Design of early clinical trials for new contraceptive methods.
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In relation to the total number of births in the United Kingdom there was an excess of hydatidiform moles arising in women over 34 years of age and possibly also under 15. The incidence of trophoblastic tumour requiring chemotherapy after hydatidiform mole was greatest in the 30 to 34 years age group and it was also high in the 20 to 24 years age group. This distribution appears to be influenced by the morphology of the moles, the mode of their removal and the use of oestrogens and progestogens in the post-evacuation period. The need for chemotherapy for trophoblastic tumour after evacuation of a hydatidiform mole was found to be two- to three-fold greater in patients who had undergone a medical induction, hysterectomy or hysterotomy compared with those whose hydatidiform moles had been evacuated by vacuum or surgical curettage, or who had aborted spontaneously. The increased risk of chemotherapy was most marked in the earlier weeks of gestation.
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A study in Bangladesh showed that the probability of use of modern contraception by eligible family members of a household increases significantly if the household head himself is a user. Multinomial logistic regression showed that contraceptive use was also significantly related with maternal age, parity, education, socioeconomic status and experience of child mortality. Inclusion of ever use of modern contraceptives by the family head or his wife, showed family head's religiosity to be a significant predictor of use, apart from his age and parity, and after controlling for socioeconomic correlates.
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In this opinion poll, 1000 women from Switzerland aged 15 to 45 years were asked about their use of contraceptives. The most favorite contraceptive is the pill (31%); however, it is more popular among younger women than older ones. Safety of contraception is mentioned as the main advantage of the pill. In second and third place come the condom (17%) and the intrauterine device and sterilization (6% each). The reasons for choosing one or the other type of contraception and the sources of information are discussed. Information and counselling from the family doctor was rated as "very good" and from the gynecologist as "good" to "very good".
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