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PubMedDate not supplied

[Changes in the nature of the differentiation of the erythroid stem cell in the bone marrow of mice as affected by the peritoneal cells of donors subjected to bloodletting].

The influence of the peritoneal cells unstimulated by an inflammatory agent (PCs) on the bone marrow erythropoiesis in the CBA mice was studied in the normal conditions and after the massive haemorrhage. The PCs obtained from the intact or anemic donors (2, 4 and 18 h after the haemorrhage) were introduced intraperitoneally into the intact syngeneic recipients. The massive haemorrhage induces a special type of differentiation of erythroid cells in bone marrow, "reserve erythropoiesis", which is characterized by a decrease, within four days, in the proliferation of basophilic proerythrocytes, stimulation of proliferation of polychromatophilic proerythrocytes and entry of oxyphilic proerythrocytes into mitosis. The transplantation of the PCs from the anemic donors induced the "reserve erythropoiesis" in the bone marrow of the recipients. The transplantation of the PCs from the intact donors did not induce the "reserve erythropoiesis" and appeared to inhibit erythropoiesis via lengthening the time of mitoses in polychromatophilic and basophilic proerythrocytes.

Anemia↗
PubMed1996

P. C. A. Louis and the birth of clinical epidemiology.

Pierre Charles Alexandre Louis (1787-1872) has been the direct or indirect mentor of influential U.S. and English scientists in public health, epidemiology, medicine, and biostatistics during the 19th and 20th century. Louis was primarily a clinician, but his name has been more closely associated with the history of epidemiology. There is an imbalance between the fame of Louis's scientific contribution and the scarcity of in depth analyses of his work. The controversy related to the usage of bloodletting for treating inflammatory diseases is one of the most famous episodes of Louis's work. A modern analysis of Louis's data confirms his original conclusions; that is, early bloodletting seems to reduce the duration of a pneumonitis disease in patients who survive from this disease but may also increase the overall short-term mortality. Some basic algebraic mistakes in computations of means tend to attenuate the verdict against bloodletting, but these are trivial relative to the rigor of the overall demonstration and to Louis's methodological contribution to clinical observation. Louis firmly belongs to the history of epidemiology. He deserves a similar place in the history of medicine.

Epidemiology↗
PubMed1979

Improvement in pulmonary function with diuretic therapy in the hypervolemic and polycythemic patient with chronic obstructive pulmonary disease.

Central hemodynamics and gas exchange were studied in six patients with chronic obstructive pulmonary disease (mean age, 60 years). Patients were selected for the study if the volume of blood was 1 L larger than the predicted normal value, if there was no history of infection, and if no drug assumed to influence pulmonary circulation had been given during the last four weeks. Measurements were first performed in the hypervolemic state. This was followed by a venesection of 0.5 L, and the measurements were repeated 15 minutes later (immediate effects of dehydration). After two weeks to two months of intensive diuretic therapy, new measurements were performed (long-term effects of dehydration). With hypervolemia, there was pulmonary hypertension, increased pulmonary vascular resistance, and normal cardiac output. The arterial oxygen tension (PaO2) was markedly reduced. The arterial carbon dioxide tension (PaCO2) was increased in two patients, and dead-space ventilation (VD/VT) increased in all. The sole immediate effect of venesection was a small increase in heart rate and a reduction in PaCO2. The long-term effects were a maintained low blood volume (on the average, 0.7 L less than before bloodletting) and lowered hematocrit reading (8 percent less than before bloodletting), a reduced and in some patients normalized pulmonary arterial pressure, a reduced pulmonary vascular resistance, and an unchanged cardiac output. The PaO2 improved, while PaCO2 did not change; neither did VD/VT. The changes correlated partly with the diminution in blood volume and partly with the reduction in hematocrit reading.

Aged↗
PubMedDate not supplied

[Use of traditional methods in medicine for treating moderately severe bronchial asthma].

Minor therapeutic "cups" bloodletting, a variety of little known in Russia but conventional in China method, was compared in efficiency to chemotherapy, acupuncture and phytotherapy in allergic and non-allergic forms of bronchial asthma. The bloodletting alone or in combination with acupuncture and phytotherapy stabilizes the course of asthma and prevents asthmatic attacks, reduces routine doses of necessary broncholytics and glucocorticosteroids.

Acupuncture↗
PubMed1992

A study of erythropoiesis and iron metabolism in the rabbit in vivo. II. Dependence of the response on iron storage and transport.

Rabbits subjected to a daily bloodletting schedule of 10 ml blood per kg body weight increase four- or fivefold their erythropoietic production compared to normal non-bled animals. The maximum response they can reach under these conditions mobilizes more than 9 mg of iron per day per rabbit into hemoglobin. When fed ad libitum with their regular diet, they do not need any further iron supplement for full erythropoiesis. The experimental increment in iron body stores and/or serum iron levels does not enhance their erythropoietic response, demonstrating that iron is not rate limiting under the conditions studied. Furthermore, although serum iron levels are elevated onefold in the controls under chronic anemia with respect to non-bled animals, the concentration of serum transferrin is only slightly increased; hence, the iron saturation of this protein changes from a 50% to an 80% level. In the absence of an extra supplement of iron, rabbits subjected to chronic bloodletting show no signs of body iron depletion, as judged by their continuous macrocytic RBC production.

Anemia↗