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[Retinal angiomatosis. Long-term follow-up].

UNLABELLED: Meyer-Schwickerath reported his first results with light coagulation in 1959. This report on the results of treatment in this disease is based on more than 34 years experience at the university eye hospital in Essen. Important prognostic factors are the number of retinal hemangiomas and secondary retinal lesions, such as exudative retinal detachment, lipid deposits, vitreous hemorrhages, preretinal membranes and traction retinal detachment. PATIENTS: Treatment was performed in 156 patients, with 220 involved eyes. The median follow-up was 8.9 years and the average age before treatment, 27.5 years. RESULTS: A positive family history was found in 36.5% and extraocular hemangiomas in 24% of all cases. There were 64 patients with bilateral hemangiomas. In 64.5% of cases the tumor was destroyed without further recurrences. Xenon light coagulation was the only treatment applied in 70%. The other patients received combined procedures with light coagulation, cryocoagulation, Ru 106 plaque and proton beam. Salvage of 90% of all treated eyes was achieved. CONCLUSION: Treatment at an early stage of the disease, before any secondary retinal damage has developed, seems to be crucial for satisfactory results. Light coagulation is extremely effective at this stage. However, the treatment options for advanced cases have also become better recently.

Adult↗

[A long-term study of morphological and functional developments after central serous chorioretinitis].

Of 163 patients suffering from central serous chorioretinopathy, 40 who had been treated by light coagulation and 40 who had been treated conservatively were selected at random. They were examined at intervals averaging 5.7 and 4.6 years respectively after the initial treatment. Central visual acuity, central visual fields and the fundus were examined. The central visual acuity of the light-coagulated patients was normal both after initial treatment as well as at re-examination. In contrast, only one-half of the conservatively treated patients had normal visual acuity following initial treatment. However, after an average of 4.6 years it was normal in 34 cases. Neither quantitatively nor qualitatively was there any significant difference in the functional defects of the central visual fields in the two groups. The incidence of degenerative central retinal changes - above all at the level of the pigment epithelium - was considerably higher in the conservatively treated group than in the light-coagulated one.

Chorioretinitis↗

Treatment of retinoblastoma by precision megavoltage radiation therapy.

The principal treatment concept in the Utrecht Retinoblastoma Centre is megavoltage irradiation, followed by light coagulation and/or cryotherapy if there is any doubt as to whether the residual tumour is still active. Radiation therapy is administered by means of a simple but highly accurate temporal beam technique. A standardized dose of 45 Gy is given in 15 fractions of 3 Gy at 3 fractions per week. From 1971 to 1982, 39 children with retinoblastoma have been irradiated in at least one eye. Of the 73 affected eyes, 18 were primarily enucleated, one received light coagulation only, and 54 received radiation therapy. Of the 54 irradiated eyes, 32 were additionally treated by light coagulation and/or cryotherapy for suspicious residual tumour (in 29 eyes), recurrent tumour (in 1 eye), and/or new tumour (in 3 eyes) and 10 were ultimately enucleated. Two eyes also received hyperthermia. The percentages of cure of the irradiated eyes with a minimum follow-up of 2 years were 100% (14/14), 100% (9/9), 83% (10/12), 79% (11/14) and 0% (0/5) in the Reese-Ellsworth groups I to V-A, respectively. Of the saved eyes 95% achieved useful vision. Eighteen eyes developed a clinically detectable radiation cataract; in five of these the lens was aspirated. Cataracts developed exclusively in those lenses of which a posterior portion of more than 1 mm had to be included in the treatment field. The likelihood and the degree of cataract formation was found to be directly related to the dose of radiation to the germinative zone of the lens epithelium. The minimum cataractogenic dose found in this series was 8 Gy.

Cataract↗

Angioid streaks.

Angioid streaks were first described by Doyne in 1889. Gronblad proposed in 1929 that they followed disruption of the elastic layer of Bruch's membrane, having noted the association between angioid streaks and pseudoxanthoma elasticum. Several other diseases have been associated with angioid streaks, including Paget's disease and sickle cell disease. Angioid streaks are found predominantly in the 20 to 50 year age-group and may be associated with minimal visual loss, but the problem is the high risk of rapid development of subretinal neovascularisation at the macula with resultant haemorrhage and scarring. Prophylactic light coagulation along the angioid streaks to prevent subretinal neovascularisation is not recommended. However, light coagulation treatment to foci of subretinal neovascularisation is possible if the network is not too close to fixation. As recurrence of neovascularisation is to be expected, very careful follow-up is necessary.

Adolescent↗

[How effective is photocoagulation? (author's transl)].

Six hypotheses relating to the mode of action of photocoagulation, based on comprehensive data gathered from the literature, are put forward and discussed. Particular emphasis is given to the question of achieving a lasting break through of the barrier represented by Bruch's membrane and the pigment epithelium and thus to the altered diffusion conditions between the choriocapillaries and the retina. In addition a peculiar marginal fluorescence in fluorescein serial angiograms of old light coagulation foci is described and compared with data from the literature. The authors put forward a new hypothesis concerning the mode of action of light coagulation; they believe that particularly in the marginal areas affected by photocoagulation, completely new conditions are created for the metabolic exchange between choroid and retina, including the formation of anastomoses and shunts.

Choroid↗

[Has photocoagulation improved the prognosis of diabetic retinopathy?].

In 192 diabetic retinopathy cases, Xenon light coagulation was performed. Afterwards, the eyes treated were examined half yearly for at least 4 years. Fundus photography and fluorescein angiography were made and the visual acuity was checked. In 64 cases the comparison could have been made in the same patient between one treated and the other untreated eye. The statistical results of this study permit us to assess the therapeutic value of light coagulation for diabetic retinopathy.

Diabetic Retinopathy↗

[Diabetic retinopathy].

Retinal complications of diabetes mellitus are chronic but late functional signs can lead to delayed diagnosis and treatments. Light coagulation (argon laser radiation) is recognized for its efficiency at the stage of "mature" retinopathy, converting the prognosis of a disease which was leading to blindness. Photocoagulation is not used in the early stages (early or strictly posterior pole diabetic retinopathy); partial regression or stabilization can be hoped with intensive medical treatment of diabetes. Treatment of diabetes could become the best preventive treatment. Light coagulation is used at stages when the disease is not reversible (non or preproliferative and proliferative). In tractional retinal detachment surgery remains active, always corresponding to too late treatments. Although pharmacology has progressed (inhibitors of platelet agregation and of non enzymatic glycation) medical therapy remains controversial.

Diabetic Retinopathy↗

Cryopexy of the reattached retina.

Light coagulation of a retinal defect or of the whole buckle following successful retinal detachment surgery, can be replaced by cryopexy. This is particularly useful in the case of opacity of the refracting media, or where too contracted a pupil hinders light coagulation. The technique and advantages of this proceeding are discussed.

Cryosurgery↗

[Treatment of capillary hemangiomas by infrared contact coagulation].

Twenty-two patients with a total of 29 hemangiomas or angiomatous lesions were treated with an infrared light coagulating device. Total clearing of the lesions was obtained with capillary hemangiomas smaller than 1 cm in diameter. Distinct improvement is achieved in senile angiomas, spider nevi and capillary hemangiomas with more than 1 cm in diameter. Using the correct dosages this therapy is nearly free of side effects and represents a practicable alternative to conventional methods.

Adult↗

A long-term follow-up study of laser coagulation of neovascular membranes in angioid streaks.

We treated 30 eyes (24 patients) with angioid streaks and neovascular membranes using light coagulation. Of 30 eyes, 16 showed either ameliorated or unchanged visual acuity. Twelve of the remaining 14 eyes retained a visual acuity of 20/200 or better. In 11 patients, the fellow untreated eye showed central macular degeneration with loss of central vision. The follow-up period ranged from two months to 16 years (mean, 3.4 years).

Adult↗

Low intensity argon laser coagulation in central serous retinopathy (csr).

Mechanisms of light coagulation effects in RPE and detached retina are discussed. 25 cases of CSR are presented in which the leaking point in the RPE was coagulated with an argon laser coagulator, the exposure parameters being set to avoid a whitening of the retina. The results suggest that the retinal whitening and consequently retinal damage does not constitute a criterium for coagulation effectiveness in CSR.

Adult↗

[Exudative retinal detachment, pigment epithelium tear and subretinal exudate in a case of central serous retinopathy].

A thirty year old patient with central serous chorioretinopathy on his right eye is presented. The signs of his disease were exsudative retinal detachment with shifting fluid, rip of the retinal pigmentepithelium and a mass of whitish-yellowish subretinal protein. After the diagnosis was made light-coagulation was performed. Within half a year the retina reattached completely, most of the subretinal protein was reabsorbed and vision slowly normalized.

Adult↗

Conservative treatment of retinoblastoma.

42 cases of retinoblastoma were treated by light coagulation with or without radiotherapy and chemotherapy. 29 cases were cured (69%). The follow-up time of these cases amounts between 3 and more than 16 years.

Bone Neoplasms↗

Adult giant hemangioma of the larynx: a case report.

We report a giant hemangioma that extended from the mesopharynx to the larynx in an adult. The patient was a 39-year-old woman who had demonstrated an asymptomatic pharyngeal hemangioma since she was 1 year-old. She developed vertigo and consulted a hospital at the age of 39. During screening by head MRI for the diagnosis of the vertigo, hemangioma of the laryngopharynx was detected. She was referred to Osaka National Hospital for further examination. Her subjective symptoms were dyspnoea in the lower left lateral-position. On observation by nasopharyngolaryngovideoscope, a giant hemangioma was diagnosed in the left mesopharynx expanding into the larynx. On MRI study, hemangioma widely extended to the right posterior wall at the mesopharynx level. Since we were concerned about risk of choking if the hemangioma of the larynx were left untreated, we recommended surgery. Under the general anesthesia, hemangioma of the larynx was light-coagulated by KTP laser through tracheotomy. The postoperative-course has been good and at 9 months postoperatively, there was no progression of hemangioma.

Adult↗

Retinal detachment surgery.

Retinal surgery commences with careful ophthalmoscopy. The surgeon must be familiar with indirect monocular and binocular ophthalmoscopy, but biomicroscopy is most essential. Buckling procedures can be produced by different techniques and should be adapted to the case. Drainage of subretinal fluid is crucial. One should avoid it if possible, but if it has to be done, care has to be taken to avoid complications. The sealing of retinal holes and tears can be performed by diathermy, cryo- and light coagulation. Each technique has its indication and should be available at the time of surgery. Vitreous surgery is still in the experimental stage, but seems to be very promising, although its main use will most probably lie outside the field of retinal detachment.

Argon↗