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PubMed1999

Citizen Involvement in Waste Management: An Application of The STOPER Model via an Informed Consensus Approach.

/ Waste management planning and implementation is not only a technological issue, but a social and political one as well. In this paper, we discuss a proposal to rethink certain aspects about waste management planning and implementation. Specifically, we present a framework whereby the ordinary citizen can proactively and constructively participate in the decision-making process. After briefly discussing the STOPER research team and certain limits inherent in current waste-management practices, we propose a mode of consultation known as the informed consensus approach. We assert that this approach incorporates social perceptions of key intervenors such as experts, decision makers, interest groups, and ordinary citizens and that this can enrich the decision-making process concerning complex environmental issues such as waste management. We focus our presentation on the results of the application of an informed consensus approach to waste management strategies in the municipality of Sherbrooke (Québec, Canada). KEY WORDS: Informed consensus; Public participation; Decision-making process; Social acceptability; Waste management

Journal Article↗
PubMed2004

A.B. Frank and mycorrhizae: the challenge to evolutionary and ecologic theory.

A. B. Frank's observations and hypotheses about mycorrhizae in 1885 flew in the face of conventional thinking of the time. He reported that what we now term ectomycorrhizae were widespread on root systems of many woody plant species in a great diversity of habitats and soils. He hypothesized that mycorrhizae represent a pervasive mutualistic symbiosis in which fungus and host nutritionally rely on each other; that the fungus extracts nutrients from both mineral soil and humus and translocates them to the tree host; and that the tree, in turn, nourishes the fungus. Initially opposed by much of the scientific community, nearly all of Frank's major hypotheses have since been unequivocally demonstrated, although many decades were required to achieve conclusive evidence. Nonetheless, the revolution in thinking about plant and fungal evolution, ecology and physiology generated by Frank is still in the process of acceptance by much of the scientific community, 120 years and tens of thousands of scientific papers since he coined the term "mycorrhiza". The reasons for this extraordinary lag time in themselves present an intriguing research subject.

Biological Evolution↗
PubMed2006

Acceptance of chronic pain.

The experience of chronic pain can be associated with significant distress and disability; however, this is not always the case. Although attempts to control or reduce pain can be helpful for many pain sufferers, on some occasions this is not an effective option and a different response is required. This different response can include a flexible mix of control and acceptance. The acceptance part of this mix entails a willingness to have pain, or other uncomfortable private experiences, without taking action to control or eliminate them. At least 15 laboratory and clinical studies make the growing case for the role of acceptance in the functioning of people with chronic pain, and evidence from treatment outcome studies is promising. It appears that acceptance-related processes will at least expand our range of psychologic treatment methods for chronic pain sufferers and, at best, significantly improve them.

Adaptation, Psychological↗
PubMed1988

Assessing changes in vaginal bleeding patterns in contracepting women.

In clinical trials comparing alternative contraceptive methods, women often discontinue for disturbances in menstrual bleeding patterns. Vaginal bleeding diaries have been used to monitor these patterns, and this paper suggests two new methods of analysis of these data. One analysis measures trends over time in the occurrence of specific patterns and, a second analysis, the relation between a woman's current experience and the probability of continuing method use. Contrasts between these approaches and the reference period method of analysis are made. A randomised clinical trial of the relative efficacy of 100 and 150 mg doses of depot-medroxyprogesterone acetate (DMPA) is used for illustration.

Amenorrhea↗
PubMed1990

Characteristics of condom use and associated problems: experience in Bangladesh.

Data from the 1983 Bangladesh Condom User Survey (BCUS) are analyzed for patterns of condom use and various problems directly influencing their effectiveness. The survey was undertaken to explain an apparent gap between reports of the number of condoms distributed in certain areas compared with prevalence of users as reported in contraceptive prevalence surveys. These data are analyzed from behavioral and management perspectives to identify various factors influencing utilization, with potential implications for understanding and improving family planning and AIDS/STD prevention service systems. Patterns of use are related to differences in source of supply through public, free or private-priced systems, differences in urban or semi-rural place of residence, and differences in perceptions of men or women. The problem with condom use most often identified by the respondents was breakage.

Adult↗
PubMed1991

Strategic control at the CEO level.

This study of 108 corporations is intended to identify and validate those strategic control factors that contribute directly to the success of strategic decisions made at the level of the CEO which are subsequently implemented throughout the organization. In direct response to a comprehensive questionnaire, 61 CEOs rated nine strategic control factors. Only the ratings of CEOs were accepted and processed in this study. Their ratings revealed areas of obvious strength and correctable weakness in their perceptions of strategic control within their respective organizations. These ratings tended to validate a conceptual process model of strategic control.

Administrative Personnel↗
PubMed1994

Fluctuation test for two-stage mutations: application to gene amplification.

The determination of mutation rates is an important experimental procedure for characterizing mutation processes. The accepted method of determining mutation rates, the fluctuation test, was introduced by Luria and Delbrück in 1943. Since then it has been applied to various microorganisms and cells. The Luria-Delbrück test is based on a restrictive hypothesis of mutations being due to single irreversible events. However, some inherited changes in phenotype, like gene amplification, may be due to two or more genetic changes, some of which may be reversible. The Luria-Delbrück model of mutation was compared to other models which included reversibility and more than one mutation stage. The Luria-Delbrück model has been confirmed to be consistent with the original bacteriophage resistance data. However, for gene amplification this model gives incompatible estimates of mutation rates by the P0 and r methods. Relaxing the hypotheses of the single-stage models did not improve the fit. In contrast, a two-stage reversible model provided a fit. Analysis of gene amplification data by the two-stage reversible model provides new information, including estimates of rates for each of the two forward stages and of the reverse step.

Animals↗
PubMed2006

Preanalytical aspects of quantitative TaqMan real-time RT-PCR: applications for TF and VEGF mRNA quantification.

OBJECTIVES: The present paper focuses on preanalytical aspects of tissue factor (TF) and vascular endothelial growth factor (VEGF) mRNA quantification: the choice of blood collection tubes and defining the time frame allowed before processing the sample. DESIGN AND METHODS: Blood was collected from healthy volunteers in K(3) EDTA tubes, CPT, endotoxin-free EndoTube tubes and in PAXgene tubes. Total RNA concentration was determined by absorbance readings at 260 nm with a GeneQuantII UV spectrophotometer. RNA quantity and quality were also determined by the Lab on a Chip technique (Agilent 2100 Bioanalyzer). Real-time RT-PCR assays were performed by the TaqMan technology. RESULTS: The more expensive PAXgene and CPT tubes and the Endo tubes did not give superior results from those obtained in inexpensive routine K(3) EDTA tubes. The PAXgene tubes preserved high molecular mass rRNA better than the other tubes. CONCLUSION: Both the PAXgene system and routine EDTA tubes are suitable for clinical purposes aimed at quantitation of mRNA for TF and VEGF. PAXgene yielded rRNA that was less degraded but had lower mRNA per microg extracted RNA. A time frame up to 24 h until sample processing is acceptable for TF and VEGF mRNA.

DNA, Complementary↗
PubMed2005

Mechanism-based inactivators of plant copper/quinone containing amine oxidases.

Copper/quinone amine oxidases contain Cu(II) and the quinone of 2,4,5-trihydroxyphenylalanine (topaquinone; TPQ) as cofactors. TPQ is derived by post-translational modification of a conserved tyrosine residue in the protein chain. Major advances have been made during the last decade toward understanding the structure/function relationships of the active site in Cu/TPQ amine oxidases using specific inhibitors. Mechanism-based inactivators are substrate analogues that bind to the active site of an enzyme being accepted and processed by the normal catalytic mechanism of the enzyme. During the reaction a covalent modification of the enzyme occurs leading to irreversible inactivation. In this review mechanism-based inactivators of plant Cu/TPQ amine oxidases from the pulses lentil (Lens esculenta), pea (Pisum sativum), grass pea (Lathyrus sativus) and sainfoin (Onobrychis viciifolia,) are described. Substrates forming, in aerobiotic and in anaerobiotic conditions, killer products that covalently bound to the quinone cofactor or to a specific amino acid residue of the target enzyme are all reviewed.

Amine Oxidase (Copper-Containing)↗
PubMed2006

Response phases in methadone treatment for chronic nonmalignant pain.

Although studies on the beliefs of persons with chronic nonmalignant pain (CNMP) are still scarce, methadone is increasingly prescribed for the treatment of CNMP. This qualitative case study uses semistructured interviews to explore the beliefs of 11 patients with CNMP and the challenges they faced coming to terms with and integrating methadone treatment into their lives. The study identifies a two-phase process of acceptance and integration. In the first phase, during acceptance of the prescribed methadone treatment, initial beliefs were mostly determined by the societal stigma that "methadone is for junkies." Different influencing factors such as knowledge about methadone for pain management, family support, and trust in physicians changed behavior in a positive way. In the second phase, patients dealt with the degree of disclosure about their treatment. Full disclosers have no problem in telling others that they were being treated with methadone, whereas partial disclosers were more selective. They were confronted with various barriers: negative encounters with family, friends, and the public; past addict experiences; safety issues; and obstacles within the health care system. As a result of these challenges, their beliefs were summarized as: "others think I'm an addict," and "methadone can harm me and/or my family."This study highlights the important role nurses have in the education of patients on the use of methadone in pain management, and in assisting patients with CNMP to gain confidence and a greater sense of control to cope with the challenging issues related to disclosing information.

Adaptation, Psychological↗
PubMed2004

Living & learning with allergy: a European perception study on respiratory allergic disorders.

BACKGROUND: Knowledge of allergy patients' perception of own disease is inadequate, and understanding of the impact of local environment, including family and health-care system, on patients' management of disease is insufficient. We examined the potential of telephone-based survey techniques for establishing this knowledge in 10 European countries. METHODS: A two-phased questionnaire developed by use of focus groups in seven countries was translated into 10 languages. To ensure that the true values of the populations were restored in randomly selected populations, 75,343 telephone numbers selected for screening represented balanced national distributions of households. RESULTS: Eight thousand two hundred and sixty-eight respiratory allergy sufferers were identified by the telephone screening process. 85.4% accepted to participate in the survey and 89.6% completed both phases comprising 34 questions and rating of 49 statements. Data for each country were weighted in terms of age, sex and the recorded allergy prevalence within age intervals. CONCLUSIONS: The telephone survey technique allowed for establishment of random representative samples, and application of mathematical weighting procedures assured that the true national values were restored in the data set. As all interviews were performed in a standardised manner we conclude that the telephone-based survey methodology enables national representative data set to be established and compared.

Adaptation, Psychological↗
PubMed1991

Further analysis of contraceptive failure of the ovulation method.

Reanalysis of data on the ovulation method of natural family planning collected by the World Health Organization yields the following conclusions. The method is effective during perfect (correct and consistent) use, with a first-year probability of failure of 3.4%. However, it is extremely unforgiving of imperfect use, with a first-year probability of failure of 84.2% if the method is not used correctly. During the initial year, 87% of the cycles were characterized by perfect use. Nevertheless, the 13% of cycles characterized by imperfect use had a tremendous impact on the overall failure rate. During the first year of typical use 22.5% of the women in the clinical trial became accidentally pregnant.

Adult↗
PubMed2001

A review of structure-based biodegradation estimation methods.

Biodegradation, being the principal abatement process in the environment, is the most important parameter influencing the toxicity, persistence, and ultimate fate in aquatic and terrestrial ecosystems. Biodegradation of an organic chemical in natural systems may be classified as primary (alteration of molecular integrity), ultimate (complete mineralization; i.e. conversion to inorganic compounds and/or normal metabolic processes), or acceptable (toxicity ameliorated). Most of the biodegradation correlations presented in the literature focus on the characterization of primary or ultimate, aerobic degradation. The US Environmental Protection Agency (USEPA) is charged with determining the risks associated with the thousands of chemicals employed in commerce, an effort that is being facilitated through much research aimed at reliable structure-activity relationships (SAR) to predict biodegradation of chemicals in natural systems. To this end, models are needed to understand the mechanisms of biodegradation, to classify chemicals according to relative biodegradability, and to develop reliable biodegradation estimation methods for new chemicals. Frequently, published correlations associating molecular structure to biodegradation will attempt to quantify the degradability of a limited set of homologous chemicals. These correlations have been dubbed quantitative structure biodegradability relationships (QSBRs). More scarce and valuable to researchers are those models that predict the biodegradability of compounds possessing a wide variety of chemical structures. The latter may use any of several techniques and molecular descriptors to correlate biodegradability: QSBRs, pattern recognition, discriminant analysis, and principle component analysis (PCA), to name several. Generally, models either predict the propensity of a chemical to biodegrade using Boolean-type logic (i.e. whether a chemical will "readily biodegrade" or not), or else they quantify the degree of biodegradation by providing information such as rate constants. Such quantitative predictions of biodegradability come in a diversity of parameters, including half-lives, various biodegradation rates and rates constants, theoretical oxygen demand (ThOD), biological oxygen demand (BOD), and others. In this paper, after describing the advantages and disadvantages of the various biodegradation estimation methods found in the literature, the best models are compared to conclude which provide the greatest utility for determining the biodegradability of chemicals with widely varying structures. The group contribution technique presented by Boethling et al. [Environmen. Sci. Technol. 28 (1994) 459] appears to be the most advantageous for use in broad screening for tendency to biodegrade. The model is simple to use, calculating a probability of biodegrading ranging from 0 (none) to 1 (certain), and has proven to be accurate for a wide range of chemical structures, as established by the large, high-quality data set (BIODEG evaluated biodegradation database, Syracuse Research Corporation, Merrill Lane, Syracuse, NY 13210) used to develop this correlation. The authors, therefore, recommend the method of Boethling et al. [Environ. Sci. Technol. 28 (1994) 459] for the initial screening of chemicals to aid in determining whether additional information is necessary to establish relative biodegradability. For readers with applications requiring more quantitative results, such as biodegradation rate constants, enough model details are presented in this paper to allow the reader to pick a suitable correlation, although the reader is cautioned to consult the original, primary reference for the complete method description, equations, and limitations.

Biodegradation, Environmental↗
PubMed2000

Comparison of BACTEC MGIT 960 and BACTEC 460 for culture of Mycobacteria.

We have compared the BACTEC 460 system with the BACTEC MGIT 960 system for culture of mycobacteria from 1800 routine clinical specimens. Rate of isolation of M. tuberculosis and time to detection of positive culture was comparable for both systems (BACTEC 460, 35 isolates, BACTEC MGIT 960, 34 isolates). Contamination of cultures was more common with the BACTEC MGIT 960 system. With intensification of the decontamination process an acceptable contamination rate was achieved in the BACTEC MGIT 960 system but time to detection of positive culture was increased by 1 to 2 days.

Bacteriological Techniques↗
PubMed1999

Producer quality assurance programs.

Essentially all animal commodity organizations have established quality assurance programs designed to ensure food safety and quality. Most of these programs were originally implemented to address problems with veterinary drug residues. Many of the current programs have or plan to include food safety critical control points with specific guidelines on how to control or reduce pathogen load. The continued focus placed on food safety by today's consumer demands that American producers ensure that their commodities are wholesome, safe, and of high quality in order to remain competitive in the global marketplace. Veterinarians should recognize that it is important to encourage food animal producers to participate in quality assurance programs for their clients' economic health and for food safety and protection of public health. Commodities certified as being produced under good production practices or by producers certified as following a recognized and validated quality assurance program often bring a premium price. Also, some slaughter establishments are beginning to require producers to be certified as practicing under a recognized quality assurance program before animals are accepted for processing. This practice is being driven partially by the demands placed on slaughter establishments by the US Department of Agriculture's implementation of the Pathogen Reduction, Hazard Analysis and Critical Control Point Systems regulation. Regardless of why producer trade association quality assurance programs have come into existence, veterinarians should promote the programs as an excellent mechanism to help ensure everyone's goal of a safe, wholesome food supply.

Animals↗
PubMed1994

The development of a massage service for cancer patients.

Despite major technological advances in the treatment of cancer, many patients are dissatisfied with conventional biomedical interventions. This is largely because they fail to resolve long term intractable problems such as chronic pain or stress. More emphasis is now being placed on quality of life. This shift in attitude has opened the door for complementary therapies as adjuvants to traditional models of cancer care. Changes within the NHS have facilitated this transition, by the creation of the 'internal market' and the development of central funding to individual clinical directorates. To exploit these opportunities, complementary, therapists must develop new skills and be prepared to adopt NHS standards of assessment to evaluate the efficacy of their work. Standards are a component of 'Quality assurance'. They are observable, achievable and measurable, and contribute towards an acceptable evaluation process. Standards are used by health care purchasers to assess which therapies should be made available to patients within the NHS. This paper describes the development of a massage service that has been integrated into the Hammersmith Oncology Department. The massage standard is seen to be fundamental and essential to the continued development and evaluation of the project.

Ancillary Services, Hospital↗