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PubMedDate not supplied

[Clarification of a forced entry theft based on a beverage bottle left at the scene and PCR DNA typing of superficial saliva traces].

This paper describes the first case in Austria where a suspect was been convicted and condemned because of salivary traces found on an empty bottle which were successfully typed by PCR-DNA-analysis. This was the only evidence in that case. In contrast to cigarette butts, which are already relatively routine for PCR-DNA-typing, bottles found on crime scenes usually contain much less material which can be investigated. As the result of permanent refinement of the methods used, it is demonstrated that it should be possible to solve other similar cases in the future.

Adult↗
PubMedDate not supplied

Epidemiology of violence and theft in the workplace.

Although homicides at work attract the media's attention, data extrapolated from the National Crime Victimization Survey show nonfatal workplace violence to be much more common. The survey estimates that 3.5 million personal crime victimizations occur annually, including 900,000 aggravated and simple assaults and 100,000 rapes and robberies.

Accidents, Occupational↗
PubMed2005

Pack-MULEs: theft on a massive scale.

It has been known for some time that plant transposons can capture and mobilize cellular genes. Recent work by Jiang and coworkers((1)) has revealed that this process has happened on a massive scale. They found that portions of more than 1000 genes in rice have been captured and mobilized by members of the MULE family of transposons. In rice, and perhaps other plants as well, it appears that thousands of genes and portions of genes have been duplicated, transposed and rearranged. These results have fascinating implications for our understanding of the mode and tempo of gene evolution in plants.

Biological Evolution↗
PubMed2005

Preventing leaf identity theft with hormones.

Genetic analysis of plant development has begun to demonstrate the importance of hormone synthesis and transport in regulating morphogenesis. In the case of leaf development, for example, auxin pooling determines where a primordium will emerge and leads to the activation of transcription factors, which determine leaf identities by modulating abscisic acid (ABA) and gibberellic acid (GA) concentrations. Signal transduction studies suggest that negative regulation of transcription factors through protein turnover is commonly used as a mechanism of hormone action. Together, these findings suggest that auxin might degrade a repressor that allows the activation of genes that modulate ABA/GA ratios in emerging leaves. With our increased understanding of the molecular basis of hormone signaling, it is becoming possible to overlay important regulators onto signaling modules that determine morphological outputs.

Abscisic Acid↗
PubMed1976

Bystander reactions to a violent theft: crime in Jerusalem.

Seventy-two male Israeli students were exposed to a violent crime in the course of a bogus discussion. Their awareness of other bystanders' lack of reaction to the emergency (social influence) and others' awareness of their actions (evaluation apprehension) were crossed in a 2 X 2 factorial design. An "alone" condition in which the subject was the only bystander controlled for the effects of others' mere presence (diffusion of responsibility). Helping was reduced by diffusion of responsibility and slowed by negative social influence but was increased by evaluation apprehension. Differences traceable to social influence appeared prior to those from the other processes. Implications of these findings for the measurement of helping and the interpretation of bystander decision making are discussed.

Awareness↗
PubMed2004

CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'.

Myelin basic protein-specific CD8(+) T cells can induce central nervous system autoimmunity; however, immune tolerance prevents these autoreactive cells from causing disease. To define the mechanisms that mediate tolerance, we developed two T cell receptor-transgenic mouse lines with different affinities for the H-2K(k)-restricted myelin basic protein epitope consisting of amino acids 79-87 (MBP(79-87)). We observed both thymic deletion and peripheral tolerance in the lower-affinity T cells. The higher-affinity T cells, however, showed no evidence of tolerance induction and were able to prevent tolerance of the lower-affinity T cells by removing H-2K(k)-MBP(79-87) complexes from antigen-presenting cells without proliferating. This form of immune regulation could limit responses of self-reactive T cells that escape other tolerance mechanisms.

Animals↗
PubMed2005

The Harvard case of Xu Xiping: exploitation of the people, scientific advance, or genetic theft?

A unique history and make-up of a population may make it an attractive research target for population geneticists and pharmaco-genomic investors. The promise of pharmaceutical profits and advances in medical knowledge attracted Harvard researchers and the company Millennium Pharmaceuticals to remote areas in Anhui Province, Central China, leading to international diplomatic disagreements about issues such as the ownership of genetic material and informed consent (IC). This article discusses the role of genomics and genetic sampling in China, the way it is related to population policies (the new eugenics), the national importance of genetic materials and the conflicts it led to between the Chinese government and Harvard University. Here many consider the Xu Xiping case as textbook example of ruthless Western exploitation of development countries, illustrating the cold rationality of science in the process of globalisation. Ten perspectives on this case show that this view is simplistic and contributes little to an understanding of bioethical issues important to the population actually donating the samples. Viewing the Xu Xiping case as the nexus of the intertwinement of international, transnational, national, and local interest groups shows how different interest groups make use of different units of analysis. It also clarifies why the same practice of genetic sampling continues under a different regime, and why the discussion about genetic sampling has shifted from a concern with health care of the poor to an issue of international exploitation, terrorism and development.

Biological Specimen Banks↗