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Results for “PROGERIA”

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At least 235 records · Page 13Linked to original sources
PubMed1984

Euploidization of human hepatocytes from donors of different ages and both sexes compared with those from cases of Werner's syndrome and progeria.

Quantitative cytochemical studies of ploidy values for mono- and bi-nucleate hepatocytes from human livers of individuals from 15 weeks to 80 years of age, confirm earlier reports that the main ploidy shifts occur at 6-7 years, puberty and 21 years of age. In addition, the pattern of ploidy increase is similar to that described for other mammals. Ploidy values obtained for hepatocytes from two patients with Werner's Syndrome are in excess of those from livers of normal individuals of similar age. In contrast, ploidy values from the liver of a single case of Hutchinson-Gilford Syndrome were similar to those from children of a similar age group.

Adolescent↗
PubMedDate not supplied

Histological and ultrastructural features of atherosclerosis in progeria.

This histological and ultrastructural study of a limited amount of vascular tissue from a progeric woman of 20 years who died of traumatic subdural hemorrhage supports the belief that the vascular changes are atherosclerotic. The unusual features observed were collagen fibrils with a relatively small diameter in the atherosclerotic intima and media, extensive loss of mural smooth muscle cells particularly in the aorta, and widespread contraction bands in smooth muscle cells in vascular and nonvascular tissues. Smooth muscle cells appear to be unusually susceptible to hemodynamic and ischemic stress. Further autopsy studies are required to elucidate the etiology and pathogenesis of this unique disease.

Adult↗