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At least 235 records · Page 13Linked to original sources
PubMed1990

[How to evaluate the long-term course of osteoarthritis. Tests for trials of fundamental treatments (spine excluded)].

The best assessment tests for long term trials on osteoarthritis (OA) of the hip and knee are the following, in order of relevance value (consensus of french experts): 1) the loss of joint space thickness on successive radiographies; 2, 3) the indices of the severity for OA of the hip and knee; the investigator's overall opinion; 4) the patient's overall opinion (visual analogue scale of handicap); 5, 6, 7) the pain level (visual analogue scale); the time for going up and down a standard flight of stairs and the time of pain in this distance; the limitation of two articular movements; 8) the increase of either analgesics or NSAIDs consumption; 9) concerning OA of fingers, the number of joints newly involved on successive radiographies. At present, only the radiological tests 1 and 9 are validated. The clinical tests 2 to 8, valuable for short term trials, have yet to be validated for long term follow-up. Recommended duration of trials is three years. A rigorous organisation is necessary to avoid erroneous inclusions: all data recorded in the pre-inclusion visit have to be checked by the principal investigator. Since we have not yet a validated chondroprotective agent as a reference drug, the trial must be randomised, double blind, placebo controlled, parallel group study.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1990

[Definitions and clinical experimentation of anti-osteoarthritis agents/chondro-protectors. Survey among private rheumatologists].

Through osteoarthritis is the most common rheumatic disease its fundamental medicinal therapy(s) remain(s) still to be discovered. Definitions of the terms anti-osteoarthritic or chondroprotective agents vary according to the conceptual ideas in presence. They are discussed. In order to know the view point of private rheumatologists, a survey has been realised. 63 rheumatologists answered a questionnaire which included three parts: the first one, semantic, concerned definitions of anti-osteoarthritic and chondroprotective drugs and their respective place in therapeutic; a questionnaire of methodology was then exploring conception and organisation of clinical trials to assess such drugs in osteoarthritis; finally questions were asked on feasibility of such trials. The results are presented and discussed below.

Cartilage Diseases↗