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PubMedDate not supplied

Biologically active constituents of leaves and roots of Aloe arborescens var. natalensis.

Several biologically active substances, such as aloenin (1), magnesium lactate, aloe-emodin (4), barbaloin (5), and succinic acid, were found to be contained in the leaf juice of Aloe arborescens Mill. var. natalensis Berger, which has widely been used in domestic medicines. Aloenin (1) and magnesium lactate were elucidated to exhibit an inhibitory action on the gastric juice secretion of rats. Various constituents other than the above bioactive substances were found in the leaves and the roots of the plant.

Aloe↗
PubMed2002

[Structural analyses of barbaloin-related compounds in aloe drinks].

Four kinds of barbaloin (BA)-related compounds (A, B, C, D) in aloe drinks were isolated by using preparative HPLC. LC/MS analyses of these compounds showed the identical quasimolecular ion peak at m/z 833 [M-H]-. The chemical structures were mainly determined by NMR, including 1H-1H two-dimensional correlation spectroscopy (COSY), nuclear Overhauser and exchange spectroscopy (NOESY), heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond connectivity (HMBC) experiments. They were identified as BA-related compounds A (10R, 10"S), B (10S, 10"S), C (10S, 10"R), and D (10R, 10"R) coupled through a C-10 to C-7' linkage, and newly found in nature. These results suggested that BA is converted to dimers during storage of aloe drinks.

Aloe↗
PubMed1989

Aloe vera and gibberellin. Anti-inflammatory activity in diabetes.

Aloe vera inhibits inflammation and adjuvant-induced arthritis. The authors' laboratory has shown that A. vera improves wound healing, which suggests that it does not act like an adrenal steroid. Diabetic animals were used in this study because of their poor wound healing and anti-inflammatory capabilities. The anti-inflammatory activity of A. vera and gibberellin was measured in streptozotocin-induced diabetic mice by measuring the inhibition of polymorphonuclear leukocyte infiltration into a site of gelatin-induced inflammation over a dose range of 2 to 100 mg/kg. Both Aloe and gibberellin similarly inhibited inflammation in a dose-response manner. These data tend to suggest that gibberellin or a gibberellin-like substance is an active anti-inflammatory component in A. vera.

Aloe↗
PubMed1991

Isolation of a stimulatory system in an Aloe extract.

The authors' previous work on a 50% ethanol extract of Aloe vera was done to evaluate anti-inflammatory activity using the croton oil-induced ear swelling assay. The anti-inflammatory activity was found in the supernatant fraction. The supernatant fraction decreased inflammation, when applied topically, by 29.2%, and the precipitate decreased inflammation by 12.1%. However, in the present work, the precipitate fraction decreased the wound diameter by an average of 47.1% (stimulatory system). Little or no wound healing activity was found in the supernatant. Aloe vera appears to act as a modulatory system toward wounds and inflammation and is a potentially valuable tool for managing lower extremity conditions.

Adult↗
PubMed1992

Aloe vera and the inflamed synovial pouch model.

Administration of air under the skin produced a pouch wall that closely resembled a synovium in that the inner lining was made up of macrophages and fibroblasts. Administration of 1% carrageenan directly into the 7-day-old air pouch produced an inflammation characterized by an increased number of mast cells in pouch fluid as well as an increase in wall vascularity. A punch biopsy weight of the pouch wall did not reveal an increase in 1% carrageenan-treated animals. However, a 10% Aloe vera treatment of carrageenan-inflamed synovial pouches reduced the vascularity 50% and the number of mast cells in synovial fluid 48%. The pouch wall punch biopsy weight was increased by A. vera, which was verified by histologic examination of the inner synovial lining. Aloe vera stimulated the synovial-like membrane, as evidenced by an increased number of fibroblasts, suggesting that A. vera stimulated fibroblasts for growth and repair of the synovial model. The synovial air pouch can be used to study simultaneously the acute anti-inflammatory and fibroblast stimulating activities of A. vera.

Aloe↗
PubMed1994

Anti-inflammatory and wound healing activity of a growth substance in Aloe vera.

Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.

Aloe↗
PubMed2002

[Quantitative determination of barbaloin in aloe capsule by high performance liquid chromatography].

Barbaloin in aloe capsule was quantitatively determined by high performance liquid chromatography with ODS column, a mixture of CH3OH-H2O (50:50, volume ratio) as mobile phase and UV detection at 298 nm. There was a good linear relationship within the range of 0.02 microgram-1.50 micrograms (r = 0.9999). The recovery was 99.0%-101.9% and the relative standard deviation was 1.37%(n = 6). The detection limit was 0.002 microgram (S/N = 2:1). The total time for separation and determination was within 10 min. The method is rapid, simple, accurate and reproducible. The method is proposed to be used for quality control of aloe capsule.

Aloe↗
PubMed2002

[Study on application of arbuscular-mycorrhizas in growing seedings of Aloe vera].

Tissue culture seedlings of Aloe vera L. inoculated with 7 AMF(arbuscular mycorrhiza fungi) in a greenhouse in Guangzhou showed that the percentage of infection was 99.67%-100%, the index of infected was 73.3%-86.67%. After being inoculated 13 months, the seedling high raised 19.88%-51.91%, the leaves length raised 13.13%-150.96%. After being inoculated 15 months, the leaves juice of Aloe vera raised 60.87%-233.8% and the dried of leaves juice raised 217%-724%.

Aloe↗
PubMed2003

[Determination of aloin in aloes by HPLC].

OBJECTIVE: To describe a simple and rapid isocratic reversed-phase high performance liquid chromatography method for the baseline separation, identification and assay of aloin in aloes. METHOD: The analytical column was a ZORBAX SB-C18(4.6 mm x 250 mm) filled with a 5 microns stationary phase. The mobile phase consisted of acetonitrile-water (25:75); the flow-rate was 1 mL.min-1. The injection volume was 10 microL. The DAD detector was set at 355 nm. RESULT: The calibration curve was linear over the range of 0.17-5.9 micrograms (r = 0.9999). The average recovery of the method was 98.6%, RSD 1.32% (n = 6). CONCLUSION: The results showed that this method was reliable and accurate. The method was applied to eleven Cape and East African aloes of different origin.

Aloe↗
PubMed2004

[Determination of germanium in aloe vera by spectrophotometric method].

OBJECTIVE: To analyze the organic germanium in aloe vera from different localities. METHODS: The method was based on germanium forms a stable complex with phenylfluorone in the acidified solution and CTMAB as solubilization agent. The contents of the organic germanium in Aloe vera from different localities were determined by spectrophotometric methods. RESULTS: The linear range of determination is 0-0.7 microg/ml. The recovery is 98.1%-99.0% and the coefficient of variation is 1.8%.

Aloe↗
PubMed2004

[Determination of trace zinc, manganese, cadmium and lead in aloe by microwave-digestion atomic absorption spectrometry].

A microwave digestion procedure was developed for the determination of trace Zn, Mn, Cd and Pb in aloe-leaf cuticle and aloe-leaf gelatin, using the obturated vessel microwave digestion system with a pressure controlling part, and the amounts of these trace metallic elements were determined by atomic absorption spectrometry after microwave digestion. The effects of the composition of digestion solution, the ratio of the sample to digestion solution, and the digestion time were studied. It is satisfactory to apply the microwave digestion procedure to the determination of Zn, Mn, Cd and Pb under the optimized condition with the recovery of 95.0% to 110.0% and RSD of 0.3% to 6.2%. The results show that this method is rapid and simple with low environmental contamination and complete digestion of the sample.

Aloe↗
PubMed2005

[The modulating of aloe polysaccharides on the cell cycle and cycle regulating protein expression in X-ray irradiated non-malignant cells].

OBJECTIVE: To study the modulating of Aloe Polysaccharides on the cell cycle and cycle regulating protein expression in X-ray irradiated non-malignant cells. METHODS: The cell cycle was analyzed by flow cytometric analyzed. The levels of cell cycle regulating protein expression were tested by Western blot. RESULTS: A distinct G2/M block happened in 293 and C. Liver cells after irradiation. The pre-treatment of AP in the concentration of 50 microg/ml caused an increasing G0/G1 phase population and decreasing G2/M phase population. Meanwhile, pre-treatment of AP could significantly decrease the high expression of p53 protein caused by irradiation and evidently enhance the expression of P21, Cyclin B1 and pRb protein. Pre-treatment of AP had no evident effect on p27,CDK4 and Cyclin D1 protein. CONCLUSION: There is a radioprotective effect of AP on non-malignant cells. This effect is related to alleviating the cell cycle turbulence. The modulating of Aloe Polysaccharides on the cell cycle regulating protein expression in X-ray irradiated non-malignant cells contributes to its alleviating effect on the cell cycle turbulence.

Aloe↗
PubMed2006

[Active constituents from Aloe arborescens as BACE inhibitors].

AIM: To seek for new components as BACE inhibitors from Aloe arborescens. METHODS: The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis. RESULTS: Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately. CONCLUSION: Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.

Aloe↗
PubMed1991

Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel.

Three women and one man aged forty-one to sixty-five years experienced a severe burning sensation following the application of aloe vera or vitamin E preparations to a skin area that had been subjected to a chemical peel or dermabrasion. Subsequently, a severe dermatitis occurred that required hospitalization of one patient and intravenous administration of steroids. The dermatitis abated very slowly in all patients: full recovery took three months or more. One patient resumed the use of vitamin E creams two years after the episode of dermatitis and experienced no adverse effect. Patients undergoing dermabrasion or chemical peel procedures should be cautioned specifically against the use of aloe vera or vitamin E topically in the first weeks after surgery.

Adult↗
PubMed1990

Glyoxalase I and glyoxalase II from Aloe vera: purification, characterization and comparison with animal glyoxalases.

Glyoxalase I and glyoxalase II from the outer green rind of Aloe vera leaves were purified by (matrix) affinity ligand-enzyme binding methods. The purified enzymes exhibited single protein bands on SDS-PAGE electrophoresis, with MW values of approximately 44,000 and 27,000 for glyoxalase I and glyoxalase II, respectively. The glyoxalase I is a basic protein (pI 7.8), while the glyoxalase II (3 protein bands) is acidic (pI 4.7, 4.8 [prevalent form], and 5.0). The kinetic constants, Km and Vmax, and Ki values for certain inhibitors are reported for both glyoxalase I and glyoxalase II. The glyoxalase enzymes from Aloe vera were compared with reported animal and plant glyoxalases.

Aloe↗
PubMed1980

Hypersensitivity to aloe.

Hypersensitivity, manifested by generalized nummular eczematous and papular dermatitis, and presumably by contact urticaria, developed in a 47-year-old man after four years of using oral and topical aloe. Patch tests for aloe were positive in this patient.

Aloe↗
PubMed1987

The safety and efficacy of topical 1% ALO 2145 (p-aminoclonidine hydrochloride) in normal volunteers.

We prospectively evaluated the efficacy and safety of the twice-daily application of 1% ALO 2145 (p-aminoclonidine hydrochloride, a topical alpha 2-agonist) in 21 normal volunteers for one month. Criteria measured included intraocular pressure (IOP), basal tear secretion, pupillary size, corneal sensitivity, heart rate, and blood pressure; urinalysis and blood chemistry studies were also performed. The mean (+/- SD) IOP fell 38.7%, from 17.5 +/- 3.9 mm Hg to 10.7 +/- 3.4 mm Hg, in five hours. The mean IOP remained between 23% and 30% below the pretreatment level when checked 12 hours after the last drop's instillation from day 8 through day 28 of the study. No clinically significant changes in mean systolic blood pressure, blood chemistry values, urinalysis results, basal tear secretion, or corneal sensitivity were noted. The mean heart rate and diastolic blood pressure were each significantly decreased at only one of nine time intervals. Dry mouth was noted at some time in 52% of volunteers. ALO 2145 seems to be effective in lowering IOP in normal volunteers, without marked cardiovascular effects.

Adult↗