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PubMed1980

[Granulomatous tumors of a pseudo-Hodgkin type of the thymus gland (thymus gland lymphogranulosarcomas)].

The group of thymic lymphogranulosarcomas are losing their pathologic individuality as autonomous thymic tumors with particular histological and special evolutive characters. Experience shows that a good number of alleged "pseudo-hodgkinian thymomas" have evoluted in the hodgkinian mode. From a total of 56 apparently autonomous thymic tumors operated on in the Department of Surgery A at this hospital, 9 thymic lymphogranulosarcomas have been identified. Our observations confirm that "pseudo-hodgkinian" tumors of the thymic lodge are rather Hodgkin's disease or a primitive-ganglion Hodgkin's disease localized in the thymic lodge. In practice, the discovery of granulomatous tissue in a thymic lodge tumor, even in the absence of typical Sternberg cells, requires a search for other localizations to determine the evolutive stage of the disease. Experience shows that partial or total surgical excision, followed by combined chemotherapy, exploratory laparotomy and radiotherapy, offer the best chances of long term survival at present.

Adult↗
PubMedDate not supplied

[Serum levels of thymus hormones and autoantibodies to the thymus epithelium in inhabitants of regions contaminated with radionuclides].

Increased level of serum thymic activity and normal serum concentration of alpha-1-thymosin were revealed in inhabitants of region polluted by radionuclides after Chernobyl accident (settlement Vyshkov, Bryansk region). In the same population the serum level of autoantibodies, reacting with thymic epithelial cell line was elevated. Similar but less prominent alterations were found in population of radiologically pure region (settlement Potchep). Revealed autoantibodies had mainly IgM isotype. The negative correlation exists between levels of autoantibodies and serum thymic activity. Sera of persons from the control group and one half of Vyshkov inhabitants reacted with thymic epithelial cells of both human and mouse origin; in other half of Vyshkov inhabitants species-specific autoantibodies were revealed. We propose that correlated increase of antithymic autoantibody level and decrease of serum thymic activity are the consequence and indicators of unfavorable ecological conditions; however the contribution of radiation factor to their induction can not be estimated on the basis of presented data.

Autoantibodies↗