SEARCH · Search PubMed
Results for “Preleukemia”
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Steroid-induced tumor lysis syndrome in a patient with preleukemia.
Tumor lysis syndrome (TLS) is a well recognized complication of chemotherapy and radiotherapy for leukemia, lymphoma as well as rapidly growing malignancies. Less described is the occurrence of TLS following steroid therapy alone. Herein, we report on a 32-year-old male with myelodysplastic syndrome, characterized by refractory anemia with excess blasts in transformation, who developed acute oliguric renal failure 12 hours after methylprednisolone 1.0 g for presumed autoimmune thrombocytopenia. Laboratory investigations revealed typical findings of TLS, including hyperkalemia, marked hyperuricemia, hyperphosphotemia, hypocalcemia and urine uric acid to creatinine ratio 1.8 (> 1.0). Long hemodialysis (8 hours) was initiated for 3 consecutive sessions. Renal function recovered 1 week later. This case high-lights that single-dose steroid administration in a patient with hematological malignancy may cause the potential life-threatening complications of TLS. Prophylactic management prior to the use of steroid therapy for a variety of purposes is absolutely required in high-risk patients.
[The uncertainty of the concept of preleukemia].
Explore the source record for details and available documents.
Preleukemia and leukemia in polycythemia vera.
A group of 76 polycythemia vera patients was followed prospectively with bone marrow examinations at regular intervals. Six terminated in acute leukemia, preceded by an indolent preleukemic phase succeeded by a very fulminant leukemia. At autopsy, all patients had extramedullary hematopoiesis. In one of them, only the bone marrow was leukemic, suggesting that it was the primary site of this transformation. In three with leukemic involvement of nonhematopoietic organs, the infiltrate consisted of myelo- or myelomonoblasts and normoblasts. The preleukemic phase was characterized by a rapidly evolving spontaneous pancytopenia, with a drop from polycythemic blood counts within 2 mo. In the bone marrow, megaloblastoid erythropoiesis with ring sideroblasts was prominent. A similar preleukemic phase evolving in other potentially leukemic conditions, has been described. Therefore, in patients at risk, the appearance of ring sideroblasts may be regarded as an early indicator of imminent acute leukemic transformation.
Acute lymphocytic leukemia with variant t(5;14) and preleukemia: expanding the spectrum of the 5q- abnormality?
Explore the source record for details and available documents.
[Preleukemia myelodysplastic syndrome after chemotherapy for multiple myeloma: "a new case"].
Explore the source record for details and available documents.
[So-called preleukemias].
Explore the source record for details and available documents.
[Reverse transcriptase activities in preleukemia].
Explore the source record for details and available documents.
Chronic myelogenous leukemia: preleukemia or leukemia?
Explore the source record for details and available documents.
Dyserythropoiesis, refractory anemia, and "preleukemia:" metabolic features of the erythrocytes.
Explore the source record for details and available documents.
[Hematologic study on preleukemia (latent period) observation on leukemia in atomic bomb survivors].
Explore the source record for details and available documents.