Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “SALIVARY DUCT”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 235 records · Page 13Linked to original sources
PubMed1995

Na+ channels in membrane vesicles from intralobular salivary ducts.

Electrical potential-driven 22Na+ fluxes were measured in membrane vesicles prepared from male and female rat submandibular intralobular ducts. A relatively temperature-independent (Q10 = 1.45 +/- 0.15), amiloride-inhibitable (mean affinity constant approximately 1 microM), rheogenic Na+ transport pathway was observed. The relative potency of amiloride analogues for inhibition of this pathway was amiloride > ethylisopropyl-amiloride > phenamil, similar to that of the "low-amiloride-affinity" Na+ channel recently observed in a number of other tissues. These results are consistent with the existence of the apical Na+ channel thought to be involved in intralobular ductal salt reabsorption. No significant difference was found in the magnitude or pharmacology of electrogenic Na+ fluxes in vesicles prepared from male and female rat intralobular ducts, suggesting that the sexual dimorphism observed in this tissue is not reflected at the level of the apical membrane Na+ channel. Amiloride-sensitive 22Na+ fluxes in intralobular ductal membranes were of the same magnitude as 22Na+ fluxes measured in similarly prepared and assayed vesicles from the toad bladder, a tissue thought to be a rich source of amiloride-sensitive Na+ channels.

Amiloride↗