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An open architecture patient monitoring system using standard technologies.

Computer-aided bedside patient monitoring is applied in areas where real-time vital function analysis takes place. Modern bedside monitoring requires not only the networking of bedside monitors with a central monitor but also other standard communication interfaces. In this paper, a novel approach to patient monitoring is introduced. A patient monitoring system was developed and implemented based on an existing industry standard communication network, using standard hardware components and software technologies. The open architecture system design offers scalability, standard interfaces, and flexible signal interpretation possibilities.

Computers↗

Development of a contamination free 6 valve injector inline monitoring system for endotoxin measurement in dialysate.

Use of dialysate as supplement fluid in hemodiafiltration requires controlling contamination by endotoxin of the dialysate. We thus aimed at developing an endotoxin monitoring system with complete exclusion of endotoxin contamination for simple, easy, and accurate measurement of endotoxin concentration in dialysate. In the present study, we used a 6 valve injector along with a high performance liquid chromatogram system. This new system showed a sensitivity of approximately 1 endotoxin units (EU)/L in the range of 0 to 30 EU/L endotoxin in dialysate and no trace of endotoxin contamination. In conclusion, the new endotoxin monitoring system showed high sensitivity and reproducibility, with easy operation.

Endotoxins↗

A wireless PDA-based physiological monitoring system for patient transport.

This paper proposes a mobile patient monitoring system, which integrates current personal digital assistant (PDA) technology and wireless local area network (WLAN) technology. At the patient's location, a wireless PDA-based monitor is used to acquire continuously the patient's vital signs, including heart rate, three-lead electrocardiography, and SpO2. Through the WLAN, the patient's biosignals can be transmitted in real-time to a remote central management unit, and authorized medical staffs can access the data and the case history of the patient, either by the central management unit or the wireless devices. A prototype of this system has been developed and implemented. The system has been evaluated by technical verification, clinical test, and user survey. The evaluation of performance yields a high degree of satisfaction (mean = 4.64, standard deviation--SD = 0.53 in a five-point Likert scale) of users who used the PDA-based system for intrahospital transport. The results also show that the wireless PDA model is superior to the currently used monitors both in mobility and in usability, and is, therefore, better suited to patient transport.

Adult↗

A portable monitoring system for measuring weight-bearing during tibial fracture healing.

An ambulatory monitoring system has been developed to measure the weight-bearing achieved by a patient on their fractured leg. The system is lightweight, portable, and can monitor weight-bearing continuously over an extended period of time. In addition to mean weight-bearing, the system can also determine temporal parameters associated with the patients' gait. This system was used to measure the weight-bearing achieved during the course of fracture healing in a small number of patients being treated by a variety of fixation methods for a tibial fracture. In general, weight-bearing was observed to increase with time post fracture, and the fixation method employed appeared to influence the rate of increase of loading of the fractured limb, more rigid methods of fixation enabling full-weight-bearing to be achieved sooner.

Adolescent↗

Substance abuse treatment and pressures from the criminal justice system: data from a provincial client monitoring system.

AIMS: Compulsory treatment is discussed increasingly as a way to reduce the population burden of addictive behaviours. This study explores the extent to which social control strategies exercised through the criminal justice system are used to bring people into substance abuse treatment at a system level. We also assessed whether particular subgroups may be more or less likely to be brought into treatment in this manner. DESIGN: We employed a secondary analysis of data from a client-based information system which captured demographic, referral and substance use characteristics from people seeking treatment for substance abuse. PARTICIPANTS: A census of clients (n = 45123) entering specialized Ontario addiction treatment programmes between 1 April 1999 and 31 March 2000. FINDINGS: Some 28.9% of clients reported legal problems at treatment intake, and 13.9% had an explicit corrections-related condition of treatment contact. Logistic regression analyses indicated that legal problems and corrections-related conditions of treatment were more prevalent among younger, unmarried and unemployed males, who had not completed high school. A number of important interactions were identified between these factors and substance of abuse. CONCLUSIONS: Implications for equity, accessibility and effectiveness of substance abuse treatment are discussed in relation to the tendency of treatment mandates from criminal justice system to disproportionately affect the entry of this segment of substance-abusing clients.

Adolescent↗

Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system (1990-1998).

Prevalence rates of birth defects in the Federal Republic of Germany are informative to assess the general background risk of having a child with a birth defect. They provide basic figures to determine temporal and regional prevalence trends, to evaluate and initiate preventive measures and to initiate research projects. To avoid observer, definition and collection bias, active monitoring systems are required. Data collected in the active monitoring system of the Mainz Birth Defects Registry are presented. From 1990-1998, 30,940 live-births, stillbirths and abortions underwent standardized physical and sonographic examinations. Anamnestic data were collected from prenatal care records, maternity files and hospital records. Major malformations were diagnosed in 2144 (6.9%) and mild errors of morphogenesis in 11,104 (35.8%) of all infants. Risk factors associated with the occurrence of major malformations were identified by comparing anamnestic data from infants with and without major malformations. Using multivariate regression models, statistically significant associations were established for 9 risk factors. Causally related risk factors were parents or siblings with malformations, parental consanguinity, more than 3 minor errors of morphogenesis in the proband, maternal diabetes mellitus and ingestion of antiallergic drugs in the first trimester of pregnancy. Conjunctional risk factors were polyhydramnios, oligohydramnios and gestational age <32 weeks at birth. Using these risk factors, populations at risk for the occurrence of major malformation can be identified.

Cohort Studies↗

Application of a gamma extremity monitoring system in a radiopharmaceutical dispensary.

A new gamma extremity monitoring system (GEMS) was used to assess finger doses of staff working in a hospital radionuclide dispensary. The system is designed to give a continuous readout of dose rate from a small probe which may be attached to a finger. It allows the contributions to radiation dose to the fingers from different parts of a procedure to be measured for the first time and the detailed pattern of radiation exposure to be determined. The dose reduction benefits of small changes in procedure and the use of syringe shields were easily demonstrated after monitoring staff for a few sessions using GEMS, which would not have been possible using thermoluminescent or other integrating dosemeters. GEMS was calibrated against 99Tc(m), 241Am, 137Cs and 131I. The main disadvantage of the system is that the response of the detector increases significantly at lower radiation energies, with that at 60 keV being approximately 70 times the response at 662 keV. In addition, the response of the current detector is nonlinear and saturates around 7000 counts s(-1), which corresponds to a dose rate of 2200 microGy h(-1) for 99Tc(m). Despite these drawbacks, GEMS can play a significant part in the analysis of finger dose patterns and assist in dose reduction.

Americium↗

Comparing risk estimates of sulphonamide-induced agranulocytosis from the Swedish Drug Monitoring System and a case-control study.

A comparison has been made of risk estimates for agranulocytosis connected with sulphasalazine and trimethoprim-sulphamethoxazole (T-SM) therapy calculated from data in the Swedish Drug Monitoring System ("spontaneous" reports, sales and prescription information) and a population based case-control study (the IAAAS). The relative risk for agranulocytosis during sulphasalazine treatment was calculated to be 107 and 123 by the spontaneous reporting system and the case-control study, respectively. The corresponding excess risk in both systems was 1.8. For T-SM the relative risk was 17 in the spontaneous reporting system and 12 in the case-control study, while the excess risk calculated for 3 days of treatment was 0.9 in the spontaneous reporting system, and 1.6 for 3 or more days of treatment in the case-control study. It is concluded that the Swedish Drug Monitoring System gives an appropriate estimate of the risk of developing agranulocytosis in association with the two drugs studied.

Adolescent↗

First human experiments with a novel non-invasive, non-optical continuous glucose monitoring system.

This paper describes a non-invasive continuous glucose monitoring system based on impedance spectroscopy. Changes in the glucose concentrations can be monitored by varying the frequency in the radio band over a range, optimised to measure the impact of glucose on the impedance pattern. A number of clinical-experimental studies (hyperglycaemic excursions) were performed with healthy subjects in order to prove the applicability of this approach. The sensor used in these experiments is the size of a wristwatch and holds an open resonant circuit coupled to the skin and a circuit, performing an impedance measurement. In most cases, the experiments showed a good correlation between changes in blood glucose and the sensor recordings. A detailed description of the trials is presented. The results of this first series of experiments can be considered as a proof of concept for this novel non-invasive monitoring approach. Nevertheless, partly due to the indirect measurement, a considerable number of questions remain to be clarified.

Blood Glucose↗

Veterinary and nonveterinary costs of disease in 29 California dairies participating in the National Animal Health Monitoring System from 1988 to 1989.

Twenty-nine California dairy herds were studied over a 12-month period from 1988 to 1989 as part of the National Animal Health Monitoring System. Monthly interviews administered to dairy producers were used to measure the costs of all health-related expenditures and disease incidence in these herds. Of the total $1,523,558 reported, $1,355,467 (89%) was attributed to cost of disease events and $168,091 (11%) to cost of disease prevention. Most (78%) of the cost of disease events was attributable to death and culling losses. Veterinary services accounted for only $54,099 (4%) of total costs, 64% of which was used for disease prevention, compared with 36% for disease treatment. Udder disease was the most costly category of diseases reported at an average of $49.85/head at risk annually, followed by reproductive problems at $38.05. Through the use of sampling strategies less biased than those used in other surveys, the National Animal Health Monitoring System is designed to provide statistically-valid estimates of disease incidence and costs across broad geographic areas, potentially benefiting all those interested in the economics of livestock diseases in the United States.

Animals↗

Neutron radiation area monitoring system for proton therapy facilities.

A neutron radiation area monitoring system has been developed for proton accelerator facilities dedicated to cancer therapy. The system comprises commercial measurement equipment, computer hardware and a suite of software applications that were developed specifically for use in a medical accelerator environment. The system is designed to record and display the neutron dose-equivalent readings from 16 to 24 locations (depending on the size of the proton therapy centre) throughout the facility. Additional software applications provide for convenient data analysis, plotting, radiation protection reporting, and system maintenance and administration tasks. The system performs with a mean time between failures of >6 months. Required data storage capabilities and application execution times are met with inexpensive off-the-shelf computer hardware.

Equipment Design↗

Automatic monitoring system for artificial hearts using self organizing map.

This study presents an automatic monitoring system for artificial hearts. The self organizing map (SOM) was applied to monitoring and analysis of an aortic pressure (AoP) signal measured from an adult goat equipped with a total artificial heart. In the proposed system, two different SOMs were used to detect and classify abnormalities in the measured AoP signal. In the first stage, an ordinary SOM, taught with only normal AoP data, was used for detection of abnormalities on the basis of the quantization error in the real-time monitoring task. In the second stage, a supervised SOM was used for classification of abnormalities. The supervised SOM can be regarded as an ordinary SOM with an extra class vector for solving the classification problem. The class vector is assigned to every node in the second SOM as an output weight learned according to Kohonen's learning rule. The effectiveness of detection and classification of abnormalities using these two SOMs was confirmed.

Animals↗

Pregnancy intention: how PRAMS data can inform programs and policy. Pregnancy Risk Assessment Monitoring System.

BACKGROUND: In most states, the Pregnancy Risk Assessment Monitoring System (PRAMS) is the only source for state-specific, population-based data on the prevalence of unintended pregnancy among women having a live birth. These data can be used in a variety of ways to inform state policies and programs aimed at the prevention of unintended pregnancy. OBJECTIVES: This paper highlights the programmatic and policy development activities undertaken by three states in relation to unintended pregnancy as well as the role that PRAMS data played in those efforts. RESULTS: Georgia, Oklahoma, and Washington have used PRAMS data to gain support for program initiatives directed at unintended pregnancy, to promote policies aimed at either monitoring or reducing unintended pregnancy, and to acquire additional funds for related programs, such as family planning.

Adolescent↗

European Concerted Action on Anticoagulation (ECAA): multicentre international sensitivity index calibration of two types of point-of-care prothrombin time monitor systems.

A multicentre modified World Health Organization (WHO)-type international sensitivity index (ISI) calibration has been performed at 10 European Concerted Action on Anticoagulation (ECAA) national laboratories using non-citrated whole-blood on two point-of-care test (POCT) prothrombin time (PT) monitor systems, CoaguChek Mini and TAS PT-NC, using single lots of test cards/strips. The relevant species (human and rabbit) WHO international reference preparations (IRPs) were tested with the manual PT technique on citrated plasma from the same blood donations. The ISI was calculated from the slope of the orthogonal regression line relating log PT (POCT) to log PT (IRP). The mean ISI of the CoaguChek Mini system was 1.75 and 1.13 with the prothrombin time non-citrated Thrombolytic Assessment System (TAS PT-NC). With the CoaguChek Mini system, seven out of 10 calibrations exceeded the current 3% WHO recommended limit for the coefficient of variation (CV) of the slope with conventional PT testing, whereas with the TAS PT-NC system, it was eight out of 10. All the POCT calibrations had a CV of the slope <5%. It is suggested that this level of precision be adopted as the limit of acceptability of calibration of these monitor systems. In these circumstances, the modified WHO-type ISI calibration appeared to be satisfactory for the POCT whole-blood monitors.

Animals↗

[Problems in clinical use of intraarterial blood gas monitoring system, Paratrend 7].

We evaluated the intraarterial blood gas monitoring system Paratrend 7 in clinical use. One hundred and sixty six sensors used for patients receiving thoracic, open heart or great vessel surgery were tested for one year, prospectively. Sensors were inserted through a 20 G intraarterial cannula into the radial artery before operation and removed when they malfunctioned or seemed to be not necessary for patient management in critical care unit. We encountered several problems such as, initial calibration failure (5/166), impossible sensor insertion (2/166), arterial pressure wave change (5/166), parameter display failure (21/166), and thrombus in the circuit (9/166). Parameter display failure after insertion tended to occur on patient's arm movement imparing the sensor. No serious accident, such as arterial thrombosis was experienced. Some troubles were due to staff's incorrect handling of the apparatus. Training of staffs is indispensable for safe and sufficient utilization of Paratrend 7.

Aged↗

Evaluation of a continuous glucose monitoring system in cats with diabetes mellitus.

A continuous glucose monitoring system (CGMS) was evaluated in 14 cats with naturally occurring diabetes mellitus. The device measures interstitial fluid glucose continuously, by means of a sensor placed in the subcutaneous tissue. All cats tolerated the device well and a trace was obtained on 15/16 occasions. There was good correlation between the CGMS values and blood glucose concentration measured using a glucometer (r=0.932, P<0.01). Limitations to the use of the CGMS are its working glucose range of 2.2-22.2 mmol/l (40-400 mg/dl) and the need for calibration with a blood glucose measurement at least every 12 h. When compared to a traditional blood glucose curve, the CGMS is minimally invasive, reduces the number of venepunctures necessary to assess the kinetics of insulin therapy in a patient and provides a truly continuous glucose curve.

Animals↗

Accuracy of the EasyTouch blood glucose self-monitoring system: a study of 516 cases.

BACKGROUND: Self-monitoring blood glucose device is an important tool for diabetes patients to efficiently control their blood glucose concentrations. We evaluated the accuracy of EasyTouch glucose monitoring system. METHODS: Capillary blood glucose concentrations measured using EasyTouch and the reference values obtained from Yellow Springs Instruments (YSI) 2300 STAT were performed in the Department of Laboratory Medicine, Wei-Gong Memorial Hospital. Results were evaluated using (1) linear regression analysis, (2) Clarke Error Grid analysis, (3) percentage of readings within a defined range of deviation from the reference value, (4) bias plots, and (5) coefficients of variation (CVs) calculated from 60 measurements in series. RESULTS: The window of the 516 EasyTouch readings covered a range from 42 to 555 mg/dl. Linear regression analysis yielded a regression slope 0.9972, intercept 1.899 mg/dl, r2 0.9571, and Syx 14.89 mg/dl. A Clarke Error Grid analysis showed 100% of the EasyTouch readings in clinically acceptable zones A and B. Of the EasyTouch readings, 98.3%, 91.9%, 78.3% and 46.9% were found within +/-20%, +/-15%, +/-10%, and +/-5%, respectively, of the reference values. Further analysis showed that the percentage of EasyTouch readings within the defined intervals was similar in three glucose ranges (< or =100, 101-200, and > or =201 mg/dl). The CVs for the four lots of strips (lot 1 to lot 4) ranged from 3.5 to 5.5%, 2.1 to 4.8%, 1.8 to 3.6%, and 3.0 to 5.7%, respectively. CONCLUSIONS: EasyTouch provides high accurate and precise glucose readings over a wide range of glucose concentrations.

Blood Glucose↗

A real time patient monitoring system on the World Wide Web.

World Wide Web (Web) technology has become increasingly popular and successful, because it uses standard communication protocols and Hyper Text Markup Language(HTML), and is supported on multiple platforms. Innovations such as server push, secure socket layer and Java make it possible to use the Web as the basis for creating monitoring systems of dynamic processes. This paper presents a project, whose goal is to develop a Web based Intelligent on-line Monitoring system for Intensive Care Units (IMI). IMI has been tested and evaluated in an intensive care unit since October 1995, and the results are promising. After presenting the motivations of using Web technology, we present the system structure and the functionality of IMI as well as the testing and evaluation results. Security issues are also addressed.

Computer Communication Networks↗