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At least 217 records · Page 12Linked to original sources
PubMed1992

Some indications for the gynaecological use of budesonide (Apulein).

Budesonide-containing Apulein ointment has been used for the treatment of 29 women suffering from vulvitis, pruritus vulvae caused by vaginal discharge, gestational inflamed hemorrhoid, hymenitis, and late postoperative suture inflammation. The ointment rapidly and completely controlled local infiltration and the accompanying subjective complaints. It did not cause local alteration, the consistency of the ointment met the requirements and it did not disturb the patients' making their toilet. According to the author's opinion the product is a potent antiphlogistic which proved to be a valuable adjuvant to target specific treatment of inflammatory processes of the external female genital organs and perianal regions.

Administration, Topical↗
PubMed1992

[Clinical and pathological differential diagnosis of condyloma and pseudo-condyloma of vulva].

Three hundred and twenty-one biopsies from vulva, comprising 18 cases of condyloma acuminata (5.6%), 202 cases of pseudo-condyloma (62.9%), and 101 cases of non-specific vulvitis (31.5%), are reported. Clinically, most condylomata acuminata appeared as multiple soft papillary and verrucous lesions with local itchiness. The majority of patients with pseudo-condyloma were symptomless but with harbor roe-like warty papulae distributed symmetrically on both labia minora. Histologically, 18 cases of condyloma acuminata presented papillomatosis, parakeratosis, dyskeratosis, acanthosis, basal cell atypical hyperplasia and distinct koilocytosis. Pseudo-condylomata showed papillomatous growth but without atypical hyperplasia of basal cells and distinct koilocytosis.

Adult↗
PubMed1992

Prepubertal vulvovaginopathies.

The vast majority of prepubertal gynecologic problems fall into three categories. The most serious category includes those "things that bleed": sarcoma botryoides, trauma (including sexual abuse), vaginal foreign objects, condylomata, urethral prolapse, and single organism vaginitis. Very rarely, the clinician will see precocious menarche, metastatic Crohn's disease, vascular vulvar lesions, and factitious cases. The next category contains entities that have an abnormal appearance: ambiguous genitalia, periurethral cysts of the newborn, hymenal variants, and agglutination of the labia and vulva. Rarely, an underlying skin disorder such as lichen sclerosus, seborrhea, or atopic vulvitis will be seen. The last and most bothersome category, distinguished by its symptoms of pruritus and discharge, includes the most common types of vulvovaginitis.

Adolescent↗
PubMed1991

General sexually transmitted diseases.

This review discusses current trends in sexually transmitted diseases. Topics include treatment and prevention of syphilis and gonorrhea, as well as the association of sexually transmitted diseases with sexual assault. Also discussed are the various organisms that cause vulvitis, including Trichomonas, Candida, and Gardnerella species, along with a discussion of vulvar lesions that are especially difficult to diagnose and treat. Diagnosis, sampling, pathogenesis, and treatment of Chlamydia trachomatis are also covered. A discussion of the various degrees of protection offered by different forms of contraception encourages use of barrier methods and oral contraceptives for teenagers as well as postponement of sexual activity. Detection, treatment, and vaccination against genital herpes are covered, along with diagnosing anogenital warts in children as either skin or genital wart virus types, and the relationship between human papillomavirus and cancer.

Humans↗
PubMed1990

[Significance of skin changes in diabetes mellitus].

500 patients of a dispensaire of diabetes were inspected dermatologically. 335 patients had a duration of the glucose metabolism intoleration less than 10 years and 165 patients more than 10 years. 215 patients stated a striking family case history according diabetes. 54 per cent (273) of the cases showed an adiposity, 418 patients (83.6 percent) had pathological changes of the skin and mucosal changes. It is clear that dermatomycoses, eczema and pyodermias occur more often with acute metabolic disorder and adiposity. Neurovascular changes of the skin occur with long persistent glucose metabolism intoleration. Bad healing tendencles of wounds, pruritus, intensive dermatomycoses, balanitis, vulvitis, furunculosis and pyodermias are important references to a glucose metabolism intoleration. They should give rise to look for a diabetes irrespective of the age of the patient.

Adolescent↗
PubMed1990

[Cholesterol in serum and vaginal content in healthy, non-pregnant women].

We examined 97 healthy and non-pregnant women aged between 17 and 58 years, who especially did not show any symptoms of vulvitis or colpitis, for the contents of cholesterol in serum and vaginal smear. In the vaginal smear we found significantly lower concentrations of total cholesterol as in serum, whereas the part of free cholesterol on total cholesterol in vaginal smear was triple than in serum and its absolutely concentration was double than that in serum. Possible reasons are discussed.

Adolescent↗
PubMed1990

Prolonged application of acetic acid for detection of flat vulval warts.

Macroscopic visualization of flat vulval warts is usually obtained by application of 3-5% acetic acid for 2-5 min. However, we have recently seen two women with symptoms suggesting the presence of condylomatous vulvitis where the use of 5% acetic acid for 10-15 min. was necessary for aceto-white lesions to develop. In both women, histologic examination indicated the presence of a Human papillomavirus infection. Prolonged application of acetic acid 5% should be considered among women in whom vulval papillomavirus infection is suspected.

Acetates↗
PubMed1978

Estrogen and alternative therapy of the menopausal patient.

Estrogen therapy is indicated for the vasomotor, genitourinary, and menstrual changes of the climacteric woman. Estrogens should be prescribed to relieve these symptoms specifically, and in the lowest dosage for the shortest time. Vaginal estrogens are appropriate in the treatment of genitourinary symptoms and may be given until sexual activity ceases. Vaginal ointments may be given even to patients in whom oral therapy may be contraindicated. Alternative therapy is helpful in the treatment of vasomotor symptoms, vulvitis, and breast tenderness. Appropriate therapy for all women includes a complete history and physical examination, and a thorough discussion of the physiologic and psychological changes of menopause. Appropriate studies include tests for estrogen effect to monitor therapy. They assist in treatment of the complexity of the menopause.

Belladonna Alkaloids↗
PubMed1989

[Problem infections of the external genital area in the female].

On account of difficult diagnostic procedures and often atypical clinical pictures, the following diseases must be regarded as problematic infections: infections with chlamydia, mycoplasma, urea-plasma, and herpes virus, as well as unspecific infections with aerobic and anaerobic bacteria. Since vulvitis and vaginitis are frequently associated with vaginal discharge, they may present a problem to dermatologists and gynecologists.

Diagnosis, Differential↗
PubMedDate not supplied

Techniques for management of vulvar cancer by irradiation alone.

Vulvar cancer has traditionally been managed surgically, rather than by means of irradiation, because of the poor tolerance of the vulvar skin and mucous membranes to X-ray treatment. The use of moderate dose (4,000 rad) external-beam radiotherapy (EXRT) combined with two interstitial 192iridium endocurietherapy (ECT) applications of 2,500 rad to 3,000 rad allows delivery of an adequate tumoricidal dose (9,000 rad to 10,000 rad total dose) without producing radiation vulvitis. Irradiation is an effective alternate means of treatment in elderly patients who are medically unfit for radical vulvectomy and lymphadenectomy. It also provides an alternative to surgery for those patients who desire preservation of the genitourinary anatomy.

Brachytherapy↗
PubMed1988

Pregnancy complicated by maternal spina bifida. A report of two cases.

Pregnancy occurred in two women who had undergone corrective surgery for meningomyelocele. Both women had urinary incontinence leading to urinary tract infections and, in one, to vulvitis urinosa. There is limited literature on maternal meningomyelocele and its complications.

Adolescent↗
PubMed1987

[Clinical effect of cefuzonam and its distribution into tissues in the field of obstetrics and gynecology].

The distribution of the new cephem antibiotic, cefuzonam (CZON) into adnexa uteri and uterine tissues, and clinical efficacy on patients with obstetric and gynecologic infections were studied. The results obtained are summarized as follows. 1. Concentrations of CZON in arterial and venous blood, oviduct, ovary, endometrium, myometrium, cervix uteri and portio vaginalis tissues were measured. The results demonstrated good transfer of the drug into various internal genital organs. 2. In clinical studies, CZON was given to 5 cases with various infections such as pyometra, acute vulvitis, pelvic peritonitis, pyelonephritis and puerperal intrauterine infection. Clinical efficacies were evaluated as excellent in 2 cases, and good in 3 cases. The efficacy rate was 100%. No side effects were observed in any cases. In laboratory tests, transient elevations of GOT, GPT and gamma-GTP were observed in 1 case. Therefore, it is concluded that CZON is a useful drug for various types of infections in the field of obstetrics and gynecology.

Adult↗
PubMed1987

[Treatment of purulent leukorrhea in young girls].

The case of a prepuberal girl complaining of a more or less purulent genital discharge, eventually associated with bleeding, evokes a vulvovaginitis. Vulvovaginitis is much less frequent than vulvitis. When a vulvovaginitis is resistant to medical treatment or is recurrent, an endoscopic examination is required in order to eliminate the presence of a vaginal foreign body. Treatment includes local cleaning, local antibiotics and sometimes a short course of oestrogen therapy. Oral antibiotics are indicated only in specific germ infections.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Acute generalized exanthematic pustulosis in children. Apropos of a case].

A seven year old girl without any personal or familial history of psoriasis presented with a maculo-papular then pustular, uniformly generalized eruption. She also had fever, neutrophilic granulocytosis, conjunctivitis and vulvitis. There was no evidence for bacterial or viral aetiology. Skin biopsy showed spongiform multilocular pustules and a vasculitis. The child recovered spontaneously within one week without further relapse.

Acute Disease↗
PubMed1986

[Vulvovaginitis in young girls].

What is required to cope with simple vulvitis in little girls is local hygeine and topical antibiotics, possibly associated with very mild estrogen therapy. In cases of gonococcus, systemic antibiotic medication is required.

Anti-Bacterial Agents↗
PubMed1985

[Preclinical and clinical studies on aztreonam in obstetrics and gynecology].

Aztreonam (AZT), a new monobactam antibiotic, was studied in obstetrics and gynecology with the following results. The tissue concentration of AZT in the female genital organs was relatively high at the portio vaginalis and the cervix uteri followed by at the ovary and the myometrium, but the distribution to the endometrium and the oviduct was a little poor. The concentration of AZT in the pelvic dead space exudate was highest at 2 hours after intravenous injection whereas it was highest at 5 hours after intravenous drip infusion. However, there was no significant difference in the concentration between intravenous injection and intravenous drip infusion and the distribution to the pelvic dead space exudate was relatively good. AZT was clinically administered to pyometra (3 cases), puerperal endometritis (3), adnexitis and endometritis (3), pelvioperitonitis (1), Bartholin's abscess (4) and purulent vulvitis (1), a total of 15 cases with an overall effective rate of 93.3%. AZT was microbiologically effective for Gram-negative bacteria such as E. coli and K. pneumoniae, but also effective for anaerobes and some Gram-positive bacteria, etc., for which MIC of AZT is high. With regard to safety of AZT, neither side effects nor abnormal laboratory findings were reported.

Adult↗
PubMed1985

[Effects of combination chemotherapy M-VEMFH including mitoxantrone in advanced breast cancer].

The effects of combination chemotherapy including mitoxantrone (MXN) "M-VEMFH" for advanced breast cancer were studied. The M-VEMFH regimen consisted of MXN 7 mg/m2, VCR 0.7 mg/m2, EX 333 mg/m2, MTX 13.3 mg/m2 i.v. on day 1, 5-FU 333 mg/m2 i.v. from day 1 to day 5 and pred. (H) 60 mg/m2 p.o. with tapering off in 2 weeks. In 7 cases heavily pretreated with combination chemotherapy including ADR, CR 2, PR 2, NC 2 and PD 1 were observed (response rate 57.1%). In 5 cases without prior ADR, PR 1, NC 2 and PD 2 were obtained. One case given 586 mg/m2 of prior ADR died of congestive heart failure after administration of 47 mg/m2 of NXN. One case died of sepsis. The other side effects were stomatitis, vulvitis, abnormal gustation, nausea, vomiting and alopecia. M-VEMFH is effective combination chemotherapy for advanced breast cancer resistant to ADR, but care must be exerted due to the accompanying cardiotoxicity and leukopenia.

Adult↗
PubMed1983

[Clinical evaluation of cefroxadine in the field of obstetrics and gynecology].

Cefroxadine (CXD), an oral cephalosporin antibiotic was studied in the field of obstetrics and gynecology and the following results were obtained. CXD was orally given to 22 cases at daily dose of 1,500 mg 3 times a day. CXD administration was given to 22 cases in all; 4 with cervicitis, 6 with endometritis, 2 with puerperal fever, 4 with bartholinitis, 5 with adnexitis and 1 with vulvitis, respectively. Overall efficacy rate was 77.3% (17/22) (excellent 4, good 13, fair 5). As for side effects, a slight diarrhea was observed. CXD was considered to be a useful antibiotic in the field of obstetrics and gynecology by above the results.

Administration, Oral↗