Intestinal helminthiasis in six selected areas of Puerto Rico.
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204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. From an urban community, 124 patients were given the same drug either as 15mg/kg bodyweight given twice in one day, with an interval of about 12 hours, or 20mg/kg bodyweight given daily for 2 days. Cure rates obtained were 100% in both groups for ascariasis; 89.2% of those given the first regimen were cured of trichuriasis compared with 71.2% of those on the second. For trichuriasis, oxantel-pyrantel given twice, 12 hours apart, appears to be the best treatment schedule and further clinical trials using this regimen are suggested.
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Analysis of available literature has shown a considerable progress in the research of the immunology of helminthoses during recent years. In the Soviet Union the study of this problem is carried out, though to a lesser extent, in the same directions as in other countries. They are as follows: 1. study of manifestation, degree of intensity and mechanisms of immunity; 2. study of antigenic structure of helminths as a basis for a purposeful search of methods of cleaning antigenes from ballast matters and criterium of taxonomy; 3. elaboration of methods for immunodiagnostics of helminthoses; 4. use of immunological methods for a study of epidemiology of helminthoses (seroepidemiology); 5. study of immunopathology.
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It was possible to realize a salvaging in urgency in a building site into the enclosure of the Hôpital Avicenne in Bobigny (seine-Saint-Denis). Into ditches, traces of a native farm from the second century AC, near miscellaneous objects (pots, hatchets, fibules, pieces) was found twelve skeletons. In the ground, extracted between the wings of ilium of an adult skeleton, with an appropriated technical, it was possible to find eggs of Trichuris trichiura and a lot of eggs of Ascaris lumbrocoides. It proves, the human manure was used very probably in the gaul gardens.
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