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Neuronal activity in frontal speech area 44 of the human cerebral cortex during word recognition.

The activity of neurons was recorded from cortical speech area 44 of human patients with diagnostic and/or therapeutical depth electrodes while they were performing word recognition and object naming tasks. Some cells responded selectively to either semantic or phonological aspects of word processing with the same latency, others responded consecutively to both semantic and phonological features. The present finding provides the first demonstration of neuronal mechanisms in frontal language cortex and evidences that both consecutive and parallel processing of these speech signs occur in neuronal activity of this area.

Frontal Lobe

Applications of an inexpensive microcomputer for the general radiologist.

Computer programs of interest to the general radiologist have been written by the author and others for an inexpensive microcomputer. Most of these programs are in the public domain and include: computer-assisted diagnosis; computer-assisted medical education; Bayesian analysis, general statistical analysis; word processing; and radiographic image analysis. Previously, computerized functions such as these have been limited to those with access to a large institutional computer. Due to the general availability of inexpensive microcomputers, the average radiologist or group can now afford the many benefits a computer can add to the practice of radiology.

Computer-Assisted Instruction

AN electronic bulletin board for instruction in reproductive endocrinology in a residency in obstetrics and gynecology.

OBJECTIVE: To explore the role of an electronic bulletin board as a means of computer-based learning in reproductive endocrinology for residents in obstetrics and gynecology. DESIGN: An electronic bulletin board was networked to all residents to present a formal lecture series in reproductive endocrinology and an informal question, answer, and discussion session after each lecture. Ten lectures were presented, one each month, throughout the academic year followed by question, answer, and discussion sessions. All lectures could be stored in an electronic file folder or printed as hard copy for review. A questionnaire was distributed at the conclusion of the project to assess previous resident experience with computers, resident response to, and utilization of the bulletin board. SETTING: A residency program in obstetrics and gynecology in a major medical center. PARTICIPANTS: Twenty-four residents in a 4-year program. MAIN OUTCOME MEASURES: Previous computer experience, ease of use, resident participation, and satisfaction with the bulletin board. RESULTS: Sixty-five percent of the residents considered themselves computer literate and 33 percent previously had taken a course in computer technology. Computer experience in word processing, spreadsheet, and database management was related by 55 percent, 40 percent, and 25 percent of the residents, respectively. Ninety-five percent of the residents accessed the bulletin board for the lectures and found this system a convenient means of review. Sixty percent reviewed the lectures and stored them in an electronic file folder for later review. Forty percent printed the lecture on hard copy. On a scale of 1 to 5 (1 = lowest; 5 = highest), overall resident satisfaction was high at 4.5. CONCLUSION: Our data suggest a potential role for electronic bulletin boards as a complement to standard teaching protocols in resident education. The relative ease of use and satisfaction suggest that these techniques are feasible and offer an effective method of on-line instruction.

Computer Communication Networks

Micro-computers: availability to and use by trainees in public health medicine.

A survey of the availability to and use of micro-computers by public health medicine trainees was undertaken in February, 1989. Most departments have access to computers and trainees possess computing skills, but almost one in 15 trainees had no access to a micro-computer, and one trainee in eleven had no computing experience while a further one in eight had not progressed beyond word-processing. Departments of Public Health Medicine should review their computing resources and ensure that they are adequate for the challenges of the 1990s.

Computer User Training

Use of notebook computers for third-year surgical students.

BACKGROUND: Computer-aided instruction has become increasingly popular in medical education. Notebook computers (NCs) are attractive, convenient microcomputers. We hypothesized that use of NCs by third-year surgical students would enhance their performance of educational activities. METHODS: During the 1994-1995 academic year 25 student volunteers used NCs during the surgery clerkship. NC software included questions for self-examination, anatomy self-instruction program, word processing and electronic mail (e-mail) for recording and sending history and physicals (H & Ps) to faculty for review, and MEDLINE search software. Identical software was available to all students at on-campus computer centers. All students were asked to record the number of hours that they used the self-examination and anatomy programs, number of H & Ps performed and reviewed by faculty, and number of literature searches performed. NC users were interviewed regarding the value of NC use and their rating of software programs. RESULTS: NC users (n = 25) used the self-examination and anatomy programs more often, performed more literature searches, and had a greater percentage of their H & Ps reviewed by faculty compared with non-NC users (n = 143) (p < 0.05 for all outcomes). Most NC users agreed that NC use was enjoyable and valuable, and they believed that all students should have NCs during the surgery clerkship. Students rated software in order of preference: e-mail > self-examination > MEDLINE search > anatomy program. CONCLUSIONS: NC use enhanced performance of educational activities in the surgery clerkship. Effort toward developing educational software for surgical students is warranted because students are likely to use such programs.

Anatomy

Use of the personal computer in clinical research.

Personal computers are quickly becoming items of everyday use. More physicians' offices are using computers for billing and patients' records. Others have purchased computers for their word processing capabilities. These computers can be used for archives of medical case records or to collect and collate data for clinical research. This article focuses on how we use a personal computer for organization and management of clinical research projects. Included is a description of how we organize a research project, gather data, write computer programs, enter data into the computer, and generate and display reports. The use of a template program and a personal computer permits creation of individual programs without the aid of a professional programmer. When a single data-management program is used, five or six research projects can be carried out at a cost comparable to that of one project using a large computer and professional programmers.

Computers

Microcomputer applications in retinal research.

A low cost microcomputer was used to: (1) word process and edit this manuscript, (2) create a patient file storage and retrieval system, (3) transcribe and store information from video display such as wide-angle fundus photographs and fluorescein angiograms, (4) plot data points in graphic display mode, (5) solve complex equations used to calculate intraocular tumor volumes, (6) search medical literature data bases, and (7) directly interface with sophisticated laboratory equipment performing complicated tasks such as multicomponent analysis and enzyme kinetics.

Computers

Computer applications in veterinary medical education.

This is a review of the various computer applications used in veterinary medical education. The various applications include drill-and-practice, tutorial, problem-solving, testing, educational management programs, educational games, word processing, educational utilities, authoring programs, and simulations.

Computer-Assisted Instruction

Building a practice with a computer.

It should be emphasized that the primary function of the computer is information-handling and communication. It remembers who and when and why, organizes the information, and then communicates by reminders, letters, labels, word processing, and statements. The computer becomes a faithful employee, not altogether immune from physical illness but generally ready to work at the flip of a switch. Best of all, the computer never asks for overtime or a percentage of the profits.

Animals

Techniques of reporting disease outbreak investigations.

Effective communication of results and recommendations among veterinarians and between veterinarians and clients is an essential but often neglected component of an outbreak investigation. Although results have been traditionally related verbally, written reports are essential to minimize possible misunderstandings and provide a reference base for future herd health visits or epidemiologic investigations. A uniform reporting scheme for disease investigations by field veterinarians does not exist, but such a system would be desirable to allow comparisons of disease rates and productivity data among herds. In this article, a report format and style is outlined to facilitate exchange of data among veterinarians and clients. Reports to other veterinarians should include the following elements: history, objectives, methodology, results, causes/hypotheses, financial impact, and recommendations. For a client, a report should emphasize causes, recommendations, and the cost of measures to control the condition. Report planning, writing, and editing are facilitated by use of word-processing software on a microcomputer. Style will vary considerably according to the writer's objectives and individual preference, but headings, subheadings, graphs, and tables can be used to increase the visual appeal and readability of a report. The level of technicality should be appropriate for the audience. Sentences should be well constructed and precise.

Animals

Time course of inhibition in color-response and word-response versions of the Stroop task.

Translation models of the Stroop effect predict inhibition when the relevant stimulus type does not match the response type, but a lack of inhibition when it matches. All 4 combinations of relevant stimulus type (color or word) and response type (color or word) were evaluated at several stimulus onset asynchronies (SOAs) in a button-pressing version of the Stroop task to assess this prediction. Inhibition was greatest when the relevant stimulus type did not match the response type. However, in contrast to predictions of translation models, color and word responses produced different patterns of inhibition and facilitation over SOA, implying differences in the word-to-color and color-to-word translation mechanisms, and inhibition was obtained in both of the color-response tasks. A modification of the translation model is proposed that incorporates a translation mechanism and accommodates special characteristics of word processing.

Color Perception

A survey of the use of micro-computers in general dental practice in Scotland.

The aim of the study was to determine current and future use of micro-computers in general dental practice. A piloted questionnaire was sent to 736 general dental practitioners in Scotland, with the intention of contacting one principal from every dental practice known to the Scottish Dental Estimates Board. A total of 390 (53%) of the questionnaires were returned. If it is assumed that those dentists who did not reply have a low interest in computers then the results of the survey are not likely to lead to an overestimation of trends. Six per cent of the 736 practices that were contacted are using a micro-computer, mainly for practice management and particularly for word processing. In addition, 25% of the replies showed some interest in introducing micro-computers in the future. Thirty-four per cent of current users and 19% of prospective users indicated a high degree of interest in direct data transmission between the practice and the Scottish Dental Estimates Board.

Attitude of Health Personnel

Source document position as it affects head position and neck muscle tension.

Measurements of head position, mechanical load at C7, and level of muscle EMG activity in the muscles of the neck were compared across six document positions in both a reading task and a typing (word processing) task. Source documents, identified as a primary visual task, were placed in two positions in front of the subject, flat on the table to each side of the keyboard, and on a document stand at each side of the keyboard. Each of the 20 subjects performed both a reading task and a typing task in each of these document positions while measurements were taken. It was found that the greatest variations in head position occurred in head rotation with documents flat on the table. This document position on each side also produced the greatest level of muscle tension in both the neck extensors and, to a lesser degree, the sternocleidomastoid muscles. In addition, greater variability between document position measures was found in the typing condition.

Adult

Analysis of ocular surface area for comfortable VDT workstation layout.

This paper proposes a comfortable visual display terminal (VDT) workstation layout based on an analysis of ocular surface area (OSA). A large OSA induces eye irritation and eye fatigue because the eye surface is highly sensitive to various stimuli. The authors considered that OSA must be one of the useful indices of visual ergonomics and applied it to evaluate VDT workstation layout. Each subject was asked to perform a word processing task using four different VDT workstation layouts. It was found that the main factor affecting OSA was not cathode ray tube (CRT) height itself but the distance between the CRT and keyboard. Thus the following workstation layout is recommended to realize comfortable VDT operation: (1) the desk height should be adjusted to the user's height; and (2) the CRT display should be set closer to the keyboard to provide a smaller OSA.

Adult

Apple II computer software for DNA and protein sequence data.

In our attempt to make the aid of a computer for the molecular biology laboratory available on a low-cost basis, we have improved the programs that we published recently. We have experienced in our laboratory, and have learned from others, that the average lab has an increasing demand to use a time-sharing-independent computer for the bulk of data handling. A microcomputer can give this independence. At the same time, a microcomputer can serve as a terminal for the few computer jobs, such as data communication or extensive search programs, which have to be conducted on a time-sharing basis. In this paper, we describe the programs which can be executed on a Apple II microcomputer using the Apple Language System. This system gives the researcher the opportunity to learn to handle sequence data, and it also includes a word processing system useful in writing letters and manuscripts and storing text.

Amino Acid Sequence

A dBASE III surgical pathology reporting and encoding microcomputer system.

The authors have developed a menu-driven dBASE III system for surgical pathology reporting and encoding in Systematized Nomenclature of Medicine (SNOMED). The system requires no knowledge of dBASE and is readily installed on any IBM-standard personal computer equipped with a fixed disk. The use of dBASE memo fields provides the integration of word processing and database functions. Preliminary gross examination reports are automatically accompanied by data from former cases on the same patient. Patient demographics, SNOMED codes, and final diagnoses are stored on the fixed disk; complete reports are saved on floppy diskettes. Cases can be retrieved by patient name, surgical number, or SNOMED codes. Daily work lists, frozen section-final diagnosis correlations, turnaround time reports, and listings of incomplete cases are easily obtained. Cytologic results can also be entered, allowing automatic correlation with surgical cases.

Humans

Sample size calculation, power analysis and randomization: research project design in Windows.

Single estimates of sample size for a study may be easily obtained by use of a hand calculator or from published tables. In contrast, performing multiple calculations is a tedious and time-consuming task, which is greatly simplified by a computer program. The computer program presented here assists the investigator in calculating sample size estimates, determining statistical power and creating randomization tables for a study. The program is designed primarily for clinical trials and thus includes some features not found in other software packages performing similar tasks. Sample size calculation and power analysis are performed for dichotomous, continuous (parametric and non-parametric tests) and time-to-failure (exponential distribution and log-rank test) response variables, and for correlation coefficients. Sample size estimates and significance levels may be adjusted for multiple participating centers, non-compliance, interim analyses and.multiple testing. The randomization subroutine generates tables for studies with up to nine treatment arms and with any valid block size. As a Windows application, the program runs in a multitasking environment, allowing switching between programs and easy pasting of results into word-processing documents and other applications. It is very simple to use, with a completely menudriven interface and sufficient built-in help to obviate the use of a manual.

Algorithms

Brain activity during reading. The effects of exposure duration and task.

Brain activity during reading tasks was investigated using PET. The aim was to account for differences in the results of two previous studies [those of Petersen et al. (Science 1990; 249: 1041-4) and Howard et al. (Brain 1992; 115: 1769-82)] by systematically varying the type of reading task and the exposure duration of the word stimuli. Both variables strongly influenced patterns of brain activity. There were three types of task: (i) reading aloud; (ii) reading silently; and (iii) lexical decision on visually presented words and pseudowords. Reading aloud and reading silently engaged the left middle and superior temporal regions, confirming the important role of these areas in visual word processing. The areas principally engaged during lexical decision were the left inferior and middle frontal cortices and the supplementary motor area; activity in these areas suggests that the subjects were using a phonological strategy to perform the task. There was also a significant effect of exposure duration, with activity being greater for short (150 ms) exposure durations than for long (1000 ms or 981 ms) exposure durations. We conclude that until we understand how subtle variations in experimental design influence brain activity during reading tasks, the association of specific processing functions with individual anatomical areas activated during reading is premature.

Adult