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At least 235 records · Page 13Linked to original sources
PubMed1996

[Glossitis granulomatosa symptom of oligosymptomatic Melkersson-Rosenthal syndrome].

Atypical forms of Melkersson-Rosenthal syndrome are difficult to diagnose, especially when occurring in uncommon facial locations. The clinical and histological characteristics of these forms are illustrated in a typical case. We report our experiences with a 59-year-old white male who had increasing swelling of his tongue for years and a recent onset of perioral swelling. A plicated tongue was present, while symptoms of facial and trigeminal nerve involvement were absent. Minor symptoms present were speech impediments, dysgeusia, episodes of hypersalivation and burning sensations on eating. Biopsies revealed sarcoid and lymphonodular-plasmocytic granulomatous infiltrates. These findings were consistent with a diagnosis of an oligosymptomatic Melkersson-Rosenthal syndrome. Swelling of the tongue and that of the perioral region was controlled with clofazimine therapy.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1998

Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism.

An unusual case of necrotic infection of the tongue and unilateral necrotic maxillar sinusitis, in a cow is reported. The prominent clinical findings were: a marked salivation, unilateral mucopurulent nasal discharge, diffuse necrotic lesions on the ventral side of the tongue and fetid breath. Clinico-pathological and pathological findings and abnormalities in the haemogram were probably caused by the toxins produced by the causative organism--Fusobacterium necrophorum like microorganism.

Animals↗
PubMed1979

Relationship between biochemical and clinical indices of B-vitamin deficiency. A study in rural school boys.

1. A study amongst schoolboys in villages around Hyderabad, India, showed that almost all the boys had riboflavin deficiency, 61% had pyridoxine deficiency, and 9.4% had thiamin deficiency as judged by enzymic tests. 2. The prevalence of angular stomatitis was 41.3% and that of glossitis was 18.2%. Biochemical deficiency of riboflavin and pyridoxine was marginally higher in children with angular stomatitis with or without associated glossitis, than in children without oral lesions. 3. Treatment with B-complex vitamins (containing 4 mg riboflavin and 10 mg pyridoxine) daily for 1 month produced significant reduction in the prevalence of glossitis but had no effect on angular stomatitis. The latter responded to topical application of gentian violet. 4. Small but significant changes in erythrocyte enzymes occurred over the period of 1 month even without vitamin supplements. 5. Results suggest that while glossitis is a relatively early manifestation of riboflavin or pyridoxine deficiency or both, angular stomatitis has a more complex aetiology perphaps associated with infection.

Adolescent↗
PubMedDate not supplied

Lesions of the oral mucosa and periodontal disease behavior in pregnant patients.

AIMS: A study is made to contrast the prevalence and severity of periodontal disease, the needs for periodontal treatment, and the prevalence of lesions of the oral mucosa in pregnant (study group) and non-pregnant women. STUDY DESIGN: During the period 1991-1999, a prospective observational study was made of 7952 women seen in the Dental School of De La Salle Bajío University (Leon, Gto. Mexico). The following variables were documented: age, disease antecedents, simplified periodontal index, and lesions of the oral mucosa. Two patient groups were defined: pregnant and non-pregnant women exhibiting a similar age distribution. The data were presented as percentages, and comparisons were made based on the chi-square test. RESULTS: Pregnancy was not found to be a decisive factor for the development of periodontal disease, no differences in the prevalence of gingivitis (54.54 and 50.50%) and periodontitis (31.82 and 31.75%) being observed between the two groups. However, the severity of periodontitis was significantly greater among the pregnant women (18.18% versus 9.88%; p< 0.01). The prevalence of oral mucosal lesions was similar in both groups (30%), 13 lesions being identified in the study group, with a predominance of leukoedema, traumatic ulceration, red traumatic lesions, benign migratory glossitis (geographic tongue), irritative keratosis and pyogenic granuloma. The non-pregnant women in turn exhibited 57 lesions. Pyogenic granuloma and benign migratory glossitis exhibited significant differences between the two groups (p< 0.005). CONCLUSIONS: Gingivitis and periodontitis showed similar prevalences in pregnant and non-pregnant women, though severe periodontitis was more frequent among the former. Pyogenic granuloma and benign migratory glossitis were the lesions with the greatest prevalences during pregnancy.

Adolescent↗
PubMed1976

Oral lesions in psoriatic patients.

Psoriasis is a chronic, recurrent, inflammatory disease of the skin. The occurence of psoriatic lesions in oral mucous membranes is a subject of controversy, and some investigators have stated that such lesions do not occur at all. In the present investigation 100 psoriatic patients were examined for the presence of oral lesions. No patient exhibited oral lesions of psoriasis; however, there was a relatively high incidence of angular cheilosis (11 per cent), fissured tongue (6 per cent), and benign migratory glossitis (5 per cent). The possibility that benign migratory glossitis is an oral manifestation of psoriasis is discussed.

Adolescent↗
PubMed1981

Candidiasis and atrophic tongue lesions.

In an attempt to shed more light on the role of Candida albicans in the genesis of median rhomboid glossitis, a three-part study of normal, atrophic, and cadaver tongues was undertaken. Occasional fungal hyphae were found in 36 percent of the clinically normal tongues. Hyphae were far more numerous in cytologic smears from atrophic tongue lesions than in those from normal tongues. More than 40 percent of the cadaver tongues showed fungal hyphae. The possible role of C. albicans as a cause of median rhomboid glossitis is discussed in the light of these findings.

Adolescent↗
PubMed2000

Insulin-dependent diabetes mellitus and oral soft tissue pathologies: II. Prevalence and characteristics of Candida and Candidal lesions.

OBJECTIVE: To assess the prevalence of Candida albicans and oral infection with Candida in patients with insulin-dependent diabetes mellitus (IDDM). STUDY DESIGN: This cross-sectional study compared the prevalence of candidiasis in 405 subjects with IDDM and 268 nondiabetic control subjects. Assessments included evidence of clinical manifestations of candidiasis and a quantitative measure of Candida pseudohyphae in a cytologic smear from the midline posterior dorsal tongue. RESULTS: More subjects with IDDM than control subjects without IDDM (15.1% vs 3.0%) were found to have clinical manifestations of candidiasis, including median rhomboid glossitis, denture stomatitis, and angular cheilitis. IDDM subjects were also more likely to have any Candida pseudohyphae in their cytologic smears (23.0% vs 5.7%; P <.0001), as well as pseudohyphae counts of >10/cm(2) (7.1% vs 0.8%; P <.0001). Diabetic subjects with median rhomboid glossitis were more likely to have a longer duration of IDDM and complications of nephropathy and retinopathy. Denture stomatitis was associated with smoking, retinopathy, higher Candida counts, poor glycemic control, and longer duration of IDDM. A multivariate regression analysis found 3 factors to be significantly associated with the presence of Candida pseudohyphae in the subjects with IDDM: current use of cigarettes (odds ratio, 2:4), use of dentures (odds ratio, 2:3), and elevated levels of glycosylated hemoglobin (odds ratio, 1:9). The use of antimicrobials, immunosuppressants, or drugs with xerostomic side effects was not related to the presence of Candida. CONCLUSIONS: Candida pseudohyphae and oral soft tissue manifestations of candidiasis were more prevalent in subjects with IDDM than in control subjects without diabetes. The presence of Candida pseudohyphae was significantly associated with cigarette smoking, use of dentures, and poor glycemic control.

Adult↗
PubMed1999

Defensin-1, an antimicrobial peptide present in the saliva of patients with oral diseases.

OBJECTIVES AND DESIGN: A preceding paper has noted a detection of defensin-1 (HNP-1), a peptide with antimicrobial and cytotoxic properties, in the saliva of patients with oral squamous cell carcinoma. The present study deals with the presence of HNP-1 in the saliva of patients with various oral diseases. METHODS: Whole saliva samples were obtained from the patients. HNP-1 in the saliva was isolated and purified by HPLC and the amino acid sequence of the peptide was determined. The molecular weight of HNP-1 was measured by mass spectrometry. The concentration of HNP-1 in saliva was determined by comparing the height of eluted HNP-1 with that of a synthetic HNP-1 standard. RESULTS: The concentrations of HNP-1 in the saliva of patients with oral lichen planus (n = 5), leukoplakia (n = 4), and glossitis associated with iron deficiency (n = 4) were 8.3 +/- 4.3 micrograms ml-1, 13.2 +/- 7.9 micrograms ml-1, and 11.4 +/- 4.9 micrograms ml-1, (mean +/- s.d.), respectively. These concentrations were significantly higher than those in healthy subjects (0.8 microgram ml-1) (P < 0.01). In contrast, salivary HNP-1 concentrations in patients with glossodynia (n = 4) and oral discomfort (n = 4) were similar to those in healthy subjects. CONCLUSIONS: Since HNP-1 is a non-specific defensive peptide present in neutrophils, it may play an important role in the protection against diseases such as oral lichen planus, leukoplakia, and glossitis associated with iron deficiency.

Adult↗