[Contribution to the pathogenesis of periodic paralysis].
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The perioperative management of patients with hypokalemic familial periodic paralysis is well known and has been described previously. This disease does not preclude surgery as long as the surgical team is aware of the diagnosis preoperatively. We describe herein a patient with familial periodic paralysis diagnosed the first time 1 day after undergoing surgery.
Recommendations for histological criteria of diagnosis of dystrophic and congenital myotony as well as familial hypopotassemic periodic paralysis based on the results of skeletal muscles biopsies are presented.
The maternal extended family of a young man shown to suffer from periodic paralysis were investigated. Several members were found to have biochemical and symptomatic evidence of muscle disorder.
Hypokalemic paralysis and/or arrhythmia must be treated cautiously and replacement therapy given slowly. The differential diagnosis should include familial periodic paralysis, an autosomal dominant disorder, which may present as hypokalemia, normokalemia, or hyperkalemia.
A thirteen-year-old girl with normokalaemic familial periodic paralysis (FPP) suffered life threatening upper airway obstruction secondary to tonsillopharyngitis resulting from infectious mononucleosis (IM). Emergency tonsillectomy was performed, but her postoperative course was complicated by persistent muscle weakness requiring a very prolonged period of artificial ventilation.
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Hypokalemic periodic paralysis occurring in thyrotoxicosis is rare in Caucasians and is not often highlighted as an endocrine emergency. Periodic paralysis, without familial background, manifests only in the thyrotoxic patient. Thyrotoxic periodic paralysis is a self-limiting disorder that is cured by the treatment of the underlying hyperthyroidism. We report an unusual case of acute onset weakness from thyrotoxic periodic paralysis in a young Chinese migrant who had a normal serum potassium level at the time of initial presentation, though on subsequent presentation one week later, he had the typically associated hypokalemia. We also review the literature on thyrotoxic periodic paralysis.