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At least 235 records · Page 13Linked to original sources
PubMed2001

Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands.

We have used DNase I footprinting to examine the interaction of several triplex-binding ligands with antiparallel TG- and AG-containing triplexes. We find that although a 17mer TG-containing oligonucleotide on its own fails to produce a footprint at concentrations as high as 30 microM, this interaction can be stabilised by several ligands. Within a series of disubstituted amidoanthraquinones we find that the 2,7- regioisomer affords the best stabilisation of this TG triplex, though the 1,8- isomer also stabilises this interaction to some extent. By contrast the 1,5- and 2,6- regioisomers show no interaction with TG triplexes. Similar studies with a 13mer AG-containing oligonucleotide show the opposite pattern of stabilisation: the 2,6- and 1,5- isomers stabilise this triplex, but the 2,7- and 1,8-compounds do not. The polycyclic compound BePI strongly stabilises TG- but not AG-containing triplexes, while a substituted naphthylquinoline interacts with both antiparallel triplex motifs.

Anthraquinones↗
PubMedDate not supplied

[Genotoxicity of urban air particulate matter].

This paper reviews the genetic toxicology of urban air particulate. Dusts present in the urban environment are composed of a special type of soot, currently mainly emitted by motor vehicles. This soot contains variable quantities of adsorbed highly active genotoxic compounds (polycyclic aromatic hydrocarbons and their nitro derivatives, i.e., nitroarenes). Nitroarenes are among the compounds with the highest genotoxic activity according to the Ames test (genetic point mutation on bacteria), and are particularly abundant in ultrafine particulate matter (< 1.1 microns) emitted by diesel engines, mainly trucks. Diesel emissions have been considered as probable carcinogenic agents for man by the International Agency for Research on Cancer (IARC). Highly mutagenic activity is present in the air of all the cities in the world, and there is increasing concern about possible carcinogenic effects on the general population as a result of exposure to urban particulate matter. Early epidemiological studies on city-dwellers exposed to heavy pollution indicate an excess of lung tumours. Lastly, there is a possible carcinogenic risk for occupationally exposed workers, such as traffic police and those working for city road cleaning services, etc., who are constantly obliged by their jobs to be exposed to polluted city air at work.

Air Pollutants↗
PubMed1975

Polycyclic aromatic isothiocyanate compounds as fluorescent labeling reagents.

Polycyclic aromatic isothiocyanates were synthesized in an attempt to produce new fluorescent agents for protein labeling and for use in microanalytical techniques. The relative fluorescence of these reagents, the required intermediates, and the derivatives were established. Of the compounds evaluated, the 9-acridine derivatives were the most promising.

Acridines↗
PubMed1983

Contact allergy to petrolatums. (III). Allergenicity prediction and pharmacopoeial requirements.

Several pharmacopoeias set limits on the polycyclic aromatic hydrocarbon content in petrolatum. UV absorbance measurement of aromatic extracts of petrolatum samples has been shown to be a more reliable method than direct UV absorbance measurement as prescribed by several pharmacopoeias for the determination of that content, but the presence of allergenic polycyclic aromatic hydrocarbons does not always correlate with lower UV absorbance. Biological tests are ultimately the only certain method of detecting biologically active compounds. Polycyclic aromatic hydrocarbons can also be irritant and carcinogenic. Therefore, universally uniform and very stringent limits should be set restricting their presence in pharmaceutical grade petrolatum.

Belgium↗
PubMed2001

Unnatural natural products from the transannular cyclization of lathyrane diterpenes.

The potential of macrocyclic diterpenoids to afford natural product-like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.

Cyclization↗