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At least 217 records · Page 12Linked to original sources
PubMed1977

Thoracic duct cannulation of the rhesus monkey (Macaca mulatta) for lymphocyte collection: thoracic approach.

The thoracic duct of the rhesus monkey (Macaca mulatta) was cannulated with medical grade tubing through a thoracatomy at right interspace 9-10. In 42 monkeys successfully cannulated, a mean of 1.194 x 10(9) lymphocytes was collected in the 70-hour period after surgery. A second collection, 1-3 weeks later, was possible for a shorter period (up to 60 hours) in a portion of these monkeys (15) with a smaller mean yield of lymphocytes (1.076 x 10(9). A third, but still shorter, collection period of up to 48 hours was possible in only five monkeys from which a mean yield of 0.698 x 10(9) lymphocytes was collected. A temporary postoperative weight loss in the monkeys was followed by a return to normal weight several months later.

Animals↗
PubMed2006

Supradiaphragmatic thoracic duct clipping for chylothorax through left-sided video-assisted thoracoscopic surgery.

Chylothorax is a life-threatening clinical entity. Traditional surgical management for cases refractory to conservative treatment is thoracic duct ligation through a right open thoracotomy or closure of the site of duct laceration through an open thoracotomy. We report herein two patients with left chylothorax successfully treated by supradiaphragmatic thoracic duct (STD) ligation through left-sided video-assisted thoracoscopic surgery (VATS). This approach offers optimal exposure for the thoracic duct ligation and is useful for treatment of left chylothorax after left-sided thoracic surgery and idiopathic left chylothorax.

Aged↗
PubMed1988

[Surgical anatomy of the abdominal part of the thoracic duct].

With the aim to determine local orienting points, that facilitate in searching the abdominal part of the thoracic duct, 43 corpses of mature persons have been investigated by means of a complex of anatomical techniques. The distance between the levels, where the superior mesenteric artery and renal arteries get off, can be used for preventing possible complications at certain surgical manipulations. In particular, when the distance from the beginning of the superior mesenteric artery is 37-64 mm, the thoracic duct is mainly situated behind the inferior vena cava; when this distance is 16-34 mm, the duct is situated between the inferior vena cava and the aorta, and when the distance between the superior mesenteric and renal arteries is 6-15 mm, the abdominal part of the thoracic duct should be searched for behind the inferior vena cava.

Aorta↗
PubMed1980

A simultaneous comparison of the cells of blood, renal hilar and thoracic duct lymph in the dog.

A simultaneous morphological and quantitative profile was obtained of the cells of blood, thoracic duct, and renal hilar lymph in the dog. Monolayer cytocentrifuged preparations were used to determine the number, type, and size of cells in the three compartments. The cell count of renal lymph was not related to that of blood or thoracic duct lymph. There was a greater percentage of lymphoid cells in the afferent lymph than could be accounted for by the random movement of cells from the blood to the lymph. Thus, there appeared to be a selective transit of cells from blood to lymph. Monocytes and neutrophils were largely absent from the thoracic duct lymph; however, eosinophils were present. Cells were observed in hilar lymph that were characteristic of cells subjected to antigenic stimulation. It was concluded that lymphocytes have a preferential pathway from blood to lymphatic and in the course of this pathway they undergo a change which is consistent with an active immunological role.

Animals↗
PubMed1979

[Visualization of the thoracic duct during surgical operations (author's transl)].

Anaesthetists generally object, because of the risk of aspiration, to the pre-operative administration of coloured cream for visualizing the thoracic duct during surgical operations on the oesophagus, lung hilus and major vessels of the mediastinum. The possibility was, therefore, studied to mark the thoracic duct without involving the digestive tract. The following method was developed: a dye was injected into the wall of the distant portion of the oesophagus; the dye passes into the lymphatics and is transported first into the abdominal vessels and subsequently into the thoracic duct. Six dyes were tested in animal experiments. Evans blue and patent blue proved suitable.

Evans Blue↗
PubMed1999

A morphological study of the thoracic duct at the jugulo-subclavian junction.

Chylous fistulae are uncommon but serious complications of neck surgery, occurring with an incidence of 1-3% after radical neck dissection. The majority occur on the left side (75-92%) and are due to damage to the terminal segment of the thoracic duct as it drains into the great veins of the neck in the region of the venous angle. The risk of trauma to the terminal thoracic duct may be influenced by anatomical variations. The macroscopic arrangement of the termination of the thoracic duct in the left neck was examined in 24 UK cadavers. Twenty-one ducts terminated as a single vessel, two ducts showed a bifid termination and one duct had three terminal branches. The precise site of termination was variable. Five thoracic ducts showed branching and reanastamosing patterns prior to their termination, irrespective of the number of terminal branches. Subsidiary cervical lymph trunks were identified in four dissections. These variations are described and their relevance to surgery involving the left side of the neck is discussed.

Adult↗
PubMed1983

IgA antibodies in rat bile are not solely derived from thoracic duct lymph.

The IgA level in rat bile was significantly decreased by drainage of the thoracic duct, and passively administered IgA antibodies to Escherichia coli O antigen decreased similarly. In contrast, specific IgA antibodies against E. coli O antigen raised by immunization in the Peyer's patches did not diminish significantly in the bile. Rats immunized in the Peyer's patches with sheep erythrocytes had IgA-forming cells in the thoracic lymph nodes, in the mesenteric lymph nodes, and in the spleen. Perfusion of the liver of immunized animals significantly decreased the bile levels of the IgA antibodies. It seems that IgA antibodies reach the bile not only via the thoracic duct but also via lymph ducts originating from thoracic lymph glands and the spleen.

Animals↗
PubMed1997

[Chyloperitoneum after traumatic rupture of subdiaphragmatic thoracic duct. A clinical case].

Chyloperitoneum following traumatic rupture of the subdiaphragmatic thoracic duct is a very rare lesion and in fact no case was found when reviewing the last five years of international literature. The authors report a case of traumatic chyloperitoneum caused by a penetrating sidearm wound in a young 19-year-old woman. Emergency exploratory laparotomy enabled the precise identification of the site of the thoracic duct lesion and to proceed to its immediate suture. At one year after the operation the patient is in good health.

Adult↗
PubMed1978

Lymphocyte migratory pathways in adjuvant disease. I. Distribution of 51Cr-labeled thoracic duct lymph-borne.

Evidence for selective extravasation of thoracic duct lymph-borne cells, derived from rats with adjuvant disease, within joints of normal or adjuvant arthritic recipients was sough by adoptive transfer of radiolabeled cells. Control studies were carried out in parallel using thoracic ducts cells from normal donors. No increased homing of lymph-borne cells to inflamed portions of the limbs was detected when cells from adjuvant arthritic donors were compared with those of normal controls. Inflammatory changes, ie, adjuvant-induced disease, in the recipient produced a significant nonspecific enhancement of extravasation; cells from normal and adjuvant arthritic donors responded equally well. One difference in migratory behavior between lymph-borne cells from adjuvant arthritic and normal animals was the increased ability of the former to localize within certain lymph nodes. A possible association between this traffic and the development of chronic inflammatory processes within joints is discussed.

Animals↗
PubMed1974

Thoracic duct and hepatic lymph in idiopathic portal hypertension.

Lymph dynamics in idiopathic portal hypertension has been studied in two phases. In the first phase thoracic duct lymph transport was studied in 11 patients with idiopathic portal hypertension by cannulating the duct. This revealed altered lymph transport in the form of a distended thoracic duct, raised pressure in the duct, and haemorrhagic lymph with an increased flow rate. The lymph flow rate was analysed in relation to various hepatic haemodynamic and biochemical parameters. In the second phase of the study hepatic lymphatics were studied by percutaneous hepatography in 16 patients with idiopathic portal hypertension. By this technique hepatic lymphatics were opacified in patients with idiopathic portal hypertension and cirrhosis with equal frequency. The significance of this finding in relation to the altered hepatic haemodynamics and thoracic duct lymph transport is discussed.

Humans↗
PubMed1998

Phenotypical characterization of cells in the thoracic duct of patients with and without systemic inflammatory response syndrome and multiple organ failure.

The subset composition and recirculation properties of the migrating lymphocyte pool in humans is largely unknown. The present study was conducted in order to phenotypically characterize cells in human thoracic duct lymph of patients under non-inflammatory and inflammatory conditions. These data were compared with data from peripheral blood, with special emphasis on those cells homing to the gut. Thoracic duct lymph and peripheral blood contained comparable proportions of B and T lymphocytes and CD8+ cells. Thoracic duct lymph contained proportionally more CD4+ cells, more CD4+CD45RO+ that express alpha 4 beta 7 cells and more CD8+CD45RO+ that express alpha 4 beta 7, as compared to peripheral blood. These data suggest an equal recirculation rate of B and T lymphocytes; a more active recirculation of CD4+ cells compared to CD8+ cells; and a more active recirculation of memory cells to the gut as compared to other extra-lymphoid sites in patients under non-inflammatory conditions. Data were also obtained in patients with the system inflammatory response syndrome and multiple organ failure. Although it is generally assumed that granulocytes and monocytes do not recirculate, lymph of multiple organ failure patients contained significantly more granulocytes than monocytes, indicating that in severe generalized inflammatory states these cells re-enter the circulation through the thoracic duct. Furthermore, no increased activation of cells homing to the gut was found in these patients.

Aged↗
PubMed1980

The inflammatory responses of rats depleted of lymphocytes or with an artificial obstruction of the thoracic duct.

Rats selectively depleted of lymphocytes by chronic drainage from the thoracic duct during a 3-day period presented a marked lymphopenia, and decreased responses to carrageenin injected into one of the hind paws. The intensity of the inflammatory responses in thse animals was restored by the i.v. administration of suspensions of viable or lysed lymphocytes, collected from the spleen or lymph of normal animals. A spontaneous reversal of the depressed responses to carrageenin was observed 40 days after the period of lymph drainage, when lymphocyte counts were again normal in blood. If highly inbred rats were used, the i.v. injection of syngeneic lymphoid cells was equally effective in restoring the inhibityed inflammatory responses resulting from lymphocyte depletion. Artificial obstruction of the thoracic duct, with interruption of lymphocyte recirculation, was followed by decreased lymphocyte counts in blood and severely depressed inflammatory responses to carrageenin. This unresponsive state was corrected as the animals recuperated, probably coincidentally with the development of collateral lymph channels and as the temporarily disturbed blood picture returned to normal. It is concluded that lymphocytes can participate in the development of non-immune inflammation through the release of pro-inflammatory factors. This release is independent of previous sensitization of the cells.

Animals↗
PubMed2003

[The optimal procedure for chylothorax after operation for thoracic esophageal cancer; reasonable approaches to the thoracic duct from the point of view of routes for esophageal replacement].

In general, chylothorax after esophagectomy with lymph node dissection under thoracotomy is a rare postoperative complication. We report a 71-year-old man who developed chylothorax following esophagectomy and 3-field lymph node dissection together with reconstruction using stomach through the posterior mediastinum, and discuss ideal approaches that are less invasive and make it possible to provide better exposure of the thoracic duct. In selecting the ideal approach, the most important thing is differences in routes for esophageal replacement. The anatomical relation between the location of a conduit adopted for reconstruction of the resected esophagus and the thoracic duct should be considered in each case. In the case of the retrosternal or antesternal route, a video-assisted thoracoscopic approach allows for easy detection of the thoracic duct while reducing surgical invasiveness, because there is no conduit in the posterior mediastinum. On the other hand, a conduit interrupts the visual field of thoracoscopy in the case of the posterior mediastinal or intrathoracic route. Drawing up of a conduit to gain a good operative field involves some risks in protection of the vascular pedicle. Therefore, a transabdominomediastinal approach is an optimal option. With this approach, we could easily find the thoracic duct and directly ligate it just cranial to the hiatus, resulting in a remarkable decrease in discharge through the thoracic drainage tube. In addition, we present an intelligible intraoperative photograph.

Aged↗
PubMed1977

[Enzymatic changes in the lymph in the thoracic duct and right lymphatic duct during extracorporeal circulation in the dog (author's transl)].

The authors analysed the various enzymes in the lymph of the thoracic duct and the right lymphatic duct in a series of 15 dogs submitted to extracorporeal circulation, the experimentors noted a series of diffuse cellular lesions which involved transiently the main organs. This lesion seems only to occur at first; independent of the duration of the by-pass, probably due to hypoxia following the rapid and massive introduction of priming. Our conclusion from this research is that lymph analysis is more revealing for knowledge of enzyme behaviour than blood analysis. A differential study of lymph in the right lymphatic duct and in the thoracic duct is surprisingly much less important.

Animals↗
PubMed1977

Long term physiologic study of thoracic duct lymph and lymphocytes in rat and man.

Techniques for study of thoracic duct lymph and lymphocyte circulations in rats and in man are presented. Radiographic observations, measurements of lymph flow, lymphocyte output, blood lymphocyte level, intra-thoracic pressures and radioactive determinations in the lymph and blood of 51Cr labelled lymphocytes, indicate that the techniques are suitable for long-term study of thoracic duct circulations under physiologic conditions.

Animals↗