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PubMed1993

Splatter during jet irrigation cleansing of a wound model: a comparison of three inexpensive devices.

STUDY OBJECTIVE: Pressurized jet irrigation is commonly used to cleanse traumatic wounds but results in splatter of blood, a biohazard. Three inexpensive irrigation devices were compared to assess the degree of splatter produced: a 1.25-in. 18-gauge angiocath, an Irrijet Irrigation System with a 12.7-cm splash shield, and a Zerowet Splashield held directly against the wound (Zerowet-C) and held 4 to 10 cm from the wound, an incorrect technique (Zerowet-I). DESIGN: A standard laceration was created in pieces of beef. This wound model was placed 1 m from the floor. Paper grid sheets were placed on the irrigator's face and chest. Six grid sheets were suspended at the 9:00, 12:00, and 3:00 positions 1 m from the wound model and 1 and 1.5 m from the floor to simulate exposure to nearby individuals. Two grid sheets were placed flat on the floor, at the 10:30 and 1:30 positions, 1 m from the base of the wound model stand. The study area was contained in a 3 x 2 x 2 m plastic sheet enclosure to prevent air drafts. INTERVENTION: Ten irrigations were performed with the angiocath, Irrijet, Zerowet-I, and Zerowet-C. Each run used 200 mL methylene blue solution delivered with a 50-mL syringe by one-hand pressure. The methylene blue splatter on each of the grids was counted by size (diameter, less than 1 mm, more than 1 mm and less than 5 mm, more than 5 mm and less than 10 mm, and more than 10 mm). RESULTS: There was significantly less splatter onto the irrigator's face and chest with Irrijet, Zerowet-I, and Zerowet-C. No facial splatter occurred with Zerowet-C. There was significantly less splatter at the 9:00 and 12:00 positions at both heights, and on the floor with Irrijet, Zerowet-I, and Zerowet-C. Less significant splatter difference was noted at the 3:00 position. CONCLUSION: Irrijet, Zerowet-I, and Zerowet-C were superior to the angiocath in preventing splatter during this wound model irrigation. The correct use of Zerowet (Zerowet-C) was particularly effective in preventing splatter onto the irrigator's face.

Decontamination↗

PubMed2002

High-pressure pulsatile lavage irrigation of contaminated fractures: effects on fracture healing.

To evaluate the effects of high-pressure pulsatile lavage (HPPL) irrigation on new bone formation and fracture union in a contaminated intraarticular fracture, 45 New Zealand white rabbits were divided into three equal groups. The control group (C) underwent an osteotomy of the medial femoral condyle, contamination with a slurry of clay mixed with Staphylococcus aureus, stabilization and closure. The bulb syringe and pulsatile groups (B and P) underwent an identical procedure, with the addition of irrigation with 11 of saline by bulb syringe or pulsatile lavage system. Two fluorescent bone stains that mark new bone formation were administered subcutaneously: xylenol orange at the time of surgery and calcein green one week postoperatively. Animals were euthanized two weeks postoperatively and femurs were retrieved for histological analysis. Union was determined by examination of microradiographs. The viability of bone along the osteotomy site in the first and second weeks after irrigation was determined by evaluation of the two fluorescent stains. The density of new bone two weeks after irrigation was assessed by digitization of the microradiographs. Nonunion was present in 77%, 53%, and 43% of animals in groups C, B, and P, respectively. There was an increase in the presence of bands of both fluorescent stains along the osteotomy site in the groups B and P compared to group C. There was no statistically significant difference between groups B and P in either fluorescent stain. On digitization of microradiographs, there was more calcified new bone on postoperative day 14 in group P than in either group B or C (p = 0.04). The addition of contamination and foreign material to an intraarticular fracture model results in lower rates of new bone formation and fracture union. Irrigation in this setting is clearly beneficial, whether the irrigant is delivered by bulb irrigation or by HPPL. The results of this study indicate using HPPL in this setting does not cause greater damage than using bulb syringe irrigation.

Animals↗

PubMed2001

Intracardiac echocardiographic evaluation of ventricular mural swelling from radiofrequency ablation in chronic myocardial infarction: irrigated-tip versus standard catheter.

INTRODUCTION: The production of larger, particularly deeper lesions may improve the success rate for radiofrequency (RF) ablation of post infarction ventricular tachycardia (VT). Therapeutic RF ablation causes left ventricular (LV) mural swelling. This swelling can be detected as increased wall thickness at the ablation site by intracardiac echocardiography (ICE) and correlates with pathologic lesion size. This study compared the extent of mural swelling caused by linear ablation lesions created with irrigated tip and standard RF ablation in a porcine model of healed anterior infarction. METHODS AND RESULTS: In anesthetized closed-chest swine ICE guided multiple RF applications to construct linear lesions at the border zone of the infarct region using an irrigated RF (n=6 swine) and a standard RF (n=6 swine) ablation catheter. 47 individual lesions were created with irrigated RF ablation; 57 lesions created with standard RF ablation. At all sites, wall thickness (measured at end-diastole Pre- and 1 min Post-RF delivery) increased following either irrigated (p<0.0001) or standard (p<0.004) RF deployment. Irrigated RF ablation produced more mural swelling at border zone sites than standard RF ablation (wall thickness increase of 21.2 versus 15.1 %, p<0.003). This difference was more pronounced at RF sites within the infarct (40.7 versus 12.0 %, p<0.0007). Thrombus formation or intramural explosion were not observed; surface crater formation was not more frequent with irrigated compared to standard RF ablation (14/47 versus 12/57 lesions, p=NS). CONCLUSION: Irrigated RF ablation may produce larger lesions than standard RF ablation, particularly for ablation targets within infarcted tissue. ICE imaging provides on line data about the characteristics of the developing lesion which may prove useful in dosing irrigated-tip RF energy application.

Animals↗

PubMed2002

Thermal changes observed at implant sites during internal and external irrigation.

In the preparation of osseointegrated dental implant sites, the use of bone drilling with conventional external irrigation has been shown to be thermally non-injurious to bovine bone, when employed as a model for dental implantology. The use of internal irrigation drilling systems is promoted on the basis of improved delivery of coolant to the bone/drill interface, which should subsequently improve local debridement and cooling, and therefore reduce thermal insults to the bone. The aim of this bovine model study was to compare the temperatures that were generated with external and internal irrigation systems during bone preparation for dental implants. A constant drill load of 1.7 kg was applied throughout the drilling procedures via a drilling rig. The burs that were used for both irrigation methods were a 2 mm twist drill for cutting the channel and a 3.25 mm drill for trephining this channel. The principal recorded parameter was the change in temperature generated via the drilling procedure. The 2 mm twist drills produced a maximum change in temperature of only 3.0 degrees C and 3.1 degrees C for the internal and external irrigation systems, respectively. Maximum changes for the 3.25 mm drills were 1.34 degrees C and 1.62 degrees C, respectively. Using the t-test, no statistical benefit was observed for one irrigant delivery system over the other. The clinical benefit of using the more expensive internal irrigation systems is therefore deemed unjustifiable, on the grounds that these systems do not appear to reduce the thermal challenge to the bone over and above that of simple flood irrigation.

Animals↗

PubMed2000

Clinical benefits of oral irrigation for periodontitis are related to reduction of pro-inflammatory cytokine levels and plaque.

BACKGROUND: Although a growing body of evidence indicates that oral irrigation with water has therapeutic benefits in periodontitis, the mechanisms of action have not been elucidated. The aims of this study were: (1) to analyze the effects of oral irrigation (Water Pik Oral Irrigator) on the clinical signs of adult periodontitis (AP) and on the levels of interleukin-1 beta (IL-beta), prostaglandin-E2 (PGE2), interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) in GCF, and (2) to analyze the influence of the periodontitis-related IL-1 genotype (IL-1GT) on these variables. METHOD: A single-center, blinded study in otherwise healthy humans (n= 52) with localized mild to moderate AP was carried out, using the following groups: group A (n= 12), no oral hygiene for 14 days; group B (n=20), routine oral hygiene (ROH) for 14 days; group C (n=20), supra-gingival oral irrigation plus ROH for 14 days. Group A patients were crossed-over to group C for 14 days (=day 28) after a professional prophylaxis. Group assignment was randomized by a coin toss, with the exception of group A subjects, who were self-selected as per recommendations of the internal review board for human subjects. GCF was sampled from 3 study teeth per patient and analyzed for IL-1 beta, PGE2, IL-10 and IFN gamma by ELISA on days 0, 7, 14 and 28. Probing pocket depths (PPD), clinical attachment levels (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were measured by a calibrated examiner (TWS) on days 0, 14 and 28. Analysis of covariance was performed using SAS 6.12 and Proc Mixed with group and IL-1GT as the factors and the baseline levels as the covariate, with output being least squares means and least significant difference (LSD). Significant differences were declared if the p-value for the F-statistic was < or =0.05. RESULTS: Oral irrigation plus ROH resulted in a significant reduction in PPD, BOP, GI and PI, as well as IL-beta levels by 7 days and PGE2 levels by 14 days, relative to ROH or no oral hygiene. Interestingly, decreased IL-1 beta levels in patients using oral irrigation plus ROH was accompanied by a trend for increased levels of the "anti-inflammatory" cytokine IL-10. ROH reduced GI, BOP and PI, and PGE2 levels by 14 days, but had no effect on IL-1 beta or IL-10 levels relative to no oral hygiene. The effects of no oral hygiene were reversed by a prophy followed by oral irrigation plus ROH for 14 days. No clinical differences were evident between IL-1 GT (+) patients (n= 1) and GT (-) patients (n=40), but the former had significantly elevated levels of GCF IL-10 and borderline increases in IL-1 beta (p=0.07). CONCLUSIONS: Oral irrigation with water for 14 days had an improved therapeutic benefit for AP over that of routine oral hygiene alone and this improvement was accompanied by a down-modulation of the pro-inflammatory cytokine profile in GCF.

Adult↗

PubMed1998

Bacterial eradication from root dentine by ultrasonic irrigation with sodium hypochlorite.

The study aimed to evaluate intracanal irrigation procedures in eradicating bacteria from surface, shallow and deep layers of root dentine using extracted human teeth. Artificial bacterial smear layer was successfully produced by rubbing a mixture of dental plaque and artificially decalcified dentine or carious dentine on root canal walls. The reservoir holes were 3.5 mm in depth, 1 mm in diameter prepared 1.5 mm apart and parallel to the root canals on the decrowned planes, in which five separate bacterial species were placed (Actinomyces israelii, Fusobacterium nucleatum, Propionibacterium acnes, Streptococcus mutans and Streptococcus sanguis). Bacterial eradication after irrigation of the prepared canals was determined by bacterial recovery (i) from the root canal surfaces and shallow layers where bacteria were smeared artificially and (ii) from deeper layers of root canal dentine reservoir holes. Ultrasonic irrigation with 5.5% and 12% NaOCl eradicated bacteria from artificial smear layer (P < 0.0001), whilst 12% NaOCl irrigation with a syringe was insufficient. Ultrasonic irrigation with water or 15% EDTA-failed to eradicate bacteria from smeared surfaces. Ultrasonic irrigation with 12% NaOCl killed A. israelii, F. nucleatum, P. acnes, S. mutans, and S. sanguis placed in reservoir channels, although for F. nucleatum, a very small number of bacteria remained in five samples out of 12. Ultrasonic irrigation with less concentrated NaOCl failed to eliminate bacteria completely from reservoir channels in most samples. Ultrasonic irrigation with 12% NaOCl appeared to eliminate bacteria efficiently from surface, shallow and deep layers of root dentine.

Actinomyces↗

PubMed2001

Nasal irrigation for the alleviation of sinonasal symptoms.

OBJECTIVE: To determine the effect of nasal irrigation on sinonasal symptoms. STUDY DESIGN AND SETTING: A total of 150 adult subjects with chronic sinusitis symptoms were recruited from the community and assigned to 1 of 3 treatment groups: nasal irrigation with bulb syringe, nasal irrigation with nasal irrigation pot, or control treatment with reflexology massage. Groups 1 and 2 performed daily hypertonic saline irrigation with 1 device for 2 weeks and then with the other device for 2 weeks. Group 3 performed reflexology massage daily for 2 weeks. Prospective data collected included pretreatment Medical Outcomes Study Short Form, pretreatment and posttreatment Rhinosinusitis Outcomes Measure, daily medication use, subjective treatment efficacy, and preference of irrigation method. RESULTS: There was a significant and equivalent improvement in Rhinosinusitis Outcomes Measure 31 score after 2 weeks of intervention in each treatment group; 35% of subjects reported decreased use of sinus medication. CONCLUSION: Daily nasal irrigation using either a bulb syringe, nasal irrigation pot, and daily reflexology massage were equally efficacious and resulted in improvement in the symptoms of chronic sinusitis in over 70% of subjects. Medication usage was decreased in approximately one third of participants regardless of intervention.

Adult↗

PubMed2002

Impact of irrigation in a new model for in vitro diffusion of mitomycin-C after episcleral application.

PURPOSE: Episcleral application of mitomycin-C (MMC) during glaucoma surgery hinders the post-operative wound healing but may lead to side effects to the ciliary body. We present an experimental model to investigate the influence of irrigation on diffusion of MMC through the sclera and into subscleral compartments. MATERIALS AND METHODS: Scleral quadrants of 10 human donor eyes were mounted on PMMA tubes filled with saline imitating the intraocular fluid. Beneath the sclera a subscleral sponge was fixed to mimic the ciliary body. The episcleral sides of the scleral quadrants were exposed to sponges soaked with 0.2 mg/ml MMC and thereafter irrigated with 0, 40, 100 and 200 ml saline. Mitomycin-C concentrations of the sclera and the subscleral compartments were analyzed by means of high-performance liquid chromatography. In a second experiment, after the application time of one minute, different times of free diffusion until analysis were allowed, to evaluate the time-course of MMC penetration. RESULTS: MMC concentrations declined from the scleral layers (1-13 microg/ml, depending on depth and irrigation) to the subscleral sponge (0.17-0.27 microg/ml) and to the subscleral fluid (0.002-0.05 microg/ml). Irrigation significantly reduced MMC concentrations in the superficial scleral layers and in the subscleral fluid to 10-30% of the no irrigation value. No effect was noted in the deep scleral layers and subscleral sponges. In the second experiment, the subscleral compartments showed higher MMC concentrations with longer diffusion times, whereas no effect on intrascleral MMC concentrations was observed. CONCLUSION: Irrigation reduced MMC concentrations in the superficial scleral layers and in the subscleral fluid by the same amount. The clinical value of irrigation should be reconsidered; a lower dose MMC application without irrigation might be a more rationale approach.

Analysis of Variance↗

PubMed2004

Irrigation of port sites: prevention of port site metastases?

INTRODUCTION: Port site metastases can occur when free viable tumor cells implant at trocar wounds. Irrigation of port sites with cytotoxic agents has been suggested to prevent port site metastases. The objective of this study is to assess whether tumor growth at port sites can be reduced by irrigation of these port sites. METHODS: WAG rats were insufflated with CO(2) for 20 minutes and 5 x 10(5) CC531 tumor cells were injected intraperitoneally. Port sites were irrigated after completion of the pneumoperitoneum with povidone-iodine, a mixture of taurolidine and heparin, or sodium chloride. Controls did not undergo any irrigation of port sites. In experiment 1, all 16 rats had all 4 irrigation modalities. In experiment 2, four groups of 20 rats had one type of irrigation on two trocar wounds. Tumor growth was evaluated 4 weeks after the procedure. RESULTS: No difference in tumor growth at trocar wounds was found between any type of irrigation and controls in both experiments. CONCLUSION: In this experimental model, no beneficial or adverse effects of irrigation of port sites could be shown.

Adenocarcinoma↗

PubMed1978

Evaluation of wound irrigation by pulsatile jet and conventional methods.

Irrigation of wounds to remove bacteria and foreign material is an essential of wound management along with debridement. The effectiveness of saline lavage by high pressure (50 psi) pulsatile jet irrigation has been compared with conventional gravity flow and bulb syringe procedures. Experimental paravertebral incisional surface wounds in 234 randomized rats were either clean or traumatized and soiled. Wounds in 200 of the rats were seeded with E. coli (log 8.80). Swab specimens of each wound were taken at incision, after seeding, after irrigation, and at three, seven, and ten days after closure. Eulates of more than 1600 specimens were cultured. No anaerobes were found. Irrigation diminished bacterial counts in all wounds, but only pulsatile jet irrigation brought about significant (P less than 0.05) reduction of bacteria in each type of wound. After three days E. coli was significantly diminished in all wounds, regardless of irrigation or none, owing to host defense mechanisms. Nevertheless, clean contaminated wounds were infected at three days but not at seven days after lavage, while traumatized wounds remained infected at ten days except for those initially irrigated by pulsatile jet. Thus, pulsatile jet irrigation removed bacterial from experimental wounds more efficiently than conventional procedures.

Animals↗

PubMed2002

Surfactant wound irrigation for the treatment of staphylococcal clinical isolates.

Deep wound infection involving an implanted biomaterial is a devastating complication in orthopaedic surgery. Two-thirds of such infections are monomicrobial and the most commonly isolated bacteria in human osteomyelitis and orthopaedic device infection are Staphylococcus aureus and Staphylococcus epidermidis. The purpose of the current study was to examine the effectiveness of the previously reported sequential surfactant irrigation protocol against human-isolated clinical strains of Staphylococcus aureus and Staphylococcus epidermidis in the rat model of orthopaedic implant contamination. The infectivity rate of human-isolated clinical strains of Staphylococcus aureus in a contaminated complex orthopaedic wound was reduced effectively by a sequential surfactant irrigation protocol. Also, in this model, the infectivity of Staphylococcus epidermidis was reduced by normal saline irrigation alone when compared with no irrigation. Therefore, the sequential surfactant irrigation protocol may represent an effective method of wound irrigation in monomicrobial Staphylococcus aureus orthopaedic implant contamination, and normal saline irrigation may suffice in cases of monomicrobial Staphylococcus epidermidis contamination. Additional studies are necessary to determine the clinical use of surfactant irrigation.

Animals↗

PubMed2002

Efficacy of instrumentation techniques and irrigation regimens in reducing the bacterial population within root canals.

The purpose of this study was to compare the in vitro intracanal bacterial reduction produced by using two instrumentation techniques and different irrigation methods. Root canals inoculated with Enterococcus faecalis were prepared by using the following techniques and irrigants: alternated rotary motions (ARM) technique, hand nickel-titanium files and 2.5% sodium hypochlorite (NaOCl) as irrigant; ARM technique and combined irrigation with 2.5% NaOCl and citric acid; ARM technique and combined irrigation with 2.5% NaOCl and 2% chlorhexidine gluconate; and Greater Taper rotary files, using 2.5% NaOCl as irrigant. Controls were instrumented by using the ARM technique and irrigated with sterile saline. Canals were sampled before and after preparation. After serial dilution, samples were plated onto Mitis-Salivarius agar, and the colony forming units that were grown were counted. All test techniques and solutions significantly reduced the number of bacterial cells within the root canal (p < 0.05). There was no significant difference between the experimental groups (p > 0.05). Nonetheless, all of them were significantly more effective than the control group (p < 0.05). These findings support the importance of using antimicrobial irrigants during the chemomechanical preparation, regardless of the solutions or instrumentation techniques used.

Anti-Infective Agents, Local↗

PubMed2004

Nasal irrigations: good or bad?

PURPOSE OF REVIEW: Nasal irrigations are often mentioned as adjunctive measures in treating many sinonasal conditions. Despite their widespread use, much mystique and uncertainty exist about the indications and therapeutic mechanisms of nasal irrigations. Anecdotal evidence and poorly controlled studies add to the confusion. Recent evidence challenges some of the assumptions underlying the use of nasal irrigations. RECENT FINDINGS: Studies of nasal irrigations continue to report the benefits in managing sinonasal complaints. Apart from improved patient symptomatology, prescription medication use is often decreased. When nasal irrigations are combined with other medical modalities, patients with chronic sinusitis may not require surgical intervention as often. In particular, patients using hypertonic saline nasal irrigations reported better outcomes. Different devices and techniques exist. Positive-pressure and negative-pressure methods are probably more effective than nebulizers. Furthermore, the popular belief that nasal irrigations need to be sterile is in question. SUMMARY: Nasal irrigations should no longer be considered merely adjunctive measures in managing sinonasal conditions. They are effective and underutilized. Some of the persisting unanswered questions will only be answered by further research.

Humans↗

PubMed1989

An in vitro comparison of ultrasonic and conventional methods of irrigant replacement.

The effectiveness of irrigant replacement in fine canals was compared using three sizes of irrigating needle and an ultrasonic method. The results showed that irrigant replacement became progressively less effective towards the apex regardless of the method of irrigation or needle size. With conventional methods, irrigation performance varied with the size of needle and volume of irrigant. With the ultrasonic method results depended on irrigation time, but was independent of irrigant flow rate through the handpiece, the size of the canal or the file size.

Root Canal Irrigants↗

PubMed1995

In-vitro measurement of apically extruded irrigant in primary molars.

This study investigated the weights of irrigant extruded apically through extracted primary molar teeth. The aim was to compare the weight of canal irrigant (isotonic sodium chloride solution) extruded through the root canal using either a syringe fitted with a 27-gauge needle or an endosonic unit. Root canals were divided randomly into five groups of 15 discrete canals. The area of each apical foramen was recorded prior to the use of the irrigant. For each irrigation technique the maximum depth of penetration of the needle tip/file was either 2-3 mm or 6-7 mm from the apical foramen. In four groups the crowns of the teeth were in a mandibular position, in the fifth group the teeth were inverted to simulate maxillary teeth. The results showed that irrigant was extruded using both methods. There was significantly less extrusion of irrigant when the endosonic unit was used (P<0.01). There was no statistically significant relationship between foramen area and amount of extruded irrigant (P>0.05). There was no significant extrusion of irrigant in teeth with closed apices when either of the two methods was used (P>0.05).

Analysis of Variance↗

PubMed1986

Determination of in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations.

The in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations were determined by utilizing high-performance liquid chromatography techniques following a once daily irrigation. A total of 14 chlorhexidine irrigations established a mean concentration of 0.006% w/v, 2-3 h post irrigation. A total of 12 noxythiolin irrigations established a mean concentration of 0.266% w/v, 2-3 h post irrigation, which correlated to a mean formaldehyde concentration of 0.0119% w/v at 2-3 h, as estimated from N-methylthiourea. For both solutions the minimum inhibitory concentration was exceeded for up to 5 h post irrigation, which is sufficient contact time to establish a total kill, thus indicating the possibility that a once daily irrigation may be appropriate in asymptomatic bacteriuria which utilizes either chlorhexidine or noxythiolin.

Aged↗

PubMed1993

The effect of oral irrigation with a magnetic water treatment device on plaque and calculus.

Calculus formation on tooth surfaces is analogous to the formation of lime and scale deposits in plumbing. Magnetic water devices have been shown to significantly reduce scale deposits in industry; therefore an oral irrigator with a magnetic water device may have a similar effect on calculus. To test this hypothesis, a double-blind clinical study was established using 64 irrigators, 30 of which had their magnetic devices removed. 54 patients with heavy supragingival calculus were given irrigators at random after prophylaxis. Instructions were given to irrigate twice a day, particularly the lower 6 anterior teeth. The patients were also told not to floss these 6 teeth which were to be the study teeth. They were examined after 3 months and measurements were taken of the accretions adhering to the study teeth. No attempt was made to determine whether the adhering material was hard or soft so it must be assumed that at least some of the measured material was also plaque. The measurements of the group using an irrigator with a magnetic device showed a 44% greater reduction in calculus volume (p < 0.0005) and a 42% greater reduction in area (p < 0.0001) over the group using an unmagnetized irrigator. There appears to be a statistically significant difference in supragingival accretion volumes between conventional irrigation and using an irrigator with a magnetic water treatment device.

Dental Calculus↗

PubMed1992

Efficacy of whole bowel irrigation using solutions with or without adsorbent in the removal of paraquat in dogs.

1. The efficacy of whole bowel irrigation with a solution containing either polyethylene glycol (PEG) with electrolyte or an adsorbent (Kayexalate with a cathartic (sorbitol) was investigated in 18 dogs who had been given 250 mg kg-1 paraquat dichloride via a jejunal tube to eliminate the influence of gastric absorption. 2. Plasma paraquat concentrations 2 and 3 h after the initiation of bowel irrigation and at the end of the study (5 h later) were significantly lower in the bowel irrigation groups than in the control (no bowel irrigation) group. 3. The total body clearances of paraquat in the bowel irrigation groups were significantly greater than in the control group. 4. There were no significant differences between the two different irrigation solution groups in plasma paraquat concentration, the area under the plasma concentration time curve and the total body clearance. 5. In the PEG with electrolyte group, about 70% of the administered dose of paraquat was removed by means of bowel irrigation (n = 4). 6. The adjunction of the adsorbent had no beneficial effects. 7. Haemodynamic changes associated with whole bowel irrigation were unremarkable except that right atrial and pulmonary arterial pressures were elevated in the latter part of the study.

Animals↗