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At least 217 records · Page 12Linked to original sources
PubMed1987

[Fatigue fracture of the proximal tibia in childhood--diagnostic and differential diagnostic problems].

Two cases of fatigue fractures of the proximal tibia of boys, 11 and 14 years old are reported. Clinical and radiological findings are discussed with special regard of the literature. Especially differential diagnostic problems, even with actual methods are discussed. An histological examination is necessary only in doubtful cases. An precise anamnesis, clinical and standard X-ray examination are very often sufficient to get an exact diagnosis.

Adolescent↗
PubMed1988

[Roentgen morphology of the eburnated vertebral body--diagnostic and differential diagnostic problems].

1. Numerous diseases may become manifest as eburnated vertebral bodies, and hence the x-ray morphological sign of eburnation is an unspecific one. Isolated characteristics such as the involvement of one or several vertebrae, an intact vertebral space, a broadening of the paravertebral accompanying shadow, and the remaining radiological skeletal status enable narrowing down the differential diagnosis, although anamnesis and clinical findings will supply the main pointers. 2. In primary tumorous eburnations radiotherapy or chemotherapy will render an x-ray morphological assessment of therapeutic success impossible. 3. In primary diagnosis of an eburnated vertebral body it is possible to apply sonography, CT and MR as diagnostic tools step by step to narrow down the differential diagnosis by detecting or excluding pathological abdominal processes such as liver or lymphatic node metastases, paravertebral or intraspinal soft-part dense space-occupying growths or bone infiltration, but it will only rarely be possible to classify the phenomenon properly as being caused by a well-defined process, even if CT and MR are employed.

Adult↗
PubMed1986

[Differential diagnostic value of the Diagnostic Test for Cerebral Damage in clinical practice].

The paper considers the effective inclusion in differential diagnosis of DCS in decisions involving groups of patients not yet primarily exposed to the process. 55 patients were involved in two samples taken within the group as a whole. One of the samples is characterised as being unambiguously diagnosed neurotic without there being any neurologic-psychiatric or other (internal medical) findings (no organic brain injury, no symptoms of seizure, no cerebro-vascular insufficiency CVI, etc.). The other sample comprehended patients with a clear CVI diagnosis, minor EEG findings, and with or without internal medical findings. By applying a specific "index of instability" resulted in an assured diagnostic distinction.

Adult↗
PubMed1973

Standardization of diagnostic materials. 1. Diagnostic materials for clinical analysis.

Standardization of diagnostic materials has lagged behind their development and application. The need to improve the accuracy of the results obtained with them has stimulated collaborative efforts to upgrade the quality of the reagents, control materials, and standards used, with the result that specifications for reagents and standards and authoritative standard materials are now available for a number of clinical tests. Achievements thus far and the efforts now in progress are reviewed.

Chemistry, Clinical↗
PubMed1983

[Selection of the information for solving medical diagnostic problems with "diagnostic games" (the example of predicting the time of sinus rhythm maintenance after eliminating atrial fibrillation)].

A new method is proposed for data selection with respect to solving medical diagnosis problems. It reduces the scope of information, leaving for further processing only the facts the physician actually needs for problem-solving. The protocols of "diagnostic games" reflect the physician's mental process and can be used in the development of a physician model.

Atrial Fibrillation↗
PubMed1993

The impact of new DNA diagnostic technology on the management of cancer patients. Survey of diagnostic techniques.

Revolutionary advances in technology have enhanced our understanding of the genetic changes that occur in cancer cells. This article summarizes some of the basic features of these techniques and describes their application to the identification of specific types of genetic alterations in cells. The emphasis is on their use in obtaining information that is of diagnostic and prognostic importance. The techniques fall into two broad categories; the first is the direct analysis of the chromosome pattern in metaphase cells or the indirect assessment of chromosome abnormalities in interphase nuclei. The second general category involves the isolation of DNA, RNA, or protein from the tumor cells and the analysis of these components for abnormalities related to the presence, absence, or amplification of a specific gene or its products or other alterations, eg, those due to chromosome translocations. The techniques described in this article have broad applicability to medicine in general and some familiarity with these techniques is critical for the practice of modern medicine.

Blotting, Southern↗
PubMed1977

Diagnostic perceptions and diagnostic behavior in a family practice unit.

Results of a pilot study with nine physicians in a model Family Practice Unit are described in this report. It was hypothesized that decisions regarding treatment priorities would lead to the "undertreatment" of ailments for which the physicians felt relatively ineffective and that feelings of efficacy would be greater for primarily organic than for primarily psychological ailments. Physician interviews and examination of the Unit's diagnostic file provided the data for this study. A treatment bias as a function of the degree to which an ailment had a psychological compenent was not demonstrated. However, the physicians did feel less effective (less comfortable) in treating problems that were significantly psychological and also felt that methods of intervention for such ailments were less clear-cut. Physician comfort level was greater when there were few alternative treatment methods generally used for the ailment and when the ailment was recorded frequently. A suggestion is made that medical curricula include more practical experience in treating ailments which have notable psychological components in order to increase physician comfort and probably physician effectiveness.

Attitude of Health Personnel↗
PubMed1996

[Diagnostic accuracy of 201T1 SPECT.MRI in brain diseases and inter-reader variance of diagnostic performance].

Fifteen-four studies of 201T1 brain tumor SPECT were independently interpreted by 9 nuclear medicine physicians with and without reference magnetic resonance images in 2 separate sessions to define an effect of referring images, and inter-observer variations. The physicians were requested to detect foci of abnormal deposits, and to discriminate whether they were malignant or not according to 5-grade scaling of subjective diagnostic confidence. Receiver-operating characteristics (ROC) analysis was performed. Mean sensitivity for presence of lesions (SEP), and sensitivity and specificity for malignancy of 201T1 SPECT were 84, and 53 and 55%, which were changed to 94, and 74 and 55% after referring to the MR images. The SFP was significantly improved (p < 0.05), but sensitivity and specificity for malignancy, assessed by areas under the ROC curves, were not significantly improved. Inter-observer variation of the SFP was significantly reduced with addition of the referring MR images. Cerebral lobar localization of lesions by SPECT showed great inter-observer variations (true localization ranged from 30 to 68.4%). It is concluded that 201T1 brain tumor SPECT has moderate sensitivity and specificity for malignancy, which is not improved by addition of anatomical reference images, that additional MR images reduce inter-observer variation of confidence on lesion presence, and that SPECT localization of lesions has great inter-observer variations.

Adolescent↗
PubMed1997

Diagnostic difficulties in extraosseous Ewing's sarcoma: a proposal for diagnostic criteria.

Five cases diagnosed as extraosseous Ewing's sarcoma (EES) during a 15-year period, and the relevant literature, were reviewed. The diagnosis in these cases was difficult to confirm, mainly because the distinction between the osseous form of Ewing's sarcoma (OES) and either periosteal reactions or direct tumour invasion into adjacent bone by EES was often unclear. The literature suggests that other authors have also encountered difficulties. The authors believe that many cases reported as EES are likely to have been OES. This distinction has some importance, as the two conditions are usually treated in differing ways. The following criteria are proposed for the diagnosis of primary EES: (i) no evidence of bony involvement on magnetic resonance imaging; (ii) no evidence of increased uptake in bone or periosteum adjacent to the tumour on static isotope bone scan images; (iii) a small round cell tumour with no differentiating features on light microscopy, immunochemistry or electron microscopy; and (iv) demonstration of cytoplasmic glycogen.

Adolescent↗