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At least 235 records · Page 13Linked to original sources
PubMed1998

Temporal cortex activation in humans viewing eye and mouth movements.

We sought to determine whether regions of extrastriate visual cortex could be activated in subjects viewing eye and mouth movements that occurred within a stationary face. Eleven subjects participated in three to five functional magnetic resonance imaging sessions in which they viewed moving eyes, moving mouths, or movements of check patterns that occurred in the same spatial location as the eyes or mouth. In each task, the stimuli were superimposed on a radial background pattern that continually moved inward to control for the effect of movement per se. Activation evoked by the radial background was assessed in a separate control task. Moving eyes and mouths activated a bilateral region centered in the posterior superior temporal sulcus (STS). The moving check patterns did not appreciably activate the STS or surrounding regions. The activation by moving eyes and mouths was distinct from that elicited by the moving radial background, which primarily activated the posterior-temporal-occipital fossa and the lateral occipital sulcus-a region corresponding to area MT/V5. Area MT/V5 was also strongly activated by moving eyes and to a lesser extent by other moving stimuli. These results suggest that a superior temporal region centered in the STS is preferentially involved in the perception of gaze direction and mouth movements. This region of the STS may be functionally related to nearby superior temporal regions thought to be involved in lip-reading and in the perception of hand and body movement.

Adult↗
PubMed1998

Speech intelligibility in children after cochlear implantation.

OBJECTIVE: This study aimed to evaluate the long-term speech intelligibility of young deaf children after cochlear implantation. STUDY DESIGN: The study design was a prospective study following a large group of consecutively implanted deaf children with up to 5 years' cochlear implant use. SETTING: The study was conducted at a pediatric tertiary referral center for cochlear implantation. PATIENTS: All children in the study were congenitally deaf or deafened before 3 years of age. They each received a Nucleus multichannel cochlear implant before the age of 7 years. Eighty-four subjects were evaluated up to 5 years after cochlear implantation. INTERVENTION: Cochlear implantation followed by an intensive program of local and center-based assessment and rehabilitation was performed. MAIN OUTCOME MEASURES: A speech intelligibility rating scale evaluated the spontaneous speech of each child before and at yearly intervals for 5 years after implantation. RESULTS: After cochlear implantation, the difference between the speech intelligibility ratings increased significantly each year for 4 years (Mann-Whitney U-test). For the first 2 years, the average rating remained "prerecognizable words" or "unintelligible speech." It was not until the 3-year interval that the average intelligibility rating became category 3 (intelligible speech if someone concentrates and lip-reads). At the 4-year interval, 85% of children had some intelligible connected speech. This improvement continued, and at the 5-year interval, the median speech intelligibility was category 4 (intelligible speech to a listener with a little experience of deaf speech) and the mode was category 5 (intelligible speech to all listeners). CONCLUSION: Congenital and prelingually deaf children gradually develop intelligible speech that does not plateau 5 years after implantation.

Cochlear Implantation↗
PubMedDate not supplied

Neural circuits involved in the recognition of actions performed by nonconspecifics: an FMRI study.

Functional magnetic resonance imaging was used to assess the cortical areas active during the observation of mouth actions performed by humans and by individuals belonging to other species (monkey and dog). Two types of actions were presented: biting and oral communicative actions (speech reading, lip-smacking, barking). As a control, static images of the same actions were shown. Observation of biting, regardless of the species of the individual performing the action, determined two activation foci (one rostral and one caudal) in the inferior parietal lobule and an activation of the pars opercularis of the inferior frontal gyrus and the adjacent ventral premotor cortex. The left rostral parietal focus (possibly BA 40) and the left premotor focus were very similar in all three conditions, while the right side foci were stronger during the observation of actions made by conspecifics. The observation of speech reading activated the left pars opercularis of the inferior frontal gyrus, the observation of lip-smacking activated a small focus in the pars opercularis bilaterally, and the observation of barking did not produce any activation in the frontal lobe. Observation of all types of mouth actions induced activation of extrastriate occipital areas. These results suggest that actions made by other individuals may be recognized through different mechanisms. Actions belonging to the motor repertoire of the observer (e.g., biting and speech reading) are mapped on the observer's motor system. Actions that do not belong to this repertoire (e.g., barking) are essentially recognized based on their visual properties. We propose that when the motor representation of the observed action is activated, the observer gains knowledge of the observed action in a "personal" perspective, while this perspective is lacking when there is no motor activation.

Adult↗
PubMed1994

Genetic analysis and overexpression of lipolytic activity in Bacillus subtilis.

The previously cloned Bacillus subtilis lipase gene (lip) was mapped on the chromosome and used in the construction of a B. subtilis derivative totally devoid of any lip sequence. Homologous overexpression was performed in this strain by subcloning the lip open reading frame on a multicopy plasmid under the control of a strong gram-positive promoter. A 100-fold overproducing strain was obtained, which should facilitate purification of the secreted protein. Furthermore, the delta lip strain BCL1050 constitutes an ideal host for the cloning of heterologous lipase genes.

Alleles↗
PubMed2006

Discriminative analysis of lip motion features for speaker identification and speech-reading.

There have been several studies that jointly use audio, lip intensity, and lip geometry information for speaker identification and speech-reading applications. This paper proposes using explicit lip motion information, instead of or in addition to lip intensity and/or geometry information, for speaker identification and speech-reading within a unified feature selection and discrimination analysis framework, and addresses two important issues: 1) Is using explicit lip motion information useful, and, 2) if so, what are the best lip motion features for these two applications? The best lip motion features for speaker identification are considered to be those that result in the highest discrimination of individual speakers in a population, whereas for speech-reading, the best features are those providing the highest phoneme/word/phrase recognition rate. Several lip motion feature candidates have been considered including dense motion features within a bounding box about the lip, lip contour motion features, and combination of these with lip shape features. Furthermore, a novel two-stage, spatial, and temporal discrimination analysis is introduced to select the best lip motion features for speaker identification and speech-reading applications. Experimental results using an hidden-Markov-model-based recognition system indicate that using explicit lip motion information provides additional performance gains in both applications, and lip motion features prove more valuable in the case of speech-reading application.

Algorithms↗