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At least 253 records · Page 14Linked to original sources
PubMed1995

Human chromosome-specific cDNA libraries: new tools for gene identification and genome annotation.

To date, only a small percentage of human genes have been cloned and mapped. To facilitate more rapid gene mapping and disease gene isolation, chromosome 5-specific cDNA libraries have been constructed from five sources. DNA sequencing and regional mapping of 205 unique cDNAs indicates that 25 are from known chromosome 5 genes and 138 are from new chromosome 5 genes (a frequency of 79.5%). Sequence complexity estimates indicate that each library contains -20% of the approximately 5000 genes that are believed to reside on chromosome 5. This study more than doubles the number of genes mapped to chromosome 5 and describes an important new tool for disease gene isolation.

Base Sequence↗
PubMedDate not supplied

Annotation: care of children in hospital. The European Association for Children in Hospitals.

The Charter for Children in Hospitals, drawn up by professional and women's groups from a number of European countries at the First Conference for the Care of Children in Hospital (Netherlands 1988) presents many fine guidelines for protecting the rights of children and their parents before, during and after hospitalization. The development of these guidelines, their current acceptance in Europe and the psychological principles underlying them, are outlined here.

Child↗
PubMedDate not supplied

Annotation. Recent biochemical and immunological observations in multiple sclerosis.

As there is evidence of early biochemical and histological changes in the normal-appearing white matter in MS, which appear to be independent of or precede demyelination, the formation of plaques may be incidental to a more primary lesion. The finding of persistently increased levels of IgG in the CSF of patients with MS points to an ongoing immune reaction in the CNS, possible against an infective agent; but virus-specific antibodies account for only a small proportion of IgG in the CSF. Furthermore, in vitro assays of T cell function suggest that there may be a regulator T cell defect in MS. Salk and colleagues (1980) have postulated that MS may be a disorder, attributable to multiple inducing agents, which is potentiated through deregulation of lymphocyte function.

Animals↗
PubMedDate not supplied

Annotation. Action of pyrethroid insecticides on the vertebrate nervous system.

The neurotoxic action of the synthetic pyrethroid insecticides has received much interest in recent years, as the number of available pyrethroids and their practical applications have greatly increased. Although the majority of pyrethroids have a low oral toxicity to mammals, they may cause severe neurotoxic symptoms whenever they reach the nervous system in sufficient amount. The principal effect of pyrethroids in the vertebrate nervous system is to induce repetitive activity, particularly in the sensory nervous system. This repetitive activity originates from a prolongation of the transient increase in sodium permeability of the nerve membrane associated with excitation. Available evidence indicates that pyrethroids primarily interfere with the sodium channels in the nerve membrane. All active pyrethroids affect sodium channel gating in a similar manner, but marked differences in neurotoxic activity exist between the various pyrethroids, especially between alpha-cyano and non-cyano compounds.

Animals↗