Materials in the French Revolutionary tracts of the British Library relating to medicine, hospitals and poor relief.
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Historical source material of all classes in all types of medical libraries.
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Libraries↗
The use of a compensator library to reduce dose inhomogeneity in tangential radiotherapy of the breast.
BACKGROUND AND PURPOSE: The dose variation throughout the volume of the breast from tangential fields can exceed 20% for large breasts. This is postulated to result in poor cosmesis [Radiother Oncol 16 (1989) 253], particularly at the inframammary fold, where the dose is highest. Compensators may be used to reduce this variation, but at the cost of the time to manufacture each unique compensator for the individual patients. This paper outlines the implementation and routine use of a library of reusable compensators. MATERIALS AND METHODS: For the period of December 1999 to May 2001, 94 patients attending for breast radiotherapy received treatment using breast compensators calculated from multiple outlines measured using the Osiris system. The compensators manufactured for the early patients were added to a library for possible reuse by later patients. Of the 94 patients, 28 patients' compensators formed the library and 66 subsequent patients have been treated using compensators derived from the library. Selection of the most appropriate library compensator was determined from the analysis of the distribution of the calculated dose-volume histogram for the whole breast, excluding lung, penumbra and build-up regions. Once the library was complete, approximately 50% of all subsequent breast patients were treated with compensators (46% from the library and 4% with individual compensators). This represented a usage rate of 92% for the library compensators for those patients requiring compensation. RESULTS: In all cases the compensators reduced the variation in the dose distribution. For example, the group treated with a library compensator demonstrated a mean reduction from 29 to 9% for the volume of breast tissue receiving more than 5% greater than the reference dose. If the same patients had been treated using their own individual compensators, the corresponding value would have been 7%. There is a small systematic, but negligible, difference in the two populations of dose variation for individual versus library compensators, but this difference (P=0.20) did not reach the level of statistical significance of P=0.05). CONCLUSION: The method of creation and selection of library compensators has proved to be simple and reliable in practice. Every patient receiving radiotherapy for breast cancer is currently investigated under full software control to ascertain whether the use of a library compensator would be advantageous.
Adult↗
Identification of novel polyphenol oxidase inhibitors by enzymatic one-pot synthesis and deconvolution of combinatorial libraries.
The feasibility of enzymatic synthesis of combinatorial libraries using multifunctional starting materials [i.e., 2,4-dihydroxy-N-(2-hydroxyethyl)benzamide, 1; 4-hydroxyphenethyl alcohol, 2; 3,5-dihydroxybenzyl alcohol, 3; and 4-hydroxybenzyl alcohol, 4] with six vinyl esters, in a one-pot reaction, was investigated. Candida antarctica lipase was employed as a biocatalyst. The resulting 24-compound library contained all the expected species with no significant bias toward particular combinations of substrates. As expected, the library contained a substance(s) that showed significant inhibition of polyphenol oxidase, which was used as a model target. The deconvolution was accomplished via resynthesis of ten partial libraries, which were prepared with either an equimolar mixture of the four alcohols and a single vinyl ester, or a single alcohol and equimolar mixture of the activated esters. Analysis of the inhibition pattern observed with these partial libraries suggested that 4-hydroxybenzyl benzoate (4e) should be the most potent inhibitor. This conclusion was confirmed by the preparation and comparison of all 24 components of the initial library. Finally, it was shown that 4e was a competitive inhibitor of polyphenol oxidase, with a K(i) of 40 microM. This value compared favorably with a K(i) of 400 microM, which was determined for parent phenol 4.
Catalysis↗
High-throughput screening system for catalytic hydrogen-producing materials.
A high-throughput screening system and methodology were developed for libraries of hydrogen (H(2)) producing catalytic materials. The system is based on the chemo-optical properties of WO(3), which give rise to reflectance changes in the presence of H(2). Pd-coated WO(3) sensors were synthesized and examined for their hydrogen sensitivity, wavelength-dependent reflectance, and performance in the presence of water vapor. For high-throughput screening, a polypropylene reactor block was designed and constructed to house 8 x 12 catalyst libraries deposited as thin films. When the library and reactor block are assembled together, 96 independent microreactor units are formed. A large-area Pd/WO(3) sensor film covers and seals all microreactors, forming a 96-element 2-D H(2) sensor array. As H(2) is produced differentially across the library, the reflectance changes of the Pd/WO(3) film are monitored by reflectivity sensors that scan the surface every 30 s. The time-dependent changes in reflectance indicate relative rates of H(2) production. A library of cathode electrocatalysts was synthesized from Ti, Pt, Ni, Au, Pd, Al, Ag, Ge, and mixtures thereof to demonstrate the H(2) high-throughput screening system. The results of the electrolytic screening are in agreement with expected literature trends: mixtures of Ni and samples containing Pt and Pd generated H(2) at the greatest rates, while Ge- and Ti-based materials were the least effective electrocatalysts. A mixture of 80% Al and 20% Pt was found to have the highest rate of H(2) production. This high-throughput screening system is applicable in a variety of catalytic screening applications where hydrogen is the desired product.
Journal Article↗
The history of medical libraries from 2000 B.C. to 1900 A.D.
Tablets said to date back to 2000 b.c. represent the earliest medical writings so far discovered. The history of the medical library (defined as a place where a collection of medical writings is kept) is traced through ancient and medieval civilizations, and the dependence of advancement or decline on the attitude toward learning and knowledge is demonstrated.The change in structure of medical libraries that took place around the 1500s with the development of scientific societies is discussed. Medical libraries of Colonial America are described and the history is brought forward to the era of public library collections of medical material in the early 1900s.
American Medical Association↗
Construction of cDNA libraries from cultures of Armillaria mellea.
1. Conditions were established for growth of mycelial cultures of Armillaria mellea such that the production of its lysine-specific proteinase was maximized. Proteinase synthesis was confirmed by immunoprecipitation. 2. Mycelia grown under these same conditions were used as a source of RNA and this RNA was translatable in a wheat germ translation system to produce proteins with M(r) in the range < 10,000- > 90,000. 3. Double-stranded cDNA was prepared and was inserted into the EcoR1 site of lambda gt10 and lambda gt11 using an adaptor ligation strategy. Packaging of these materials yielded large cDNA libraries. The form lambda gt10 contained 2.9 x 10(6) pfu/ml with 70% recombinants whereas that from lambda gt11 contained 2.2 x 10(6) pfu/ml with 60% recombinants.
Agaricales↗
Trisomy 5q12-->q13.3 in a patient with add(13q): characterization of an interchromosomal insertion by forward and reverse chromosome painting.
We report on a patient with azoospermia, mild mental retardation, and minor physical anomalies. Chromosome analysis demonstrated the presence of additional material on the long arm of one chromosome 13. Forward chromosome painting using chromosome-specific libraries showed an insertion of material from chromosome 5. Further characterization with flow sorting of the aberrant chromosome and amplification by DOP-PCR followed by reverse chromosome painting showed specific trisomy of 5q12-->q13.3.
Adult↗
Pain and palliative care in Issue Number 3, 2001 of The Cochrane Library.
A brief description of how an individual can access The Cochrane Library and navigate within it is provided. The National Library of Medicine medical subject heading (MeSH) terminology is described. Selected new reviews from a recent edition of The Cochrane Library are listed in an annotated bibliography together with a description of the current volume of material now available on the library.
Humans↗
Large-scale analysis of 73 329 physcomitrella plants transformed with different gene disruption libraries: production parameters and mutant phenotypes.
Gene targeting in the moss Physcomitrella patens has created a new platform for plant functional genomics. We produced a mutant collection of 73 329 Physcomitrella plants and evaluated the phenotype of each transformant in comparison to wild type Physcomitrella. Production parameters and morphological changes in 16 categories, such as plant structure, colour, coverage with gametophores, cell shape, etc., were listed and all data were compiled in a database (mossDB). Our mutant collection consists of at least 1804 auxotrophic mutants which showed growth defects on minimal Knop medium but were rescued on supplemented medium. 8129 haploid and 11 068 polyploid transformants had morphological alterations. 9 % of the haploid transformants had deviations in the leaf shape, 7 % developed less gametophores or had a different leaf cell shape. Other morphological deviations in plant structure, colour, and uniformity of leaves on a moss colony were less frequently observed. Preculture conditions of the plant material and the cDNA library (representing genes from either protonema, gametophore or sporophyte tissue) used to transform Physcomitrella had an effect on the number of transformants per transformation. We found correlations between ploidy level and plant morphology and growth rate on Knop medium. In haploid transformants correlations between the percentage of plants with specific phenotypes and the cDNA library used for transformation were detected. The number of different cDNAs present during transformation had no effect on the number of transformants per transformation, but it had an effect on the overall percentage of plants with phenotypic deviations. We conclude that by linking incoming molecular, proteome, and metabolome data of the transformants in the future, the database mossDB will be a valuable biological resource for systems biology.
Bryopsida↗
Building precepts and library programs.
The quality of a library's design can often be determined by the amount of preplanning done before it was built. The paper discusses three components of a library: the users, staff, and materials. Before any design is contemplated for new or additional space, a philosophy or purpose of the library must be determined. Some questions that need to be asked about users are used as an illustration to show the kinds of information that is needed before a librarian can begin to write a program. Only after such information has been gathered can textbook formulas be applied. The librarian will have to synthesize general purposes and facts into a functional program which the architect can use as a basis for design. A common way to demonstrate how space should be utilized is through diagrams. The determination of why one building is better than another for a specific environment is not a matter of guess work or applying formulas, but a matter of intellectual work.
Architectural Accessibility↗
An integrated map with cosmid/PAC contigs of a 4-Mb Down syndrome critical region.
The major phenotypic features of Down syndrome have been correlated with partial trisomies of chromosome 21, allowing us to define the candidate gene region to a 4-Mb segment on the 21q22.2 band. We present here a high-resolution physical map with megabase-sized cosmid/PAC contigs. This ordered clone library has provided unique material for the integration of a variety of mappable objects, including exons, cDNAs, restriction sites, etc. Furthermore, our results have exemplified a strategy for the completion of the chromosome 21 map to sequencing.
Bacteriophage P1↗
Continuing Medical Education in Clinical Pharmacology and Therapeutics: report of a questionnaire survey.
AIMS: To seek the views of medically qualified members of the Clinical Section of the British Pharmacological Society (BPS) on their perceived needs for Continuing Medical Education (CME); on how and by whom these needs should be addressed; and on how the outcome of any educational intervention might best be assessed. METHODS: A structured questionnaire. RESULTS: Of 233 recipients, 140 (60%) responded, but only 123 of these fulfilled the criteria for analysis. A large majority of respondents were clinicians, most of whom devoted at least 25% of their working week to their NHS commitment. There was widespread reliance on textbooks and journals as sources of CME, supplemented by discussions with specialist peers at national and international meetings. Many felt that fulfilling even this agenda was stretching their commitment to the limit, and their greatest need was for protected time in which to learn. There was a desire among 49% of all respondents for the BPS Clinical Section to take some responsibilty for addressing the future needs of its members, and 75% took the view that academic departments should contribute to the development and updating of materials. There was no clear agreement about what these should comprise, but around half of all respondents favoured web-based, journal-based or computer-assisted educational material offering self-assessment opportunities; and CME symposia or workshops at BPS meetings. Almost half (46%) felt that assessment of CME should be integrated with a well-organized appraisal system and the use of portfolios. Six out of 10 respondents were already, or were about to be, regularly appraised at their place of work. CONCLUSIONS: The questionnaire survey revealed a broad canvas of views and little evidence of consensus except for a general plea for more time in which to learn. The aim of the Clinical Section should be to facilitate and help its members to organize their learning, in a way that is consistent with national trends in Continuing Professional Development. The Clinical Section should co-ordinate the setting up of an electronic library of appropriate published material, compiled by academic and industrial sources, that would guide members seeking up-to-date knowledge of Clinical Pharmacology and Therapeutics. The British Journal of Clinical Pharmacology (BJCP) should commission review articles on recent developments where no suitable published material exists. Academic departments should also be invited to identify or develop self-assessment material that members could use to reinforce their learning, and demonstrate their knowledge to relevant professional bodies. The Clinical Section should organize Symposia and Workshops at which contentious issues in Clinical Pharmacology and Therapeutics can be discussed and resolved.
Education, Medical, Continuing↗
EDUCATION AND TRAINING OF THE MEDICAL LIBRARIAN IN GREAT BRITAIN.
This paper describes the education of the librarians under whose care the medical libraries of Great Britain have flourished and the way junior assistants now move toward higher qualification. It expresses the hope that the changed Library Association syllabus gives the medical library assistant an earlier chance of using his knowledge of medical library practice in the papers presented; that the inclusion of medical material in the examination will encourage library schools to provide appropriate instruction in this field, thus achieving a system like that in the United States. For its encouragement of continuing education for the senior librarian, our debt is acknowledged to the Medical Section or Group of the Library Association, which through its meetings gives opportunity for cooperation and discussion of suggestions for further improvement.
Dental Assistants↗
Protein arrays from cDNA expression libraries.
This chapter describes the production of a cDNA expression library from human fetal brain, the construction of a high-density protein array from such a library, and two applications to screen the array for binding proteins. After producing the library and decollating the expression clones, one can pick thousands of expression clones with a laboratory robot and can deposit them into microtiter plates in an ordered manner. Such ordered clone libraries are the starting material for the construction of a high-density protein array. This array is constructed by spotting the expression clones onto a protein-binding membrane. Following cell growth and induction of protein expression on the membrane, the cell spots are lysed and their recombinant protein immobilized on the membrane. The so-constructed array carries thousands of proteins without the need to clone, express, and spot individual proteins. Such arrays allow one to screen for numerous protein functions in a high-throughput manner.
Amino Acid Sequence↗
A study of library use in problem-based and traditional medical curricula.
A key question for librarians and medical educators who are planning for curriculum change is whether students and faculty in problem-based learning (PBL) programs use the library and its resources differently than do participants in traditional programs. During 1991, this research question was explored at three medical schools in the province of Ontario, Canada. At the time of the study, McMaster University medical school was totally problem-based, the University of Western Ontario had one PBL day each week for first-year medical students, and the University of Toronto, although planning for medical curriculum change, had not yet initiated PBL. Data collected in the study suggest that more medical students in the problem-based curriculum than in the more traditional programs use the library and that, when the PBL students use the library, they do so more frequently, for longer periods of time, and as a source of a greater proportion of their study materials. PBL students also use the library more than their counterparts as a place to study and meet other students. Students in the problem-based curriculum use the following resources more extensively: end-user MEDLINE searching, library journals, reserve or short-term loan materials, photocopy services, and audiovisual materials. PBL students also report purchasing more textbooks. In contrast to the differences found among medical students, however, patterns of library and resource use by medical faculty at the three schools were quite similar.
Computer-Assisted Instruction↗
Can't get to the library? Then we'll come to you. A survey of library services to people in their own homes in the United Kingdom.
AIMS: To determine the current level of library service to people in their own homes in the United Kingdom and to compare it with results from previous surveys. It is many years since a similar survey has been undertaken or guidelines produced and it is hoped that this work will help fill the gap. METHODS: A questionnaire was sent in January 2004 to all public library authorities in the UK, a total of 208; 72% (149) were returned in the timescale allowed. The questionnaire covered the criteria for eligibility to receive a home library service; service structure and delivery: who delivers the service (specialist librarians or specialist non-professional staff, branch library staff or volunteers); training; range of material and services provided; reading aids; materials for reminiscence; information provision; transporting people to the library; services to people in residential homes, sheltered accommodation, nursing homes and day centres; reader development; lifelong learning; and publicity and promotion. The focus of the survey was on quality issues and good practice wherever possible. RESULTS: The number of customers receiving a service to 'housebound' readers in the UK in 2001/2 was 123 407. In 1984 it was 43 807 people in England. This still bears little relation to the number of people who should be receiving the service. The majority used paid staff (88%). Volunteers supported 52% of the services, with most having links with staff. There were opportunities to improve and develop services under the Disability Discrimination Act 1995. The service was publicized and promoted by only 62% of the respondents. Of those that use paid staff and that answered this question, 73% provide disability equality training for staff. Only 21% provide disability equality training for volunteers. Only 36% are involved in reader development or lifelong learning and only 23% provide a newsletter in print, 11% on tape and 3% in Braille; 12% take laptops into people's homes. CONCLUSIONS: Many authorities were still providing a tokenistic service and were reluctant to publicize for fear of not coping with demand, which makes them vulnerable legally under the DDA. However, there were some excellent examples of good practice where the full range of services are provided to a high standard.
Adult↗
Synthetic, site-specific biotinylated analogs of human MCP-1.
Human monocyte chemoattractant protein 1 (MCP-1, CCL2) is a 8.6-kDa protein that has been implicated in a number of diseases including atherosclerosis, rheumatoid arthritis, chronic obstructive pulmonary disease and cancer. As part of a program to identify antibodies against MCP-1, we synthesized site-specific, biotinylated human MCP-1 analogs to be used for panning of an antibody phage display library. In contrast to material obtained from random biotinylation, the site-specific biotinylated analogs were homogeneous and retained full activity.
Amino Acid Sequence↗