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PubMedDate not supplied

Salivary fluoride levels in overdenture wearers after topical fluoride gel application.

This study describes salivary fluoride levels after topical fluoride gel application on overdenture abutments. Fluoride levels were evaluated separately for the subjects with normal unstimulated salivary flow rate (n = 16) and for those with a low flow rate (n = 8). One drop of fluoride gel (Karigel-N, Lorvic) was placed in two abutment depressions of the duplicated overdenture, after which unstimulated whole saliva was collected for 30 minutes. Samples for fluoride analysis were taken at 5-minute intervals. Two additional samples were taken at 45 and 60 minutes. Fluoride concentration at the abutment-denture interface (remaining fluoride concentration) was measured at the end of the study. Salivary fluoride concentrations decreased gradually in both groups of subjects, but after 1 hour they remained at a higher level in subjects with low flow rates. Subjects' salivary flow rates correlated negatively with remaining fluoride concentration at the denture-tissue interface. Consequently, mean remaining fluoride concentration was significantly higher in subjects with low flow rate than in their normal counterparts.

Aged↗
PubMed1997

Fluoride content and mineralization of red deer (Cervus elaphus) antlers and pedicles from fluoride polluted and uncontaminated regions.

Fluoride, calcium, and phosphorus content as well as ashpercentage and ash density of primary antlers and pedicle bones were studiedin nine yearling red deer stags from a fluoride polluted region in NorthBohemia (Czech Republic) and in nine control animals from two uncontaminatedareas in West Germany. Fluoride levels in antlers (845 +/- 257 mgF-/kg ash, mean +/- SD) and pedicles (1,448 +/- 461 mgF-/kg ash) of the N-Bohemian specimens exceeded that of thecontrols (antlers: 206 +/- 124 mg F-/kg ash, pedicles:322 +/- 157 mg F-/kg ash) by factors of 4.1 and 4.5,respectively. Antler and pedicle fluoride concentrations of the deer(n = 18) were closely correlated (r = 0.975,p < 0.001). Analyses of ash percentage and ash density revealed that theantlers of the N-Bohemian deer contained significantly less mineral and weresignificantly less dense than both their pedicles and the control antlers. Inthe pooled antler samples (n = 18), bone fluoride concentration wasnegatively correlated with ash density (r = -0.826, p < 0.001)and ash percentage (r = -0.759, p < 0.001), whereas nonsignificant, positive correlations existed for the pooled pedicle samples. Ash percentage and ash density of the antlers and their correspondingpedicles were uncorrelated. It is concluded that increased fluoride exposureof deer leads to reduced mineral content and mineral density of antler boneand that it is the rapidity of their growth and mineralization that makesantlers especially susceptible to fluoride action. Due to their ability toaccumulate high amounts of fluoride during a defined, limited timespan andthe apparently dose-dependent negative effect of fluoride on their densityand mineral content, (primary) antlers can be recommended as monitoring toolsfor studying environmental pollution by fluorides.

Animals↗
PubMed1986

Enamel-fluoride levels in deciduous and permanent teeth of children in high, medium and low fluoride areas.

The surface enamel-fluoride concentration (approximately 4 microns) of both deciduous and permanent teeth of the central upper incisors were determined in 5-7 and 11-13-year-old children, who were born and bred in isolated areas with naturally high (3.7 parts/10(6)), medium (0.6 parts/10(6)) and low (less than 0.1 parts/10(6)) fluoride in the drinking water. Samples were taken in vivo by an acid-etch procedure and fluoride levels measured with an adapted fluoride-ion selective electrode. There were no significant differences in the fluoride concentrations or between etching depths between boys and girls, none between the contralateral incisors nor between the etching depths of deciduous and permanent teeth either in a single area or the three different ones. However, a highly-significant difference (p less than 0.01) was found in the enamel fluoride levels between the deciduous and permanent teeth in a fluoride area or among the three different fluoride areas. The ratio of the mean enamel fluoride concentration of permanent teeth to that of deciduous teeth increased with rise in fluoride in the drinking water. It is concluded that the different lengths of time, during which the crowns of deciduous and permanent incisor mineralize, contribute to this differing ratio.

Adolescent↗
PubMed1976

Effect of dietary fat on fluoride absorption and tissue fluoride retention in rats.

The effect of dietary fat on fluoride toxicity was investigated in rats fed isoenergetic diets with graded levels of fat (0, 10%, 30% or 50% of energy) containing 400 ppm fluoride. Growth rate was depressed in all groups receiving fluoride but most severely in the 50% dietary fat group. Plasma, liver and femur fluoride concentrations were increased by increasing dietary fat. This was apparently due to increased absorption of fluoride, since urinary fluoride increased and fecal fluoride excretion decreased as fat intake was elevated. The enhancement of fluoride absorption by fat is believed to be due to the delaying effect of fat and fluoride on gastric emptying, thereby allowing more time for the fluoride to be absorbed from the stomach.

Absorption↗
PubMed1977

Fluoride content of dental plaque before, during and after ingestion of sucrose modified with fluoride or bicarbonate-phosphate.

Students ingested tablets daily during a period of 3 d growth of dental plaque and in connection with the collection of plaque specimens. The tablets varied in composition: sucrose (C), sucrose containing sodium bicarbonate-monopotassium orthophosphate and fluoride (BPF), and sucrose modified with fluoride (F). The daily fluoride dose in conjunction with the growth of plaque and the collection of specimens was 0.5 mg of total fluoride and 0.2 mg in the determination of ionized fluoride. The fluoride taken during the growth period did not significantly affect the total and ionized fluoride contents of the plaque. During the consumption of all the tablets, the total fluoride content of the plaque increased temporarily, after which a drop took place to close to the original value. In the case of the C- and the BPF-tablets, the increase was statistically significant (P-values less than 0.02 and less than 0.001, respectively). During the consumption of the BPF- and F-tablets, the ionized fluoride content dropped significantly (P-values less than 0.001 and less than 0.01, respectively). The investigation showed that a binding of the free fluoride ions in dental plaque takes place in connection with fermentation.

Administration, Oral↗
PubMed1985

Fluoride release from a fluoride-containing amalgam in vivo.

Six test subjects using a low fluoride diet collected saliva samples each morning for 1 wk to determine the normal fluoride concentration. During the following 8 wk an acrylic plate, containing amalgam "fillings" corresponding to 6 MOD amalgams in premolars, was worn each night. Saliva samples were collected every morning and analyzed with a fluoride-ion electrode. Normal fluoride values ranged from 1.22 microM to 0.57 microM. The first days after insertion of the plates the fluoride concentration ranged from 91.06 microM to 12.26 microM in the subjects. The following 25-30 days there was an exponential decline of the fluoride concentration in saliva with a half-life of 6 to 7 days. The fluoride level was significantly higher (P less than 0.01) than basal levels in all subjects during this period. The following 20-25 days the fluoride level decreased more slowly, approaching the basal level. One subject had a significantly higher fluoride level for all 8 wk. Since the saliva fluoride concentrations registered seem to be sufficient to enhance remineralization, it is concluded that restorations with this material may have a favorable effect not only on secondary caries, but on any initial demineralization in the mouth.

Dental Amalgam↗
PubMed1992

Comparison of salivary fluoride concentrations after administration of a bioadhesive slow-release tablet and a conventional fluoride tablet.

The in-vitro and in-vivo fluoride release of bioadhesive, slow-release tablets prepared from a mixture of polyethylene glycol polymers, containing 0.1 mg of fluoride as NaF was studied, and their ability to sustain fluoride levels in saliva were compared with conventional fluoride tablets with the same fluoride content. In-vitro release experiments showed that the bioadhesive tablets needed 8 h to release all their fluoride compared with less than 1 h for the conventional fluoride tablets. In-vivo, the bioadhesive tablets had a retention period of 6 h and could sustain a salivary fluoride level of more than 10 microM above the baseline for 7 h. The conventional fluoride tablets achieved a peak concentration of 0.5 mM directly after dissolution in the mouth, but the fluoride level could not be sustained for longer than 1 h. A good agreement was found between the in-vitro swelling behaviour of the bioadhesive tablets and their in-vitro and in-vivo release characteristics and their in-vivo retention time.

Adult↗
PubMedDate not supplied

Fingernail fluoride: a method for monitoring fluoride exposure.

This work was based on the hypothesis that fingernail clippings can be used as a biomarker for the subchronic exposure to fluoride. The results provide data on factors that may affect the concentration of fluoride in fingernail clippings as determined with the electrode following HMDS-facilitated diffusion. The following variables had only minor or no effects on the concentrations: (1) the surface area of the clippings (intact, minced or filed into powder) that were placed into the diffusion dishes; (2) soaking in deionized water for up to 6 h; (3) soaking in fluoridated water (1.0 ppm) for 2 h, and (4) removal of the organic material of nails by dry ashing. Fingernail fluoride concentrations were approximately 50% higher than those in toenails. A 1-month period of increased fluoride intake by one of the authors resulted in significant increases in fingernail fluoride concentrations after a lag time of approximately 3.5 months. The fluoride concentrations in fingernail clippings obtained from three groups of Brazilian children were directly related to the concentrations in the drinking water (0.1, 1.6 or 2.3 ppm). The results indicate that: (1) HMDS-facilitated diffusion completely separates fluoride from intact nail clippings, so the need for ashing or other preparative methods is obviated; (2) fingernail fluoride is derived mainly from the systemic circulation, and (3) fluoride intake is reflected by the concentrations in fingernails.

Analysis of Variance↗
PubMed1986

Surface enamel fluoride concentrations of different types of human teeth in a high- and near-optimal-fluoride area.

The surface enamel (approximately 4 micron) fluoride concentrations of different tooth types (11, 21, 22, 23, 24) were determined in 12-13-year-old children who were life-long residents in a naturally high (3.70 ppm) and in a near optimal (0.62 ppm) fluoride area. Enamel biopsies were taken by means of an acid-etch procedure, and the fluoride levels were measured with an adapted fluoride-ion-selective electrode. The enamel fluoride concentrations were related to the fluoride levels of the drinking water, and it appeared that the enamel fluoride concentrations of the different tooth types (except for the pre-molars) were associated with the length of the pre-eruptive period. In general, for both areas, the mean enamel fluoride concentrations increased from the central incisor to the lateral incisor and were found to be the highest in the canine, while the mean fluoride content of the first pre-molar nearly equaled that of the central incisor. No statistically significant differences (p greater than 0.05) were found between the enamel fluoride concentrations of the different tooth types or the etching depths, from different sexes.

Acid Etching, Dental↗
PubMed1998

Distribution of fluoride in the oral cavity after application of a bioadhesive fluoride-releasing tablet.

Bioadhesive fluoride tablets are fluoride-releasing devices that can be applied to the oral mucosa by the patient and release fluoride for several hours. From earlier research, it is known that a single fluoride source in the mouth can lead to an uneven distribution of fluoride in the oral cavity. In this study, fluoride concentrations were determined at different sites of the oral cavities of 13 healthy human volunteers after the application of a bioadhesive fluoride tablet containing 0.5 mg fluoride. The sites were: (1) labial surfaces of the upper central incisors, (2) lingual surfaces of the lower central incisors, (3) labial surface of the first upper left molar, and (4) labial surface of the lower right first molar. The tablet was fixed either centrally on the palate or in the lower labial sulcus in two consecutive experiments. Saliva was sampled with polyethylene sponges 5, 10, 20, 30, 60, 120, 180, and 240 minutes after tablet insertion. Fluoride was determined electrochemically. It could be shown that the area under the curve (AUC) values were significantly (p < 0.05) higher after tablet insertion in the lower labial sulcus at sampling site 1, a trend (p = 0.06) could be calculated for sampling sites 2 and 3, and no difference was found at sampling site 4. Fluoride could be detected in concentrations above 0.01 mmol.L-1 at all sampling sites after tablet insertion in the lower labial sulcus. This location seems to be a more appropriate tablet location than the palate.

Adhesives↗
PubMed1991

Fluoride sources and dental attendance habits among adults in communities with optimal and low water fluoride concentrations.

The aim of this study was to obtain data on local fluoride supply, dental attendance, and dental care habits in two sociologically similar municipalities with optimal, 1.0 ppm, and low, 0.3 ppm, water fluoride concentrations, respectively. The participants in the study were 30- to 40-year-old lifetime residents in the two municipalities: 569 individuals from the 1-ppm fluoride community and 466 from the low-fluoride community. There were no intergroup differences in the fluoride mouthrinse utilization rate of 1%. Fluoride toothpaste was much more common in the low-fluoride area. In the 1-ppm fluoride area more people drank tea, and they went more regularly to the dentist. It is suggested that dental attendance habits and various fluoride sources should be taken into account in studies evaluating the effect of fluoride in drinking water.

Adult↗
PubMed2006

Dental caries and enamel fluorosis among the fluoridated population in the Republic of Ireland and non fluoridated population in Northern Ireland in 2002.

BACKGROUND: An all Ireland/North South survey of Oral Health was carried out in 2001/2002. AIMS: To compare levels of dental caries and enamel fluorosis among children and adolescents in the fluoridated Republic of Ireland (RoI) with those in the non fluoridated North of Ireland (NI). METHODOLOGY: Cross sectional oral health survey of a representative, random, stratified sample of 5-, 8-, 12- and 15-year-olds in Rol and in NI (N = 19,950). WHO examination criteria with the addition of visible, non cavitated dentine caries were used for recording caries. Fluorosis was measured using Dean's Index. RESULTS: In the RoI, the mean d(3c)mft / D(3c)MFT for 5-, 8-, 12-, and 15-year-olds with full domestic water fluoridation (n = 9,975), was 1.0, 0.3, 1.1 and 2.1 respectively. The corresponding means in non fluoridated NI (n = 1,475) were 1.8, 0.3, 1.5 and 3.6 respectively. (p < 0.0001, NS, p < 0.0005 and p < 0.0001). The prevalence of enamel fluorosis has increased in RoI since 1984, 23% and 36% of 8- and 15-year olds respectively in fluoridated areas had Dean's Index scores at the questionable or greater level in 2002 compared with 6% and 5% respectively in 1984. CONCLUSIONS: In 2002 apart from 8-year-olds, caries levels were lower amongst children resident in fluoridated communities in RoI than amongst corresponding age groups in non-fluoridated NI. Caries has declined in fluoridated and non fluoridated groups in both jurisdictions since the early 1960s. In RoI fluorosis levels were higher amongst lifetime residents of fluoridated communities and have increased since 1984.

Adolescent↗
PubMed1989

[The effect of fluoride-containing tooth paste on dental plaque and on fluoride level in the mouth].

Various kinds of fluoride have been used for a long time and there are many reports concerning fluorides and their effects. Recently, the caries-inhibiting action of fluoride-containing tooth paste has been given much attention. In this study, I tried to clarify the residual time and amount of fluoride derived from the fluoride-containing tooth paste in the mouth, as well as to assess possible variation in bacterial composition in the dental plaque bacteriologically and biochemically. In the study on the fluoride clearance from the mouth, both 1.0 g and 0.5 g of paste showed the same reduction rates; and about an 80% reduction was recognized between the value at 3 minutes and that at 30 minutes, and about a 40% reduction from the 30-minute to the 60-minute interval. Next, a study on the variation in plaque bacteria was carried out. The total number of the CFU on each plate was not different between samples obtained before and after the use of the tooth paste; moreover, no difference was noted between aerobic and anaerobic culture. However, when plaque before and after brushing with fluoride-containing tooth paste were cultured in 10% sucrose solution, the differences of acid production such as lactic acid, acetic acid, and formic acid were demonstrated. Namely, these acid productions were inhibited after the use of fluoride, especially lactic acid was strongly inhibited. On the other hand, when Str. mutans from the plaque obtained after the use of fluoride-containing tooth paste was cultured in fluoride-free BHI broth, the inhibition of acid from carbohydrates was not shown clearly.(ABSTRACT TRUNCATED AT 250 WORDS)

Bacteria↗
PubMedDate not supplied

Determination of fluoride in fluoride tablets and solutions by ion-selective electrode: collaborative study.

A proposed method using the fluoride (F) ion-selective electrode has been developed for determining the fluoride ion concentration in tablets and solutions containing sodium fluoride. The method has been subjected to collaborative study. Eight samples consisting of 2 authentic fluoride solutions, 2 commercial fluoride solutions, and 4 commercial fluoride tablets were sent to each of 11 collaborators together with a copy of the method. Single assays on the authentic fluoride solutions known to contain 1 mg F/5 mL were performed with average recoveries of 99.5 and 99.6% and relative coefficients of variation (CV) of 2.11 and 1.91%, respectively. Single assays of 2 commercial fluoride solutions declared at 1 mg F/5 mL gave mean values of 0.994 and 0.990 mg and relative CV values of 1.88 and 2.36%, respectively. Single assays of 2 commercial fluoride tablet preparations declared at 0.5 mg F gave mean values of 0.485 and 0.478 mg and relative CV values of 3.12 and 3.71%, respectively. Single assays of 2 commercial fluoride tablet preparations declared at 1 mg F gave mean values of 0.991 and 0.981 mg and relative CV values of 2.99 and 2.85%, respectively. The method has been adopted official first action.

Buffers↗
PubMedDate not supplied

Dental fluorosis in children exposed to multiple sources of fluoride: implications for school fluoridation programs.

Naturally occurring fluorides of varying levels made possible a study do determine if continuous, lifetime use of home drinking water fluoridated to optimum levels combined with the use of school fluoridated water beginning at school age causes objectionable levels of dental fluorosis as defined by Dr. H. Trendley Dean in 1936. Examinations were performed on 120 children who had fluoride concentrations in home well water ranging from 0.1 to 6.5 ppm and attended a school with a private water source containing 4.5 ppm natural fluoride (5.6 times the optimum for community fluoridation in the area). Fluorosis scores were calculated for each of four groups formed according to fluoride concentrations in home water supplies. The group with an average concentration of 0.87 ppm was found to have a Community Index of Dental Fluorosis well within Dean's normal limits. The results suggest that children consuming water at home containing the optimal fluoride concentration and drinking water at school containing the recommended fluoride level (4.5 times the optimum) are not at risk to dental fluorosis that impairs appearance. If this finding is corroborated by future clinical studies, the target population for school fluoridation can be expanded and the administration of these programs facilitated.

Adolescent↗
PubMed1993

Formation of the stable myosin-ADP-aluminum fluoride and myosin-ADP-beryllium fluoride complexes and their analysis using 19F NMR.

The effects of aluminum fluoride and beryllium fluoride on smooth muscle myosin and its subfragments were studied. Mg(2+)-ATPase activity was inhibited in the presence of aluminum fluoride (beryllium fluoride). [3H]ADP bound to heavy meromyosin (HMM) in the presence of aluminum fluoride (beryllium fluoride) and was not dissociated after 3 days of dialysis demonstrating that [3H]ADP was trapped in HMM. These results suggest the formation of a stable HMM-ADP-fluoroaluminate (fluoroberyllate) complex. The intrinsic tryptophane fluorescence intensity was increased in the presence of ADP and aluminum fluoride (beryllium fluoride). Acto-S1 was dissociated upon the formation of S1-ADP-fluoroberyllate and actin destabilized S1-ADP-fluoroberyllate complex, while S1-ADP-fluoroaluminate failed to bind to actin. Furthermore, when S1 formed the complex with actin, nucleotide trapping did not occur in the presence of fluoraluminate. These results indicated that the myosin-ADP-fluoroberyllate complex resembles a weak binding state while myosin-ADP-fluoroaluminate complex is a distinct conformation although the binding to actin was also weak. The structure of the ternary complex was investigated using 19F NMR. The 19F NMR spectrum of the S1-ADP-fluoroaluminate complex showed a peak at -66.7 ppm which is due to the binding of fluoraluminate to S1. The peak was not observed when 5'-adenylylimidodiphosphate was substituted for ADP suggesting that aluminum fluoride plays a role as a phosphate analogue. The stoichiometry of the bound fluoride was determined to be 3.8 mol/mol S1 suggesting that the bound species is AlF-4.

Adenosine Diphosphate↗
PubMed1996

Evaluation of fluoride uptake by enamel in children from fluoride dentifrices.

Fluoride dentifrices are well accepted for their caries preventive effects. Although it is generally accepted that the presence of fluoride in the enamel protects teeth against carious attack, at the same time, there is some concern that ingestion of fluoride from toothpastes may substantially contribute to the total intake of this element. The present study was undertaken to clinically evaluate the fluoride uptake by human enamel after the use of lower concentrations of fluoride dentifrices and compare their potency to higher concentration in increasing the uptake of fluoride by enamel. Enamel biopsy was conducted on first permanent molars of 100 school children, aged 6-8 years before brushing and at intervals of one hour, 3 weeks, 6 weeks and 12 weeks following brushing with different concentrations of fluoride dentifrices. The fluoride content of the enamel biopsy samples were estimated using the Orion microprocessor ion analyser and by taking into consideration the enamel biopsy mass and depth of the etch. The results of the present study suggest that low fluoride concentration dentifrices provide similar fluoride uptake by enamel when compared with that of higher concentrations.

Analysis of Variance↗
PubMed1996

Determination of fluoride from fluoride-releasing elastomeric ligature ties.

Unaesthetic white spot lesions or larger unsightly areas of decalcification around orthodontic brackets remain a significant problem during fixed appliance treatment. This study determined the in vitro fluoride release from 200 fluoride-containing elastomeric ligature ties. With the potentiometric analytic method, the fluoride release was determined in distilled water, for 10 groups of 20 elastomerics, representing the clinical usage in a patient. Readings were taken every 24 hours for 5 days and then every second week for 6 months. The data were analyzed with the Wilcoxon matched pairs signed ranks test. Fluor-I-Ties (Ortho Arch Company Inc., Hoffman Estates, III.) released significant amounts of fluoride compared with the control readings. The fluoride release was characterized by an initial burst of fluoride during the first day and second day, followed by a logarithmic decrease. By the end of the second week 88% of the total fluoride had been leached from the elastomerics, but adequate magnitudes of fluoride were released over the remainder of the test period to aid theoretically in the prevention of demineralization and enhance remineralization of enamel through calcium fluoride and fluorapatite formation. For optimum clinical benefit, Fluor-I-Ties should be replaced monthly. Future prospective longitudinal clinical studies are indicated.

Apatites↗