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Influence of choking and arm lock technique in judo on the acoustic reflex threshold (art) in healthy well-trained male and female judoka.

The objective of this controlled parallel group study was to assess the effects of standardized choke holds (test) and arm lock techniques (controls) in on the acoustic hearing threshold. 104 (test group, 32 female subjects and 72 male subjects, mean age = 28.0 years, SD = 7.9 years) and 51 experienced judoka (controls. 21 female subjects, 30 male subjects; mean age = 26.8 years; SD = 13.2 years) participated. Acoustic reflex thresholds (ART [dB]) were measured separately before and after each manoeuvre both for air and bone conduction of the right and left side. The difference Dart of the ART before and after a manoeuvre (Dart = ARTbefore - ARTafter) was calculated. Data were presented descriptively and nonparametric statistics was applied for nonrelated (Kruskal Wallis ANOVA) or related samples (Friedman ANOVA). Wilcoxon tests were used for pre/post comparisons of original ART values. The effect of choking on Dart was significantly different from the effect of the arm lock technique on Dart independent of the experimental condition. A significant influence of applied frequencies on Dart was ascertained if a choking technique was used. For all frequency ranges applied a highly significant improvement of the ART after choking was found. With regard to bone conduction thresholds increased by an average of 6.1 dB and for air conduction the average increase was 4.9 dB. On the contrary, arm locks induced a slight mean deterioration of the ART for bone conduction of 1.8 dB. The ART for bone conduction also showed a trend towards a reduction after arm locks with a mean decrease of about 1.2 dB. In conclusion, standardized choking manoeuvres reduced the ART corresponding to an improved hearing both with regard to air and bone conduction. Such an effect on hearing ability was not found for arm lock techniques.

Adolescent↗

ART is the heART: a palette of possibilities for hospice care.

Comprehensive hospice care for children who are dying or dealing with the death of a parent, sibling, or other family member must include psychologic, emotional, and spiritual support. Increasingly, the arts are being recognized as a powerful tool for this support. In 1999, WVSA arts connection, a community-based, arts and education, non-profit organization in Washington, DC, developed and launched a unique arts-in-health care program, ART is the heART. The program trains and brings artists to children and families in home or hospice care. Through ART is the heART, children learn to use the arts as a healthy and effective coping strategy. The program is now being replicated in other communities across America.

Adaptation, Psychological↗

Art and "the language of well-being" in adolescent health care.

Feeling effective as a young person depends on a capacity to draw upon one's own resources in the service of healthy living and development. In adolescent health care, there is the need to call upon the talents and creativity of young people, to introduce new and exciting experiences, and to facilitate involvement in their own care in order to nurture optimal growth and development on a physical and psychological level. While hospitalisation can represent a major crisis point in adolescence, the provision of a stimulating environment and the opportunity for creative activities offers an exciting, transformative and healing experience. Art allows adolescents to use alternative languages beyond illness, to engage in endeavours that are distanced from overt therapeutic intent, and to embrace attributes of self-esteem and resilience. Through the process and production of art, and the inclusion of music, poetry, film or theatre, young people can experience personal growth, acquire skills, develop socially and contribute to environmental change. In seeking to illustrate the value and importance of such approaches, this paper draws upon the experiences of a youth arts program attached to an adolescent ward. In a project called Art Injection, art students worked with adolescents to make sculptures from old hospital equipment, with startling results. More recently, the development of personal totem poles and an imaginative mosaic mural has powerfully engaged creativity and community in care. Group and individual art sessions, including the media arts project Creative Well, are offered on weekdays as part of the general hospital routine, enabling hospitalised young people to experience creativity as a daily part of their lives.

Adolescent↗

The functions of art-making in CISD with children and youth.

Very little has been written about the use of art materials in the debriefing process with young children apart from the familiar assumptions of increasing comfort in the situation and providing a more concrete way for young children to communicate. In this study, art-making was introduced as an integral, although optional, component of the debriefing process in order to examine more fully the functions of art-making in this context. This paper describes a research process and findings from a series of debriefings with four different groups of children and adolescents who had experienced either primary traumatic effects (i.e., were present during a traumatic event) or secondary traumatic effects (i.e., were impacted by a trauma that happened to someone else). The analysis of the artwork and of the comments of the participants are integrated within a theoretical framework combining ideas from the fields of art therapy and the treatment of trauma. From this analysis, there is a description of four functions of art-making in CISD with this population: (a) to increase comfort and emotional safety, (b) to promote expression of thoughts and feelings, (c) to enhance appropriate containment of emotion, and (d) to support ego-strengths. The primary contribution of this research is to offer a clear articulation of the rationale for the consistent use of art-making in CISD with children and youth, and to do so in a way that makes this option available for all debriefers, not just those who are trained as art therapists.

Adolescent↗

[The art of nursing management].

It is often said that management is a science as well as an art. Nursing managers have to master the science of management and make management an art, which is the goal of nursing leadership. The purpose of this paper was to integrate the views of Eastern and Western scholars and propose a combination of science and art in nursing management, to include the following components: the art of management and leadership; the art of to manage or not to manage, the art of leadership, and the art of delegation. The concept of "government by doing nothing that goes against nature," of Taoism, "Zen management," from Buddhism, and "situational leadership" have also been considered in this paper in the hope of providing guidance for nursing management.

Art↗

[Attempt at a psychoanalytic approach to "concept art"].

In a short review the development of psychoanalytic explorations in art from "pathography to psychobiography" is given. Chasseguet-Smirgel's critique on a limitation to looking for connections between the biography of the artist and his work is discussed as well as Eissler's proposal of an "endopoetic approach". The characteristic of most of the psychoanalytic publications is their orientation on the psychoanalytic conflict-model. New impulses to psychoanalytic interpretations of art were given by ego-psychology. The author tries to understand the artistic creations of "Concept Art" which appeared in the late Sixties, by the psychoanalytic model. It can be shown that especially in these productions which made their theme the "idea" and which are characterised by a degree of abstractness which had not been known before the ego-psychological approach seems to be the most adequate one. Ego performances manifest themselves in these works of concept art at an extreme intensity while the conflictual material of the id is reduced to a minimum or is totally eliminated. The concept artist is not only showing us a mirror of the pathology of our time, but is also giving us ways to overcome these problems. The hypothesis is formulated that concept art is giving us responses to three main problems of our time which is makes it's theme and by doing so tries to solve: it is dealing with the fear of a common psychic disintegration, especially with the danger of outbreaks of aggressive impulses. Moreover single central ego-functions are demonstrated by the concepts to the recipient and he has (actively) to discover them. Lastly the communicative function of art is formulated in concept art in such a radical way as has not been known before. In some of the artistic concepts the recipient is not only meant to reflect upon them, but is also forced to communicative actions.

Art↗

Art and trauma.

The authors of this paper attempt to show that 'the art of trauma', because of its indirect, unaestheticised and dialogic nature, may be the only possible medium for effective representations of trauma. The real witnessing presence created in the art of trauma can act as an antidote to the annihilation of the internal 'other' that occurs in the traumatic experience and to the resulting absence, which both constitutes the core of trauma and precludes its representation. Important elements of the art of trauma are illustrated using the work of Paul Celan, Anselm Kiefer, Claude Lanzmann, Art Spiegelman, and Anne-Marie Levine and texts by Aharon Appelfeld. Examining more closely what Holocaust survivors say in their testimonies, the authors contend that survival itself should be considered as a type of art of trauma when it is made possible by a creative comprehension of reality analogous to that which characterises more conventional forms of the art of trauma. The authors proceed to explore both the possible limits to the extent that trauma may be represented and the continuous struggle involved in attempting to 'know' trauma. They also discuss how art dealing with trauma may circumscribe a double locus: one of witnessing as well as one of emptiness or execution.

Adaptation, Psychological↗

Aesthetic inquiry and the art of nursing.

This article describes the development of aesthetic inquiry and the emerging conceptualization of the art of nursing as an art form. Aesthetic knowing, which emerges from aesthetic inquiry, is described as connoisseurship of the art of nursing and includes appreciation of the art form and insight into meanings of the art. A method of aesthetic criticism is described that links artistic experience, history, form, alternate meanings, and future possibilities. The inquiry yielded two essential elements of the art of nursing, movement and narrative, which, when manifested as an art form have the capacity to shift experience into a different realm.

Art↗

Pharmacokinetics and safety of a novel recombinant soluble human thrombomodulin, ART-123, in healthy male volunteers.

The safety and pharmacokinetics of a novel recombinant soluble human thrombomodulin, ART-123 were evaluated in single- and multiple-dose studies involving 16 healthy male volunteers. ART-123 was administered by intravenous infusion over 2 hours. The single-dose study indicated that plasma ART-123 levels at doses of 0.03, 0.1, and 0.3 mg declined biexponentially and those half-lives were approximately 4 hours (t1/2 alpha) and 20 hours (t1/2 beta), respectively. The mean plasma peak concentration and area under the plasma concentration-time curves increased in proportion to the given doses. Mean urinary recovery within the first 48 hours was between 54.3% and 59.8% of dose. In the multiple-dose study, ART-123 was administered at a dose of 0.2 mg once daily for 3 days. ART-123 did not accumulate as judged from plasma concentrations and urinary recovery. There were no abnormal findings in objective symptoms and laboratory findings, including blood pressure, heart rate, electrocardiogram, body temperature, hematology, bleeding time, coagulation and hemostatic parameters, blood chemistry, and urinalysis. There were no significant adverse reactions or abnormalities in physical and laboratory examinations that could definitely be attributed to the drug at a dose of 0.3 mg as a single administration and at a dose of 0.2 mg once daily for 3 days. These results indicate that ART-123 is safe at doses up to 0.2 mg once daily for 3 days and may have clinical application. Further studies are needed, however, to evaluate the safety and pharmacokinetics of ART-123 in the targeted population.

Adult↗

A novel recombinant soluble human thrombomodulin, ART-123, activates the protein C pathway in healthy male volunteers.

The effect of a novel recombinant soluble human thrombomodulin, ART-123, on protein C activation was investigated by measuring plasma prothrombinase activity in four healthy male volunteers. ART-123 at a dose of 0.3 mg was administered as a bolus intravenous injection for 1 minute. Plasma ART-123 concentration and prothrombinase activity were determined before and immediately, 24, and 48 hours after injection, and thromboelastography was recorded before and immediately and 24 hours after injection. The mean elimination half-life was 19.82 +/- 2.10 hours. Compared with pretreatment levels, ART-123 reduced prothrombinase activity by 44.2 +/- 11.7%, 52.1 +/- 10.8%, and 61.0 +/- 14.7%, respectively, immediately, 24, and 48 hours after injection, suggesting that ART-123 activated the protein C pathway. ART-123 did not affect thromboelastography values. There were no abnormal findings for objective signs or laboratory tests, including blood pressure, heart rate, electrocardiogram, body temperature, hematology, coagulation and hemostatic parameters, blood chemistry, and urinalysis. Based on these observations, ART-123 at a dose of 0.3 mg can activate the protein C pathway in healthy volunteers.

Adult↗

The impact of the ART approach on the treatment profile in a mobile dental system (MDS) in South Africa.

The changing profile of oral care rendered through the Mobile Dental System (MDS), after the introduction of the Atraumatic Restorative Treatment (ART) approach is described. During the first year of introduction of ART, the percentages of amalgam restorations and tooth extractions decreased significantly (P < 0.0001). This is partly ascribed to a change in choice of treatment by dental operators in favour of ART and also due to an increase in acceptance by patients because of the reduced fear, and the patient-friendly nature of the ART approach. The reduction in amalgam restorations was 16.0 per cent for permanent and 1.4 per cent for primary posterior teeth. Extraction of posterior teeth was reduced by 17.4 per cent in the permanent and 35.7 per cent in the primary dentitions. The restorative component of oral care increased by 33.4 per cent in the permanent and 37.1 per cent in primary posterior teeth. The one-year survival of one-surface ART restorations using Fuji IX and KetacMolar was 93.6 per cent. Full and partial (more than 90 per cent) retention of the sealant part of the ART restoration was obtained in 75 per cent of the cases after one-year. During the one-year period, infection control was made more simple and this facilitated easier maintenance of mobile dental equipment. The introduction of the ART approach reduced extraction, restored more teeth and made oral care in the MDS more preventive, less threatening and thus more patient-friendly.

Child↗

Microsurgical varicocelectomy for infertile couples with advanced female age: natural history in the era of ART.

Varicocele represents the most common cause of male infertility, and most reports indicate that varicocelectomy has a beneficial effect on male fertility and pregnancy outcome. Assisted reproductive technologies (ARTs) are an alternative to varicocelectomy for the management of couples with a varicocele. The age of the female partner is important in the decision-making process; however, the true influence of female age on pregnancy outcome following varicocelectomy or ART in these couples is unknown. We evaluated the outcomes of 2 cohorts of infertile men with a varicocele and a female partner 35 years of age or older; one group selected varicocelectomy and the other a nonsurgical approach. We reviewed a group of consecutive infertile men who underwent microsurgical varicocelectomy and whose partners are 35 years of age or older (n = 110). We also reviewed a consecutive group of men with varicoceles who elected not to have surgery and whose partners are 35 years of age or older (n = 94). The outcome measures included changes in semen parameters, pregnancy rates (assisted and unassisted), and use of ART. The surgical and nonsurgical groups had comparable semen parameters and female ages. Mean sperm concentration and motility increased significantly after varicocelectomy (P < .05). At a mean of 30 months follow-up, 35% of couples in the surgical group achieved a spontaneous pregnancy and an additional 6% achieved a pregnancy via ART (20% of this group attempted ART). In the nonsurgical group, 25% achieved a spontaneous pregnancy and an additional 16% achieved a pregnancy with ART (40% of this group attempted ART). This study on the natural history of infertile men with varicocele and advanced female age suggests that the surgical and nonsurgical approaches offer comparable pregnancy outcome (combined assisted and unassisted pregnancy rates are about 40%). Overall, these data suggest that varicocelectomy is an acceptable option for couples with advanced female age, but other female factors must be considered in the decision-making process.

Adult↗

Isolation and characterization of a glycoprotein allergen, Art v II, from pollen of mugwort (Artemisia vulgaris L.).

A glycoprotein allergen, Art v II, was isolated from pollen of mugwort by two different isolation procedures. Art v II-A was isolated by a combination of ion-exchange chromatography on DEAE-Sepharose, affinity chromatography on Con A-Sepharose and ion-exchange chromatography on Mono P. Art v II-B was isolated by a combination of preparative IEF in Ultrodex granulated gel, affinity chromatography on Con A-Sepharose and HPLC size exclusion on Ultropac TSK G2000SW. Art v II-A and Art v II-B were shown to be antigenically identical with the allergen we have formerly denoted Ag7. The MW of Art v II A/B was determined to be 34,000-38,000 by HPLC size exclusion, and 35,000 and 20,000 by SDS-PAGE under non-reducing and reducing conditions, respectively. Art v II was found to consist of 6(7) isoforms with pI 4.10, 4.20 (major component), 4.35, 4.45, 4.55, 4.65, (4.80). The glycoprotein allergen had a protein to carbohydrate ratio of 10:1 and the carbohydrate part contained mannose (70.7%), N-acetyl-glucosamine (17.0%), glucose (7.0%) and galactose (5.3%). In R(R)IE the purified allergen bound IgE from 5 (33%) of 15 sera from patients with clinical allergy against mugwort pollen and from 13 (52%) of 25 sera from patients selected only on the basis of a RAST-class 4 against mugwort pollen.

Allergens↗

Order of Search in Fuzzy ART and Fuzzy ARTMAP: Effect of the Choice Parameter.

This paper focuses on two ART architectures, the Fuzzy ART and the Fuzzy ARTMAP. Fuzzy ART is a pattern clustering machine, while Fuzzy ARTMAP is a pattern classification machine. Our study concentrates on the order according to which categories in Fuzzy ART, or the ART(a) model of Fuzzy ARTMAP are chosen. Our work provides a geometrical, and clearer understanding of why, and in what order, these categories are chosen for various ranges of the choice parameter of the Fuzzy ART module. This understanding serves as a powerful tool in developing properties of learning pertaining to these neural network architectures; to strengthen this argument, it is worth mentioning that the order according to which categories are chosen in ART 1 and ARTMAP provided a valuable tool in proving important properties about these architectures. Copyright 1996 Elsevier Science Ltd.

Journal Article↗

Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation.

ARTS is a mitochondrial protein that promotes apoptosis induced by a variety of proapoptotic stimulators. ARTS induces apoptosis, at least in part, through binding to and antagonizing IAPs (inhibitors of apoptosis proteins). As a result of ARTS binding to IAPs, caspase inhibition is removed and apoptosis can be executed. Here we show that high cellular levels of ARTS protein sensitize cells toward apoptosis. Accordingly, in healthy cells ARTS levels are kept low through constant ubiquitin-mediated degradation. Upon proapoptotic stimuli, the ubiquitination process is inhibited, resulting in increased levels of ARTS. Increased ARTS in turn leads to a decrease of Bcl-2 and Bcl-xL protein levels, cytochrome c release from mitochondria and apoptosis.

Animals↗

Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus.

The androgen receptor (AR) is a ligand-regulated transcription factor that stimulates cell growth and differentiation in androgen-responsive tissues. The AR N terminus contains two activation functions (AF-1a and AF-1b) that are necessary for maximal transcriptional enhancement by the receptor; however, the mechanisms and components regulating AR transcriptional activation are not fully understood. We sought to identify novel factors that interact with the AR N terminus from an androgen-stimulated human prostate cancer cell library using a yeast two-hybrid approach designed to identify proteins that interact with transcriptional activation domains. A 157-amino acid protein termed ART-27 was cloned and shown to interact predominantly with the AR(153-336), containing AF-1a and a part of AF-1b, localize to the nucleus and increase the transcriptional activity of AR when overexpressed in cultured mammalian cells. ART-27 also enhanced the transcriptional activation by AR(153-336) fused to the LexA DNA-binding domain but not other AR N-terminal subdomains, suggesting that ART-27 exerts its effect via an interaction with a defined region of the AR N terminus. ART-27 interacts with AR in nuclear extracts from LNCaP cells in a ligand-independent manner. Interestingly, velocity gradient sedimentation of HeLa nuclear extracts suggests that native ART-27 is part of a multiprotein complex. ART-27 is expressed in a variety of human tissues, including sites of androgen action such as prostate and skeletal muscle, and is conserved throughout evolution. Thus, ART-27 is a novel cofactor that interacts with the AR N terminus and plays a role in facilitating receptor-induced transcriptional activation.

Amino Acid Sequence↗

Fast and efficient method for computing ART.

Angular radial transform (ART), which is the region-based shape descriptor of MPEG-7, has desirable properties for representing shape information in a small number of features with no redundancy. However, in order for ART to be useful, especially in limited computing environments, the computational cost of ART must be greatly reduced. In this paper, we derive symmetric/antisymmetric properties from the basis functions of ART and present a fast and efficient method to compute the ART coefficients using these properties. The proposed method significantly reduces the number of sinusoidal operations and multiplications in computing the coefficients of ART. Moreover, the memory requirements needed to store the ART basis functions in lookup tables are only 25% of the conventional method. The experimental results are presented to show the effectiveness of the proposed method.

Algorithms↗

Atraumatic restorative treatment (ART): a three-year community field trial in Thailand--survival of one-surface restorations in the permanent dentition.

This study compares the Atraumatic Restorative Treatment (ART) technique to conventional amalgam restorations in the management of dental caries. The present report is limited to the results for one-surface restorations in the permanent dentition over a three-year period. A community field trial was carried out in rural villages in northeastern Thailand. Dental caries was treated using the ART technique in one village where 144 persons were treated with 241 restorations. In a second village, 205 conventional amalgam restorations were provided to 138 persons using mobile dental equipment. Both ART and amalgam restorations were performed by one dentist and two dental nurses without administering local anesthesia. Clinical evaluation was carried out one, two, and three years after placement. The longevity of the restorations was determined by computing the estimated cumulative survival rates according to the life table method. The survival rates of ART restorations (93%, 83%, 71% in years one, two, and three, respectively) were close to those for amalgam restorations (98%, 94%, 85%); however, differences were statistically significant. No statistically significant differences were observed between ART restorations in children and adults, or between those placed by the dentist and dental nurses. Survival rates were lower for occlusal surface restorations compared to those in other surfaces. ART is a feasible approach for the management of dental caries, especially for one-surface lesions in the permanent dentition. Because of its simplicity as a minimal intervention technique, ART can make the control of dental caries available to all people irrespective of their economic and living conditions.

Adolescent↗