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PubMed1993

[Changes in serum zinc level of periodontitis with kidney deficiency].

The study is to explore the possible relationship between the level of trace element zinc in serum and periodontitis with Kidney deficiency. The level of serum zinc in 40 cases of periodontitis and in 19 normal controls was examined by atomic absorption spectrum analysis. The results indicated that there was only a descending trend of serum zinc in periodontitis group as compared with normal group. But further analysis revealed that according to the severity of periodontitis and the theory of Syndrome differentiation in TCM, it showed that the drop of serum zinc had not only a negative correlation with the severity of periodontitis, but also was co-related to whether there was Kidney deficiency or not. Serum zinc of periodontitis with Kidney Deficiency group was significantly lower than that of normal control group as well as the group of periodontitis without Kidney deficiency (P < 0.05). The data suggested that the decline of serum zinc level is closely related to the occurring and development of periodontitis with Kidney Deficiency.

Adolescent↗
PubMed1993

[134 patients with adult primary nephrotic syndrome treated with combined traditional Chinese medicine and Western medicine].

This paper studied the method and effect of adult primary nephrotic syndrome (PNS) with the integrated traditional Chinese and Western medicine (TCM-WM) treatment. 134 patients were divided into WM group (66 cases) and TCM-WM group (68 cases). Both groups were mainly treated with corticosteroid. The latter group was treated with corticosteroid plus Chinese medicinal herbs. The results showed that total effective rate of WM group and TCM-WM group was 56.1% and 85.3% respectively, while the occurrence rate of side effect was 48% and 14.8% respectively. It indicated that corticosteroid plus Chinese medicinal herbs could enhance curative effect and reduce side effect.

Adolescent↗
PubMed1995

[Relationship between thymectomy and syndrome differentiation-typing treatment of myasthenia gravis].

According to the theory of traditional Chinese medicine, 37 patients suffering from myasthenia gravis were Syndrome-differentiated into following types preoperationally: (1) Both Qi-Yin Deficiency of Kidney-Spleen, 21 cases. (2) Yang Deficiency of Kidney-Spleen, 15 cases. (3) Qi Deficiency of Spleen only, one case. Thymectomy were done in all cases. Among them, 19 cases had thymoma. The results showed the relationship between the types and the resectionability rate and post-operative crisis rate. On the first two types, they were 95.2% and 9.5%, 46.7% and 73.3% respectively. It was considered that Syndrome differentiation-typing in TCM in the myasthenia gravis patients would provide an positive and reliable index for predicting the resectionability and prognosis of the patient.

Adolescent↗
PubMed1995

[Correlation between kidney deficiency syndrome and bone density].

In order to study the relationship between Kidney Deficiency Syndrome (KDS)and bone density (BD), the BD of 2068 subjects (40-69 years old)was measured with SPA-IIC type monophoton BD scanning device made in China. The subjects including 1144 cases of KDS (320 males and 824 females); 608 cases without KDS (306 males and 302 females); 164 cases of Lung Deficiency (80 males and 84 females); 152 cases of Spleen Deficiency (76 males and 76 females). Through comparison with the same sex and age group, it was found that BD in KDS patients was significantly lower than that in the normal subjects and those without KDS, also lower than that in the Lung and Spleen Deficiency patients. It indicated that KDS had the corresponding BD changes, which confirmed the TCM classical theory "The Kidney governs the bone". Based on the measuring data, the authors took the lower limit of BD normal value minus two folds of SD as the critical value for KDS diagnosis in 40-49 years age group, i. e., male BD < 0.6 g/cm2, female BD < 0.5 g/cm2. The clinical feedback showed that the male and female related coincident rates were 76% and 80% respectively. Therefore, the critical value could be taken as an objective index for KDS diagnosis after excluding other affecting factors.

Adult↗
PubMed1996

[Clinical study on anti-senility effect of kuangquan 851 oral liquor type R and type Y].

The anti-senility effects of Kuangquan 851 Oral Liquor type R and type Y were studied and compared with Qing Chun Bao Oral Liquor as control in 303 subjects of geratic period or presenium with senile syndromes of Kidney or Spleen Deficiency. The results indicated that both type R and Y could improve the Kidney and Spleen Deficiency. The effective rates of type R and Y were 96.6% and 92.3% respectively and were much better than that of the control group. The laboratory findings before and after treatment revealed that effects of Kuangquan 851 Oral Liquor were as follows: increasing antioxidation and clearing away free-radicals; promoting collagen metabolism; enhancing the function of T lymphocytes; improving pulmonary, cardiovasular, brain function; raising male serum testosterone and estradiol levels. The two types were similar in effect.

Aged↗
PubMed1996

[Study on relation of kidney-deficiency with hearing damage and serum trace elements in patients with chronic nephropathy].

The hearing and serum trace element of 73 cases of chronic nephropathy were measured. Results showed that the incidence of hearing damage in high frequency was 68.5% with a mean hypoacusis of 35.1 +/- 6.1 dB, while in 55 patients of Kidney Deficiency type, the incidence of hearing damage in high frequency was 83.6%, it was significantly higher than that in patients without Kidney Deficiency. The serum levels of trace elements (iron and zinc) in patients with Kidney Deficiency were lower than that of normal level and in patients without Kidney Deficiency, and the decrease of serum iron was directly proportional to the degree of hearing damage. There were close relationship between the Kidney Deficiency with the hearing damage as well as the serum levels of iron and zinc.

Adult↗
PubMed1996

[Clinical and experimental observation of xilixin granule combined with radiotherapy in treating malignant-tumors].

Thirty six patients of pulmonary or nasopharyngeal carcinoma were treated with Xilixin granule (XLXG) combined with radiotherapy and compared their efficacy with that of 31 patients treated by Zhenqi Fuzheng granule combined with radiotherapy for control. Results showed that the symptoms of Yin Deficiency syndrome in treated group were obviously improved, the leucocyte decreased by 5.6%, while in control group it reached 25.8%, the 3 year survival rate was significantly higher in treated group (75.0%) than that in control group (51.6%). Animal experiment revealed that XLXG had the effects of tumor inhibition, it could increase white blood cells, platelets and hemoglobin of patients, especially in using large dosage. These results suggested that XLXG have some protective effect against radiotherapeutic damage in patients with malignant tumor.

Adolescent↗
PubMed2003

[Clinical investigation on characteristics of traditional Chinese medical syndrome of hepatocirrhosis].

OBJECTIVE: To explore the characteristics of traditional Chinese medical syndrome (TCM syndrome) of hepatocirrhosis. METHODS: Clinical information from the four diagnosis methods of traditional Chinese medicine (TCM) and related laboratorial indexes were systematically collected from 223 hepatocirrhosis cases, and the multi-statistical methods including systematic cluster analysis, principal component analysis, stepwise discrimination and variance analysis were made with the software SAS 6.11. RESULTS: Multi-analysis showed that there were 3 categories of syndrome characteristics. Type 1 (134 cases): damp heat, blood stasis, deficiency of liver and spleen Qi; Type 2 (62 cases): deficiency of both Qi and Yin with severe deficiency of Qi, heat with severe dampness, blood stasis; Type 3 (27 cases): deficiency of both Qi and Yin with severe deficiency of Yin, stasis and heat or dampness. Analysis of the changes of the related laboratorial indexes among the three types of syndrome showed that Type 1 mainly manifested asthenia syndrome with sthenia syndrome, and its indexes of AST, ALT, GGT levels were markedly higher than those of Type 2 and Type 3, both of which mainly showed sthenia syndrome with asthenia syndrome, and that Type 3 was in active inflammation, deficiency of both Qi and Yin (deficiency of Yin > deficiency of Qi), and its FN, Alb, FV, FVII, PLT, PCT levels were obviously reduced. CONCLUSION: The multi-statistical methods can reveal the characteristics and regularity of TCM syndrome of hepatocirrhosis, and the 3 categories of syndrome characteristics basically conform to clinical manifestations. The result of TCM syndrome distribution and laboratorial indexes infer that damp heat is the pathological basis of hepatocirrhosis, and the degree of liver function disorder and liver damage may be the pathological basis of deficiency of Yin of both liver and kidney.

Adult↗
PubMed2006

[Study on TCM syndrome differentiation rules in coronary artery bypass grafting patients during peri-operation period].

OBJECTIVE: To study the TCM syndrome differentiation rules in coronary artery bypass grafting (CABG) patients during peri-operation period. METHODS: According to the Guideline for Clinical Trail of Traditional Chinese New Drugs and experience of Professor DENG Tie-tao, the standard of TCM syndrome differentiation for CABG patients was established, with which 161 CABG patients were classified before and two weeks after CABG operation. RESULTS: Before CABG, the qi stagnation and blood stasis syndrome type was the type most commonly seen (46.0%), the next in turn was the phlegm stagnation type (24.8%), the yang-qi deficiency type (15.5%), and the yin-blood deficiency type (13.7%). While after CABG, the phlegm stagnation syndrome type was the most frequently occurred one (35.9%), then in turn was the yang-qi deficiency type (30.8%), the yin-blood deficiency type (21.2%) and the qi stagnation with blood stasis type (12.2%). CONCLUSION: For patients before CABG, the pathological characteristic is mostly the deficiency in root with excess in superficiality, and the commonest syndrome is the qi stagnation with blood stasis type. For patients after CABG, both deficiency and excess is the pathological characteristic, the Xin-qi and Xin-yang deficiency syndrome the commonest type, and with phlegm as the main pathologic factor.

Adult↗
PubMed1992

[Analysis of the correlations between immunological changes and syndrome groups in patients with immunological thrombocytopenic purpura (ITP)].

To study the relationship between the immunological changes and syndrome (Zheng,) groups by TCM of ITP, the T-lymphocyte subsets, B-lymphocyte, NK cell, platelet-associated IgG (PAIgG, PAIgA, PAIgM) and antiplatelet-autoantibodies (GPIIb, GPIIIa, GP I b) of 66 patients with ITP were assisted using APAAP and ELISA method separately. It was found that the T-lymphocyte subsets, PAIg and syndrome groups of ITP were closely related. From the group of blood-heat (Xuerewangxing) to the group of deficiency of both Qi and blood, the group of asthenia of both Spleen and Kidney, the group of deficiency of Liver-yin and Kidney-yin, and the group of deficiency Yin and Yang Ts lymphocyte successfully increased (from 29. 0 +/- 8.0% to 47.2 +/- 10.0%), Th/Ts ratio declined (from 1.35 +/- 0.60% to 0.69 +/- 10%), PAIg increased gradually except for PAIgM,PAIgG of the group of deficiency Yin and Yang. Only the Th of the group of asthenia of both Spleen and Kidney among 5 syndrome groups was decreased significantly and contrary to the group of deficiency of Liver-Yin and Kidney-Yin. These results indicated that every syndrome group has specific characteristics, and immunological changes of ITP could have prognostic value.

Adolescent↗
PubMed1991

[Prediction and prevention of hypertension syndrome of pregnancy].

Analysis of mean artery pressure (MAP-2) according to the differentiation of symptom complex of TCM can predict the occurrence of hypertension syndrome of pregnancy (HSP) at patients' first visit to hospital during their middle gestational period (less than 24 pregnant weeks). 424 pregnant women (MAP-2 greater than or equal to 12kPa) were divided into 4 groups and given preventive treatment as follows: (1) The control group, 122 women, no drugs were given; (2) the Theragan group, 102 women; (3) the TCM (A) group, 100 women, those with Liver-Kidney deficiency of Yin or no apparent signs were given Qiju Dihuang Wan, and those with Spleen-Kidney deficiency of Yang were given Shenqiwan; (4) the TCM(B) group, 100 women, were given Salvia miltiorrhiza plus (A) group's drugs. The results of prediction: (1) The occurrence rate of HSP in the MAP-2 less than 12kPa group was 10. 5%; in the MAP-2 greater than or equal to 12kPa group, 49.2%. The difference was significant. (2) The rate of deficiency of Yin in the MAP-2 greater than or equal to 12kPa was significantly higher than in the MAP-2 less than 12kPa. The rate of HSP in the deficiency of Yin was higher than in the nondeficiency of Yin. The rate of HSP increased to 70. 7% in the MAP-2 greater than or equal to 12kPa with deficiency of Yin. The results of prevention: (1) The occurrence rates of HSP in 4 groups were 49.2%, 30.4%, 15% and 14% respectively. (2) There was no side effect for mother and infant after preventive treatment. No eclampsia occurred.

Drugs, Chinese Herbal↗
PubMed1991

[Treatment of climacteric syndrome with new gengnian prescriptions].

It was found by the observations of clinical treatment that the three indexes of epinephrine(E), norepinephrine(NE) and dopamine(D) of urinary catecholamine(CA) increased (P less than 0.001, P less than 0.05 and P less than 0.001) for the climacteric patients who suffered from the deficiency of Yin leading to the hyperactivity of the internal heat of the heart, and the urinary 17-hydroxycorticosteroid (17-OHCS) increased (P less than 0.001) for the patients who suffered from the deficiency of Yin leading to the hyperactivity of the internal heat of the liver. Both the three indexes and urinary 17-OHCS increased for the two groups (P less than 0.01). However, for all the above groups who suffered from the deficiency of Yin leading to the hyperactivity of the internal heat, the NE/E ratio was larger than the normal ratio, which stands for the level of central catecholamine. After the treatment with new Gengnian prescriptions, the clinical symptoms of the patients were improved, and in the meantime urinary CA. 17-OHCS and NE/E were decreased. The total efficiency was 89.2%. The principle of treatment with this prescription may be due to the fact that the level of central catecholamine decreased so that the excessive excitation of sympathetics-adrenocortical system and sympathetics-adrenocortical system was restrained.

17-Hydroxycorticosteroids↗
PubMed1994

Contents of trace elements in the hair of aplastic anemia patients and their treatment based on an overall analysis of symptoms and signs.

The content of 12 trace elements in the hair of 20 aplastic anemia patients was determined and compared with that of normal subjects as control. The results showed that patients with deficiency of yin had a significant decrease in lithium, calcium, strontium, and chromium, those with deficiency of yang had a distinct decrease in zinc magnesium barium, strontium, calcium, and lithium, and those with deficiency of both yin and yang had a general decrease in all the 12 trace elements. Changes in trace element content in hair may serve as a guide to opening up new vistas in the treatment of aplastic anemia on the basis of an overall analysis of symptoms and signs.

Adolescent↗
PubMed1992

[Correlation between syndrome types of traditional Chinese medicine and peripheral T lymphocytes subsets in Graves' disease].

This paper reports the determined results of OKT3, OKT4, OKT8, ERFC, smIg and CIC, TMCA, TGA in 31 cases of Graves disease and in 20 normal controls. The results showed that the OKT3, OKT4, OKT8, ERFC were significantly lower than those in the normal controls, whereas the smIg was higher than that in normal controls. The difference between the two groups was very significant. Even though the ratio of OKT4/OKT8 showed no significance of both. Typology of Graves disease according to the theory of TCM, all 31 cases were divided into two types: (1) 14 cases of depression of Liver-energy and asthenia of Spleen; (2) 17 cases of deficiency of yin leads to hyperactivity of Fire. The OKT8 and the ratio of OKT4/OKT8 in the latter respectively were lower and higher than those of the former. The difference between the two types was significant (P less than 0.01, P less than 0.05) whereas the positive rates of the CIC, TMCA, TGA also were higher in the deficiency of Yin leads to hyperactivity of Fire than those in the depression of Liver-energy and asthenia of Spleen. After treatment with combined TCM-WM on 31 cases of Graves disease, it was found that the OKT4, OKT8, ERFC were significantly elevated, the smIg was markedly decreased than those without treatment. It was also found that smIg markedly decreased in two types, OKT8, ratio of OKT4/OKT8 in the latter and ERFC in both types all returned to normal. Remainder indexes had no obvious change before and after treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed2002

Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats.

AIM: To study the effect of yam in Taiwan, which is a commonly used Chinese medicine, on hepato-nephro-toxicity in rats. METHODS: Crude water extract of yam (Dioscorea alata L), was used to treat rats with an acute toxicity induced by acetaminophen (APAP) challenge. RESULTS: The pharmacological and biochemical studies showed the extract of yam had the effect of kidney secureness and liver fortification (P < 0.01). The pathologic sections showed good improvements in renal tubular degranulation changes, necrosis and disintegration. The extract of yam also possessed a good protection against the inflammation of central vein and necrosis of liver tissue. CONCLUSION: The liver and kidneys are originated from the same source. Pathologically, deficiency of the life essence in the kidney may lead to the blood deficiency in the liver. The results showed that the yam could prevent the damages of the liver and kidneys, thus preserving their functions. This could b e the reason why the yam was commonly used in traditional Chinese medicine, as seen in Liuwei Dihuang Wan be used in the case of deficiency of liver-yin and kidney-yin.

Acetaminophen↗
PubMed1992

[Research of the relation between the type of asthenia of the spleen and kidney and platelet associated antibodies and T-lymphocyte subsets in idiopathic thrombocytopenic purpura].

Idiopathic thrombocytopenic purpura (ITP) is a kind of disease associated with immunity. At present a great quantity of study on ITP has been made on humoral and cellular immunity. But there are few reports about the relationship between the types based on the differential diagnosis of TCM and immune rationale of ITP. In order to deeply explore the relationship between the types based on differential diagnosis of TCM and immune rationale of ITP., the authors measured PAIg and T lymphocyte subsets of 34 ITP patients of asthenia of both Spleen and Kidney. The value of PAIgG increased in both types of Spleen failing to control blood (SFCB) and deficiency of Spleen-yin and Kidney -yin (DSYKY), and the value of PAIgG of the type of DSYKY was significantly higher than that of SFCB (P less than 0.01). OKT3, OKT4/OKT8 of the type of SFCB remarkably decreased (P less than 0.05), OKT4, OKT4/OKT8 of DSYKY also remarkably decreased (P less than 0.001), while OKT8 significantly increased (P less than 0.001). The above results suggested that the type of DSYKY has more serious immune dysfunction than the type of SFCB, and the types of SFCB and DSYKY has close relationship with PAIg T lymphocyte subsets.

Adolescent↗