Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “First Birth Intervals”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 235 records · Page 13Linked to original sources

[Birth order, behavioural problems, and the mother-child relationship in siblings aged 4 to 11 years from a 2-child family].

UNLABELLED: Birth Order, Behavioural Problems, and the Mother-Child Relationship in Siblings Aged 4 to 11 Years From a 2-Child Family OBJECTIVE: This study was designed to define the relation between some sibling characteristics (birth order, sex, and interval between successive births) and some behavioral problems in children, on the one hand, and certain dimensions of the mother-child relationship, on the other hand. METHOD: The sample, from National Longitudinal Survey of Children and Youth, included 1,196 families with 2 biological children aged 4 to 11 years. Behavioural problems and dimensions of the mother-child relationship were assessed by mothers. Repeated-measures multivariate analyses of variance were conducted. RESULTS: Analyses showed that first-born children have more internalized symptoms than second-born children. Second-born children also have more positive interactions with their mothers than first-born children. The interval between successive births does not affect these results. CONCLUSION: Several differences emerged between siblings. Health professionals should take these findings into account in their clinical assessments.

Birth Order↗

Analyzing fertility histories: do restrictions bias results?

The straightforward tests we have conducted lead to two major conclusions. First, parameter estimates, such as the proportions that practice contraception or that breastfeed, can be biased in data restricted to the last closed and open interval. This is particularly true the further back in time one goes. However, the second conclusion is that these restrictions do not bias estimates of the structure of the relationships predicting fertility. This may seem surprising, and perhaps even magical. The reason is that multivariate life table techniques allow one to reach the same conclusion even if the proportions in various categories are altered by a criterion such as limiting the analysis to intervals begun by the last and next-to-last live births. Limiting the analysis in this way means that there are fewer short intervals and thus fewer cases of intervals with characteristics associated with short intervals (e.g., no contraceptive use, no breastfeeding, or infant mortality). As long as the model specified in the multivariate life table is an appropriate one, that is, it is not misspecified, and as long as the skew produced by the WFS restriction is not too extreme, then the multivariate life table procedures can produce unbiased estimates of the structure of the relationships predicting birth interval dynamics. Thus even though the WFS data are in fact inappropriate for some simple parameter estimation procedures, they appear to be adequate for the more complex multivariate procedures of the sort used here. Several caveats must be added to the foregoing results. First, we have performed this test in only one country, Korea; it is possible that the same results might not be obtained in other countries. We expect, however, that they would. Second, our procedure only looks at the first 40 months of experience in the birth interval. A procedure that incorporates the long tails of the birth interval distribution may obtain different results. In fact, we caution against analyzing the tail of the distributions using data from the normal WFS sample, since these would be most affected by the restriction to last closed and open intervals. Third, the extent to which these results are generalizable to other types of substantive problems is unknown at present. We suspect, however, that examining the determinants of lengths of breastfeeding will produce similar results. Finally, even with multivariate procedures, it would be highly misleading to impose the WFS restrictions and then examine trends in the length of birth intervals.(ABSTRACT TRUNCATED AT 400 WORDS)

Birth Intervals↗

The comparative role of consanguinity in infant and childhood mortality in Pakistan.

As part of the 1990/1991 Pakistan Demographic and Health Survey, data were collected on the outcome of 26,408 births to 6,611 women, with mortality rates investigated at specific age intervals during the first 5 years of life. Bivariate and multivariate logistic regression analyses were employed to examine the comparative roles of consanguineous marriage and a number of demographic and socioeconomic factors, including the sex of the child, maternal age, maternal education, birth interval and birth order, as determinants of early death. The results indicate that, even after controlling for these non-genetic variables, inbreeding at the level of first cousin exerted a significant adverse effect on survival in four of the five age intervals examined, neonatal, post-neonatal, infant and under 5 years.

Child, Preschool↗

Microvolt T wave alternans inducibility in normal newborn puppies: effects of development.

INTRODUCTION: The cause of sudden infant death syndrome is unknown, but increased cardiac vulnerability due to repolarization instability may be a contributing factor. The QT interval normally is long at birth and increases further during the first few postnatal months. Although excessive QT intervals indicate increased cardiac vulnerability in the long QT syndrome, the impact of less pronounced QT prolongation during this developmental period is unclear. In adults and older children, the ease of inducing microvolt-level T wave alternans (TWA) is used as a measure of repolarization instability and arrhythmia vulnerability. The aim of this study was to determine if TWA is inducible in normal newborn puppies. METHODS AND RESULTS: Atrial pacing was performed in 15 anesthetized beagle puppies 7 to 35 days old. The pacing drive cycle length was systematically decreased in 20-msec steps from baseline until AV conduction blocked. Pacing was performed for 8 minutes at each cycle length. Three-lead ECGs were recorded continuously during the last 5 minutes of pacing at each cycle length. The recordings were analyzed off-line for the presence of microvolt-level TWA using a sensitive spectral analysis technique. Microvolt-level TWA was present in all puppies. TWA was not present at baseline but developed and increased in amplitude as heart rate increased. The threshold heart rate for TWA did not correlate with age. However, due to age-dependent changes in baseline heart rate, the 7- to 14-day-old animals needed a 50% to 78% increase in heart rate to reach threshold heart rate, whereas the oldest animals needed only a 5% to 25% increase. CONCLUSION: These data suggest that developmentally dependent dynamic repolarization instability exists in puppies as manifest by the inducibility of TWA.

Age Factors↗

[Quantitative changes in piriform neurons of human cerebellar cortex from birth to 20 years].

Age changes of size parameters of piriform (Purkinje) neurons in visual cerebellar cortex (pyramid and lateral areas of right and left digastric lobes) were studied at monthly intervals (during the first postnatal year) and at annual intervals (since birth up to 20 yrs) using computer optic image analyzer. Postnatal development of piriform neurons from human cerebellar visual cortex was found to be periodic (cyclic); each morphological cycle is characterised by certain duration and a series of quantitative and qualitative changes.

Adolescent↗

Relationships between calf birth weight, prepartum concentrations of plasma energy metabolites and resumption of ovulation postpartum in Limousine suckled beef cows.

The aim of this study was to determine the relationship between energy status before calving and calf birth weight and their potential effects on interval between calving and first ovulation. Sixty-nine Limousine, suckled beef cows were sampled weekly over a 3-yr period during the last 2 m.o. of pregnancy to determine the concentrations of nonesterified fatty acids (NEFA), beta-3-hydroxybutyrate (beta-OHB), glucose and glycerol. After parturition, progesterone concentrations were measured weekly to determine time of resumption of ovulation. Cows were allotted to 3 groups according to calf birth weight (Heavy: > 44 kg, n = 37; Medium: 39 to 43 kg, n = 56; and Light: < 38 kg, n = 45) and to postpartum ovarian resumption of cyclicity (Late: > 11 wk, n = 41; Mid: 7 to 10 wk, n = 57; and Early: < 6 wk, n = 40). Puerperium glycaemia of the dams was steady state (0.66 +/- 0.03 g/L) and was not related to calf birth weight. Plasma NEFA, beta-OHB and glycerol values were higher (P < 0.05) in Heavy than in Medium and Light group dams during the last 4 wk of pregnancy. Interval between calving and first ovulation was significantly longer for primiparous than for multiparous cows (respectively, 9.9 +/- 2.0 and 7.7 +/- 1.4 wk; P < 0.05). Calf birth weight was not related to time of first ovulation. Late primiparous cows had higher NEFA plasma concentrations than Mid and Early group primiparous cows during the last 4 wk of pregnancy, whereas NEFA plasma concentrations were not related to interval between calving and first ovulation in multiparous cows. Thus, lipomobilization increased with calf birth weight during the last 4 wk of pregnancy. High level of body reserves mobilization was associated with delayed first ovulation in primiparous but not in multiparous cows.

3-Hydroxybutyric Acid↗

Time since last birth and the risk of ovarian cancer.

OBJECTIVES: While parity is a protective factor in ovarian cancer, the role of time factors of pregnancy and birth is still controversial. We considered therefore the role of birth timing in the risk in ovarian cancer from a large case-control study. METHODS: Cases were 971 women (age range 22-74 years, median age 54) with histologically confirmed, incident epithelial ovarian cancer, interviewed between 1983 and 1991 in a network of hospitals in Milan, Italy. Controls were 2758 women (age range 23-74 years, median age 52) admitted to the same hospitals where cases were identified for acute, nonneoplastic conditions. RESULTS: In comparison with nulliparous women, the multivariate odds ratios (OR) were 0.8 for women reporting one or two and 0.6 for those with three or more births. No clear association emerged between time since last birth and ovarian cancer. Compared to women who had last given birth since > or =20 years, a moderately increased risk of ovarian cancer was observed in the first 10 years after last birth, with an OR of 1.7 (95% confidence interval, CI 1.0-2.9). When we considered only multiparous women and included in the multivariate analysis allowance for age at first birth, the OR decreased to 1.2 (95% CI 0.6-2.4). No consistent pattern of trends was observed > or =10 years since last pregnancy. CONCLUSIONS: This study confirms the protective effect of parity on ovarian carcinogenesis, but shows no consistent pattern of risk across time since last birth.

Adult↗

Continued follow-up of pregnancy outcomes in diethylstilbestrol-exposed offspring.

OBJECTIVE: To evaluate long-term pregnancy experiences of women exposed to diethylstilbestrol (DES) in utero compared with unexposed women. METHODS: This study was based on diethylstilbestrol-exposed daughters, the National Collaborative Diethylstylbistrol Adenosis cohort and the Chicago cohort, and their respective nonexposed comparison groups. Subjects who could be traced were sent a detailed questionnaire in 1994 that contained questions on health history, including information on pregnancies and their outcomes. We reviewed 3373 questionnaires from exposed daughters and 1036 questionnaires from unexposed women. RESULTS: The response rate was 88% among exposed and unexposed women. Diethylstilbestrol-exposed women were less likely than unexposed women to have had full-term live births and more likely to have had premature births, spontaneous pregnancy losses, or ectopic pregnancies. Full-term infants were delivered in the first pregnancies of 84.5% of unexposed women compared with 64. 1% of exposed women identified by record review (relative risk [RR] 0.76, confidence interval [CI] 0.72, 0.80). Preterm delivery of first births occurred in 4.1% of unexposed compared with 11.5% of exposed women, and ectopic pregnancies in 0.77% of unexposed compared with 4.2% of exposed women. Spontaneous abortion was reported in 19.2% of DES-exposed women compared with 10.3% in control women (RR 2.00, CI 1.54, 2.60). According to complete pregnancy histories (many women had more than one pregnancy), preterm births were more common in DES-exposed women (19.4% exposed versus 7.5% unexposed (RR 2.93 CI 2.23, 3.86). Second-trimester spontaneous pregnancy losses were more common in DES-exposed women (6.3% versus 1.6%; RR 4.25, CI 2.36, 7.66). More first-trimester spontaneous abortions occurred in DES-exposed women than in controls (RR 1.31, CI 1.13, 1.53), and DES-exposed women had at least one ectopic pregnancy more often than unexposed women (RR 3.84, CI 2.26, 6.54). CONCLUSION: Pregnancy outcomes in DES-exposed women were worse than those in unexposed women.

Abortion, Spontaneous↗

Echocardiographic growth patterns of intracardiac dimensions and determination of function indices during the first year of life.

Cardiac dimensions and left and right ventricular function indices were studied consecutively in 53 healthy newborn babies throughout their first year of life. Cardiac dimensions, except right ventricular (RV) dimension, increase linearly with age, weight and body surface area, the relation being best described as a linear function of BSA. Left ventricular function indices do no change significantly during the first year of life. Right ventricular systolic time interval ratio (RVPEP/RVET) is high at birth, but declines rapidly during the first hours and days. This change is best described as a parabolic function and is an indicator of the physiological fall of pulmonary vascular resistances.

Anthropometry↗

Life course breast cancer risk factors and adult breast density (United Kingdom).

OBJECTIVE: To determine whether risk factors in childhood and early adulthood affect later mammographic breast density. METHODS: Subjects were 628 women who attended a medical examination at the University of Glasgow Student Health Service (1948-1968), responded to a questionnaire (2001) and had a screening mammogram in Scotland (1989-2002). Mammograms (median age of 59 years) were classified using a six category classification (SCC) of breast density percent. Logistic regression was used to determine associations between risk factors and having a high-risk mammogram (>or = 25% dense). RESULTS: In multi-variable analyses, high-risk mammograms were associated with parity (adjusted odds ratio (OR) per child: 0.77 (95% confidence interval (CI) 0.61-0.99)), age at first birth, OR per year: 1.05 (0.99-1.11), smoking at university, OR smokers versus non-smokers: 0.58 (0.36-0.92) and body mass index (BMI) while at university, OR per 1 kg/m2 0.75 (0.69-0.82). No associations with SCC were found for age at menarche, birth weight, oral contraceptive (OC) use, height, leg length or exercise at age 20. CONCLUSIONS: We confirm previous findings that breast density is affected by reproductive events and some anthropometric measures, however most of the risk factors acting throughout the life course which we examined were not closely related to adult breast density.

Adolescent↗

Ultrasound progression of prenatally detected multicystic dysplastic kidney.

OBJECTIVES: To evaluate the sonographic involution of prenatally detected multicystic dysplastic kidney (MCDK). METHODS: A total of 53 children with unilateral MCDK detected by prenatal ultrasonography between 1989 and 2004 were included in this analysis. All children received conservative management with follow-up visits every 6 months. Follow-up ultrasound examinations were performed at 6-month intervals during the first 2 years after birth and yearly thereafter. A linear mixed effect model was constructed, including MCDK length as the dependent variable and body size parameters and contralateral renal dimensions as independent variables. RESULTS: The mean follow-up time was 68 months. A total of 334 ultrasound scans were analyzed. The ultrasound scan demonstrated partial or total involution of the MCDK in 48 cases (91%). A consistent negative correlation was found among MCDK length, patient age, and body size parameters. As a whole, the MCDK length reduction was estimated to be 0.29 mm/mo. The rate of reduction was not constant over time and was intense during the first 30 months of age. According to the regression model, MCKD reduced in length by 0.80 mm/mo during the first 30 months of age, 0.26 mm between 30 and 84 months old, and 0.30 mm in children older than 84 months. CONCLUSIONS: Our results suggest a clear tendency of MCDK to decrease in size, with the rate of the involution greater during the first 30 months than the rate in older children.

Child, Preschool↗

Risk factors for endometrioid, mucinous and serous benign ovarian cysts.

To evaluate the risk factors for serous, mucinous and endometrioid ovarian cysts, data were collected in a case-control study conducted in the greater Milan area based on 202 women with benign cysts (114 endometrioid and 88 serous or mucinous) of the ovary and 1127 controls. Questions were asked about menstrual and reproductive characteristics, marital status, education, history of various diseases, and lifetime use of oral contraceptives and other hormonal treatments. Higher social class, earlier menarche and longer interval between age at first marriage and first birth, a likely indicator of subfertility, were associated with an increased risk of serous, mucinous and endometrioid cysts. Women with endometrioid cyst were characterized by low parity, less frequent irregular or long menses, more frequent oral contraceptive use and low body mass index, while the most relevant risk factor associated with serous and mucinous cysts was greater age at first birth. The present data point out the epidemiological differences between endometrioid and serous or mucinous cysts. Further, they suggest that analyses of risk factors for epithelial ovarian cancer subdivided by various histotypes may be of interest in order to confirm possible heterogeneities in the aetiology of ovarian epithelial neoplasms.

Adult↗

Lactation history and breast cancer risk.

Lifetime lactation in relation to breast cancer risk was examined in a case-control study in two counties in western New York. Cases were women age 40 years and over with incident, primary, histologically confirmed breast cancer. Controls were age- and county-frequency matched, selected from New York State driver's license records (for those less than age 65 years) and from Health Care Finance Administration Records (for those age 65 or more). Included were women with at least one livebirth (253 premenopausal and 367 postmenopausal cases and 266 premenopausal and 427 postmenopausal controls). Breast cancer risk was very weakly associated with long duration of lactation among premenopausal women; the odds ratio for at least 20 months lifetime lactation was 0.50 (95% confidence interval 0.21-1.12). Among postmenopausal women, the protective effect of lactation was restricted to women with first lactation before age 25 years (odds ratio = 0.67, 95% confidence interval 0.46-0.95). However, age at first birth was highly correlated with age at first lactation. Neither insufficient milk as a reason for not breastfeeding nor having received medication to stop milk flow was associated with increased risk. These findings are in accordance with accumulating evidence that lactation may have a weak protective effect on breast cancer risk.

Aged↗

Behaviour of thoroughbred foals during nursing.

Thoroughbred foals were found to nurse in bouts of nursing activity delimited by intervals of non-nursing activity lasting 27 secs or longer. Nursing activity included nosing, sucking and interval behaviour. During the first week after birth, foals nursed, on average, seven times an hour with a mean bout duration of 147 secs but were not successful at sucking during all nursing bouts. Time spent nursing decreased as the foals grew older until before weaning, at 24 weeks of age, the foals were nursing once an hour with a mean bout duration of 74 secs. The dams hindered their foals' nursing activity in several ways during Weeks 2 and 3 post partum and it was suggested that at this time nursing was painful for the dams.

Animals↗