLA/TCP composites as bone fracture internal fixation.

Polyesters based on the lactic acid have been reported safety and biodegradation in the human beings for two decades. The greatest advantage of the material is its degradation only conducted by the hydrolysis, where the ester backbones are supposed to be unchained in the aqueous condition. The final degradable products are carbon dioxide and water which can be metabolized and digested in the physiological environment. The goal of this study was aimed to develop a composite sintered with poly-DL-lactide (PDLLA) and tricalcium phosphate (TCP) ceramic particles as orthopedic application. The TCP particles in a range of 30-60 wt% (with 5 wt% increment) were doped into the PDLLA matrix for the reinforcement, which were prepared by the melting and hot pressing techniques. The basic mechanical strength, biodegradable behavior, and biological response of the composites will be investigated in the study. Various techniques, such as pH meter, UV, FTIR, XRD ect., were used to examine and record the degradable process of the composites soaked in the saline for 1-16 weeks. The rabbit femur condyle fracture fixation test was used to evaluate the tissue compatibility and the effects of bone fracture fixation of the composites. The histological observation and x-ray photography were applied for investigating assistance. In the histological evaluation of rabbit femur condyle fracture fixation test, the surface of the composite with 50 wt% TCP addition was attached by the new generated bone without fibrous tissue around after 8 weeks implantation. The fracture bone was gradually healing and the composite always firmly and properly fixed on the fracture area during the implanted period, which provided a breeding environment for normal bone remodeling. The developed composite was thought to be an alternative material for orthopedic application in the future, especially in bone screw and bone plate.

Animals↗

The study of lifetime of polymer and composite bone joint screws under cyclical loads and in vitro conditions.

The "strain-life time" method has been adapted for life-time prediction of polymer and composite bone joint screws. Mechanical and fatigue properties of screws made of biostable (polysulfone), biosorbable (poly(lactide-co-glycolide) and short carbon fibre reinforced polymer composite materials have been examined in this study. The lifetime predictions under in vitro conditions were calculated for polymer and composite implants. The forecasting of joint screws stability under conditions close to natural body environment is shown to be feasible based on equations describing lifetime of the examined joint screws.

Analysis of Variance↗

Use of tension band wires in horses with fractures of the ulna: 22 cases (1980-1992).

Twenty-two horses with ulnar fractures were treated, using tension band wires alone or tension band wires in combination with pins or cortical bone screws. Age of the horses ranged from 2 weeks to 12 years (median, 4 months), and body weight ranged from 68 to 477 kg (median, 181 kg). Fractures were classified according to the Donecker and Bramlage ulnar fracture classification and included type 1-a (4 horses), type 1-b (4), type-2 (6), type-3 (1), type-4 (3), and type-5 (4), fractures. Tension band wires alone were used in 7 horses. Tension band wires were used in conjunction with unthreaded pins in 10 horses. In 3 horses, 5.5-mm cortical bone screws were inserted longitudinally instead of pins. A combination of a 5.5-mm cortical bone screw and a pin was used in 2 horses. In addition to pins and tension band wires, 4.5-mm cortical bone screws were placed in lag fashion to aid reduction of comminuted or oblique fractures in 7 of the 22 horses. Fractures healed in 18 (82%) horses. Four horses were euthanatized because of complications that included catastrophic failure of fixation during recovery from general anesthesia in 1 foal, septic arthritis and hyperextension of the contralateral metacarpophalangeal joint in 1 foal, and wound infection with partial disruption of repair in 2 horses. Nonfatal complications developed in 6 horses and included incision infection, partial wound dehiscence, carpal contraction, carpus varus of the contralateral forelimb, slight distraction of proximal fragments of the fractures, bent implants, and distal migration of pins. Long-term monitoring was performed on 17 horses.(ABSTRACT TRUNCATED AT 250 WORDS)

Anesthesia, General↗

Avascular femoral head necrosis following fracture fixation.

A prospective, randomized trial of 104 consecutive patients with displaced fractures of the femoral neck treated with either a sliding screw plate or four AO cancellous bone screws was performed to study the influence of the fixation device and the fixation procedure on the vascularity of the femoral head. The vitality of the femoral head was determined by 99mTc-MDP scintigraphy performed 2-3 months after the operation. Eighty-seven patients (84 per cent) were available for assessment. The two treatment groups were comparable with regard to age, degree of primary displacement and quality of reduction. There were significantly more (P less than 0.01) avascular femoral heads or femoral heads with reduced vascularity in the sliding screw plate group (14/40, 35 per cent) than in the four AO cancellous bone screw group (5/47, 11 per cent).

Adult↗

A new bioresorbable polymer for screw augmentation in the osteosynthesis of osteoporotic cancellous bone: a biomechanical evaluation.

The aim of the study was to assess the mechanical efficacy of a new resorbable polymer developed on the basis of alkylene bis(dilactoyl)-methacrylate to improve the anchorage of osteosynthesis material in cancellous bone. Cancellous bone screws were inserted in bovine as well as in human vertebrae and human femoral condyles and were augmented with the new polymer or polymethylmethacrylate (PMMA), respectively. Nonaugmented screws were used as controls. A removal torque test, a dynamic fatigue test, and a pullout test were performed. Augmentation with the new polymer increased the removal torque by 84% in human femoral bone. In the dynamic fatigue test of bovine vertebrae, the removal torque after cyclic loading was 115% higher for the new polymer compared to the nonaugmented controls. In the human vertebrae, the reinforcement with the new polymer increased the removal torque after dynamic loading by 114%. The augmentation with the new polymer increased the pullout force by 88% in bovine vertebrae and by 118% in human vertebrae in comparison to nonaugmented screws. It was concluded that augmentation by the new resorbable polymer significantly enhanced the anchorage of bone screws in cancellous bone. The mechanical efficiency of the new polymer was comparable to that of PMMA cement.

Aged↗

Comparison of bone-patellar tendon-bone interference screw fixation and hamstring transfemoral screw fixation in anterior cruciate ligament reconstruction.

While bone-patellar tendon-bone (BPTB) interference screw anterior cruciate ligament (ACL) reconstruction is a biomechanically sound construct, alternative techniques have been developed secondary to potential donor site morbidity. This study evaluates a system designed to address this problem that involves a transfemoral screw fixation device and stapling of hamstring tendons. Seven pairs of cadaveric knees underwent ACL reconstruction using either BPTB interference screw technique or semitendinosus gracilis (STG) transfemoral screw fixation and stapling. Tensile testing was performed. There was no significant difference between the two fixation types with regard to stiffness, maximum load to failure, elongation, energy to failure and yield load, displacement, and energy.

Aged↗

[Complications following osteosynthesis management of femoral neck fractures with spongiosa locking screws].

Osteosynthesis under pressure using two perforating cancellous bone screws in medial and lateral fractures of the neck of the femur and in some cases also in pertrochanteric fractures of the femur has proved successful, in our opinion, in surgery aimed at preserving the head of the femur, as has been confirmed at our hospital by follow-up studies. A striking fact that came to light during follow-up was that there was a higher percentage of incidence of necroses of the femoral head following Pauwels-I-type fractures. However, in our case it was only one necrosis of the head of the femur in a total of five Pauwels-I-type fractures treated by osteosynthesis. A final judgment can surely be passed only by studying a larger number of cases for a longer period of time. We will, therefore, follow up the fractures of the neck of the femur a few years later by re-examination. As a matter of principle, the aim of surgery in osteosynthesis of a medial femoral neck fracture can be attained by means of the cancellous bone screws. A very important aspect which is most essential for successful surgery is the accurate and controlled introduction of the screws via the guide wire. The infection risk is reduced by the small operative approach. In view of the fact that the follow-up examinations revealed more than 72% well-healed fractures of the neck of the femur, we do not think it necessary to effect any changes in our surgical procedure at the present time.

Bone Screws↗

Cortical margining capabilities of fins associated with ventral cervical spine instrumentation.

Fins incorporated into the design of a dynamic cervical spine implant have been employed to enhance axial load- bearing ability, yet their true biomechanical advantages, if any, have not been defined. Therefore, the goal of this study was to assess the biomechanical and axial load-bearing contributions of the fin components of the DOC ventral cervical stabilization system. Eighteen fresh cadaveric thoracic vertebrae (T1-T3) were obtained. Three test conditions were devised and studied: Condition A (DOC implants with fins were placed against the superior endplate and bone screws were not inserted); Condition B (DOC implant without fins was placed and bone screws were inserted); and Condition C (DOC implant with fins were placed against the superior endplate and bone screws were inserted). Specimens were tested by applying a pure axial compressive load to the superior platform of the DOC construct, and load-displacement data were collected. Condition C specimens had the greatest stiffness (459 +/- 80 N/mm) and yield load (526 +/- 168 N). Condition A specimens were the least stiff (266 +/- 53 N/mm), and had the smallest yield loads (180 +/- 54 N). The yield load of condition A plus condition B was approximately equal to that of condition C, with condition A contributing about one-third and condition B contributing two-thirds of the overall load-bearing capacity. Although the screws alone contributed to a substantial portion of axial load-bearing ability, the addition of the fins further increased load-bearing capabilities.

Bone Plates↗

Effect of pegs and screws on bone ingrowth in cementless total knee arthroplasty.

The purpose of the present study was to assess the effects of pegs and screws on bone ingrowth into the tibial component in cementless total knee replacement. Left total knee replacements were performed in 21 mature male dogs with 3 cementless porous-coated tibial tray configurations (7 animals per group): (1) 4-peg design implanted with cortical screws passing through the pegs; (2) 4-peg design implanted without screws; and (3) pegless design secured by 4 cortical screws. The animals were allowed unrestricted activity and were euthanized 6 months postoperatively. The pegless components (Group 3) had the highest extent of bone ingrowth into the tray (90.3% +/- 9.4%), followed by the components with 4 pegs only (Group 2, 82.8% +/- 9.2%), and the components with 4 pegs and 4 screws (Group 1, 75.9% +/- 11.8%). The difference between Groups 1 and 3 was statistically significant (p < 0.05). The volume fraction of bone ingrowth in the tray did not differ among the 3 groups, with an overall mean of 22.5% (+/- 4.6%). At the posterolateral quadrant, Group 1 had significantly less bone ingrowth than Group 3 within the tray whether measured as the extent (63.6% +/- 20.5% versus 91.0% +/- 10.6%, p < 0.05) or volume fraction (19.1% +/- 8.8% versus 32.9% +/- 10.5%, p < 0.05). There were no between-group differences at the other quadrants. This study indicated that pegs provided no added benefit in a circumstance where sufficient initial fixation was obtained with screws.

Animals↗

The treatment of scaphoid nonunion. A review of a novel technique using precision bone grafting compared with Herbert screw fixation and bone graft.

We have retrospectively reviewed the results of 40 consecutive patients with nonunion of the scaphoid treated by the senior author (PG) between 1993 and 1996. These comprised two groups of patients. Group 1 comprised 20 patients treated between 1993 and 1994, with a Herbert screw and autograft, and Group 2, which also comprised 20 patients treated with the precision bone grafting technique which we describe. The precision bone grafting technique employs simple instrumentation to harvest bone percutaneously from the iliac crest and then insert it at the scaphoid nonunion site. The evaluation consisted of a clinical and radiological assessment of union and wrist function. Our review demonstrates a higher rate of union with the precision bone grafting technique than by the Herbert screw fixation with bone grafting.

Adult↗

A histological study of stainless steel and titanium screws in bone.

This study compared histologically the tissue response of stainless steel and titanium screws when inserted into the calvaria of eight beagle dogs for periods of 1, 4, 12, and 24 weeks. There was minimal fibrous reaction around both screw types with excellent long-term bone healing. After 24 weeks there was no discernable difference in the tissue reaction between the two types of screw.

Animals↗

A new method of fixation in osteoporotic bone. A preliminary report.

Over-tightening of cortical bone screws in osteoporotic bone results in weak fixation. Once a screw is over-tightened and the bone thread form is stripped, there are limited means at the surgeon's disposal to rescue the situation, none of them entirely satisfactory. We describe a simple device that is specifically designed to resolve this problem. It consists of a nylon cavity plug and applicator. The plug is inserted into the stripped hole and the screw re-applied and tightened in the normal manner. The plug expands and forms a load-bearing region on the inner face of the bone. Tests on osteoporotic cadavaric bone have shown that the plug effectively re-establishes screw fixation. When compared to an over-tightened screw, the plug is at least twice as resistant to loads acting to pull the screw out of the surrounding bone.

Bone Screws↗

Initial biomechanical properties of staple-anchor Achilles tendon allograft and interference screw bone-patellar tendon-bone autograft fixation for anterior cruciate ligament reconstruction in a cadaveric model.

PURPOSE: Anterior cruciate ligament (ACL) reconstruction is a common procedure that has a fairly high success rate. Despite such success, controversy exists with regard to fixation and graft type. The purpose of this study was to quantify the maximum load to failure for staple-anchor freeze-dried Achilles tendon allograft fixation compared with interference screw bone-pattelar tendon-bone autograft fixation at the time of insertion for ACL reconstruction. METHODS: Eleven pairs of cadaveric knees were prepared for ACL reconstruction by disarticulation before graft insertion. The tibia and femur were mounted separately onto an MTS machine and were loaded to failure in line with the tunnels. Femoral fixation for the allograft was provided by a staple anchor; tibial fixation was provided by a suture anchor. Titanium interference screws on the femoral and tibial sides provided autograft fixation. A paired t test was performed to compare mechanical testing results in the 2 groups. RESULTS: Mean maximum load to failure for the allograft was 58.7 N (range, 32.3 to 92.6 N) and 119.6 N (range, 82 to 165.9 N) for the femur and the tibia, respectively, compared with 228.2 N (range, 74.2 to 352 N) and 232.9 N (range, 65.1 to 553.1 N) for the autografts. This difference was statistically significant (P < .001) for femoral fixation, but it was not statistically significant for tibial fixation (P = .186). CONCLUSIONS: Soft tissue Achilles tendon allograft with staple fixation is a significantly weaker fixation construct when compared with autograft bone-patellar tendon-bone with interference screw fixation. CLINICAL RELEVANCE: This study shows significantly weaker fixation in the staple-alograft construct and yet this construct has had at least equivalent results over a 5-year time frame, indicating that rigid femoral fixation may not be a critical factor in long-term results.

Achilles Tendon↗