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PubMed2005

Longitudinal changes in dietary intake in Scottish women around the menopause: changes in dietary pattern result in minor changes in nutrient intake.

OBJECTIVE: To examine dietary change that has occurred over 5 to 6 years. SUBJECTS: A cohort of Scottish women (n=898) with a mean age of 47.5 years (range 45-54 years) at baseline. DESIGN: Dietary intake was assessed by validated food-frequency questionnaire (FFQ) and analysed using the UK Composition of Foods database. RESULTS: Since the first dietary assessment, mean daily energy intake had decreased from 8.2+/-2.3 to 7.9+/-2.2 MJ. The degree of low energy reporting (defined as ratio of energy intake to basal metabolic rate <1.1) had increased from 18.7% at baseline to 25.6% at follow-up. Low energy reporters were significantly heavier than 'normal' energy reporters (mean weight at follow-up, 68.9+/-12.6 vs. 66.8+/-11.3 kg) and could be deliberately restricting intake rather than underreporting. Overall there were decreases in intakes of red meat, processed meat and cheese, but increases in poultry and non-oily fish consumption. Consumption of bread, biscuits and cakes had gone down and there was an increase in cereal and rice/pasta consumption. Intake of potatoes had decreased whereas fruit intake had increased. There were small but statistically significant differences in intakes for most nutrients (<8% change). Nutrient intakes at both visits were similar across menopausal status and usage groups of hormone replacement therapy. Modifications to the computer version of the McCance and Widdowson nutrient database, which differed from the published version, were noted. These changes altered the original baseline values for our study. CONCLUSIONS: The menopause per se is not a period of marked change in nutrient intake. Caution is advised when using computer databases of food compositions for longitudinal studies.

Basal Metabolism↗
PubMed2006

Longitudinal changes in central corneal thickness and their relation to glaucoma status: an 8 year follow up study.

AIMS: To determine if central corneal thickness (CCT) changes over time and if this change relates to glaucoma progression. METHODS: 39 patients (64 eyes) with open angle glaucoma, ocular hypertension, glaucoma suspect status, or a normal eye examination were examined at two visits. CCT, age, race, sex, family history of glaucoma, presence of diabetes and systemic hypertension, diagnosis, visual acuity, spherical equivalent, intraocular pressure, vertical and horizontal cup to disc ratios, number of glaucoma medications prescribed, Advanced Glaucoma Intervention Study (AGIS) score and mean deviation of Humphrey visual fields, and interventions required were recorded. Statistical analysis used the Wilcoxon signed ranks test, linear regression, and analysis of variance. RESULTS: Between the two visits (mean 8.2 years apart), mean CCT decreased by 17 mum in right eyes (p<0.002) and by 23 mum in left eyes (p<0.001). This decrease was greater in right eyes of patients with primary open angle glaucoma than in normals (p = 0.041). There was no significant association between change in CCT and other examination parameters. Change in CCT was not associated with topical carbonic anhydrase inhibitor use. CONCLUSION: In this longitudinal study, CCT decreased over time, but this may not be related to glaucoma progression.

Adult↗
PubMed1992

Longitudinal changes in adjustment after spinal cord injury: a 15-year study.

Research on changes in adjustment after spinal cord injury (SCI) has produced mixed results. Whereas cross-sectional research has suggested that adjustment declines with increasing age, but improves with greater time since injury, longitudinal research has suggested that some limited positive changes in adjustment occur over an 11-year period. The purpose of the current study was to identify the stability of adjustment over a 15-year period after SCI. One hundred thirty-five participants with SCI completed Life Situation Questionnaires (LSQ) in both 1974 and 1989. T-test comparisons were made on five adjustment scales and 15 individual items. The results suggested several positive changes in adjustment during the 15 years including increased sitting tolerance, more years of education, greater satisfaction with finances and employment, and a higher percentage of persons working. Decreases were noted in the number of hospitalizations and the number of days hospitalized. Given the average number of years since injury (9.3 years in 1974; 24.3 years in 1989), the results suggest that adjustment will at worst be stable, and at best will improve significantly with time.

Adult↗
PubMed2005

Longitudinal changes in the visual field and optic disc in glaucoma.

The nature and mode of functional and structural progression in open-angle glaucoma is a subject of considerable debate in the literature. While there is a traditionally held viewpoint that optic disc and/or nerve fibre layer changes precede visual field changes, there is surprisingly little published evidence from well-controlled prospective studies in this area, specifically with modern perimetric and imaging techniques. In this paper, we report on clinical data from both glaucoma patients and normal controls collected prospectively over several years, to address the relationship between visual field and optic disc changes in glaucoma using standard automated perimetry (SAP), high-pass resolution perimetry (HRP) and confocal scanning laser tomography (CSLT). We use several methods of analysis of longitudinal data and describe a new technique called "evidence of change" analysis which facilitates comparison between different tests. We demonstrate that current clinical indicators of visual function (SAP and HRP) and measures of optic disc structure (CSLT) provide largely independent measures of progression. We discuss the reasons for these findings as well as several methodological issues that pose challenges to elucidating the true structure-function relationship in glaucoma.

Adult↗
PubMed1996

Natural history of prostatism: longitudinal changes in voiding symptoms in community dwelling men.

PURPOSE: We report the results of 3 contacts during 42 months of The Olmsted County Study of Urinary Symptoms and Health Status Among Men, a longitudinal cohort study of men 40 to 79 years old that was initiated in 1990 to describe changes in lower urinary tract symptom severity. MATERIALS AND METHODS: At baseline and followup, men completed questionnaires that elicited urinary symptom severity with questions nearly identical to those of the American Urological Association symptom index: RESULTS: Overall, there was an average increase in American Urological Association symptom index of approximately 0.18 (95% confidence interval 0.13 to 0.24) points per year of followup. The average annual symptom score slope and variability in slope increased with patient age at baseline from a mean of 0.05 +/- 1.06 (standard deviation) per year among men in the forties to 0.44 +/- 1.35 per year for men in the sixties, and decreased to 0.14 +/- 1.42 per year for men in the seventies. The age-related changes in symptom severity mirror previous estimates of prostatic growth from autopsy prevalence studies. CONCLUSIONS: These results demonstrate a slow but measurable progression in urinary symptom severity among community dwelling men for 42 months of followup.

Adult↗
PubMed2003

Longitudinal changes in bone mineral density during normal pregnancy.

Pregnancy is a common physiological event that could affect peak bone mass and the risk of developing osteoporosis later in life. There have been few longitudinal studies over a complete reproductive cycle of any size to show whether bone mineral density (BMD) changes. We have measured BMD by dual-energy X-ray absorptiometry in 46 normal women before conception and then again immediately after delivery and compared them with 30 control women who failed to conceive. Fifteen women were osteopenic in preconceptual BMD, but there was no difference between those who did or did not become pregnant. During pregnancy there was a small and statistically nonsignificant decline in BMD at all sites. The decrease at the trochanteric region was 4.2%, while losses at other sites were about 1%. The decline at the trochanter exceeded the least significant change between two measurements (5.04%) in 17 women (40.5%) with significant changes within individuals being much less common at the other measurement sites. The nonpregnant controls showed small increases in BMD of 0.3%-1.9% but no woman lost more than the least significant change. At the trochanter there was a significant difference (P = 0.013) between those who did and did not become pregnant. There was a good correlation between changes in BMD at all sites and no significant difference in the slope of these correlations between the pregnant and control groups. Correlations with lumbar spine were total hip, r = 0.46, P = 0.0001; femoral neck, r = 0.49, P = 0.0005; and trochanter, r = 0.66, P < 0.0001.

Absorptiometry, Photon↗
PubMed1998

Longitudinal changes in fatness in white children: no effect of childhood energy expenditure.

Reduced energy expenditure may predispose children to the development of obesity, but there are limited longitudinal studies to support this theory. We studied 75 white, preadolescent children over 4 y by taking annual measures of body composition and resting energy expenditure (by indirect calorimetry) and two annual measures of total energy expenditure and physical-activity-related energy expenditure (by doubly labeled water). Body composition of parents was assessed at the onset of the study with use of underwater weighing. The major outcome variable was the individual rate of change in fat mass (FM) adjusted for fat-free mass (FFM). The influence of sex, energy expenditure components, initial FM, and parental FM on the rate of change in FM was analyzed by hierarchical linear modeling and analysis of variance. The rate of change in absolute FM was 0.89 +/- 1.08 kg/y (range: -0.44 to 5.6 kg/y). The rate of change in FM adjusted for FFM was 0.08 +/- 0.64 kg/y (range: -1.45 to 2.22 kg/y) and was similar among children of two nonobese parents and children with one nonobese or one obese parent, but was significantly higher in children with two obese parents (0.61 +/- 0.87 kg/y). The major determinants of change in FM adjusted for FFM were sex (greater fat gain in girls), initial fatness, and parental fatness. None of the components of energy expenditure were inversely related to change in FM. The main predictors of change in FM relative to FFM during preadolescent growth are sex, initial fatness, and parental fatness, but not reduced energy expenditure.

Adipose Tissue↗
PubMed1997

Longitudinal changes in diary- and laboratory-based sleep measures in healthy "old old" and "young old" subjects: a three-year follow-up.

We report a longitudinal study of diary- and laboratory-based sleep measures in 50 healthy elderly subjects followed prospectively over a 3-year interval. Our hypothesis was that "old old" subjects (aged 75 to 87; n = 27) would show decline over time in measures of sleep quality, continuity, and depth, whereas "young old" subjects (aged 61 to 74; n = 23) were expected to show stability of outcome measures. Using analysis of variance-based planned contrast procedures, we found that this hypothesis was strongly supported for subjective sleep quality and laboratory measures of sleep latency, sleep efficiency, wakefulness after sleep onset, and slow-wave sleep percent. These changes were accompanied by increased napping in the old old. However, there was no change of habitual time in bed (total time or temporal placement of nighttime sleep), daily social rhythms, or sleep apnea. Change in medical burden scores did not correlate significantly with change in sleep efficiency or other outcome variables in the old old. Intervention designed to slow age-dependent decreases in sleep quality, continuity, and depth is discussed. The current results are representative of healthy elderly; sleep would probably deteriorate earlier and more quickly in elderly with more serious health problems and heavier medication use.

Aged↗
PubMed2005

Scaling of visuospatial attention undergoes differential longitudinal change as a function of APOE genotype prior to old age: results from the NIMH BIOCARD study.

The effect of apolipoprotein E (APOE) genotype on longitudinal cognitive decline in midlife was investigated with attentional scaling. Healthy individuals (mean age 59.6 years) genotyped for APOE were tested at 3 12-month intervals on a cued visual search task. A random effects model revealed significant interaction in effect of precue size on search speed between APOE-epsilon4 gene dose and assessment, with longitudinal increases in noncarriers and heterozygotes but longitudinal decreases in homozygotes. Association of APOE-epsilon4 with cognitive decline in midlife is consistent with an Alzheimer's disease (AD) prodrome, albeit a decade or more before average age of AD diagnosis. However, cognitive decline in midlife associated with a gene modulating neuronal response to insult argues that the concept of an AD prodrome includes factors that allow as well as cause AD.

Age Factors↗
PubMed2006

Longitudinal changes in forearm bone mineral density in women and men aged 45-84 years: the Tromso Study, a population-based study.

The aim of this study was to describe changes in bone mineral density in Norwegian women and men aged 45-84 years in a population-based, longitudinal study. Bone mineral density (g/cm2) was measured at distal and ultradistal forearm sites with single x-ray absorptiometric devices in 3,169 women and 2,197 men at baseline in 1994-1995 and at follow-up in 2001 (standard deviation, 0.4 years). The mean annual bone loss was -0.5% and -0.4% in men and -0.9% and -0.8% in women not using hormone replacement therapy at the distal and ultradistal sites, respectively. In men, age was a negative predictor of bone mineral density change at both sites. Women not using hormone replacement therapy had the highest bone loss at the ultradistal site 1-5 years after menopause. The correlation between the two measurements was high: r = 0.93 and r = 0.90 in women and r = 0.96 and r = 0.93 in men for the distal and ultradistal sites, respectively. More than 70% kept their quartile positions, indicating a high degree of tracking of bone mineral density measurements. Although the study population live above the polar circle, the rate of bone loss was not higher at the distal and ultradistal forearm sites compared with that of other cohorts.

Absorptiometry, Photon↗
PubMed1991

Longitudinal changes in lung function during the first three years of premature infants with moderate to severe bronchopulmonary dysplasia.

Bronchopulmonary dysplasia (BPD) is a chronic obstructive pulmonary disease of prematurely born infants following prolonged mechanical ventilation and oxygen therapy. Developmental changes in pulmonary function of children with BPD during their early years have been difficult to study. We longitudinally studied maximal expiratory flow-volume curves by the forced deflation technique in 11 infants who had previous tracheostomy with moderate to severe BPD. Patients were classified into: those who were mechanically ventilated for less than 5 months (Group A), and those who were ventilated for 10 or more months (Group B). At 6 months of age, forced vital capacity (FVC) was 28.1 and 25.5 mL/kg in Group A and B, respectively, significantly less than normal (41.8 mL/kg). The maximum expiratory flow at 25% FVC (MEF25) at 6 months of age was 6.9 and 8.1 mL.kg-1.s-1 in Group A and B, respectively, (predicted value, 39.2 mL.kg-1.s-1). FVC reached the normal range by 12 months of age in Group A, but remained lower until 36 months of age in Group B. MEF25 gradually increased in Group A, reaching 18.0 mL.kg-1.s-1 at 36 months of age, whereas in Group B it was severely decreased at the same age (3.5 mL.kg-1.s-1). More than 75% of the patients had airway hyperreactivity at all ages. We have demonstrated that in patients with moderate to severe BPD, vital capacity is moderately decreased, but catches up to normal levels by 36 months of age. In contrast, severe lower airway obstruction persists in all infants, although in those with moderate BPD gradual improvement is seen. These findings suggest that in BPD neither obstruction of the smaller intrathoracic airways nor bronchial hyperreactivity resolves during the first 3 years of life.

Bronchial Hyperreactivity↗
PubMedDate not supplied

Longitudinal changes in stages of change for condom use in women.

PURPOSE: This study identifies how women naturally progress through the Transtheoretical Model stages of condom use over a 1 year period, using the longitudinal dynamic methodology of latent transition analysis (LTA). DESIGN: As part of a larger study of human immunodeficiency virus risk in women, participants were assessed for their stage of condom use two times, 1 year apart. SUBJECTS: A total of 491 women who completed both assessments of the study were included in this analysis. MEASURES: Stage of condom use was assessed using two questions, which placed women into one of five stages of change for condom use (alpha = .90). RESULTS: Latent transition analysis identified the best-fitting model of naturalistic stage progression, which included both forward and backward movement. Precontemplation and maintenance were found to be the most stable stages (more than 50% of the participants remaining in that stage 1 year later), and the action stage was the least stable (15% remaining in this stage). Transition probabilities for all stages showed a high rate of relapse in the sample. CONCLUSIONS: A high proportion of women will remain within their stage of condom use over a 1-year period if no intervention is introduced. Interventions that are aimed at increasing condom use in women need to incorporate relapse prevention. In addition, the transition probabilities for the stages will help establish reasonable rates of change for intervention programs.

Adult↗
PubMed1991

[Longitudinal changes of serum specific antibodies in Lewis rats immunized with IRBP].

The serum antibodies specific to either interphotoreceptor retinoid-binding protein (IRBP) or retinal S-antigen were longitudinally determined in Lewis rats immunized with 50 x 10(-6)g of IRBP emulsified with complete Freund's adjuvant. To our knowledge, it is the first time to purify IRBP and to address the experiment with IRBP in China. It was shown that the antibody specific to IRBP appeared on the 7th day, followed by a gradual increase, and reached its peak on the 26th day after immunization. No antibody specific to S-antigen was found. The relation between anti-IRBP antibody and experimental autoimmune uveoretinitis (EAU) which occurred in the increasing phase of the antibody suggests that the humoral immunity may be implicated in the pathogenesis of EAU.

Animals↗
PubMed1997

Longitudinal changes in ultrasound parameters of the calcaneus.

We examined with a median follow-up of 1.4 years (range 1.0-2.0 years) the rates of change per year in ultrasound parameters of the calcaneus. Speed of sound (SOS), Broadband ultrasound attenuation (BUA) and Stiffness were measured twice in 543 subjects (224 men) participating in the Rotterdam Study. SOS fell by -2.5 m/s per year in both sexes (95% CI -4.0 to -1.1 m/s per year in men and -3.6 to -1.4 m/s per year in women). Stiffness decreased by -0.62 (-1.33 to 0.09) per year in men and -0.66 (-1.24 to -0.08) per year in women. In men the rate of change in SOS and Stiffness tended to increase with age. BUA did not change significantly during follow-up in either sex. The prospectively assessed rates of loss differed considerably from those observed cross-sectionally, especially for SOS in men (cross-sectional -0.7 m/s per year, longitudinal -2.5 m/s per year). There was substantial variation between individuals both in changes per year in SOS and in changes per year in BUA. With a median follow-up time of 1.4 years, approximately 27% of the variation in the rate of change for SOS could be explained by measurement error while for BUA this was approximately 9% and for Stiffness 11%. Only a small percentage of subjects had changes larger than could be accounted for by measurement error (SOS: men 26.8%, women 21.6%; BUA: men 28.5%, women: 38.8%; Stiffness: men 32.6%, women 35.1%). The latter may limit the use of ultrasound measurements as a follow-up tool in individuals rather than in populations.

Age Factors↗
PubMed2006

Clinical characteristics and longitudinal changes of informal cost of Alzheimer's disease in the community.

Most estimates of the cost of informal caregiving in patients with Alzheimer's disease (AD) remain cross-sectional. Longitudinal estimates of informal caregiving hours and costs are less frequent and are from assessments covering only short periods of time. The objectives of this study were to estimate long-term trajectories of the use and cost of informal caregiving for patients with AD and the effects of patient characteristics on the use and cost of informal caregiving. The sample is drawn from the Predictors Study, a large, multicenter cohort of patients with probable AD, prospectively followed annually for up to 7 years in three university-based AD centers in the United States (n=170). Generalized linear mixed models were used to estimate the effects of patient characteristics on use and cost of informal caregiving. Patients' clinical characteristics included cognitive status (Mini-Mental State Examination), functional capacity (Blessed Dementia Rating Scale (BDRS)), comorbidities, psychotic symptoms, behavioral problems, depressive symptoms, and extrapyramidal signs. Results show that rates of informal care use and caregiving hours (and costs) increased substantially over time but were related differently to patients' characteristics. Use of informal care was significantly associated with worse cognition, worse function, and higher comorbidities. Conditional on receiving informal care, informal caregiving hours (and costs) were mainly associated with worse function. Each additional point on the BDRS increased informal caregiving costs 5.4%. Average annual informal cost was estimated at $25,381 per patient, increasing from $20,589 at baseline to $43,030 in Year 4.

Aged↗
PubMed2000

Longitudinal changes in 11-13-year-olds' physical activity.

UNLABELLED: The influence of age, sex, maturity, body mass and body fatness on the physical activity (PA) of 11-13-y-olds was examined longitudinally. Body mass, triceps and subscapular skinfold thickness and pubic hair were recorded and 3-d continuous heart rate (HR) monitoring was used to estimate PA on each annual measurement occasion. At the onset, subjects were 11.0 (0.4)-y-old and data were available on 202, 143 and 160 subjects in years 1 to 3, respectively with an almost equal sex distribution. Multilevel regression modelling examined age-, sex- and maturity-related changes in time spent with HR above 139 (moderate activity) and 159 (vigorous activity) bpm. Sustained (10 or 20 min) periods of moderate or vigorous activity were not characteristic of PA patterns. Both PA measures declined with age, with a consistent sex difference reflecting the lower PA levels of girls. Body mass and fatness were not significant explanatory variables, but an additional decrement in activity was evident in late maturity. CONCLUSION: Few children experience extended bouts of PA, and from 11-13 y, PA decreases, with more girls than boys becoming inactive. The data emphasize the importance of promoting active lifestyles during youth.

Adolescent↗
PubMed2006

Correlations between longitudinal changes in transitional zone volume and measures of benign prostatic hyperplasia in a population-based cohort.

OBJECTIVE: To determine whether measures of transitional zone volume (TZV) are more strongly associated than total prostate volume with longitudinal urologic outcomes. METHODS: In 1990, 2,115 randomly selected Caucasian men from Olmsted County, Minnesota (USA) completed validated questionnaires during a home visit. A 25% subsample underwent clinical evaluation that included transrectal ultrasonography, assessment of serum prostate-specific antigen levels, and maximum urinary flow rates. Examinations and questionnaires were repeated biennially through 2004. TZV measures were taken at the fifth through eighth visits. Men with at least one TZV measurement were included in this study (n=336). RESULTS: Changes in TZV correlated weakly with changes in peak urinary flow rate and urinary symptoms. After accounting for age and change in total prostate volume, change in TZV added no information to models that predict changes in urinary symptoms and peak urinary flow rates. Men who experienced the most rapid annual changes in TZV were not more likely to experience more rapid changes in urinary symptoms or maximum flow rate. CONCLUSION: Tracking changes in TZV over time may be unlikely to provide a good surrogate measure for the development of benign prostatic hyperplasia.

Cohort Studies↗
PubMed2003

Longitudinal changes in photopic OPs occurring with vigabatrin treatment.

PURPOSE: Vigabatrin (gamma-vinyl-GABA) is an antiepileptic drug successful in the management of infantile spasms. Photopic ERGs were tested in children followed longitudinally before and during vigabatrin treatment. METHODS: Subjects were 26 infants (age range 1.5-24 months, median 7.6 months) on vigabatrin treatment who had been tested on multiple visits (two to four visits; mean, three visits). Eighteen of these were assessed initially before starting vigabatrin therapy and eight were assessed within 1 week of initiation of the drug. ERGs were recorded at 6-month intervals. Standard ISCEV protocol with Burian-Allen bipolar contact-lens electrodes (standard flash 2.0 cd.s/m2) was used. Although ISCEV standards were followed, a higher flash intensity (set at 3.6 cd.s/m2) was chosen for single-flash cone assessment to provide a better definition of OPs. Photopic OPs were divided into categories of early OPs and late OP (OP4). Responses were compared with age corrected limits extrapolated from our lab control database. RESULTS: Results showed differential effects of vigabatrin on the summed early OP amplitudes versus the late OP (OP4) and cone b-wave amplitude. The early OPs showed significant decrease (p = 0.0005, repeated measures analysis of variance) after 6 months and remained decreased for the duration of treatment. There was no significant change seen in the late OP. The cone b-wave amplitude showed initial increase (p = 0.04) after 6 months, followed by a decrease after 18 months; a trend similar to that of the late OP. CONCLUSION: Early photopic OPs were disrupted more than the late OP, suggesting relative deficit in the ON (depolarizing) retinal pathways.

Anticonvulsants↗