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Sushil Kumar Verma v. Usha, 30 August 1983.

The husband plaintiff petitioned for divorce on the ground of cruelty after his wife became pregnant one month after their marriage and had the fetus aborted at a government-approved pregnancy termination centre without telling him of either the pregnancy or the abortion. The Court granted the petition, holding that the abortion of a fetus during the first pregnancy by a deliberate act without the husband's consent constitutes cruelty under Section 13(1)(ia) of the Hindu Marriage Act of 1955. It also stated that if one party to a marriage deliberately avoids procreation without the consent of the other spouse, the very purpose of the marriage is frustrated.

Abortion, Induced↗

Prenatal diagnosis of congenital adrenal hyperplasia (21-hydroxylase deficiency) in Croatia.

We report on the prenatal diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase in 20 at-risk pregnancies (16 salt-wasting and 4 simple virilizing families). We have diagnosed 3 affected fetuses (2 males and 1 female), 3 healthy homozygotes (2 males and 1 female), and 14 healthy heterozygotes (7 females and 7 males). These data were collected over 4 years. In 16 fetuses, the diagnosis was made with measurements of 17-hydroxyprogesterone (17-OHP) and delta-4-androstenedione (delta) in amniotic fluid (AF), human leukocyte antigen (HLA) typing of amniotic cells, as well as karyotypes between the 16th and 18th weeks of gestation. In 4 fetuses, DNA analysis of amniotic cells was also performed. In 3 pregnancies in which affected fetuses were suspected (on the basis of HLA typing and measurements of 17-OHP and delta concentrations in AF), the fetuses were electively aborted between the 17th to 19th weeks of gestation by parental decision. In all aborted fetuses, diagnosis was confirmed with HLA typing, autopsy findings of hyperplastic adrenal glands, and ambiguous genitalia in female fetuses. Postnatal diagnosis was confirmed in healthy fetuses with HLA typing and serum measurements of 17-OHP concentrations, and in 4 of them with DNA analysis. In 3 of the 4 families, DNA analyses revealed the following mutations: in Family 1, the index case mutation was Intron 2, Exon 3/Exon 6, and the fetus was Normal/Exon 6; in Family 2, the index case mutation was Ex1 Int2 Ex3/ Int2, and the fetus was Ex1 Int2 Ex3/Normal; and in Family 3, the index case mutation was Ex8(356)/Ex8(356), and the fetus was Ex8(356)/ Normal. We also report one case of prenatal diagnosis and treatment. Dexamethasone 0.5 mg BID (20 micrograms/kg/d) was given starting at 6th week of gestation. Prenatal diagnosis suggested, but did not prove, that the female fetus was a heterozygote as the fetus lacked the paternal mutation Ex8(318). No mutation was found in the mother. The fetus, the mother, and the affected sib shared a haplotype, further suggesting heterozygosity. The unaffected status was confirmed postnatally.

17-alpha-Hydroxyprogesterone↗

[Neospora caninum causes abortions in a cattle herd in North Rhine Westphalia].

In a cattle herd in North Rhine-Westphalia a series of eight abortions occurred between 15th August and 14th October, 1996. Four of the aborted fetuses were histopathologically, virologically, bacteriologically and parasitologically examined. A multifocal necrotising encephalitis was observed in two fetuses. In addition, the liver of two fetuses and the placenta of one fetus contained infected foci. In three fetuses protozoan stages were detected which were identified as N. caninum by immunohistochemistry. A polymerase chain reaction conducted with histological material revealed N. caninum-DNA in the placenta of an aborted fetus. When seven cows that had aborted were tested for antibodies directed against N. caninum, six animals were positive by immunofluorescence and all seven by immunoblotting. The serological examination of the entire herd revealed a high herd seroprevalence of antibodies directed against N. caninum. Potential modes of infection with N. caninum in the herd are discussed, in particular the possibility of exposure to a point source (definitive host).

Abortion, Veterinary↗

[Demonstration of immunoglobulin levels in aborted bovine fetuses in relation to the results of histological, microbiological and viro-serological investigations].

In the pectoral body fluid or in the stomach contents of 63 aborted foetuses, IgG and IgM was demonstrated in 38 foetuses from the fourth month to the end of pregnancy. Out of the 38 foetuses in which immunoglobulins were found to be present, 23 had a positive bacteriological finding. In one case in which Streptococcus agalactiae was isolated, neither IgG nor IgM was found. In the foetuses with a positive bacteriological finding, IgG was found in the body fluid at the average level of 36.75 mg in 14 foetuses, and in the stomach contents at the average level of 17.48 mg per 100 ml in 17 foetuses. IgM was detected in nine foetuses, and in two cases the average level was 7.16 mg and 12.6 mg per 100 ml. In the foetuses with a negative bacteriological finding IgG was found in 14 body fluid samples at the level of 15.06 mg, and in nine foetuses IgG was present in the stomach contents at the level of 17.26 mg per 100 ml; IgM was found in three body fluid samples at the average level of 14.12 mg per 100 ml. Antibodies were demonstrated in the PI3 virus in 28 foetuses and in the BVD-MD virus in 35 foetuses. The serological examination with other antigens was negative. A suspected and positive histological finding was obtained in 30.2% of the foetuses studied. Immunoglobulins were detected in 43.5% of the foetuses with a positive and suspected histological finding. Immunoelectrophoretic examination revealed IgG in 24 foetuses and IgM in 12 foetuses. Transferrin was not demonstrated in nine foetuses at the age from the fifth to the seventh month of pregnancy. Albumin, alpha, and beta-globulins were demonstrated to be present in all foetuses.

Abortion, Veterinary↗

Candidosis and aspergillosis as autopsy findings from 1994 to 2003.

We analysed the autopsy records of the Greifswald University Institute of Pathology (located in Eastern Germany) in respect of findings of candidosis and aspergillosis from 1994 to 2003. We also present eight immature aborted fetuses and premature infants with a mycosis. In a total of 2027 autopsies we found 164 cases of invasive candidosis and aspergillosis (8.1%) including a combination of both on four occasions. Other authors cited between 0.7 and 7.3%. In these 10 years in our material mycoses and in particular candidosis increased in spite of slightly decreased numbers of autopsies. The differences comparing the 5-years periods (1994-98 and 1999-2003) are highly significant for both mycoses and candidosis. They are not significant for aspergillosis. A similar relationship was observed in the distribution of mycotic organs and causative origin for candidosis alone. In the last 5 years the gastrointestinal and respiratory tracts, including the peritoneum, were more frequently infected by Candida. Non-haematological neoplasia and pneumonia as basic diseases more often appeared in cases of candidosis. All eight immature aborted fetuses and premature infants suffered from candidosis. The survey confirms the importance of autopsy as a tool for education and quality control in medical diagnostic and therapeutic activity in the field of mycoses, too.

Aborted Fetus↗