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PubMed1985

Gudden's tegmental nuclei and their connections to the hypothalamus and the reticular formation. I. An experimental study using retrograde labelling with HRP or iron-dextran in the rat.

31 rats were studied for the retrograde transport of HRP or dextran-fer from the corpus mamillare, anterior hypothalamus or reticular formation to the cells of the ventral (VG) and dorsal (DG) Gudden's tegmental nuclei. Judging by the position of the projection cells the VG was found divisible into the peripheral and central parts, a finding out of line with the conventional cytoarchitectonic division. The two parts differ in part of their projections. While both project jointly to the medial mamillary body, the peripheral part has a separate projection to the whole lateral hypothalamus whereas the central part projects also to the RF (ncl. pedunculopontinus and ncl. pontis oralis). The group of cells localized close to the cranial field of the VG, cytoarchitectonically referred to as the pars compacta ncl. centralis superioris, has the same projections as the external parts of the VG and can, therefore, be seen as a component of the VG peripheral part like the cells over the caudal field of the VG (pars intrafascucularis localized already among FLM fibres). The central part is made up of cells localized in the middle portions of the bulk of the VG cells. The dorsal Gudden's tegmental nucleus projects its ventral part to the lateral mamillary body, to the medial and lateral hypothalamus and to the RF (ncl. pontis oralis). The dorsal part of the DG projects solely to the RF (ncl. pontis oralis).

Animals↗
PubMed1985

Gudden's tegmental nuclei and their connections to the hypothalamus and the reticular formation. II. An experimental study using retrograde double labelling with HRP and iron-dextran in the rat.

12 rats in double experiments were studied for the simultaneous retrograde transport of HRP and Dextran-fer from injections in the mamillary body and in the reticular formation or in selected diencephalic structures into the cells of Gudden's tegmental nuclei. The results of this particular study corroborated the findings of retrograde transport in single experiments (see Part I) showing all the cells of ventral Gudden's nucleus as projecting into the mamillary body, the cells of its peripheral parts as projecting also via a collateral to the lateral hypothalamus, and the cells of its central parts as projecting, in addition, via a collateral to the reticular formation (ncl. pedunculo-pontinus and ncl. pontis oralis). Cells of the ventral part of the ncl. dorsalis tegmenti Guddeni project into the lateral mamillary body and some of then also through a collateral into the whole of the hypothalamus. Part of its cells project independently into the RF (ncl. pontis oralis). The dorsal part of the ncl. dorsalis tegmenti Guddeni projects bilaterally to the ncl. pontis oralis.

Animals↗
PubMed1985

Intramuscular iron replenishment and replacement combined with testosterone enanthate in maintenance hemodialysis anemia: a follow-up of up to 8 years on 16 patients.

Sixteen chronic uremics who showed exhausted bone marrow iron stores and mean hematocrit values of 20.9 +/- 4.2% at the time of starting maintenance hemodialysis (HD) were treated by means of intramuscular iron dextran (IMD) (400 mg/month) for six months. By the end of this replenishment period, stainable bone marrow iron was observed and mean hematocrit values increased to 27.2 +/- 4.9% (p greater than 0.001). At this time, 200 mg of IMD/month and testosterone enanthate (1.5 g/month) were prescribed for the whole follow-up period (up to 8 years). The observed mean hematocrit values were up to 46.1 +/- 1.6%. Major side effects were not observed. The process of slow iron reabsorption from the intramuscular injection site (up to 4 weeks) also implies the splitting of iron from dextran, therefore preventing bone marrow deposits of iron dextran complexes which make iron unavailable for erythropoiesis. High doses of testosterone enanthate can normalize hematocrit values of maintenance hemodialysis patients with replenished bone marrow iron stores.

Adolescent↗
PubMed1985

Gastrointestinal flora in iron-deficient piglets.

The pH and microflora of the contents of the stomach and small intestine were studied in iron-treated and iron-deficient piglets. Compared with their iron-treated littermates, the gut contents at several sites in iron-deficient animals had a higher pH and contained greater numbers of coliforms, lactobacilli, total aerobes and total anaerobes. The possible relationship of these findings to previous findings in such animals and to their high incidence of diarrhoea is discussed.

Anemia, Hypochromic↗
PubMed1979

[Effect of various preparations of iron on the growth and haemoglobin levels of newborn piglets (author's transl)].

Four preparations of iron dextran, which differed markedly in price, were compared in an experimental study. 100 or 200 mg. of iron were injected intramuscularly on the first, second or third day of life of the piglets. Differences in weight or concentration of haemoglobin were not detectable during the first eight weeks of life, neither at a dosage of 100 mg. nor at a dosage of 200 mg. of iron.

Anemia↗