EFFECT OF THE ERGOT INHIBITOR (CLAVICEPS PURPUREA L.) ON THE TOBACCO MOSAIC VIRUS (TMV).
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The impact of changes in the ratio of the medium-668 components on growth and synthesis of ergot alkaloids in saprotrophic cultures was studied with mathematical design of the experiment. Medium-668 used for cultivation of strain VNIIA-312A-producing peptide +ergot alkaloids was shown to be balanced with respect to the ratio of all the medium components. An important role of phosphate in control of culture growth and alkaloids synthesis was elucidated. It was demonstrated that by changing the ratio of the medium components it was possible to control accumulation and excretion of the alkaloids which permitted development of the conditions required for product isolation.
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It has been tested the bacteriolytic activity and the interaction among the development of the bacteriophage T4 and Ergot alkaloids. It has been determined a bacteriolytic action on the bacterial stub "E. Coli host of bacteriophage T4. It exist an interaction also among such alkaloids and the development of the bacteriophage T4, which appears through an increase of the quantity of lysis areas, becoming evident in solid bodies containing the lysing bacterium. Further researches with other bacterial and virus stubs will be effected and mentioned afterward.
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