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Results for “11-Hydroxycorticosteroids”

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PubMedDate not supplied

[Seasonal changes of corticosteroid content in practically healthy young persons under condition of monsoon climate of Khabarovsk].

In 195 apparently healthy young men, residents of Khabarovsk, a study was made of the contents of the sum total 11-OCS, corticosteroids--free and protein-bound, cortizol and corticosterone in the blood plasma, and 17-OCS in the urine, depending on the season of the year, climatic and weather factors. Seasonal changes of glucocorticoid function of the adrenal cortex with the maximal plasma hormone level during winter and their greatest urinary excretion during summer were found. An increase of free (biologically-active) corticosteroid fraction was recorded during bad weather at all the seasons.

11-Hydroxycorticosteroids↗
PubMed1977

[Biogenic amines and adrenal cortical function in breast cancer].

Under study were the content of serotonin and 11-OCS in blood and diurnal excretion of 5-OIAA, adrenaline and noradrenaline in 71 pateints with breast cancer. The data obtained indicated that the examined patients, compared with the control group, show a reliably higher concentration of serotonin and 11-OCS in blood (70.4% and 19.5% correspondingly), an insignificantly increased excretion of 5-OIAA, a markedly increased diurnal excretion of adrenaline (by 96.4%), whereas a decreased excretion of noradrenaline (by 73.1%). The character of changes in the indices under study was definitely dependent on the stage of the disease (in stages 1-11 these changes were mostly pronounced), and patients' age (in young patients the adrenal cortex activity was rather intensive, whereas in aged patients biologically active substances were manifest).

11-Hydroxycorticosteroids↗
PubMed1978

[Glucocorticosteroid, catecholamine and protein-bound iodine (PBI) plasma levels in swine following electrocutaneous stimulation].

Application of electrocutaneous stimuli for short-time excitation of swine, accompanied by high locomotor activity, led in animals weighing between 30 kg and 45 kg to steep rises of catecholamine and glucocorticosteroid plasma concentrations, while little change was recordable from protein-linked iodine. Increase in plasma glucose and RQ in animals with higher rises in plasma-borne catecholamines and glucocorticoids was higher than that in animals with lower catecholamine deflection. Both the results reported in this paper and findings obtained from other studies into swine are likely to suggest major involvement of the sympathico-adrenomedullary system in the buildup of transport stress. Interdependence was found to exist between the intensity of the adrenergic reaction, on the one hand, and rises in plasma glucose and RQ as well as drop of pH, on the other. Those findings from various tests seem to support the conclusion that under conditions of severe excitation and high locomotor activity the differentiated resistance of swine to stress is atributable to different intensities of sympathico-adrenergic reaction of the animal concerned.

11-Hydroxycorticosteroids↗
PubMed1977

[The clinical effect of antibiotics in the macrolide family on bronchial asthma. Non-antimicrobial actions of oleandomycin [author's transl)].

Non-antimicrobial actions of oleandomycin (triacetyloleandomycin and oleandomycin phosphate) were studied in patients with bronchial asthma. Twenty-one cases of the disease without associating infections entered the study, and they were given 750mg of oleandomycin or triacetryloleandomycin in three divided doses daily for two weeks. Clinical manifestations and laboratory findings were compared to assess the effectiveness of the antibiotic therapy between the three 2-week periods before, during and after the therapy. Improvements in clinical manifestations were attained in 11 of 21 cases (52.3%), and last after discontinuance of the therapy in 8(38.1%). The blood level of 11-OHCS as determined by the Demoorr's fluorescence method increased by greater than 20% at the end of thearpy in 7 of 18 cases (38.9%). In 5 of the 7 cases favorable responses were seen clinically to the oleandomycin therapy. The serum IgE level determined by the radioimmunosorbent test was compared before and after the therapy to reveal that oleandomycin caused decrease of IgE in 10 and increase in 9 of 20 cases examined. The oleandomycin therapy resulted increases by greater than 20% of the vital capacity and FEV 1.0 in 2 and 3, respectively, of 15 cases. Jaundice in association with elevations of the GOT, GPT and alkaline phosphatase developed in one patient, and generalized skin eruption in another. Both of these cases were given triacetyloleandomycin.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Effect of the preliminary action of angiotensin on the sensitivity of the adrenal cortex of dogs to this peptide].

Experiments on dogs demonstrated that an increase of aldosterone secretion depended not only on the angiotensin II level in the blood, but also on the character of the changes in the peptide concentration: reaction of the glomerular zone of the adrenal cortex to this octapeptide increased after a preliminary angiotensin stimulation of the adrenal glands. The effect revealed was independent of the sum total dose of the preparation administered and was not accompanied by any increase in the glucocorticosteroid level in the plasma. This effect permitted the renin-aldosterone system to change under definite conditions to increased functional level without any marked rise of renin secretion and angiotensin II formation.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Effect of hypothalamic differentation on the functional state of the hypohyseal-adrenal system].

It was shown in experiments on rats that the hypothalamus, isolated from the afferent influences of the overlying structures of the brain, could maintain the ACTH-glucocorticoid secretion at the normal level, but under these conditions there was an increase of its sensitivity to noradrenaline and serotonin, and also to single immobilization; there was also a reduction of the adrenocorticotropic activity of the adenohypophysis and a reduction of the rate of corticosteroid secretion by the adrenal glands into the blood.

11-Hydroxycorticosteroids↗
PubMed1977

[Mechanism of the lipid mobilizing effect of etimizol].

The influence of ethymizol on the mobilization of free fatty acids and the role of hormones of the pituitary-adrenal system in the lipolytic effect of this drug was studied in experiments on rats. The lipomobilizing effect of ethymizol was clearly expressed in the intact, hypophysectomized and adrenalectomized rats. The effect of the drug disappears in rats with a simultaneous extirpation of the pituitary and the adrenal glands, but it again manifests itself after hydrocortisone injection to these animals. A conclusion on the presence of direct ethymizol action on the mobilization of fatty acids and on the permissive role of corticosteroids in lipid mobilization effect of ethymizol was made.

11-Hydroxycorticosteroids↗
PubMed1976

[Adrenal cortical function in rats with traumatic shock following removal and deafferentation of the hypothalamus].

The 11-oxycorticosteroid (11-OCS) content was studied in the blood plasma of sham-operated rats, rats with intact, ablated and deafferentated medial-basal hypothalamus (MBH) in traumatic shock. There were no reliable differences in the 11-OCS basal level in various groups of rats. MBH ablation led to the reduction in the weight of adrenal and pituitary glands and MBH deafferentation -- to increase in the weight of the former. The 11-OCS level was reliably higher in traumatic shock of rats with complete MBH deafferentation than in sham-operated animals.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[The reactivity of the hypophyseal-adrenal system in the suslik Citellus erythrogenus major awaking from hibernation].

It has been shown that corticosteroid content of the blood in hibernating ground squirrels is the lowest. In spring, before the arousal, some increase in corticosteroid content is observed, although the latter remains lower than that in non-hibernating animals. During the arousal, corticosteroid content of the blood in the ground squirrels increased slowly and gradually. It is suggested that warming is not a stress factor for the arousing ground squirrels. The hypothalamo-hypophyseal-suprarenal system of hibernating ground squirrels is also insensitive to the additional stimulation of the adrenergic mechanisms by novodrin. However, functional activity of the system hypophysis-suprarenal cortex in the arousing ground squirrels is rather high: inhibition of warming by propranolol, serotonin and 5-hydroxytryptophan results in significant stimulation of this system.

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