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Gender differences in outcomes among patients with cancer.

This study examined gender differences in 162 female and 65 male patients with cancer referred to home care. Data were collected before hospital discharge using the Multidimensional Functional Assessment Questionnaire, the Karnofsky Performance Status, and the Quality of Life-Cancer Scale. Controlling for age and stage of disease, the results showed that men reported significantly more cancer-related impairments, more limitations in activity of daily living, and poorer social resources than women. No gender differences were found in quality of life, perceived emotional health, perceived physical health, performance status, and comorbidity. Significant predictors of self-care activities were: for women perceived physical health, Karnofsky Performance Status, and stage of disease (58% variance explained); for men Karnofsky Performance Status and medication taken (67% variance explained). Gender differences should be considered in discharge planning to provide appropriate home care services for male and female patients with cancer.

Activities of Daily Living↗

Gender differences of young adults with schizophrenic disorders in community care.

Gender differences were studied in the lives of 122 young adults (mean age = 23.11 years) with schizophrenia or schizophrenia-related disorders who are participants in a long-term study of progressive community care. Across the first 2 years, males who required hospitalization showed a trend toward greater recidivism and spent more time in institutions than women who required hospitalization. Women spent more time in inpatient medical settings for nonpsychiatric reasons. In community living domains, significant gender differences were found in parent roles, frequency of heterosexual relationships and behaviors, substance use, arrest rates, the number who spent time in jail, and residential settings. In the study to date, more males than females have committed suicide. We discuss specific ways in which treatment can be sensitive to these gender-relevant issues. We also note the need for future research on gender differences in schizophrenia to consider the very different community lives of men and women.

Adult↗

Gender differences among African-American substance abusers.

The purpose of this investigation was to determine if there were gender differences in 80 medical records (37 African-American men and 43 African-American women) from one drug treatment facility located in a midwestern city. Using independent t-tests and chi square analyses to determine group differences, there were significant gender differences relative to childhood sexual abuse experiences and maternal alcohol and other drug abuse; however, there were no gender differences relative to most drug-related behaviors and to paternal alcohol or other drug abuse. Implications for further study are discussed.

Adult↗

Gender differences in response to lorazepam in a human drug discrimination study.

Gender differences in the discriminative stimulus properties of drugs of abuse have sometimes been reported, although we have previously found no differences in subjective or discriminative responses in human subjects acquiring an alcohol discrimination. The aim of the present work was to determine if there were gender differences in the effects of lorazepam, a benzodiazepine-receptor agonist which substituted for the alcohol stimulus in trained social drinkers. Volunteers who had already acquired an alcohol (0.2g/kg) placebo discrimination were administered (double-blind) either placebo (nine females, nine males) or lorazepam 2mg (six females, six males). They then sampled a series of five drinks and rated each one for likeness to the training stimulus (the generalization response). In addition they completed rating scales for subjective effects and the Digit Symbol Substitution Test (DSST). Lorazepam substituted for the alcohol stimulus equally in both sexes and increased associated scores for lightheadedness. Females however, showed a much greater DSST performance impairment following lorazepam, compared with males. This effect was independent of body weight differences and sedation. These results are discussed in the light of current knowledge of gender differences in response to drugs of abuse and suggest that the stimulus and cognitive effects of benzodiazepine-receptor agonists are modulated by different brain mechanisms.

Adolescent↗

Race and gender differences in C-reactive protein levels.

OBJECTIVES: This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels. BACKGROUND: Few data are available comparing CRP distributions in different race and gender groups. Recent clinical practice recommendations for CRP testing for cardiovascular risk assessment suggest a uniform threshold to define high relative risk (>3 mg/l). METHODS: We measured CRP in 2,749 white and black subjects ages 30 to 65 participating in the Dallas Heart Study, a multiethnic, population-based, probability sample, and compared levels of CRP between different race and gender groups. RESULTS: Black subjects had higher CRP levels than white subjects (median, 3.0 vs. 2.3 mg/l; p < 0.001) and women had higher CRP levels than men (median, 3.3 vs. 1.8 mg/l; p < 0.001). The sample-weight adjusted proportion of subjects with CRP levels >3 mg/l was 31%, 40%, 51%, and 58% in white men, black men, white women, and black women, respectively (p < 0.05 for each group vs. white men). After adjustment for traditional cardiovascular risk factors, estrogen and statin use, and body mass index, a CRP level >3 mg/l remained more common in white women (odds ratio [OR] 1.6; 95% confidence interval [CI] 1.1 to 2.5) and black women (OR 1.7; 95% CI 1.2 to 2.6) but not in black men (OR, 1.3; 95% CI, 0.8 to 1.9) when compared with white men. CONCLUSIONS: Significant race and gender differences exist in the population distribution of CRP. Further research is needed to determine whether race and gender differences in CRP levels contribute to differences in cardiovascular outcomes, and whether thresholds for cardiovascular risk assessment should be adjusted for different race and gender groups.

Adult↗

Gender differences in the risk of developing disability among older adults with arthritis.

OBJECTIVES: Although older women are disabled from arthritis at higher rates than men, there is an inadequate understanding of the factors that place women at higher risks. The purpose of this research is to improve understanding of gender differences in the process of becoming disabled among older adults with arthritis. METHODS: Gender differences in risk factors associated with developing a disability during a 30-month period are examined among a sample of noninstitutionalized elders with arthritis (N = 749). RESULTS: Results from discrete time-hazard models indicate that sociodemographic factors account for gender differences in disability with activities of daily living (ADLs). However, for difficulties performing instrumental activities of daily living (IADLs), gender differences remain unexplained by variations in demographic and health factors. DISCUSSION: More descriptive and explanatory work needs to focus on gender differences in IADL disability; however, these findings suggest that the gendered nature of the IADL tasks influences gender differences in IADL disability.

Activities of Daily Living↗

The gender difference in distance running performance has plateaued: an analysis of world rankings from 1980 to 1996.

PURPOSE: Annual world rankings from 1980-1996 were used i) to determine if the gender difference in distance running events has stabilized, and ii) to examine whether the relative decline in pace as race distance increases is different between men and women. World best (WB) and 100th best times in the 1500 m and the marathon (42 km) for each of the 17 years were the indices used to represent overall trends in men's vis-à-vis women's distance running. METHODS: These data were analyzed using regression analyses to develop and compare gender-specific equations. In the 1500 m, the gender difference in WB times (11.1 +/- 1.1%) was consistent from 1980 to 1996, and the slight rate of improvement in event depth (i.e., 100th rankings) was similar for men and women. RESULTS: In the marathon, the gender difference in WB times (11.2 +/- 0.9%) was essentially the same as for the 1500 m. In 1980, the marathon was a fairly new event for the women, having only just been sanctioned by the International Amateur Athletics Federation (IAAF). As a consequence, the depth of the field increased quickly from 1980 to 1984. Since the mid-1980s, the rate of improvement for women in 100th-ranked times has leveled off to equal that of men. The average declines in relative pace for men and women from the 1500 m to the 10 km to the marathon were found to be remarkably similar with no diminishing of the gender difference as race distance increased. CONCLUSIONS: Based on worldwide indices of competitive distance running, the gender difference in distance running performance has plateaued in recent years. Concomitantly, over the past decade, opportunities for women to train and compete have approached parity with those of men. It is likely that the current gender difference in performance will remain fairly constant because of biological differences between men and women that give men an advantage in distance running.

Databases as Topic↗

Gender differences in sleep patterns for early adolescents.

PURPOSE: To describe gender differences in self-reported sleep disturbances and daytime sleepiness in an urban sample of early adolescents (11-14 years of age). METHODS: One hundred and forty-four racially diverse sixth- to eighth-grade students responded to an investigator-developed sleep questionnaire. Variables included school night and weekend sleep patterns as well as factors that influence sleep and daytime sleepiness, such as sleep/wake routine and alcohol and caffeine consumption. RESULTS: Boys consumed significantly more caffeinated beverages than girls, but this did not correlate with self-reports of waking after sleep onset. Caffeine intake was significantly related to self-reported parasomnias. Significant gender differences were found for self-reports of daytime sleepiness. There were also large variations between weekday and weekend sleep schedules. Weekday wakeup time for boys was significantly later compared to girls. Those who reported consumption of alcohol during the past week were likely to fall asleep in the classroom before lunch. Girls, who awakened earlier than boys on school days, were more likely to report falling asleep on the way home from school. CONCLUSIONS: These descriptive data support the need for further investigation into the relationship between caffeine intake and parasomnias, as well as into the observed gender differences.

Adolescent↗

Cartilage contribution to gender differences in joint disease progression. A study with rat articular cartilage.

OBJECTIVE: Rheumatoid arthritis is associated with a worse prognosis in females and is influenced by sex hormone changes. Similar observations in osteoarthritis support the hypothesis that gender differences in cartilage make a hitherto unrecognized contribution to gender differences in arthritis. The aim of the present study was to investigate potential gender differences in articular cartilage biochemistry, metabolism and response to inflammatory mediators. METHODS: Femoral head cartilages from age-matched male and female Wistar rats were analysed for the water, glycosaminoglycan, hydroxyproline and collagen crosslink contents. Proteoglycan loss and synthesis were assessed in vitro, and in the presence and absence of serum and interleukin-1. An in vivo model of inflammation-induced cartilage degradation was employed to investigate gender differences in cartilage susceptibility to erosion caused by granulomatous tissue. RESULTS: Articular cartilage from male Wistar rats presented higher levels of both proteoglycan and collagen and showed a lower spontaneous glycosaminoglycan loss and higher proteoglycan synthesis in vitro than cartilage from females. Proteoglycan synthesis from female, but not male, cartilage was significantly stimulated by foetal calf serum. Female cartilage was more sensitive to IL-1 inhibition of proteoglycan synthesis while the opposite was observed in IL-1-induced proteoglycan loss. Female cartilage was more susceptible to granuloma-induced degradation than male when implanted into female mice, but no differences were observed between male and female cartilage implanted in male mice. CONCLUSION: These results demonstrate important gender differences in cartilage biochemistry, metabolism and susceptibility to inflammatory mediators which may have important consequences for the joint destruction in arthritis and support a role for hormone therapy.

Animals↗

Gender differences in laterality on a dichotic task: the influence of report strategies.

Four experiments were conducted to investigate the influence of report strategies on gender differences in laterality. Ten males and 10 females completed a dichotic consonant-vowels pairs task under four conditions manipulating reporting strategies. Free recall allowed participants to report syllables in any order they chose, whereas order of report control required the report of a pre-specified ear first. In focused attention, they reported only one response from a pre-specified ear. Finally, in ABX discrimination, participants were required to indicate whether a binaural probe was one of the stimuli presented dichotically on the same trial. It was hypothesized that improved control of report strategies would increase the likelihood of detecting significant gender differences in laterality. This was confirmed when results showed no significant gender differences in laterality for the free recall and order of report control conditions, whereas focused attention produced marginal gender differences and clearly significant differences were obtained in the ABX discrimination condition. These findings have implications for interpretations of gender differences in laterality based on strategy effects. Interpretations emphasize the role of attention deployment in the measurement of laterality.

Adolescent↗

A construct-driven investigation of gender differences in a leadership-role assessment center.

This study examined gender differences in a large-scale assessment center for officer entry in the British Army. Subgroup differences were investigated for a sample of 1,857 candidates: 1,594 men and 263 women. A construct-driven approach was chosen (a) by examining gender differences at the construct level, (b) by formulating a priori hypotheses about which constructs would be susceptible to gender effects, and (c) by using both effect size statistics and latent mean analyses to investigate gender differences in assessment center ratings. Results showed that female candidates were rated notably higher on constructs reflecting an interpersonally oriented leadership style (i.e., oral communication and interaction) and on drive and determination. These results are discussed in light of role congruity theory and of the advantages of using latent mean analyses.

Adolescent↗

Identification and the commitment shift: accounting for gender differences in relationship illusions.

Previous work revealed gender differences in relationship illusions. Women, and not men, perceived their dating partners more favorably than their partners' self-perceptions. In two studies, the authors replicated these findings and showed they are moderated by relationship commitment but not by relationship satisfaction. Dating men low in commitment devalued their partners' virtues, whereas those high in commitment exaggerated their partners' virtues compared to their partners' self-perceptions. In contrast, dating women showed relationship illusions irrespective of their commitment. In Study 2, similar results were obtained with relationship-specific identification. Moreover, men's commitment mediated the effect of identification with the relationship. This suggests that gender differences in relationship identities exist at a general level and that men need to identify with and then commit to a specific relationship before they exhibit pro-relationship thinking, which women exhibit as general dispositions.

Adolescent↗

Gender differences in the relationship between empathy and forgiveness.

Much research has shown that women are more empathic than men. Yet, women and men are equally forgiving. However, it is not clear whether empathy is more important to forgiveness for men or for women. The purpose of the present study was to examine gender differences in levels of empathy and forgiveness and the extent to which the association of empathy and forgiveness differed by gender. Participants were 127 community residents who completed self-report measures of empathy and forgiveness. The present results showed that women were more empathic than men, but no gender difference for forgiveness was apparent. However, the association between empathy and forgiveness did differ by gender. Empathy was associated with forgiveness in men--but not in women.

Adaptation, Psychological↗

Gender differences in preschoolers' help-eliciting communication.

Gender differences in help-eliciting communication and the relationship of such utterances with ability were explored. A sample of 71 preschoolers (38 boys, 33 girls; mean age 4 years 3 months) were videotaped as they solved a difficult puzzle. Spontaneous talk was analyzed for orientation (to whom or to what an utterance referred) and for the frequency of utterances coded as help eliciting. Significant main effects for gender were observed, with more frequent help-eliciting utterances (HEUs) made by the girls than by the boys, particularly HEUs about themselves (self-disclosing). Although the girls' HEUs were not predictive of ability on the puzzle, the boys' were. No gender differences in puzzle-solving ability were observed. Findings are discussed with regard to problem solving and social/linguistic development.

Child↗

Gender differences in perceptual-motor performance.

Do gender differences exist in perceptual-motor performance, and, if so, are the differences as substantial as those observed in trade/technical knowledge tests? What roles do general cognitive ability and videogame experience have in determining perceptual-motor performance? To address these questions, we administered a battery of computer-based tests requiring multilimb coordination and perceptual matching to a sample of 392 USAF enlistees (72% male). Our main findings were that general cognitive ability had the expected positive main effect on performance and gender and videogame experience had an interactive effect, such that videogame experience benefited men's but not women's performance. The role of experience on perceptual-motor performance merits further attention, especially with regard to gender differences.

Adolescent↗

Gender differences in functioning for older adults in rural Bangladesh. The impact of differential reporting?

BACKGROUND: The purpose of this study is to examine gender differences in functional ability among older adults in rural Bangladesh in terms of both self-reported activities of daily living and observed physical performance and to evaluate the extent to which differential reporting by gender contributes to disparities between the two measures. METHODS: In 1996, the Matlab Health and Socio-Economic Survey collected data on self-reported activities of daily living (ADLs) and observed physical performance for 1,893 men and women aged 50 and older in the Matlab Surveillance area in rural Bangladesh. Gender differences were examined in both self-reported ADLs and physical-performance measures. With physical-performance measures as the gold standard, logistic regression was used to determine how much of the gender difference in the self-reported function was explained by physical-performance ability controlling for age. RESULTS: Older women in this study population consistently had more limitations than men in both self-reported ADLs and observed physical performance. For the same level of observed physical performance, however, older women were more likely than men were to report a higher level of ADL limitation. This reported female health disadvantage varied considerably depending on the nature of the ADLs being examined and the type of scoring system used for the ADLs. CONCLUSIONS: One has to be somewhat cautious in interpreting gender differences in self-reported ADL limitations, as they are affected by the gender-specific nature of the reported activity and by gender differences in the perception of response categories.

Activities of Daily Living↗

Gender differences in defensive style.

This study examines gender differences in defensive style across the domains of work and intimate relationships. Participants (47 women and 38 men) completed two versions (work-related; interpersonally related) of Bond's (1983) Defense Style Questionnaire (DSQ). Results showed that, while all participants use primarily mature defenses, they are significantly more likely to use immature defenses in love than at work; men are also significantly more likely than women to use immature defenses at work. In addition, women report significantly more use of intermediate defenses than men at work, while men report significantly more use of intermediate defenses than women in love. Results are discussed in light of Chodorow's (1978) theory of gender differences in development.

Adult↗

Gender Differences in Writing Motivation and Achievement of Middle School Students: A Function of Gender Orientation?

The aim of this study was to determine whether gender differences in the writing motivation and achievement of middle school students (N = 497) are a function of gender-stereotypic beliefs rather than of gender. Girls reported stronger writing self-efficacy, writing self-concept, self-efficacy for self-regulation, value of writing, and task goals, and they received higher grades in language arts. Boys reported stronger performance-approach goals. All gender differences favoring girls in writing motivation and achievement were rendered nonsignificant when feminine orientation beliefs were controlled. Findings suggest that a feminine orientation is adaptive in the area of writing, whereas a masculine orientation is beneficial when escorted by a feminine orientation. Results are interpreted from the perspective of A. Bandura's (1986) social cognitive theory. Copyright 2001 Academic Press.

Journal Article↗