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Results for “para-Aminobenzoates”

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At least 217 records · Page 12Linked to original sources
PubMed1979

[Exocrine pancreatic function test by N-benzoyl-L-tyrosyl-p-aminobenzoic acid (author's transl)].

Urinary excretion of p-aminobenzoic acid (PABA) within 6 h after oral administration of N-benzoyl-L-tyrosyl-P-aminobenzoic acid (Peptide-PABA) was measured. In healthy subjects PABA-excretion rate was not different after 150 mg and 1 g Peptide-PABA. PABA-recovery was significantly lower in patients with chronic pancreatitis. Seperation between healthy persons and patients with chronic pancreatic insufficiency was better with 1 g Peptide-PABA.

4-Aminobenzoic Acid↗
PubMed1988

Effect of inhibitors of poly(ADP-ribose) polymerase on the heat response of HeLa S3 cells.

The purpose of this study was to investigate a possible involvement of poly(ADP-ribosyl)ation reactions in hyperthermic cell killing and hyperthermic DNA strand-break induction and repair in HeLa S3 cells. The inhibitors of poly(ADP-ribose) polymerase, 3-aminobenzamide (3AB) and 4-aminobenzamide (4AB), were used as tools in this study. Both inhibitors could sensitize the cells for hyperthermic cell killing equally well, although 3AB is known to be a more effective enzyme inhibitor. The heat sensitization at the level of cell killing could be reversed when the compounds were still present during a 4-h postincubation at 37 degrees C. More heat-induced DNA strand breaks were formed in the presence of 3AB and 4AB. Repair of strand breaks was inhibited during the postincubation at 37 degrees C. Thus the effect of 3AB and 4AB on DNA strand-break repair was different from the cited effect on cell survival. It is concluded that the sensitizing effect of 3AB and 4AB on hyperthermic cell killing is not caused by inhibition of poly(ADP-ribose) polymerase and is also not related to repair of DNA strand breaks.

4-Aminobenzoic Acid↗
PubMed1979

Use of antifibrinolytic therapy in prostate surgery.

The prophylactic use of the antifibrinolytic drug, PAMBA, in a small intravenous dose preoperatively, combined with local irrigation postoperatively, effectively reduces blood loss. The drug is safe and relatively free of adverse side effects, but attentive postoperative care is warranted.

4-Aminobenzoic Acid↗
PubMed1988

Clinical and experimental study of pancreatic exocrine function after pancreaticoduodenectomy for periampullary carcinoma.

The residual pancreatic exocrine function before and after pancreaticoduodenectomy (PD) for periampullary carcinoma was studied clinically as well as experimentally. In clinical instances (n = 35), the N-Benzoyl-L-Tyrosil-p-Aminobenzoic Acid test (BTPABA test) before and within two months after PD revealed reduction of the function compared with those in the control study. However, the test result one year after PD was improved compared with those before and within two months after operation, without differences from that of the control group. In new canine PD models in which drainage of the pancreatic duct, 50 per cent pancreatectomy and duodenojejunectomy were performed after three months of pancreatic duct obstruction, fibrosis surrounding the pancreatic duct was disclosed. However, the results of examination five months after PD revealed a milder degree of pancreatic fibrosis without aggravation of the lesion. The aforementioned findings indicated that the exocrine pancreas before PD was impaired due to obstructive pancreatitis and that the postoperative pancreatic function was well preserved at the level close to that in the control group even after approximately 50 per cent resection of the pancreas, if pancreatic duct drainage was effectively performed.

4-Aminobenzoic Acid↗
PubMed1988

[Specificity and sensitivity of the 4-N-acetyl-L-tyrosyl-p- aminobenzoic acid test in childhood with serum p-aminobenzoic acid determination].

Specificity and sensitivity of ALTAB test have been estimated in 40 healthy children and 13 cystic fibrosis patients. The test has been carried out in the modification as 2-hour-serum PABA-test. The found specificity was 90%, the sensitivity 100% respectively. Therefore this test is suitable for evaluation of exocrine pancreas function.

4-Aminobenzoic Acid↗
PubMed1988

Liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites in serum.

This is a high-performance liquid-chromatographic method for measuring p-aminobenzoic acid (PABA) and its metabolites in plasma or serum. Samples are deproteinized, then extracted with organic solvents before chromatography. For quantification, the peak height of the individual compound is compared with that of the internal standard. Analytical recoveries ranged from 41% to 100%, depending on the compound studied. Comparison of patients' samples after oral administration of either N-benzoyl-L-tyrosyl-p-aminobenzoic acid or free PABA revealed that PABA is extensively metabolized and conjugated to either p-acetamidobenzoic acid, p-aminohippuric acid, or p-acetamidohippuric acid. PABA concentrations in serum as measured with the Bratton-Marshall ultraviolet spectrophotometric procedure would appear predominantly to reflect measurements of metabolites, with only a minor contribution from PABA itself.

4-Aminobenzoic Acid↗
PubMed1979

Effect of intestinal gamma-glutamyl transferase inhibitor on the amount of gamma-glutamyl metabolites in mouse.

Experimental mice fed a balanced rodent chow, called LSM fodder, had markedly lower gamma-glutamyl transferase activity in the epithelium of intestinal villi then control mice fed wheat. After oral administration of gamma-14C-glutamyglycine, oxidized 14C-glutathione or gamma-glutamyl-p-amino-benzoate the amounts of gamma-glutamyl substrates and their metabolites in intestines, livers and kidneys of experimental mice were significantly lower than those in control mice. L-serine simultaneously administered with gamma-14C-glutamylglycine reduced the radioactivity of gamma-glutamyl substances in organs of the control mice. No differences in organ radioactivity of experimental and control mice were observed when some uniformly labeled with 14C amino acids were given. The obtained results are not in aggreement with hypothesis on a role of gamma-glutamyl transferase in amino acid transport.

4-Aminobenzoic Acid↗
PubMedDate not supplied

[Study of the histaminergic mechanisms of the action of malaben].

In rabbits (intact and with experimental myocardial infarction) histamine metabolism (histamine content and diaminoxidase activity) following introduction of malaben was studied. In intact animals the ability of malaben to reduce the blood histamine level and to activate diaminoxidase was discovered. Administration of malaben in experimental myocardial infarction promotes a quicker normalization of the disturbed metabolism of histamine.

4-Aminobenzoic Acid↗