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[Program for the development and storing of images].

This procedure has been carried out on the bases of the most updated computer science technologies. This program aims at making use of the computer both as a storing and date processor instrument and as an examination aid with a visual result. Promed Phlebology makes it possible to carry out the test starting straight from the patients medical filing card. The storing system has been simplified at most, all the obliged steps being eliminated. The user will be able to choose the file according to his own needs, as well as avoid the intermediate steps by creating practical and synthetic files. This procedure allows enclosing of data to patient related images (photographs, instrumental text, X-rays, intraoperatory images, etc.), directly drawn by any video source (camera or still video camera). With this way, it is possible to use data storing to practical and statistical goals and to look quickly through the file.

Humans↗

Computational tools for the modern andrologist.

With such a wide array of computational tools to solve inference problems, andrologists and their mathematical or statistical collaborators face perhaps bewildering choices. It is tempting to criticize a method with which one is unfamiliar for its apparent complexity. Yet, many methods are quite elegant; neural computation uses nature's own best biological classifier, for example, and genetic algorithms apply rules of natural selection. Computer scientists will likely find no one single best inference engine to solve all classification problems. Rather, the modeler should choose the most appropriate computational tool based on the specific nature of a problem. If the problem can be separated into obvious components, a Markov chain may be useful. If the andrologist would like to encode a well-known clinical algorithm into the computer, the programmer may use an expert system. Once a modeler builds an inference engine, that engine is not truly useful until other andrologists use it to make inferences with their own data. Because a wide variety of computer hardware and software exists, it is a significant endeavor to translate, or "port," software designed and built on one machine to many other different computers. Fortunately, the World Wide Web offers a means by which computational tools may be made directly available to multiple users on many different systems, or "platforms." The World Wide Web refers to a standardization of information traffic on the global computer network, the Internet. The Internet is simply the linkage of many computers worldwide by computer operators who have chosen to allow other users access to their systems. Because many different types of computers exist, until recently only communication in very rudimentary form, such as text, or between select compatible machines, was available. Within the last half-decade, computer scientists and operators began to use standard means of communication between computers. Interpreters of these standard languages, such as Mosaic and Netscape, are now widely available, and they allow the casual user to access the most sophisticated multimedia aspects of computer information on a variety of different systems. Andrologists may thus use the World Wide Web to make inference engines that they have programmed available to other clinicians and researchers. For example, we programmed a World Wide Web interface to the neural networks that we trained in order to solve a number of andrology classification problems. Interested users connect to our address (at this writing http:@godot.urol.uic.edu), and they may fill out electronic forms with their own patient data, press a "predict" button, and nearly immediately view the results of our neural networks' prediction on their own computers. With the explosion in computer hardware technology, mathematics and computer science that once seemed esoteric can now be investigated on computers available to nearly all andrologists. Rapid advances in computer network technology now render a tool developed by one andrologist immediately available to many. Clearly, andrologists may expect that computational investigations in their field will be a productive ground in the near and far future.

Algorithms↗

Recombination, rationality, reductionism and romantic reactions: culture, computers, and the genetic algorithm.

The genetic algorithm (GA) is a computational procedure that 'evolves' solutions to optimization problems by generating populations of possible solutions, and then by treating these solutions metaphorically as individuals that can 'mate' and 'compete' to 'survive' and 'reproduce'. In this paper, I explore how culturally specific notions of evolution, population, reproduction, sex/gender, and kinship inflect the ways GAs are assembled and understood. Combining the results of fieldwork among GA workers with analysis of GA texts, I contend that the picture of 'nature' embedded in GAs is resonant with the values of secularized Judeo-Christian white middle-class US-American and European heterosexual culture. I also maintain that GA formulations are accented by languages inherited from sociobiology. I argue that examining GAs can help us track how dominant meanings of 'nature' are being stabilized and refigured in an age in which exchanges of metaphor between biology and computer science are increasingly common.

Algorithms↗

Quantifying biofilm structure: facts and fiction.

There is no doubt among biofilm researchers that biofilm structure is important to many biofilm processes, such as the transport of nutrients to deeper layers of the biofilm. However, biofilm structure is an elusive term understood only qualitatively, and as such it cannot be directly correlated with any measurable parameters characterizing biofilm performance. To correlate biofilm structure with the parameters characterizing biofilm performance, such as the rate of nutrient transport within the space occupied by the biofilms, biofilm structure must first be quantified and expressed numerically on an appropriate scale. The task of extracting numerical parameters quantifying biofilm structure relies on using biofilm imaging and image analysis. Although defining parameters characterizing biofilm structure is relatively straightforward, and multiple parameters have been described in the computer science literature, interpreting the results of such analyses is not trivial. Existing computer software developed by several research groups, including ours, for the sole purpose of analyzing biofilm images helps quantify parameters from biofilm images but does nothing to help interpret the results of such analyses. Although computing structural parameters from biofilm images permits correlating biofilm structure with other biofilm processes, the meaning of the results is not obvious. The first step to understanding the quantification of biofilm structure, developing image analysis, methods to quantify information from biofilm images, has been made by several research groups. The next step is to explain the meaning of these analyses. This presentation explains the meaning of several parameters commonly used to characterize biofilm structure. It also reviews the authors' research and experience in quantifying biofilm structure and their attempts to quantitatively relate biofilm structure to fundamental biofilm processes.

Anti-Bacterial Agents↗

Entropy-based analysis of the number partitioning problem.

In this paper we apply the multicanonical method of statistical physics on the number partitioning problem (NPP). This problem is a basic NP-hard problem from computer science, and can be formulated as a spin-glass problem. We compute the spectral degeneracy, which gives us information about the number of solutions for a given cost E and cardinality difference m. We also study an extension of this problem for Q partitions. We show that a fundamental difference on the spectral degeneracy of the generalized (Q>2) NPP exists, which could explain why it is so difficult to find good solutions for this case.

Journal Article↗

John von Neumann: the founding father of artificial life.

Aside from being known for his contributions to mathematics and physics, John von Neumann is considered one of the founding fathers of computer science and engineering. Not only did he do pioneering work on sequential computing systems, but he also carried out a major investigation of parallel architectures, leading to his work on cellular automata. His exceptional vision and daring, borrowing from biology the concept of genomic information even before the discovery of DNA's double helix, led him to propose the concept of self-reproducing automata.

Artificial Intelligence↗

Computers and occupational therapy.

The benefits and applications of computer science for occupational therapy are explored and a basic, functional description of the computer and computer programming is presented. Potential problems and advantages of computer utilization are compared and examples of existing computer systems in health fields are cited. Methods for successfully introducing computers are discussed.

Computers↗

An overview of neural networks.

Some of the world's leading researchers in neural networks submitted their most recent results concerning their research in neural networks to the author for inclusion in this survey. Descriptive accounts of their collective papers are presented as well as a list of sources of information concerning neural networks, such as journals, books, and technical reports. The material is broken into categories related to established areas in computer science, robotics, neural modeling, and engineering.

Algorithms↗

A vision of hand surgery over the next 25 years.

Predictions for hand surgery advances over the first 25 years of the new millennium are made. Anticipated changes are categorized as societal, technologic, and research with clinical applications. Certainly advances in computer science and molecular biology will affect all aspects of our lives. Within hand surgery, tissue engineering, materials science, and nanotechnology offer great promise.

Computers↗

Binocular vision: moving closer to reality.

Vision science is a truly interdisciplinary field of research, lying at the interface between psychology, computer science and neurobiology. It spans a broad range of research questions, from what visual neurons in the brain do, to the design and use of virtual reality technology. Here, I will take one well-researched area of human vision binocular depth perception, as an exemplar of the various ways in which the processes of human perception can be studied: from basic questions about the sensitivity of binocular vision to understanding how having two eyes helps us function in the natural environment.

Animals↗

A primer on aspects of cognition for medical informatics.

As a multidisciplinary field, medical informatics draws on a range of disciplines, such as computer science, information science, and the social and cognitive sciences. The cognitive sciences can provide important insights into the nature of the processes involved in human- computer interaction and help improve the design of medical information systems by providing insight into the roles that knowledge, memory, and strategies play in a variety of cognitive activities. In this paper, the authors survey literature on aspects of medical cognition and provide a set of claims that they consider to be important in medical informatics.

Cognition↗

Advances in text analytics for drug discovery.

The automated extraction of biological and chemical information has improved over the past year, with advances in access to content, entity extraction of genes, chemicals, kinetic data and relationships, and algorithms for generating and testing hypotheses. As the systems for reading and understanding scientific literature grow more powerful, so must the infrastructure in which to assemble information. Advances in infrastructure systems are discussed in this review. Research efforts have flourished as a result of text analytics competitions that attract participants from various disciplines, from computer science to bioinformatics.

Animals↗

Mechanisms of theory formation in young children.

Research suggests that by the age of five, children have extensive causal knowledge, in the form of intuitive theories. The crucial question for developmental cognitive science is how young children are able to learn causal structure from evidence. Recently, researchers in computer science and statistics have developed representations (causal Bayes nets) and learning algorithms to infer causal structure from evidence. Here we explore evidence suggesting that infants and children have the prerequisites for making causal inferences consistent with causal Bayes net learning algorithms. Specifically, we look at infants and children's ability to learn from evidence in the form of conditional probabilities, interventions and combinations of the two.

Bayes Theorem↗

Interactive computer technology, behavioral science, and family practice.

In this paper we discuss conceptual and practical uses for interactive computer applications (ICAs) for family practice, with an emphasis on implications for patient self-management, physician-patient relationships, primary care research, and health care systems quality improvement. We discuss recent behavioral science advances in patient self-management and the advantages and potential limitations of ICAs for medicine. We describe the benefits and risks of using ICAs for providing information, coping-skills training, and social support for patients and for improving the consistency and quality of care given by physicians. There are currently many effective ICAs, and they will play a central role in future health care. There is also the risk of inappropriate use of ICAs. We provide a summary of the empirical literature examining the use of ICAs to aid patients and providers in behavioral change and guidelines adherence efforts. We advise those people researching and applying ICAs in health care to be bold in what they attempt, but cautious in what they claim. Rigorous scientific evaluation and standardized reporting criteria can help quicken this advance, and there are important policy and ethical issues to consider. We conclude with a list of issues for family practices to consider when selecting and using ICAs.

Ambulatory Care Information Systems↗

Computer-based learning materials for medical education: a model production.

Computer-based learning materials (CBL or courseware) have the potential to be valuable learning resources for medical education. However, CBL has failed to realize its potential primarily because of unstructured approaches towards design and development. This paper describes the courseware development model (CDM), a conceptual model produced and used by the Medical Education Unit at The University of Liverpool. The model describes a structured multi-disciplinary approach to the design and production of CBL materials. It promotes meticulous planning, communication and organization. The CDM draws on three areas of expertise: (1) education; (2) computer science; and (3) medical content.

Computer Systems↗

Improving scientists' interaction with complex computational-visualization environments based on a distributed grid infrastructure.

The grid has the potential to transform collaborative scientific investigations through the use of closely coupled computational and visualization resources, which may be geographically distributed, in order to harness greater power than is available at a single site. Scientific applications to benefit from the grid include visualization, computational science, environmental modelling and medical imaging. Unfortunately, the diversity, scale and location of the required resources can present a dilemma for the scientific worker because of the complexity of the underlying technology. As the scale of the scientific problem under investigation increases so does the nature of the scientist's interaction with the supporting infrastructure. The increased distribution of people and resources within a grid-based environment can make resource sharing and collaborative interaction a critical factor to their success. Unless the technological barriers affecting user accessibility are reduced, there is a danger that the only scientists to benefit will be those with reasonably high levels of computer literacy. This paper examines a number of important human factors of user interaction with the grid and expresses this in the context of the science undertaken by RealityGrid, a project funded by the UK e-Science programme. Critical user interaction issues will also be highlighted by comparing grid computational steering with supervisory control systems for local and remote access to the scientific environment. Finally, implications for future grid developers will be discussed with a particular emphasis on how to improve the scientists' access to what will be an increasingly important resource.

Computer Graphics↗