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At least 235 records · Page 13Linked to original sources

Integration of a blood pressure controller and an infusion toolbox system using client-server technology.

This paper shortly describes an Infusion Toolbox and a blood pressure (BP) control application. It explains how we applied an agent model and client-server technology to integrate them. We show that by using this framework and object oriented technologies the necessary changes to the existing applications are reduced. Many elements of the tested original systems could be re-used, which enhances safe development.

Anesthesia↗

How much information can one store in a nonequilibrium medium?

It has recently been emphasized again that the very existence of stationary stable localized structures with short-range interactions might allow one to store information in nonequilibrium media, opening new perspectives on information storage. We show how to use generalized topological entropies to measure aspects of the quantities of storable and nonstorable information. This leads us to introduce a measure of the long-term stably storable information. As a first example to illustrate these concepts, we revisit a mechanism for the appearance of stationary stable localized structures that is related to the stabilization of fronts between structured and unstructured states (or between differently structured states).

Computers, Molecular↗

Developments in component-based normalization for 3D PET.

Normalization in positron emission tomography (PET) is the process of ensuring that all lines of response joining detectors in coincidence have the same effective sensitivity. In three-dimensional (3D) PET, normalization is complicated by the presence of a large proportion of scattered coincidences, and by the fact that cameras operating in 3D mode encounter a very wide range of count-rates. In this work a component-based normalization model is presented which separates the normalization of true and scattered coincidences and accounts for variations in normalization effects with count-rate. The effects of the individual components in the model on reconstructed images are investigated, and it is shown that only a subset of these components has a significant effect on reconstructed image quality.

Adult↗

EEG data compression techniques.

In this paper, electroencephalograph (EEG) and Holter EEG data compression techniques which allow perfect reconstruction of the recorded waveform from the compressed one are presented and discussed. Data compression permits one to achieve significant reduction in the space required to store signals and in transmission time. The Huffman coding technique in conjunction with derivative computation reaches high compression ratios (on average 49% on Holter and 58% on EEG signals) with low computational complexity. By exploiting this result a simple and fast encoder/decoder scheme capable of real-time performance on a PC was implemented. This simple technique is compared with other predictive transformations, vector quantization, discrete cosine transform (DCT), and repetition count compression methods. Finally, it is shown that the adoption of a collapsed Huffman tree for the encoding/decoding operations allows one to choose the maximum codeword length without significantly affecting the compression ratio. Therefore, low cost commercial microcontrollers and storage devices can be effectively used to store long Holter EEG's in a compressed format.

Algorithms↗

Automatic "pipeline" analysis of 3-D MRI data for clinical trials: application to multiple sclerosis.

The quantitative analysis of magnetic resonance imaging (MRI) data has become increasingly important in both research and clinical studies aiming at human brain development, function, and pathology. Inevitably, the role of quantitative image analysis in the evaluation of drug therapy will increase, driven in part by requirements imposed by regulatory agencies. However, the prohibitive length of time involved and the significant intraand inter-rater variability of the measurements obtained from manual analysis of large MRI databases represent major obstacles to the wider application of quantitative MRI analysis. We have developed a fully automatic "pipeline" image analysis framework and have successfully applied it to a number of large-scale, multicenter studies (more than 1,000 MRI scans). This pipeline system is based on robust image processing algorithms, executed in a parallel, distributed fashion. This paper describes the application of this system to the automatic quantification of multiple sclerosis lesion load in MRI, in the context of a phase III clinical trial. The pipeline results were evaluated through an extensive validation study, revealing that the obtained lesion measurements are statistically indistinguishable from those obtained by trained human observers. Given that intra- and inter-rater measurement variability is eliminated by automatic analysis, this system enhances the ability to detect small treatment effects not readily detectable through conventional analysis techniques. While useful for clinical trial analysis in multiple sclerosis, this system holds widespread potential for applications in other neurological disorders, as well as for the study of neurobiology in general.

Algorithms↗

The virtual cell.

This paper describes a computational framework for cell biological modeling and simulation that is based on the mapping of experimental biochemical and electrophysiological data onto experimental images. The framework is designed to enable the construction of complex general models that encompass the general class of problems coupling reaction and diffusion.

Cell Physiological Phenomena↗

[The results and outlook for the use of mathematical methods and computer technology in dentistry].

Development and introduction into wide practice of various mathematical methods (systemic, regression, and factor analyses, etc.) and modern computation devices (personal computers, local computer network, etc.) is shown. These devices extended the potentialities of differential diagnosis and pathogenetic (including laser) therapy of the major oral diseases (dental carries, pulpitis, periodontitis, periodontal diseases and buccal mucosa, odontogenic inflammations, tumors, etc.).

Computing Methodologies↗

Implementing cognitive learning strategies in computer-based educational technology: a proposed system.

Switching the development focus of computer-based instruction from the concerns of delivery technology to the fundamentals of instructional methodology, is a notion that has received increased attention among educational theorists and instructional designers over the last several years. Building upon this precept, a proposed methodology and computer support system is presented for distilling educational objectives into concept maps using strategies derived from cognitive theory. Our system design allows for a flexible and extensible architecture in which an educator can create instructional modules that encapsulate their teaching strategies, and mimics the adaptive behavior used by experienced instructors in teaching complex educational objectives.

Cognition↗

Computers in a human perspective: an alternative way of teaching informatics to health professionals.

An alternative way of teaching informatics, especially health informatics, to health professionals of different categories has been developed and practiced. The essentials of human competence and skill in handling and processing information are presented parallel with the essentials of computer-assisted methodologies and technologies of formal language-based informatics. Requirements on how eventually useful computer-based tools will have to be designed in order to be well adapted to genuine human skill and competence in handling tools in various work contexts are established. On the basis of such a balanced knowledge methods for work analysis are introduced. These include how the existing problems at a workplace can be identified and analyzed in relation to the goals to be achieved. Special emphasis is given to new ways of information analysis, i.e. methods which even allow the comprehension and documentation of those parts of the actually practiced 'human' information handling and processing which are normally overlooked, as e.g. non-verbal communication processes and so-called 'tacit knowledge' based information handling and processing activities. Different ways of problem solving are discussed involving in an integrated human perspective--alternative staffing, enhancement of the competence of the staff, optimal planning of premises as well as organizational and technical means. The main result of this alternative way of education has been a considerably improved user competence which in turn has led to very different designs of computer assistance and man-computer interfaces. It is the purpose of this paper to give a brief outline of the teaching material and a short presentation of the above mentioned results.(ABSTRACT TRUNCATED AT 250 WORDS)

Attitude to Computers↗

Efficiency of parallel direct optimization.

Tremendous progress has been made at the level of sequential computation in phylogenetics. However, little attention has been paid to parallel computation. Parallel computing is particularly suited to phylogenetics because of the many ways large computational problems can be broken into parts that can be analyzed concurrently. In this paper, we investigate the scaling factors and efficiency of random addition and tree refinement strategies using the direct optimization software, POY, on a small (10 slave processors) and a large (256 slave processors) cluster of networked PCs running LINUX. These algorithms were tested on several data sets composed of DNA and morphology ranging from 40 to 500 taxa. Various algorithms in POY show fundamentally different properties within and between clusters. All algorithms are efficient on the small cluster for the 40-taxon data set. On the large cluster, multibuilding exhibits excellent parallel efficiency, whereas parallel building is inefficient. These results are independent of data set size. Branch swapping in parallel shows excellent speed-up for 16 slave processors on the large cluster. However, there is no appreciable speed-up for branch swapping with the further addition of slave processors (>16). This result is independent of data set size. Ratcheting in parallel is efficient with the addition of up to 32 processors in the large cluster. This result is independent of data set size.

Algorithms↗

Measurement of electrical current density distribution in a simple head phantom with magnetic resonance imaging.

Knowledge of the influence of the human skull on the electrical current (d.c.) distribution within the brain tissue could prove useful in measuring impedance changes inside the human head. These changes can be related to physiological functions. The studies presented in this paper examine the current density distribution in a simple phantom consisting of a saline filled tank (to simulate scalp and brain) and a ring made of dental grade plaster of Paris (to simulate the human skull). Images of the distribution of the d.c. density of the phantom with and without the plaster of Paris ring were produced using a magnetic resonance imaging technique. These images indicate that the skull is likely to produce a more uniform d.c. density within the brain.

Brain↗

A parallel framework for the FE-based simulation of knee joint motion.

We present an object-oriented framework for the finite-element (FE)-based simulation of the human knee joint motion. The FE model of the knee joint is acquired from the patients in vivo by using magnetic resonance imaging. The MRI images are converted into a three-dimensional model and finally an all-hexahedral mesh for the FE analysis is generated. The simulation environment uses nonlinear finite-element analysis (FEA) and is capable of handling contact of the model to handle the complex rolling/sliding motion of the knee joint. The software strictly follows object-oriented concepts of software engineering in order to guarantee maximum extensibility and maintainability. The final goal of this work-in-progress is the creation of a computer-based biomechanical model of the knee joint which can be used in a variety of applications, ranging from prosthesis design and treatment planning (e.g., optimal reconstruction of ruptured ligaments) over surgical simulation to impact computations in crashworthiness simulations.

Computer Simulation↗

Remote processing server for ECG-based clinical diagnosis support.

In this paper, we present the development of a remote server that provides a user-friendly access to advanced electrocardiographic (ECG) signal processing techniques. The prototype supplies telemedicine facilities to doctors for clinical indexes remote computation to support diagnosis through the Internet. The user-friendly interface is based on the selection of the desired ECG signal processing tools on a Web browser window. The centralized structure of the system permits unique and user-independent update and management of the software and, therefore, is especially suitable for remote or rural regions to have access to the new ECG information techniques.

Algorithms↗

Fusing images with different focuses using support vector machines.

Many vision-related processing tasks, such as edge detection, image segmentation and stereo matching, can be performed more easily when all objects in the scene are in good focus. However, in practice, this may not be always feasible as optical lenses, especially those with long focal lengths, only have a limited depth of field. One common approach to recover an everywhere-in-focus image is to use wavelet-based image fusion. First, several source images with different focuses of the same scene are taken and processed with the discrete wavelet transform (DWT). Among these wavelet decompositions, the wavelet coefficient with the largest magnitude is selected at each pixel location. Finally, the fused image can be recovered by performing the inverse DWT. In this paper, we improve this fusion procedure by applying the discrete wavelet frame transform (DWFT) and the support vector machines (SVM). Unlike DWT, DWFT yields a translation-invariant signal representation. Using features extracted from the DWFT coefficients, a SVM is trained to select the source image that has the best focus at each pixel location, and the corresponding DWFT coefficients are then incorporated into the composite wavelet representation. Experimental results show that the proposed method outperforms the traditional approach both visually and quantitatively.

Algorithms↗