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At least 235 records · Page 13Linked to original sources
PubMed2006

Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm.

Since their discovery in 1991, members of the odorant receptor (OR) family have been found in various ectopic tissues, including testis and sperm. It took, however, more than a decade for the first mammalian testicular ORs to be functionally characterized and implicated in a reproductively relevant scenario. Activation of hOR17-4 and mOR23 in human and mouse sperm, respectively, mediates distinct flagellar motion patterns and chemotactic behavior in various bioassays. For hOR17-4, receptor function and downstream signal transduction events are shown to be subject to pharmacological manipulation. Further insight into the basic principles that govern sperm OR operation as well as into the molecular logic that underlies OR-mediated signaling could set the stage for pioneering future applications in procreation and/or contraception.

Animals↗
PubMed1990

Pederasty among primitives: institutionalized initiation and cultic prostitution.

For several reasons it is difficult to find examples of pederastic practices in historical and ethnological sources. Besides the social taboo, these practices have always been mixed up with other forms of sexual contact. However, existing material shows pederastic practices in primitive societies as initiation rituals for male youth. Several examples of institutionalized pederasty, especially from the area of Papua-New Guinea and Melanesia are described. These practices, with a clear societal function, are part of a distinct outlook on life and only superficially resemble the man-boy relationships we can observe today. In other parts of the world, pederastic practices were forms of prostitution. Taking place in a religious context, it was also a different form of prostitution than the one we commonly know. Both forms of man-boy involvement attempt to attain assimilation through physical contact. In these practices sexuality serves purposes other than sexual satisfaction and procreation.

Adult↗
PubMed1987

Abnormalities of ejaculation.

The normal physiologic processes of emission and ejaculation require coordination of neurophysiologic, anatomic, and, in certain cases, psychological phenomena. Disruption of any component, from the embryologic development of the müllerian duct through the medications used for nonrelated systemic disease, can alter the efficient function of ejaculation. Evaluation of the urologic patient who has any of a number of abnormal ejaculatory states requires an understanding of the many possible mechanisms of failure. The majority of these men need evaluation because of a possible male-factor infertile marriage. The potential for improvement is significant, given the development of improved techniques to stimulate ejaculation and the promise shown by extracorporeal fertilization techniques such as in vitro fertilization and gamete intrafallopian tube transfer. These patients deserve complete assessment and optimization of any factors that will enable them to achieve their goal of procreation.

Adolescent↗
PubMed1995

Age and assisted reproduction.

Parenthood is conceptualized as a commitment. Responsible parents are reasonably certain that they will be able to meet their parental obligations and responsibilities. Two factors which may cause the failure to meet the commitment are discussed: (1) lack of time and (2) insufficient personal resources and capacities. Since these capacities are no longer present in most people in their seventies, the age limit for parenthood is placed around 50. The use of the average competent life span as a reference for decisions about the cut-off age limit is closely connected to an opinion about what constitutes a complete life. A complete life is a life in which (a) one's moral obligations and responsibilities have been discharged; and (b) one's life possibilities have on the whole been accomplished. Both conditions are fulfilled if procreation takes place before the age of 50.

Age Factors↗
PubMed1999

[Eating disorders. Osteoporosis and infertility after anorexia nervosa].

EATING DISORDERS: The development of somatic complications observed in patients with eating disorders depends both on the duration of the clinical course and on the gravity of the symptoms and psychological factors. It would thus appear advisable to obtain a complete endocrine (gonadotropic, thyroid, hypothalamo-hypophyseal-adrenal) work-up which could be repeated every year after the patient has controlled the behavior disorder. Two aspects of these complications predominate: osteoporosis and infertility. OSTEOPOROSIS: A common finding after anorexia nevrosa, osteoporosis can lead to multiple, sometimes spontaneous, fractures. Bone mass can be assessed with biphotonic absorptiometry. The indication for estroprogestogen prophylaxis is debatable, depending on the patient's psychological profile, but also because efficacy has not always been demonstrated. Third-generation biphosphonates appear to offer promising results. INFERTILITY: Among a population of women consulting for infertility, a non-negligible percentage have infraclinical manifestations of anorexia nevrosa. The question of prescribing estroprogestogens, which would allow normal cycles and a certain vaginal trophicity, is often raised. We advocate a dose coordination between endocrinologists, infertility specialists and psychiatrists in order to better define the precise modalities of a given treatment aimed at regulating hypothalamo-pituitary function or favoring procreation.

Adult↗
PubMed1995

A comparative, randomized study of three different progesterone support of the luteal phase following IVF/ET program.

The use of luteal phase support has been demonstrated in patients undergoing IVF/ET in cycles stimulated after pituitary desensitization with gonadotrophin releasing hormone agonists. However, it is still not clear which is the most suitable kind of supplementation. This study was designed to compare the absorption and the efficacy of three different luteal support. We randomly administered progesterone i.m. (50 mg/day), human chorionic gonadotrophin (hCG) (2000 IU every three days), progesterone vaginal cream (100 mg/day) or nothing (controls) to 176 women treated for assisted procreation. We were not able to show any statistical differences for the percentage of pregnancy rate between groups. The serum progesterone (P) and 17-beta-estradiol (E2) and E2/P ratio levels of the luteal phase were compared with the control not supplemented group. All the treatments were able to increase significantly the luteal P values versus controls (p < 0.01). Moreover, vaginal cream and natural P im significantly decreased E2/P ratio (p < 0.05). Serum P levels were more steady with P vaginal cream than im injection. Vaginal cream for better bioavailability and acceptance appear the most suitable and comfortable method for luteal phase support.

Adult↗