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At least 235 records · Page 13Linked to original sources
PubMed1985

Origins of life: conformational energy calculations on primitive tRNA nestling an amino acid.

We report conformational energy calculations on our proposal of a molecular interaction theory for the origin of the nucleic acid-directed, adaptor-mediated synthesis of proteins that links the phenomena of chemical and biological evolution. A particular conformation of a pentanucleotide turns out to be a double-sided template for a primitive decoding system. It is able to neatly nestle an amino acid via hydrogen bonds, and this complex is found to be an energetically favourable conformation. The total potential energy of the complex is calculated using semi-empirical potential energy functions. A local-minimum conformation is obtained and its features are reported. The template conformation of the pentanucleotide is found to have an energy value far lower than a regular helical conformation. When the amino acid is nestled in the cleft of the template-conformation through specific hydrogen bonds, the energy is further lowered. A D-amino acid nestled into the PIT (Primitive tRNA) is found to be less stable than its L counterpart, as revealed by energy calculations.

Amino Acids↗
PubMed2006

The chemistry of life's origin: a carbonaceous meteorite perspective.

Carbonaceous chondrite meteorites are primitive asteroidal fragments that contain organic carbon and offer a glimpse of the abiotic chemical processes that preceded the onset of life. Their organic material displays structures as diverse as kerogen-like macromolecules and simpler soluble compounds that range from polar amino acids and polyols to nonpolar hydrocarbons. Several of these compounds have identical counterparts in terrestrial biomolecules and some of the amino acids show a unique l-asymmetry, suggesting their possible contribution to terrestrial molecular evolution and the origin of biological homochirality.

Amino Acids↗
PubMed1982

Probing the presently tenuous link between comets and the origin of life.

A unique set of millimeter-wave experiments for future cometary space missions is discussed. These experiments could yield answers to many basic questions about the presently undetermined nature of cometary nuclei and inner comae. This same set of experiments, designed to do fundamental cometary research, could simultaneously provide information on whether the accepted biological requirements necessary for the development of life are met in comets.

Astronomical Phenomena↗