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Hepatitis B surface antigen (HBsAg) in feces of convalescent hepatitis B patients.

In 1983, 13 subjects were selected from a factory where an outbreak of viral hepatitis B occurred in October 1982. About 5-7 months later, 13 patients with viral hepatitis B were studied by RPHA and ELISA for HBsAg in feces. Presence of HBsAg was confirmed by specific blocking procedure. HBsAg was found in feces in 69% (9/13) of patients and 30.2% (26/86) of samples collected. 14 fecal specimens found to be positive for HBsAg by RPHA or ELISA examined by immune electron microscopy. Small aggregates of 20-28 nm HBsAg spherical particles were found in three fecal samples. 40-50 nm Dane's-like particles were also observed in one sample. The results suggested that in convalescent period of viral hepatitis B the HBsAg might be excreted through feces.

Convalescence↗

[The bile cholate-cholesterol coefficient for assessing the causes of a protracted convalescence in patients with viral hepatitis].

Changes of the content of bile acids, cholate-cholesterol coefficient, bile acid fraction ratios in the bile were assessed in patients with viral hepatitis and chronic cholecystitis. A scheme is proposed for evaluation of bile bladder function considering four states: functional hypocholia, cholecystitis, threat of cholelithiasis. It is shown that in 23-28% protracted convalescence in viral hepatitis and manifested in prolonged blood serum ALAT activity is caused by the presence of subclinical form of cholecystitis.

Bile↗

[Pulmonary tuberculosis convalescents (group IV D) at the outpatient tuberculosis and lung disease clinics in Poland 1967-1986].

An analysis of risk rates of tuberculosis incidence in convalescents registered in tuberculosis dispensaries in Poland in the years 1967-1986 was made. In Poland they are registered in group IVD. Since 1978 this group is steadily decreasing although in 1986 it made up 1.27% of the whole country's population, and was the highest risk group. In 1986 the risk of a tuberculosis infection was six fold higher in this group, and eight fold higher confirmed bacteriologically. Out of this group 8.3% of new infections are derived, and 11.1% of freshly diagnosed cases of bacteriologically confirmed tuberculosis. Heterogeneity of this group suggests different proceedings.

Convalescence↗

Anesthetic technique and surgical convalescence.

This brief review presents an update of studies on postoperative fatigue and convalescence and the way in which they are affected by anesthetic technique. Development of postoperative fatigue is related to the degree of surgical trauma, but not to general anesthesia, and it cannot be predicted from age, sex, duration of surgery, or preoperative assessment of various nutritional parameters. Postoperative fatigue correlates with deterioration in nutritional status and impaired adaptability of heart rate to orthostatic stress and bicycle exercise. Decreases in muscle performance and endurance are associated with postoperative fatigue, but psychological factors such as preoperative degree of anxiety do not appear to be important factors. Pain relief with regional anesthetics does not improve postoperative fatigue after abdominal surgery; however, no studies are available that evaluate the effects of regional analgesia with concomitant inhibition of the stress response. Controlled studies suggest that the use of regional anesthesia with local anesthetics reduces duration of hospitalization and time to ambulation. Further studies are needed to define the relative roles of immobilization, impaired nutritional intake, and surgical stress response in the pathogenesis of postoperative fatigue.

Anesthesia, Conduction↗

[Status of the duodenum in the early period of convalescence in viral hepatitis].

The results of study of the clinical picture of residual phenomena of virus hepatitis are presented as well as the data of intragastroduodenal pH-metry, gastric and duodenal endoscopy, morphological, histochemical and morphometric study of the duodenal biopsy specimens in 277 virus hepatitis convalescents. On the extensive material it has been proved that gastroduodenal system is actively involved in the pathological process during an early recovery period. The revealed changes have unidirectional pattern and reflect the preulcerous status.

Adult↗

[Immune response to various antigenic preparations of Bordetella pertussis in whooping cough patients and convalescents studied by immunoenzyme analysis].

The content of antibodies to B. pertussis disintegrated cells, protein fraction and lipopolysaccharide in the blood of patients and convalescents has been studied. The study has revealed that in the blood sera of whooping cough patients the titers of antibodies to lipopolysaccharide considerably exceed the titers of antibodies to other antigenic fractions. The titers of IgM to lipopolysaccharide have been shown to exceed the titers of IgM to other fractions 1.5-2 times.

Adult↗

Early rehabilitation of patients in the convalescence phase after myocardial infarction. Results of a multicentre study in GDR health resorts.

Carried out within the framework of the GDR myocardial infarction control programme, this study presents the organisational model of early rehabilitation of post-infarction patients in convalescence (phase II according to WHO) in health resorts and sanatoria. By referring to a multicentre study conducted on 5,069 patients in six sanatoria of the GDR, a higher physical performance and cardiac relaxation are set forth as essential results, coupled with a decline in the sympathico-adrenergic response, which are concomitant with an improved state of health. Twelve months following the cure, 77% of the patients regained their ability to work, with 71% of them back in their former jobs.

Adult↗

[Bronchomotor hyperreactivity and bronchial patency in patients with acute pneumonia during clinico-roentgenological convalescence].

A study of bronchial permeability in 98 patients with acute pneumonia during clinico-roentgenological convalescence using a method of the analysis of the flow-volume loop diagram showed disorders of bronchial permeability in 73.46% of the patients, of them obvious disorders in 21.42% and latent ones in 52.04%. Hyperreactivity of the tracheobronchial tree to acetylcholine was established in 84.4% of the patients without signs of obvious obstruction and in some cases only to obsidan indicating the presence of disorders of vagotonic regulation without change in the functioning of beta-adrenoreceptors.

Acetylcholine↗

Passive immunization of mice against Trypanosoma cruzi using convalescent mouse serum.

Groups of 10 mice were infected by the s.c. injection of blood trypomastigotes of Trypanosoma cruzi, strains "Y" and "Tulahuen". They were injected i.p. with convalescent mouse-anti-T. cruzi serum (CMATS) at various times. A single dose of CMATS (Y) was most effective when injected one day after homologous infection -31 of 40 mice survived the infection, whereas all controls, both untreated and injected with normal serum, died. CMATS was significantly less effective in treating mice infected with the Tulahuen strain. Sera from animals immunized with killed epimastigotes or trypomastigotes showed only very slight passive immunizing properties.

Animals↗

The value of skin test in Q fever convalescents and vaccinees as indicator of antigen exposure and inducer of antibody recall.

The skin test (ST) with Q fever chemovaccine revealed more positive reactors than the serological examination by microagglutination (MA) test among humans, who had suffered from Q fever one to eleven years ago or who had been vaccinated with Q fever chemovaccine from three months to four years ago. When examining the sera harvested either at skin-testing or two weeks thereafter by MA test, seroconversion or rise in antibody titres were found to both main Coxiella burnetii (C. b.) antigens. The rise or appearance of antibody response was similar in Q fever convalescents and vaccinees, in the latter occurring more often in ST positive than in ST negative individuals. Results of ST at different postvaccination (p.v.) intervals corresponded well to those of lymphocyte transformation (LT) test, but not to those of inhibition of leukocyte migration ( ILM ) test.

Agglutination Tests↗

Field studies with convalescent serum and infectious bursal disease vaccine to control turkey coryza.

Convalescent serum given to 1-day-old poults delayed clinical signs of turkey coryza by several days and reduced mortality on infected farms. Turkey breeders immunized with cell-culture-adapted infectious bursal disease virus (IBDV) or turkey infectious bursal disease virus (TIBDV) had a marked increase in virus-neutralization (VN) antibody titers. The VN antibody titer was significantly higher in progeny poults than in poults from unimmunized breeders. Clinical turkey coryza and mortality was considerably less in poults from IBD- or TIBD-vaccinated breeders than in control poults. They also responded more favorably to hemorrhagic enteritis and fowl cholera vaccination.

Animals↗

Increased renal perfusion and kidney size in convalescent burn patients.

Renal blood flow was elevated in convalescent burn patients shortly before discharge (992 +/- 112 mL/min/sq m in burn patients vs 551 +/- 37 mL/min/sq m in normal subjects; mean +/- SE). Autopsy studies demonstrated that renal enlargement was a constant feature of patients after a prolonged hospital course; the kidneys of 28 patients who died after 60 days of hospitalization weighed 241 +/- 10 g vs 153 +/- 8 g in control subjects. The increase in renal weight was primarily related to cellular hypertrophy and hyperplasia. These physiological and morphological findings in thermally injured patients may be a form of renal work hypertrophy following increased protein catabolism accompanying severe injury.

Adult↗

Behaviour of specific IgM, IgG and IgA class antibodies in human leptospirosis during the acute phase of the disease and during convalescence.

The behaviour of specific IgM, IgG and IgA class antibodies in human leptospirosis was studied by ELISA. Two groups of patients were followed up, 57 of them in the acute phase and 10 during convalescence, the latter with a mean follow-up of 10.5 months. IgM class antibodies were detected starting on the 2nd day of symptoms and were observed in 100% of patients up to the 5th month, in 66.7% up to the 7th month and in 50% up to the 12th month after the onset of symptoms. IgG class antibodies were first detected on the 7th day of symptoms in 9.1% of patients, with maximum reactivity (87.5%) between the 2nd and 3rd month, and were not detected at all in one patient. IgA class antibodies were detected starting on the 5th day of symptoms in 7.7% of patients, and in all patients on the 15th day, persisting in 100% of cases up to the 9th follow-up month. During the 12th month, they were observed in 83.3% of patients. The results indicate that an anti IgA ELISA could be of great value in seroprevalence studies on human leptospirosis.

Adolescent↗

[The immune response in those ill with and convalescing from Q fever studied by using immunoenzyme analysis].

The study of immune response in Q-fever patients and convalescents at different periods from the beginning of the disease demonstrated the diagnostic possibilities of the complement fixation test (CFT), the microagglutination test (MAT), the passive immunofluorescence test (PIFT) and the enzyme immunoassay (EIA). High effectiveness of EIA in comparison with CFT, MAT and PIFT was noted (97, 63, 87 and 91% respectively). The sensitivity of EIA was not less than 100-250 times higher than that of CFT, 15-100 times higher than that of MAT and 30-80 times higher than that of PIFT.

Agglutination Tests↗

[Pain and convalescence after ambulatory inguinal herniotomy during local anesthesia].

Postoperative pain and convalescence following ambulatory inguinal herniotomy in local infiltration anesthesia was evaluated in this descriptive study. Sixty consecutive patients (median age 63 yr) were included. Per- and postoperative pain treatment were pre- and postoperative oral tenoxicam and methadone plus infiltration of the surgical field with up to 60 ml of 0.25% bupivacaine. Intraoperative pain intensity was slight and was treated with supplemental bupivacaine. Patients were totally relieved of pain at rest and during mobilisation in the first hours after surgery, but more than half of the patients had moderate pain from the first to the third postoperative day and still had light pain seven days after surgery. Normal daily activity was re-established five days postoperatively (median). Fifty-two patients were satisfied with the anesthesia and eight patients not satisfied due to fear of intraoperative pain. This study shows that inguinal herniotomy can be performed routinely as an outpatient procedure under local infiltration anesthesia. However, late postoperative pain was significant and should be improved with multi-modal analgesia.

Adult↗

[The iron overload syndrome in patients with severe bacterial inflammatory diseases and convalescents].

In convalescents after and in patients with sepsis, purulent meningoencephalitis, severe pneumonia the study of iron metabolism provided biochemical criteria of iron excess: low serum transferrin against high transferrin iron, elevated ferritin. The risk of hyperferremia rises considerably after blood or erythrocyte transfusions. The liver got affected in the presence of infectious toxicosis. The authors believe it risky to practice uncontrolled administration of iron preparations in subjects recovering from severe bacterial and inflammatory diseases in view of threatening hemochromatosis.

Acute Disease↗

Back transfer: capability of community hospitals to serve chronically ill and convalescing infants.

Severe crowding in neonatal intensive care facilities may prevent many critically ill newborn infants from receiving optimal care. Crowding could be alleviated by back transferring chronically ill or convalescing infants to intermediate-level community hospitals where community-based care can be delivered. The purpose of this study was to assess the ability of such hospitals in North Carolina to care for these children. A telephone survey was administered to all 35 intermediate-level community hospitals that had > or = 600 births per year. Hospital resources were assessed on the first call, and a 1-day census was taken for three successive months. Total daily nursery census was 288. Back-transferred infants (32) and infants whose stay exceeded 5 days (32) constituted 24% of the nursery population. Each hospital had a pediatric medical director and necessary equipment to care for back transfers, and 80% of the hospitals could accept a back-transferred infant who was in a neonatal incubator, tube fed, receiving oxygen, 1400 gm, with mild and infrequent apnea and bradycardia--a common clinical picture in such infants. The most severe limitation to accepting infants for back transfer was the shortage of nursing staff appropriately trained to care for this population. These data have implications for effective discharge planning and the development of appropriate community-based, service-delivery systems.

Chronic Disease↗

[From spas and convalescent homes to retraining institutions].

The traditional types of health care institutions, the spas and convalescence homes, were reorganised in Norway in 1992 to become retraining units group I and group II. The new regulations demanded that the institutions should upgrade and strengthen their treatment facilities. The physician in charge of group I institutions has to have rheumatological or physical medical qualifications, and the institution itself has to have sufficient nursing and other medical staff to be able to treat patients in need of a higher level of therapy than required by patients at group II institutions. A survey of the institutions concludes that most of them now conform with the new regulations.

Baths↗