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Current educational issues in the clinical neurosciences.

OBJECTIVE: Canadian training in the clinical neurosciences, neurology and neurosurgery, faces significant challenges. New balances are being set by residents, their associations and the Royal College of Physicians and Surgeons of Canada between clinical service, education and personal time. The nature of hospital-provided medical service has changed significantly over the past decade, impacting importantly on resident training. Finally, future manpower needs are of concern, especially in the field of neurosurgery, where it appears that soon more specialists will be trained than can be absorbed into the Canadian health care system. METHODS: A special symposium on current challenges in clinical neuroscience training was held at the Canadian Congress of Neurological Sciences in June 2000. Representatives from the Canadian Association of Interns and Residents, the Royal College of Physicians and Surgeons of Canada and English and French neurology and neurosurgery training programs made presentations, which are summarized in this report. RESULTS: Residency training has become less service-oriented, and this trend will continue. In order to manage the increasingly sophisticated hospital services of neurology and neurosurgery, resident-alternatives in the form of physician "moonlighters" or more permanent hospital-based clinicians or "hospitalists" will be necessary in order to operate major neuroclinical units. Health authorities and hospitals will need to recognize and assume this responsibility. As clinical experience diminishes during residency training, inevitably so will the concept of the fully competent "generalist" at the end of specialty training. Additional subspecialty training is being increasingly sought by graduates, particularly in neurosurgery. CONCLUSIONS: Training in neurology and neurosurgery, as in all medical specialties, has changed significantly in recent years and continues to change. Programs and hospitals need to adapt to these changes in order to ensure the production of fully qualified specialists in neurology and neurosurgery and the provision of optimal care to patients in clinical teaching units.

Education↗

Freud's 'problem': cognitive neuroscience & psychoanalysis working together on memory.

The first part of this paper discusses the development of Freud's views on memory from the time of the Project up to the formulation of the second topography. Freud's attempts to match his psychological views with an organic model were necessarily inconclusive, but in the process many innovative ideas about memory can be seen to resonate with recent developments in cognitive neuroscience. A brief discussion of perceptual identity, internal perception and Freud's affect theory introduce the central theoretical idea in the second half of the paper, namely that Identification can be seen as a form of memory. Modern memory theory is linked with the superego, following which the author proposes that internal objects might be renamed 'memory-objects' and that these can be understood in terms of the distinction made in cognitive neuroscience between implicit and explicit memory and between different parts of the brain, in particular the amygdala, the basal ganglia and the hippocampus. Klein's 'memory in feeling' and the views of Fairbairn and Ogden in relation to the dynamic nature of internal objects are briefly discussed. The paper ends with a few comments on the aberrations of memory and some implications of the implicit memory-object system.

Cognitive Science↗

[Advances in the applications of DNA chips and proteomics approaches for neurosciences].

DNA chips and proteomics are two of the recently developed high-throughput technologies that allow us to simultaneously analyze the expression levels of multiple genes and the interactions of their products in the brain. Their applications in neuroscience provide us with the unprecedented opportunities for understanding of the brain. A typical gene chip experiment contains a series of steps, including preparations (or purchase) of DNA chips, target DNA and probes, hybridization of chips with target DNA, chip scanning, and imaging analysis. The technologies in proteomics are more complicated, which comprise of three main aspects of technologies: protein isolation, identification and bioinformatic analysis of data. If protein isolation is based on 2-D, it includes the preparation of protein sample, 2-D, staining gels, spot excision, proteolysis, mass spectrometry of purified protein and finally undergoing bioinformatic analysis. Here we review the two technologies with emphasis on their applications in neurosciences. The challenges, advantages and disadvantages of the two techniques, and perspectives for their developments are discussed.

Animals↗

Clinical mass spectrometry in neuroscience. Proteomics and peptidomics.

In this review we discuss the merits and drawbacks with the use of proteomic and peptidomic strategies for identification of proteins and peptides in their multidimensional interactions in complex biological processes. The progress in proteomics and peptidomics during the last years offer us new challenges to study changes in the protein and peptide synthesis. These strategies also offer new tools to follow post-translational modifications and other disturbed chemical processes that may be indicative of pathophysiological alteration(s). Furthermore these techniques can contribute to improvements in the diagnosis and therapy of neurodegenerative diseases, such as Alzheimer's disease, and psychiatric diseases, as depression and post traumatic stress disorders. We also consider different practical aspects of the applications of mass spectrometry in clinical neuroscience, illustrated by example from our laboratories. The new proteomic and peptidomic strategies will further enable the progress for clinical neuroscience research.

Arteriosclerosis↗

[Neurosciences and philosophy of mind].

In this paper we argue that the interaction between neurosciences and philosophy of the mind is on the way to understand consciousness, and to solve the mind-body or mind-brain problem. Naturalism is the view that mental processes are just brain processes and that consciousness is a natural phenomenon. It is possible to construct a theory about its nature by blending insights from neuroscience, philosophy of the mind, phenomenology, psychology and evolutionary biology.

Consciousness↗

BioMediator data integration: beyond genomics to neuroscience data.

The BioMediator system developed at the University of Washington (UW) provides a theoretical and practical foundation for data integration across diverse biomedical research domains and various data types. In this paper we demonstrate the generalizability of its architecture through its application to the UW Human Brain Project (HBP) for understanding language organization in the brain. We first describe the system architecture and the characteristics of the four data sources developed by the UW HBP. Second we present the process of developing the application prototype for HBP neuroscience researchers posing queries across these semantically and syntactically heterogeneous neurophysiologic data sources. Then we discuss the benefits and potential limitations of the BioMediator system as a general data integration solution for different user groups in genomic and neuroscience research domains.

Brain↗

Benjamin Franklin and the neurosciences.

Benjamin Franklin (1706-1790), who is better known in other fields, especially colonial politics and international diplomacy, was an early, major contributor to the neurosciences from the New World. Among his accomplishments are: experiments on medical electricity as a possible cure for the palsies and hysteria; the first descriptions of how electricity affecting the brain can cause a specific type of amnesia; supporting the idea that cranial shocks might provide a cure for melancholia; showing that the cures performed by the Mesmerists to remove obstructions, including nerve blockages, rest on gullibility and suggestion, and recognizing the dangers, including those to the nerves, posed by exposure to lead. Franklin?s neuroscience was firmly based on experiments, careful observations, and hard data ? and finding clinical relevance for new discoveries was always on his mind.

Amnesia↗

Australian neuroscience in 2006--highlights from the scientific meeting.

The annual meeting of the Australian Neuroscience Society (ANS) was held in Sydney, Australia, January 31-February 3, 2006. The main meeting was preceded by four satellite meetings. This report predominantly considers some of the drug targets highlighted at the ANS meeting, and at the Dementia, Ageing and Neurodegenerative Diseases Group (DANDIS) satellite. The targets considered are for neurodegeneration, stroke and neuroprotection. Also, various receptors, transporters and channels are considered as therapeutic targets in neuroscience.

Aging↗

[Neurosciences and philosophy].

The goal of this paper is to show the paralelism between the objectives of both, neurosciences and philosophy. First, a historical review of the common works on both fields of study is made; next, the implications of the brain-mind relationship and how the use of a cerebral function theory that help us to solve the problem are discussed. Finally, the social implications of cooperation between neurosciences and philosophy are analyzed.

Brain↗

On psychoanalysis and neuroscience: Freud's attitude to the localizationist tradition.

This study examines the relationship between psychoanalysis and neuroscience. It argues that the Project, the traditional starting-point for such an examination, provides few substantial links between Freud's neurological and psychoanalytic careers. The neurological model that the Project endorsed was not derived from Freud's formal neurological education, as has so often been assumed. It was based, instead, on the Jacksonian model that he developed in 'On aphasia' in 1891. 'On aphasia' appears to be the real 'missing link' between Freud's neurological and psychological years. The fundamental principles that it endorsed provided the framework within which psychoanalysis developed. After Freud's death, Luria developed the science of dynamic neuropsychology, which is based on the same fundamental neurological assumptions as 'On aphasia'. Dynamic neuropsychology approaches brain functioning in a way that would have been entirely acceptable to Freud. Considering the deep-rooted compatibility between Luria's neuropsychology and Freud's psychoanalysis, it would be beneficial for both sciences if they were to collaborate on issues of common interest. This makes Freud's lifelong ambition that psychoanalysis be rejoined with neuroscience a very real possibility.

Aphasia↗

Identifying nursing research priorities: general and neuroscience specific at an acute care hospital.

As a result of economic and health care changes the role of the nurse continues to expand and research-based practice is changing its focus. Limited resources and staff shortages have revealed new areas for research study. Clinical nurses have valuable questions to share that can form the basis of future nursing research. The purposes of the study were to: (a) Determine the priorities for nursing research within a single acute care teaching hospital; (b) Promote nurses' awareness of the importance of research-based practice; (c) Facilitate the development of future nursing research. It was assumed that nurses who carry out direct and indirect patient care roles are "experts" and therefore, are in a position to identify what they see as important questions and in need of further investigation. Three hundred and sixty-six nurses (24%) responded to round #1 of the open ended survey and submitted a total of 912 clinical practice issues. Initially, issues were broadly categorized into clinical and indirect clinical themes in a series of subcategories. Round #2 was conducted to identify nurses' ratings of the priority of the final 123 research issues for future clinical research and practice improvement efforts. Results of the two rounds will be presented, including issues identified by neuroscience nurses. This information will provide a valuable source for additional neuroscience research at either the local or international level.

Acute Disease↗

[Self-recognition in the mirror of another? On the significance of cognitive neuroscience for psychoanalysis].

Current concepts in cognitive neuroscience are presented: neuroimaging, connectionism, models for visual perception and memory. Encountering a convergence of certain concepts like the one for memory between cognitive neuroscience and psychoanalysis makes it necessary to compare the framework assumptions underlying these concepts in each discipline. As it turns out, only a change away from the traditional functionalist framework to a modern, externalist form of non-reductionism makes it possible to use the theoretical convergences in a coherent manner. Conceptual consequences of this change in framework assumptions are discussed, particularly for the role of (neuronal) causes versus reasons in the explanation of behaviour within a broadly psychoanalytic context.

Brain↗

Overview of Microwave Applications in the Neurosciences.

This paper gives an overview of Microwave Applications in the Neurosciences and introduces this issue of the Journal of Neuroscience Methods. Emphasis is laid on: temperature, hotspots, hazards and cycle times in the use of the microwave oven. Consequences of the tissue dimensions and masking of antigens are discussed. Special problems encountered are: bulk preparation of specimens, brain electron microscopy, cooling of specimens during microwaving and the combination of microwave techniques. The recent developments discussed are vacuum-microwave application for large brain specimens and antigen retrieval.

Animals↗

Exploration and virtual experimentation in a local neuroscience database.

Work is currently being done by a number of groups to investigate the possibility of creating one or more neuroscience databases. These databases could provide: (1) a means for conveying complete descriptions of experiments; (2) a platform for virtual experiments; (3) and an interface where modeling and experimental results could be exchanged. This paper describes work towards creating a local database with these capabilities by creating a set of experimental neurophysiology software tools that are tied to a database of experiment descriptions via external scripting mechanisms. These tools provide a means of exploring results and data that can lead to insights into the data that suggest new avenues of research. Because the scriptability of the tools allows for automation of re-analysis of the data, virtual experiments for testing new hypotheses over large datasets becomes possible. Such virtual experiments are particularly relevant to computational neuroscience, as they allow hypotheses generated by models to be immediately tested without further collection of experimental data.

Animals↗

A brief sketch of Soviet neuroscience.

Social and cultural philosophy in the guise of various forms of materialism has long been the basis on which Soviet science (including neuroscience) is founded. Neuroscientific research developed within a number of 'schools', each associated with the doctrine of their founders and concentrated in a few large cities. Currently, central governmental funding covers research within state neuroscience programmes.

Academies and Institutes↗

Neuroscience training in the USA and Canada: observations and suggestions.

Neuroscience training programs in the USA and Canada are awarding about 1000 PhDs each year. This number exceeds the faculty vacancies in these programs by a ratio of three to one. Nonetheless, virtually all graduates are finding employment, usually after a period of postdoctoral experience. On the other hand, recent surveys suggest that there are many other concerns to be addressed. These include an attrition of women during training and within the faculty ranks, a low percentage of minorities throughout the neuroscience community, and a relative lack of federal training funds.

Canada↗

The status of cognitive neuroscience.

Cognitive neuroscience rests on findings, methods, and theory from three fields: experimental psychology, systems-level neuroscience, and computer science. The strong trend over the past few years has been for a greater integration across these fields. The influence of this interdisciplinary approach on current research on memory, perception, and language will be illustrated.

Animals↗

Speech and other central auditory processes: insights from cognitive neuroscience.

Recent advances in cognitive neuroscience, particularly studies utilizing functional neural imaging and animal models, are providing unique insights into the neural substrates of speech and other central auditory processes. In particular, the acoustic-phonetic aspects of speech appear to provide an important organizing principle for linking systems neuroscience research to cognitive and linguistic theories.

Animals↗