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At least 235 records · Page 13Linked to original sources
PubMed1998

Multistate outbreak of hemolysis in hemodialysis patients--Nebraska and Maryland, 1998.

From May 13 through May 23, 1998, a total of 30 patients in three states developed hemolysis with or without chest pains, shortness of breath, nausea, or abdominal pain while undergoing hemodialysis (HD). Two patients died. This report summarizes the preliminary findings of investigations in Nebraska and Maryland and implicated lot number 04015309 of Cobe Centrysystem 3 Blood Tubing sets (Gambro Healthcare, Lakewood, Colorado) as the cause of these reactions.

Aged↗
PubMed1998

Revision of the genus Torogregarina and description of Torogregarina sphinx n. sp. (Apicomplexa: Eugregarinida) from a Missouri river bank beetle, Bembidion laevigatum (Coleoptera: Carabidae), in southeastern Nebraska.

Torogregarina is revised to clarify the nature of the epimerite-protomerite complex and the method of gametocyst dehiscence, removed from the family Gregarinidae, and placed among the Hirmocystidae. Torogregarina sphinx n. sp. (Apicomplexa: Eugregarinida) is described from Bembidion laevigatum (Coleoptera: Carabidae) collected along the Missouri River near Peru, Nemaha County, Nebraska. Measurements are means in micrometers. Association is precocious and caudofrontal. Primite epimerite depressed ovoid and persistent through syzygy; length 25.2, width 41.0. Protomerite a high toroid collar between epimerite and deutomerite; length 13.5, width 35.4. Deutomerite obovoid; length 137.3, width 90.7. Total length including epimerite 172.2. Satellite epimerite protomerite complex concentrically formed by a depressed ovoid epimerite within a transversely oblong protomerite, the protruding dome of the epimerite fitting into a posterior depression on the primite and the transverse anterior margin of the protomerite mating with the posterior margin of the primite to form the syzygial junction; length 25.0, width 48.8. Deutomerite obovoid; length 113.5, width 63.5. Total length 138.6. Gametocysts roughly spherical; diameter 142.9. Gametocysts mature and dehisce by simple rupture, extruding oocysts in a single mass without an epispore packet. Oocysts axially symmetric, dolioform in dorsal aspect, concavoconcave in transverse plane, uniform in size and shape; length 5.2, terminal width 2.4, equatorial width 3.1.

Animals↗
PubMed1998

[Applicability of the screening test for the Luria-Nebraska Neuropsychological Battery in Taiwan].

The study was to examine the applicability of the screening test for the Luria-Nebraska Neuropsychological Battery in Taiwan. This screening test contains 15 items. It could be used at the first stage of neuropsychological assessment process and served as a screening tool for brain-damaged patients. In this study, 50 brain-damaged patients, 50 normal controls receiving physical examination, and 100 normal controls from local communities were sampled and administered with the screening test. Based on test results, item analysis and factor analysis were performed, reliability and validity data were established, and temporary local norm and subgroup norm were also developed. It also investigated the effects of age and educational level on test performance. Further factor analysis with total subjects showed that three factors were extracted. Factor 1 was number concept and simple calculation. Factor 2 was higher cortical function. Factor 3 was motor control and rhythm. These three factors accounted for sixty percent of total variance. In addition, cut-off scores were set for low and high education groups.

Adult↗
PubMed2000

Mantle cell lymphoma. A clinicopathologic study of 68 cases from the Nebraska Lymphoma Study Group.

Although mantle cell lymphoma (MCL) is considered a distinctive disease entity within non-Hodgkin's lymphoma (NHL), the cytology and growth pattern of MCL can be quite variable and the clinical significance of these features is unclear. Also, the role of anthracyclines in the management of MCL is unclear. Therefore, we examined our experience with MCL in an effort to clarify these important issues. We identified 68 patients with MCL who were evaluated clinically and treated by the Nebraska Lymphoma Study Group. Treatment consisted of combination chemotherapy containing an anthracycline in 76% of the patients. The cases were grouped by blastic or lymphocytic cytology, and the latter were divided by growth pattern into nodular (or mantle-zone) and diffuse types. The clinical and pathological variables were then evaluated for their prognostic value. The median overall survival (OS) and failure-free survival (FFS) for the entire group were 38 months and 12 months, respectively, and there was no survival advantage for those who received an anthracycline. The cases were grouped as follows: blastic type, 26%; nodular lymphocytic type, 44%; and diffuse lymphocytic type, 30%. Both the cytology and pattern of growth were predictive of OS and FFS. The median OS was as follows: blastic type, 55 months; nodular lymphocytic type, 50 months; and diffuse lymphocytic type, 16 months (P = 0.0038). The clinical features that predicted for a shorter survival included bone marrow involvement, advanced stage disease, B symptoms, a poor performance score, and the International Prognostic Index. We conclude that new therapeutic approaches, with the patients stratified by histologic type and clinical prognostic factors, are clearly needed for MCL.

Humans↗
PubMed2000

Stream Invertebrate Communities, Water Quality, and Land-Use Patterns in an Agricultural Drainage Basin of Northeastern Nebraska, USA.

We used invertebrate bioassessment, habitat analysis, geographic information system analysis of land use, and water chemistry monitoring to evaluate tributaries of a degraded northeast Nebraska, USA, reservoir. Bimonthly invertebrate collections and monthly water chemistry samples were collected for two years on six stream reaches to identify sources contributing to reservoir degradation and test suitability of standard rapid bioassessment methods in this region. A composite biotic index composed of seven commonly used metrics was effective for distinguishing between differentially impacted sites and responded to a variety of disturbances. Individual metrics varied greatly in precision and ability to discriminate between relatively impacted and unimpacted stream reaches. A modified Hilsenhoff index showed the highest precision (reference site CV = 0.08) but was least effective at discriminating among sites. Percent dominance and the EPT (number of Ephemeroptera, Plecoptera, and Trichoptera taxa) metrics were most effective at discriminating between sites and exhibited intermediate precision. A trend of higher biotic integrity during summer was evident, indicating seasonal corrections should differ from other regions. Poor correlations were evident between water chemistry variables and bioassessment results. However, land-use factors, particularly within 18-m riparian zones, were correlated with bioassessment scores. For example, there was a strong negative correlation between percentage of rangeland in 18-m riparian zones and percentage of dominance in streams (r(2) = 0.90, P < 0.01). Results demonstrate that standard rapid bioassessment methods, with some modifications, are effective for use in this agricultural region of the Great Plains and that riparian land use may be the best predictor of stream biotic integrity.

Journal Article↗
PubMed1985

Nucleotide sequence of the structural glycoprotein VP7 gene of Nebraska calf diarrhea virus rotavirus: comparison with homologous genes from four strains of human and animal rotaviruses.

A full-size cloned cDNA copy of the rotavirus gene encoding the structural neutralization glycoprotein (VP7) of Nebraska calf diarrhea virus (NCDV), a strain recently shown to be effective as a vaccine in children, has been sequenced. Comparison of the deduced amino acid sequence of NCDV (serotype 6) VP7 with that of four other rotavirus strains (human WA serotype 1, human HU-5 serotype 2, simian SA-11 serotype 3, and bovine UK serotype 6) indicates that the degree of amino acid homology among VP7 neutralization proteins of these serotypes ranges from 75 to 86%. Four hydrophilic regions at amino acid residues 174-183, 248-256, 287-294, and 310-317 exhibit significant homology and hence may represent common antigenic determinants, while one hydrophilic area at amino acid residues 83-102 exhibits sufficient divergence to suggest it may be involved in serotype specificity.

Amino Acid Sequence↗
PubMed1991

Evaluating cognitive impairment in depression with the Luria-Nebraska Neuropsychological Battery: severity correlates and comparisons with nonpsychiatric controls.

Depressed patients often complain of memory and attentional difficulties, and some research suggests an increased incidence of neuropsychological impairment in depression. Yet, many prior studies contain methodological problems, including the following: (1) inclusion of medicated patients, (2) small sample sizes, and (3) tests with unknown psychometric properties. We administered the Luria-Nebraska Neuropsychological Battery (LNNB) to 28 unmedicated inpatients who met Research Diagnostic Criteria for major depression. Twenty of the 28 patients were given additional cognitive measures (e.g., Wechsler Adult Intelligence Scale-Revised, Benton Tests). The depressed patients performed similarly to an age- and education-matched nonpsychiatric reference sample. When data for a subset of the most severely depressed patients were analyzed separately, these patients too were found to perform similarly to matched controls. There were no relationships between Hamilton rating scale measures of depression severity and any cognitive measures among the depressed patients. The results suggest that cognitive functioning in depressed patients does not differ significantly from that in carefully matched controls and is independent of symptom severity.

Adult↗
PubMed1975

New complement-fixation test for the human reovirus-like agent of infantile gastroenteritis. Nebraska calf diarrhea virus used as antigen.

A complement-fixation (C.F.) test for the human reovirus-like agent of infantile gastroenteritis has been developed using the serologically related Nebraska calf diarrhoea virus (N.C.D.V.) as antigen. Most infants and children who shed the agent in stools and/or who demonstrated serological (C.F.) evidence of infection with a reovirus-like-particle-positive human stool-filtrate C.F. antigen also demonstrated serological evidence of infection when a concentrated N.C.D.V. preparation was employed AS C.F. antigen. The N.C.D.V., which was previously shown to be related to the human reovirus-like agent, was found to be related antigenically to the epizootic diarrhoea of infant mice (E.D.I.M.) virus also. Studies on the prevalence of C.F. antibody in sera from infants and young children revealed a pattern of rapid acquisition of antibody to both the human reovirus-like agent and the N.C.D.V. as over 80 percent of these individuals possessed antibody to each agent by 36 months of age. A strong positive association was found in the results obtained with the two antigens. The ready availability of cell-culture grown N.C.D.V., and its ability to serve as a "substitute" C.F. antigen for the human reovirus-like agent, should enable the serodiagnosis of many cases of disease due to the human agent and facilitate seroepidemiological studies of such infections. In addition, the observation that a large proportion of individuals infected with the human reovirus-like agent develop serological evidence of infection not only to the human agent but to the calf agent as well may have important implications in the immunoprophylaxis of disease caused by the human reovirus-like agent.

Animals↗
PubMed1999

An analysis and report of custodial deaths in Nebraska, USA.

All medico-legal cases from the Lancaster County Coroner's Office in Lincoln, Nebraska USA, between 1991 and 1996, were reviewed for deaths which occurred in custody. The leading causes of death, in ranked order include: natural 45.1% (23/51), suicide 33.3% (17/51), homicide 11.8% (6/51), accident 7.8% (4/51), and undetermined 2% (1/51). Each cause of death was explored using the following variables: cause of death, age, sex, and race of the decedents. The findings of this investigation are compared with previous studies in other geographic regions of the country. Many similarities and differences in the frequencies of the modes of death are discussed. In addition, six unusual case studies including one accidental death, one homicide, and four suicides are presented and may serve as a reference for pathologists, forensic physicians and other forensic scientists confronted with aberrant cases.

Journal Article↗
PubMed1999

Costs of care associated with high-dose therapy and autologous transplantation for non-Hodgkin's lymphoma: results from the University of Nebraska Medical Center 1989 to 1995.

The purpose of this paper was to (1) comprehensively analyze transplant-related costs for predicted temporal cost shifting and (2) to evaluate whether previous findings of decreasing costs of care persisted using a cost analysis of 353 NHL patients who received autologous stem cell transplantation (SCT) at the University of Nebraska Medical Center. All transplant-related costs between the patient's initial consult and program dismissal were obtained and inflated to constant 1995 dollars. Homogeneous resources were categorized into six cost-drivers and subdivided into outpatient, transplant, and additional inpatient time periods in order to evaluate resource utilization and cost shifting patterns. Between 1989 and 1991 both the average length of stay and comprehensive costs decreased 4.9 days and 14%, respectively. By 1995 additional decreases of 25.7 days and 51% led to an overall 7 year cost decline of 65%. Percent contributions of the six cost-drivers remained similar demonstrating uniformed suppression in transplant-related resource consumption. In contrast, the timing of resource utilization changed dramatically, with transplant hospitalization costs accounting for 83% of the overall costs in 1989, 71% by 1992, and only 45% in 1995, while total outpatient's contribution was 14%, 26% and 49%. Before 1991 ebbing costs were likely related to the development of new technologies such as hematopoietic growth factors and peripheral SCT, while the three-fold larger improvement in costs reported by 1995 are presumably associated with learning curve effects such as organizational changes, increased use of coordinated outpatient facilities, and the more cost-effective use of laboratory tests and pharmaceuticals.

Adolescent↗
PubMed1983

Test-retest stability of the Hiskey-Nebraska Test of Learning Aptitude in a sample of hearing-impaired children and adolescents.

The test-retest stability of the Hiskey-Nebraska Test of Learning Aptitude (H-NTLA) was examined in a group of hearing-impaired children and adolescents. Test-retest correlations for subjects retested after approximately 1 year, 3 years, and 5 years were .79, .85, and .62 respectively. These findings are similar to those reported for normal subjects in studies using verbal intelligence measures. In spite of reasonably high test-retest correlations, more than one half of the sample showed a 10-point or greater difference in Learning Quotient between the two evaluations, and more than one third of the sample showed a 15-point or greater difference. These findings demonstrate the necessity of basing important decisions on more than one measure of intelligence.

Adolescent↗
PubMed1993

Phonologic error distributions in the Iowa-Nebraska Articulation Norms Project: consonant singletons.

The errors on consonant singletons made by children in the Iowa-Nebraska Articulation Norms Project (Smit, Hand, Freilinger, Bernthal, & Bird, 1990) were tabulated by age range and frequency. The prominent error types can usually be described as phonological processes, but there are other common errors as well, especially distortions of liquids and fricatives. Moreover, some of the relevant phonological processes appear to be restricted in the range of consonants or word-positions to which they apply. A metric based on frequency of use is proposed for determining that an error type is or is not atypical. Changes in frequency of error types over the age range are examined to determine if certain atypical error types are likely to be developmental, that is, likely to self-correct as the child matures. Finally, the clinical applications of these data for evaluation and intervention are explored.

Age Factors↗
PubMed1993

Phonologic error distributions in the Iowa-Nebraska Articulation Norms Project: word-initial consonant clusters.

The errors on word-initial consonant clusters made by children in the Iowa-Nebraska Articulation Norms Project (Smit, Hand, Freilinger, Bernthal, & Bird, 1990) were tabulated by age range and frequency. The error data show considerable support for Greenlee's (1974) stages in the acquisition of clusters: the youngest children show cluster reduction, somewhat older children show cluster preservation but with errors on one or more of the cluster elements, and the oldest children generally show correct production. These stages extended to three-element clusters as well. Typical cluster reduction errors were (a) reduction to the obstruent in obstruent-plus-approximant clusters and (b) reduction to the second element in /s/-clusters. When clusters were preserved, but one member was in error, the error was typically the same as for the singleton consonant. Cluster errors are discussed in terms of theories of phonologic development, including open genetic programs and feature geometry. These data are expected to be useful in evaluation and treatment of disorders of phonology.

Articulation Disorders↗
PubMed1983

The Luria-Nebraska Neuropsychological Battery: a promise that may be partly fulfilled.

This paper reviews the literature to date on the Luria-Nebraska Neuropsychological Battery (LNNB). Consideration of the literature leads to the conclusion that the battery does not meet the stated goal of combining Luria's qualification of the symptom approach with a standardized, quantitative approach to neuropsychological assessment. While the LNNB does not approximate Luria's approach, there are data to suggest that the battery may have potential as a quantitative, standardized battery. However, numerous substantial statistical and methodological problems with the research base preclude the endorsement of the battery for clinical use. Nevertheless, the efficacy of the LNNB in clinical situations will rest, not on the developer's and publisher's claims, or on detractor's critiques, but on carefully planned and well-executed research. Until such research appears, caution is urged to those who would attempt to use this instrument in clinical situations.

Brain Damage, Chronic↗
PubMed1999

Performance scales for the Luria-Nebraska Neuropsychological Battery-Form I.

Regression equations were developed to adjust raw scores on Luria-Nebraska Neuropsychological Battery-Form I (LNNB-I) clinical scales for the effects of age and education. Corrected raw scores were then used to develop performance scales for the LNNB-I on which normal individuals anchored the low end of the scales and increasingly impaired patients occupied higher intervals. The resulting scales represent equal intervals of age- and education-corrected test impairment for each LNNB-I clinical scale and should facilitate interpretation of LNNB-I test performances.

Journal Article↗
PubMed1988

Diagnostic parameters of an odd-even item short-form of the Luria-Nebraska Neuropsychological Battery.

The current study examined the concurrent validity of a new short form of Luria-Nebraska Neuropsychological Battery (LNNB). LNNB profiles of 100 subjects of a mixed brain damaged, psychiatric and normal pool were obtained from previously published sources. Levy corrected correlations among both the odd and even number short-forms with the full test ranged from.81 to.90. For the entire sample, absolute numbers of scales above the critical level, number of cases following within a given range of the critical level, and number of cases within each subscale exceeding the critical level were computed. Chi square values revealed significant differences only for the visual, reading, and memory subscales exceeding the critical level.

Journal Article↗
PubMed2004

Genetic recombination between two genotypes of genogroup III bovine noroviruses (BoNVs) and capsid sequence diversity among BoNVs and Nebraska-like bovine enteric caliciviruses.

To determine the genogroups and genotypes of bovine enteric caliciviruses (BECVs) circulating in calves, we determined the complete capsid gene sequences of 21 BECVs. The nucleotide and predicted amino acid sequences were compared phylogenetically with those of known human and animal enteric caliciviruses. Based on these analyses, 15 BECVs belonged to Norovirus genogroup III and genotype 2 (GIII/2) and were genetically distinct from human Norovirus GI and GII. Six BECVs had capsid gene sequences similar to that of the unclassified Nebraska (NB)-like BECV. The 15 bovine noroviruses (BoNVs) were more closely related to Bo/NLV/Newbury-2/76/UK (GIII/2) and other known genotype 2 BoNVs than to genotype 1 Bo/NLV/Jena/80/DE. The BoNV Bo/CV521-OH/02/US showed high nucleotide and amino acid identities (84 and 94%, respectively) with the capsid gene of Bo/NLV/Newbury-2/76/UK, whereas the nucleotide and amino acid sequences of the RNA polymerase gene were more closely related to those of Bo/NLV/Jena/80/DE (77 and 87% identities, respectively) than to those of Bo/NLV/Newbury-2/76/UK (69 and 69% identities, respectively), suggesting that Bo/CV521-OH/02/US is a genotype 1-2 recombinant. Gene conversion analysis by the recombinant identification program and SimPlot also predicted that Bo/CV521-OH/02/US was a recombinant. Six NB-like BECVs shared 88 to 92% nucleotide and 94 to 99.5% amino acid identities with the NB BECV in the capsid gene. The results of this study demonstrate genetic diversity in the capsid genes of BECVs circulating in Ohio veal calves, provide new data for coinfections with distinct BECV genotypes or genogroups, and describe the first natural BoNV genotype 1-2 recombinant, analogous to the previously reported human norovirus recombinants.

Animals↗
PubMed1988

Comparative analysis of the VP3 gene of divergent strains of the rotaviruses simian SA11 and bovine Nebraska calf diarrhea virus.

The gene encoding outer capsid protein VP3 of subpopulations of two animal rotaviruses, simian SA11 and Nebraska calf diarrhea virus (NCDV), was analyzed. Two laboratory strains of simian SA11 rotavirus (SA11-SEM and SA11-FEM) differed with respect to VP3. This dimorphism was indicated by a difference in electrophoretic mobility and a difference in reactivity with anti-VP3 monoclonal antibodies. The overall VP3 amino acid homology between the two SA11 VP3 proteins was 82.7%, whereas the VP3 protein of SA11-FEM was 98.5% homologous in amino acid sequence to NCDV VP3, suggesting that SA11-FEM VP3 was derived by gene reassortment in the laboratory during contamination with a bovine rotavirus. A comparison of the deduced amino acid sequence of the VP3 of two virulent NCDV strains and an attenuated NCDV strain (RIT 4237), revealed only five amino acid differences which were scattered throughout the protein but did not involve the trypsin cleavage sites. Of interest, the VP3 of the standard strain of NCDV which is virulent for cows differed in only one amino acid (position 23, Gln to Lys) from the VP3 of an NCDV mutant which was attenuated both for cows and for children.

Amino Acid Sequence↗