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PubMed1999

How do early stages of information processing influence social skills in patients with schizophrenia?

Persons with schizophrenia show deficits across a broad range of cognitive domains, and their social skill deficits are thought, to some extent, to be caused by cognitive dysfunction. In this study, we attempted to replicate the correlation between the early stages of information processing and non-verbal skills. Subjects for the study included 22 men and six women who met DSM-IV criteria for the diagnosis of schizophrenia. All subjects were attending a rehabilitation program at the day-treatment centers of their hospitals. Social skills were assessed using a structured role-play test. The Degraded-Continuous Performance Test (CPT) and Span of Apprehension Test (SPAN) were used. Non-verbal skills were significantly correlated with CPT-False Alarm Rate (the rate of commission errors of all trials) in multiple regression analysis, but the receiving-processing skills did not have any relation to CPT or SPAN score. Non-verbal skills may be related to early information-processing deficiency, especially the response-inhibiting system. Receiving and processing skills may be related to later stages of information processing, or may reflect not only 'molecular' stages of information processing (less complex and less integration task in a continuum of complexity of cognitive processes) but also other factors such as social learning.

Adult↗
PubMed1989

The effects of clonidine and yohimbine on human information processing.

The effects of clonidine and yohimbine on human information processing were tested in six normal volunteers ages 18-30 years. Subjects were tested in a pre-post design with sessions conducted at weekly intervals. Three drug conditions were: Placebo (lactose), 0.2 mg clonidine, and 30 mg yohimbine. Two choice reaction time (RT) tasks were used. One was a stimulus evaluation-response selection task (SERS) that has been shown to be sensitive to d-amphetamine, methylphenidate and scopolamine. The other task was to assess stimulus pre-processing and used spatial frequency as a discriminative stimulus. The principle finding was that clonidine slowed RT; this effect was significant for both tasks. In contrast, yohimbine tended to speed RT, but the effects were significant only for the spatial frequency task on some analyses while not for others. RTs to high spatial frequency stimuli were speeded more than for low spatial frequency. The effects of these two NE drugs were compared with findings with d-amphetamine and scopolamine and interpreted within the framework of a serial information processing model proposed by Callaway (1983). Specifically, it is suggested that yohimbine and clonidine affect an early pre-processing stage.

Adolescent↗
PubMed2003

Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing.

OBJECTIVE: The purpose of this study was to determine the effect of docosahexaenoic acid supplementation on plasma phospholipid docosahexaenoic acid content and indices of depression and information processing for women who breast-feed. STUDY DESIGN: Mothers who planned to breast-feed their infants were assigned randomly in a double-masked fashion to receive either docosahexaenoic acid (approximately 200 mg/d) or placebo for the first 4 months after the delivery. Major outcome variables included plasma phospholipid fatty acid patterns and scores on a self-rating questionnaire of current depression symptoms. A structured clinical interview of depression, scores on another self-rating questionnaire of depression symptoms, and a laboratory measure of information processing were obtained in subgroups of the total population. RESULTS: Plasma phospholipid contents of docosahexaenoic acid at baseline were 3.15 +/- 0.78 and 3.31 +/- 0.70 (mg/dL of total fatty acids) in the docosahexaenoic acid and placebo groups, respectively. After 4 months, the plasma phospholipid docosahexaenoic acid content of the docosahexaenoic acid group was 8% higher (3.40 +/- 0.97 mg/dL), whereas that of the placebo group was 31% lower (2.27 +/- 0.87 mg/dL). Despite the higher plasma phospholipid docosahexaenoic acid content of the supplemented group after 4 months, there was no difference between groups in either self-rating or diagnostic measures of depression; information processing scores of the two groups also did not differ. CONCLUSION: Docosahexaenoic acid supplementation ( approximately 200 mg/d) for 4 months after the delivery prevented the usual decline in plasma phospholipid docosahexaenoic acid content of women who breastfeed but did not influence self-ratings of depression, diagnostic measures of depression, or information processing.

Adult↗
PubMed1985

Acute effects of oxygen treatment upon information processing in hypoxemic COPD patients.

The present study investigated the effects of oxygen therapy upon human information processing for hypoxemic COPD patients. Each of ten patients was admitted to a general clinical research center for a two-day period. In a randomly counter-balanced factorial design, patients breathed either room air or enriched oxygen for either six hours or 20 minutes prior to testing. The tests evaluated speed of information processing, ability to detect correct sequence of tones, and serial memory. In addition, patients were evaluated on critical flicker fusion and story recall. The results suggested that acute oxygen therapy does not reverse information processing deficits observed in hypoxemic COPD patients.

Aged↗
PubMed2002

Evidence of conscious and subconscious olfactory information processing during word encoding: a magnetoencephalographic (MEG) study.

The present study was meant to distinguish between unconscious and conscious olfactory information processing and to investigate the influence of olfaction on word information processing. Magnetic field changes were recorded in healthy young participants during deep encoding of visually presented words whereby some of the words were randomly associated with an odor. All recorded data were then split into two groups. One group consisted of participants who did not consciously perceive the odor during the whole experiment whereas the other group did report continuous conscious odor perception. The magnetic field changes related to the condition 'words without odor' were subtracted from the magnetic field changes related to the condition 'words with odor' for both groups. First, an odor-induced effect occurred between about 200 and 500 ms after stimulus onset which was similar in both groups. It is interpreted to reflect an activity reduction during word encoding related to the additional olfactory stimulation. Second, a later effect occurred between about 600 and 900 ms after stimulus onset which differed between the two groups. This effect was due to higher brain activity related to the additional olfactory stimulation. It was more pronounced in the group consisting of participants who consciously perceived the odor during the whole experiment as compared to the other group. These results are interpreted as evidence that the later effect is related to conscious odor perception whereas the earlier effect reflects unconscious olfactory information processing. Furthermore, our study provides evidence that only the conscious perception of an odor which is simultaneously presented to the visual presentation of a word reduces its chance to be subsequently recognized.

Adult↗
PubMed1995

Chronic pain is associated with deficits in information processing.

Beginning with the theoretical premise that pain stimuli are liable to perturb the ordinary dynamical state of the brain, we hypothesized that individuals in pain may experience impaired information processing. A sample of 19 persons complaining of chronic pain and a comparison sample of 25 persons having sustained head trauma were obtained by retrospective chart review. The chronic-pain group consisted of 19 persons whose primary complaint was significant chronic pain, with no known history of head trauma or neurologic disorder. The comparison group consisted of 25 persons who had sustained mild to moderate head traumas. All subjects were administered information processing and motor subtests of the Human Performance Measurement System, a computerized set of measures. Both groups obtained mean z scores below the normative mean on all measures except visual digit span. There were no differences between groups on motor measures, visual digit span, and visual-spatial memory. On 2 of 6 information-processing tests, pain patients performed more poorly than head-trauma patients. The results suggest that pain may disrupt cognitive performances which depend on intact speed and capacity of information processing.

Adult↗
PubMed2006

Functional outcome in TBI II: verbal memory and information processing speed mediators.

Following traumatic brain injury (TBI), patients often report memory difficulties, as well as reduced information processing speed. However, it remains unclear the extent to which these deficits contribute to functional impairment. In the present study, we compared the relative contribution of verbal memory and information processing speed to functional impairment at 12-month post-injury, in 87 patients with moderate-to-severe TBI. Employing structural equation modeling, we found that information processing speed, but not verbal memory functions, significantly mediated the relationship between TBI severity and post-TBI adaptive functioning. These findings suggest that despite the pervasive memory complaints among patients with TBI, it is the impact of neurotrauma on frontal systems that appears to be primarily responsible for patients' difficulties in social and occupational functioning.

Adaptation, Physiological↗
PubMed1997

Information processing and affective distress in osteoarthritis patients.

The relationship between affective distress and chronic illnesses is well recognized. Recent research has focused on depressive symptomatology among patients with chronic pain. The present study was conducted to (a) examine depressive information processing in osteoarthritis patients and (b) assess whether the presence of somatic items on a depression measure would affect the observed associations between information processing and affective distress in arthritis patients. A group of 40 osteoarthritis patients was assessed using the Beck Depression Inventory, and a non-self-report measure of depressive self-schemas. Results suggest that observed depressive cognitive structures appear to be better differentiated by a nonsomatic measure of affective distress and that individuals selectively process information to fit the parameters of their currently active self-schema.

Aged↗
PubMed2005

Visual information processing in the lion-tailed macaque (Macaca silenus): mental rotation or rotational invariance?

Mental rotation is a widely accepted concept indicating an image-like mental representation of visual information and an analogue mode of information processing in certain visuospatial tasks. In the task of discriminating between image and mirror-image of rotated figures, human reaction times increase with the angular disparity between the figures. In animals, tests of this kind yield inconsistent results. Pigeons were found to use a time-independent rotational invariance, possibly indicating a non-analogue information processing system that evolved in response to the horizontal plane of reference birds perceive during flight. Despite similar ecological demands concerning the visual reference plane, a sea lion was found to use mental rotation in similar tasks, but its processing speed while rotating three-dimensional stimuli seemed to depend on the axis of rotation in a different way than found for humans in similar tasks. If ecological demands influence the way information processing systems evolve, hominids might have secondarily lost the ability of rotational invariance while retreating from arboreal living and evolving an upright gait in which the vertical reference plane is more important. We therefore conducted mental rotation experiments with an arboreal living primate species, the lion-tailed macaque. Performing a two-alternative matching-to-sample procedure, the animal had to decide between rotated figures representing image and mirror-image of a previously shown upright sample. Although non-rotated stimuli were recognized faster than rotated ones, the animal's mean reaction times did not clearly increase with the angle of rotation. These results are inconsistent with the mental rotation concept but also cannot be explained assuming a mere rotational invariance. Our study thus seems to support the idea of information processing systems evolving gradually in response to specific ecological demands.

Animals↗
PubMed1998

Social information-processing patterns as predictors of social adaptation and behavior problems among maltreated children in foster care.

OBJECTIVE: The goal of this investigation was to determine if social information-processing patterns were predictive of later social adaptation and behavior problems within a group of maltreated children in foster care. METHOD: A longitudinal design was used to address the study hypotheses. The sample consisted of 124 maltreated children ages 5 to 10 who had been placed into foster care. Twelve months following entrance into foster care, children were presented with age-relevant hypothetical vignettes to assess the quality of the way in which they process social information. Six to 8 months following this assessment, caregivers completed the Vineland Adaptive Scales and the Child Behavior Checklist. RESULTS: Measures reflecting unbiased and competent processing were predictive of social adaptation, whereas measures reflecting biased and incompetent processing were predictive of behavior problems. In aggregate, processing measures accounted for a significant proportion of the variance in the outcome measures. CONCLUSIONS: The findings suggest that the manner in which maltreated children process social information has a bearing on their later social adaptation and behavioral adjustment. Therefore, maltreated children in foster care may benefit from interventions that target the manner in which they process social information.

Child↗
PubMed2006

Information processing capacity while wearing personal protective eyewear.

It is difficult to overemphasize the function vision plays in information processing, specifically in maintaining postural control. Vision appears to be an immediate, effortless event; suggesting that eyes need only to be open to employ the visual information provided by the environment. This study is focused on investigating the effect of Occupational Safety and Health Administration regulated personal protective eyewear (29 CFR 1910.133) on physiological and cognitive factors associated with information processing capabilities. Twenty-one college students between the ages of 19 and 25 years were randomly tested in each of three eyewear conditions (control, new and artificially aged) on an inclined and horizontal support surface for auditory and visual stimulus reaction time. Data collection trials consisted of 50 randomly selected (25 auditory, 25 visual) stimuli over a 10-min surface-eyewear condition trial. Auditory stimulus reaction time was significantly affected by the surface by eyewear interaction (F2,40 = 7.4; p < 0.05). Similarly, analysis revealed a significant surface by eyewear interaction in reaction time following the visual stimulus (F2,40 = 21.7; p < 0.05). The current findings do not trivialize the importance of personal protective eyewear usage in an occupational setting; rather, they suggest the value of future research focused on the effect that personal protective eyewear has on the physiological, cognitive and biomechanical contributions to postural control. These findings suggest that while personal protective eyewear may serve to protect an individual from eye injury, an individual's use of such personal protective eyewear may have deleterious effects on sensory information associated with information processing and postural control.

Adult↗
PubMed2003

Automatic-controlled information processing and error detection in a simulated pharmacy-verification task.

The relationships between attentional variables and information-processing demands of pharmacy dispensing tasks that contribute to difficulties in cognitive performance are not well-known. In the present study, a psychological approach to medical dispensing errors, the cognitive-systems performance model of Grasha, was employed to evaluate the contributions of individual differences in attention and alterations in visual task information on simulated pharmacy-verification performance, perceived workload, and self-reported stress. 73 college-age volunteers completed a pretest battery containing psychological measures of automatic and controlled information processing, and one-week later spent 265 min. completing the end visual-inspection process for 200 simulated prescriptions, 27% of which contained artificially inserted errors. Evidence suggesting that both automatic and controlled processes underlie performance of a simulated pharmacy-verification task was obtained. Individual differences in controlled information processing were mildly predictive of detection accuracy, while contrary to expectations, automatic processing scores did not produce significant relationships. Detection associated with experimental alterations in font size (12-pt. vs 6-pt.) of critical prescription label information was partially in line with expectations from the cognitive-systems performance model, while additional visual enhancements via a magnification/illumination device yielded mixed results. Finally, reports of perceived workload (NASA Task Load Index) and specific patterns of self-reported stress (Dundee Stress State Questionnaire) were consistent with a three-tier behavioral framework offered recently by Matthews, Davies, Westerman, and Stammers for predicting behaviors along the automatic-controlled continuum.

Adult↗
PubMed2006

Synaptic information processing by astrocytes.

Glial cells were classically considered as supportive cells that do not contribute to information processing in the nervous system. However, considerable amount of evidence obtained by several groups during the last few years has demonstrated the existence of a bidirectional communication between astrocytes and neurons, which prompted a re-examination of the role of glial cells in the physiology of the nervous system. This review will discuss recent advances in the neuron-to-astrocyte communication, focusing on the recently reported properties of the synaptically evoked astrocyte Ca2+ signal that indicate that astrocytes show integrative properties for synaptic information processing. Indeed, we have recently shown that hippocampal astrocytes discriminate between the activity of different synapses, and respond selectively to different axon pathways. Furthermore, the astrocyte Ca2+ signal is modulated by the simultaneous activity of different synaptic inputs. This Ca2+ signal modulation depends on cellular intrinsic properties of the astrocytes, is bidirectionally regulated by the level of synaptic activity, and controls the spatial extension of the intracellular Ca2+ signal. Consequently, we propose that astrocytes can be considered as cellular elements involved in information processing by the nervous system.

Animals↗
PubMed1998

Dynamics and information processing in adaptive systems.

An adaptive system is capable of functioning despite some degree of environmental uncertainty. This requires an ability to identify relevant states of the environment, to adjust the value of internal variables so as to maintain a characteristic pattern of activity and, of course, to respond appropriately to environmental stimuli. Biological systems have responded to this challenge by developing information processing systems that are highly compatible with their functions. In this paper we analyze the relationship between dynamics and information processing in biological systems and refer to basic principles of biological information processing. An important trend that can be observed is that the specialization of information processing functions increases with the complexity of the environment faced by the systems. At the level of human populations, man-made organizations in particular, our study suggests that the design of computer-based information systems must be sensitive to the existing biological infrastructure if they are to effectively extend the cognitive and computational capabilities of organizations.

Adaptation, Physiological↗
PubMed1994

Assessment of attention: relationship between psychological testing and information processing approaches.

Examined the relationship between the psychological testing and information processing approaches in assessing attention. Eighty-seven subjects (57 females, 30 males) undertook eight psychological tests of attention and a visual-spatial reaction-time task. Using the cognitive-correlate method (Posner & McLeod, 1982), it was found that three components of attention (viz., visual-motor scanning, sustained selective processing, and visual/auditory spanning) derived from the psychological tests could be significantly predicted by specific, yet different, combinations of six indices of information processing (mean reaction time (RT), mean movement time (MT), feature extraction, identification, response selection, and motor adjustment): (a) mean RT and mean MT were found to be the most important indices for predicting performance on visual-motor scanning; (b) the motor-adjustment stage was found to be the most important index for predicting performance on sustained selective processing; (c) the response-selection stage was found to be the most important index for predicting performance on visual/auditory spanning. These relationships are important for supporting the construct-related validity of the psychological tests of attention and for extending the generality and applicability of the RT task.

Adolescent↗
PubMed2000

Differential information processing by hippocampal and subicular neurons.

It has been known for some years that hippocampal neurons are critically involved in processing of information necessary for encoding memories. What is less understood is the role of the subiculum in this process. We describe here differential response characteristics of subicular and hippocampal neurons in rats during execution of a delayed-nonmatch-to-sample short-term memory task. Subicular neurons, unlike hippocampal neurons, fire primarily in the delay interval of the task and appear to provide a temporal linkage between events encoded in hippocampus during the sample and nonmatch phases. Indeed, a large proportion of subicular neurons fire robustly for the entire duration of the delay only. Further analyses using electrical activation methods indicate that subicular neurons that receive short latency inputs from the anterior thalamus and do not project to cingulate cortex are the most responsive to stimuli with behavioral significance.

Afferent Pathways↗
PubMed2005

Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only.

BACKGROUND: Omitting radiotherapy for central nervous system (CNS) prophylaxis has improved the overall quality of life for long-term survivors of childhood acute lymphoblastic leukemia (ALL). However, recent reports suggest minor cognitive impairment in survivors who received chemotherapy only. PROCEDURE: This study focused on attentional functioning and speed of information processing in 23 children previously treated for ALL according to EORTC 58881 and EORTC 58951 protocol. Patients received intrathecal methotrexate combined with high doses intravenous methotrexate as CNS prophylaxis. Cognitive functioning was assessed with the Amsterdam Neuropsychological Tasks, a computerized attention assessment program. Variables of both speed and accuracy of the patients were compared with those obtained from 23 age- and sex-matched control children. RESULTS: Patients were equal to control children concerning baseline speed, sustained attention, response inhibition, and response organization. However, they were significantly slower than controls in three tasks: encoding, memory search letters, and focused attention 4-letters. Interactions with the difficulty of the task were found. There were no differences in number or type of errors between groups on all tasks. CONCLUSIONS: ALL survivors treated with chemotherapy have specific information processing difficulties. They process information slower than control children, especially when more information has to be processed or when attention has to be focused precisely. In spite of being slower, patients are equally accurate compared to control children.

Antineoplastic Agents↗