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Geographical distribution and host preference of common bunt Tilletia foetidae (Wallr.) Liro and Tilletia caries (DC) Tul. on bread wheat and durum wheat.

Based on the morphological characteristics of the ustilospores, the geographical distribution and host preference of common bunt Tilletia foetidae and T. caries on bread wheat and durum wheat in Syria has been studied. The spore wall structure forms the most feasible and convenient method for differentiation between the two pathogens. Accordingly, T. foetidae is the most prevalent pathogen in North Syria and the predominant pathogen in the bread wheat. T. caries was widespread in durum wheat in South Syria. This phenomenon has been confirmed in artificial inoculation tests and discussed as host-preference in T. foetidae and T. caries irrespective of the geographical area in which the disease is observed and irrespective of the environmental conditions. T. foetida, however was the predominant pathogen on bread wheat, while T. caries preferentially attacks durum wheat.

Basidiomycota↗

Genetic characterization of the body attributed to the evangelist Luke.

Historical sources indicate that the evangelist Luke was born in Syria, died in Greece, and then his body was transferred to Constantinople, and from there to Padua, Italy. To understand whether there is any biological evidence supporting a Syrian origin of the Padua body traditionally attributed to Luke, or a replacement in Greece or Turkey, the mtDNA was extracted from two teeth and its control region was cloned and typed. The sequence determined in multiple clones is an uncommon variant of a set of alleles that are common in the Mediterranean region. We also collected and typed modern samples from Syria and Greece. By comparison with these population samples, and with samples from Anatolia that were already available in the literature, we could reject the hypothesis that the body belonged to a Greek, rather than a Syrian, individual. However, the probability of an origin in the area of modern Turkey was only insignificantly lower than the probability of a Syrian origin. The genetic evidence is therefore compatible with the possibility that the body comes from Syria, but also with its replacement in Constantinople.

Base Sequence↗

Routines in facility-based maternity care: evidence from the Arab World.

OBJECTIVES: To document facility-based practices for normal labour and delivery in Egypt, Lebanon, the West Bank (part of the Occupied Palestinian Territory) and Syria and to categorise common findings according to evidence-based obstetrics. DESIGN: Three studies (Lebanon, West Bank and Syria) interviewed a key informant (providers) in maternity facilities. The study in Egypt directly observed individual labouring women. SETTING: Maternity wards. SAMPLE: Nationally representative sample of hospitals drawn in Lebanon and Syria. In the West Bank, a convenience sample of hospitals was used. In Egypt, the largest teaching hospital's maternity ward was observed. METHODS: Shared practices were categorised by adapting the World Health Organization's (WHO) 2004 classification of practices for normal birth into the following: practices known to be beneficial, practices likely to be beneficial, practices unlikely to be beneficial and practices likely to be ineffective or harmful. MAIN OUTCOME MEASURES: Routine hospital practices for normal labor and delivery. RESULTS: There was infrequent use of beneficial practices that should be encouraged and an unexpectedly high level of harmful practices that should be eliminated. Some beneficial practices were applied inappropriately and practices of unproven benefit were also documented. Some documented childbirth practices are potentially harmful to mothers and their babies. CONCLUSION: Facility practices for normal labour were largely not in accordance with the WHO evidence-based classification of practices for normal birth. The findings are worrying given the increasing proportion of facility-based births in the region and the improved but relatively high maternal and neonatal mortality ratios in these countries. Obstacles to following evidence-based protocols for normal labour require examination.

Delivery, Obstetric↗

[The malaria situation in the WHO eastern Mediterranean region].

About 45% of the population of the Eastern Mediterranean Region live under the risk of both falciparum and vivax malaria, and additional 15% under the risk of P. vivax alone. The estimated annual number of malaria cases is about 14 million, out of which 95% occur in four countries: Afghanistan, Somalia, Sudan and Yemen. In Afghanistan malaria is endemic throughout the country at altitude below 1500 m. About 80-90% of malaria cases belong to P. vivax, the rest to P. falciparum (the latter is prevalent mostly in the South and in Badakhshan). In Islamic Republic of Iran 16% of the population live in initially non-malarious areas, 66% in areas freed from malaria, 12% in areas with sporadic transmission, mostly of P. vivax, and only 6% in areas of continuous transmission with a high proportion of P. falciparum. As much as 77% of the recorded cases belong to the latter territories. Iraq. After the Gulf war, the situation deteriorated in the three north-eastern governorates, and malaria spread outside this area and rooted in the south (Basra). Syria. Transmission of P. vivax still occurs, mostly along the western part of the border with Turkey and in the north-eastern corner of the country. At present, there are three areas that causes concern along borders between the European and Eastern Mediterranean Regions: Afghanistan is a source of importation of malaria to all its neighbours; areas on the borders between Iran, Azerbaijan and, to some extent, Armenia; 4 northern governorates of Iraq and parts of southeastern Turkey, with repercussions in Syria and, to a Lesser extent in Iran, along its western border. To some extent, Cyprus is also threatened, since importation of malaria to the northern part of the island from Turkey has been documented. In practical terms, there is a need for co-ordination of antivectorial activities and standardization of control methods between the countries with strong programmes and relatively intense transmission in border areas, i.e. between Iran, and Azerbaijan, Iraq and Turkey, Syria and Turkey.

Disease Outbreaks↗

[Helminth fauna of Syrian lambs].

A study of the helminth fauna of lambs in Syria was made on 40 gastrointestinal tubes and 500 lungs from animals slaughtered in the abattoir of Hama. The parasites isolated were 21 nematode species, 4 cestode species and 2 bladderworm species (Cysticercus tenuicollis and Echinococcus species). Nematodirus oiratianus, Moniezia benedeni and Neostrongylus linearis were found for the first time in lambs in Syria. A detailed description is given of morphologic characteristics of Nematodirus oiratianus.

Abattoirs↗

Vertical distribution and inventories of 137Cs in the Syrian soils of the eastern Mediterranean region.

Vertical distribution and inventories of (137)Cs have been determined using radiocesium distributions in presumably undistributed soil profiles, collected from 36 sites distributed all over Syria (eastern Mediterranean region). Vertical distributions of (137)Cs in the collected profiles were found to be strongly correlated with soil type and five groups were identified. Based on these profiles, total (137)Cs inventory (bomb test and Chernobyl) varied between 320 Bq m(-2) and 9,647 Bq m(-2). Geographical mapping of (137)Cs inventories showed that the highest values were found in the coastal, middle and north-east regions of Syria indicating that Chernobyl atmospheric contribution to the total (137)Cs deposition in the region is predominant. In contrast, the lowest values were found in the south-east region (Syrian Badia), where a relatively uniform distribution was observed, which may only be attributed to the past global nuclear bomb test. The measured inventories were also compared with a mathematical model for estimating bomb derived (137)Cs reference inventories.

Cesium Radioisotopes↗

Measuring exposure to environmental tobacco smoke (ETS): a developing country's perspective.

AIMS: To assess exposure to ETS among nonsmokers in the community and examine the relation between various subjective and objective measures of exposure to ETS in a developing country's setting. METHODS: An interviewer-administered population-based survey of adults 18-65 years residing in Aleppo, Syria. From a total number of 2038 participants, a sub-sample of 419 nonsmokers (27.2% men, 72.8% women, mean age 34 years) underwent subjective and objective assessment of exposure to ETS (saliva cotinine, breath CO, self-reported measures of exposure combined into ETS exposure scale). RESULTS: Overall, 97.6% of adults nonsmokers assessed in this study, 72.9% of whom were women, have detectable saliva cotinine levels (mean +/- SD 1.7 +/- 1.5 ng/ml). Correlation between self-reported exposure measures and saliva cotinine was moderate with the strongest observed for number of cigarette smokers in the house, average number of cigarettes smoked daily in the house, house policy regarding smoking, and total ETS score (r 0.3-0.4). These same variables were among the best predictors of saliva cotinine according to stepwise linear regression analysis, but their individual relevance differed between men and women reflecting underlying differences in gender-based behavior-mobility patterns. Generally, subjective measures could explain 22% of the variability in cotinine levels in men and 19% in women. CONCLUSIONS: Exposure to ETS is universal among adult nonsmokers in Syria. Saliva cotinine correlated moderately with self-reported measures, whereby selected subjective measures can be as informative as composite scores incorporating multiple measures. Even in this environment of omnipresence of smoking, household restrictions seem to offer protection against ETS exposure.

Adolescent↗

[The Leafhopper Neoaliturus haematoceps (Mulsant & Rey) is a vector of Spiroplasma citri in the Mediterranean].

Among the many leafhoppers which we have collected and identified in Morocco, Turkey, Syria and France (Corsica), only the species Neoaliturus haematoceps was found to be infected with Spiroplasma citri. In Syria, this leafhopper was encountered on ornamental stock plants (Matthiola incana L.) in the Oronte valley, and on Salsola kali L., a wild Chenopodiacae of the semi-arid regions of the coastal area. In Corsica, we found it on wild stock plants (Matthiola sinuata R.Br.) of the oriental coast and on bush plants. A breeding of this leafhopper was initiated, and we demonstrated that it was able to acquire S. citri from infected periwinkles, multiply the organisms in its body and transmit them to healthy plants. This leafhopper can also be infected after injection of S. citri. The leafhoppers thus inoculated can transmit the spiroplasma very efficiently to healthy plants. This is the first report of the transmission of S. citri by Neoaliturus haematoceps both after acquisition on a diseased plant and after injection.

Animals↗

Fecundability and husband's age.

The effect of husband's age on the probability of conception is evaluated from World Fertility Survey data in five developing countries: the Ivory Coast, Ghana Kenya, the Sudan, and Syria. Proportional hazards models, which include wife's age, husband's age, marriage duration, union type, and post-partum exposure as covariates, are used to describe the monthly conception rate for second and higher-order birth intervals in which no contraception was used. With the exception of Syria, the resulting models indicate that the effects of male age are generally small in relation to the influences of marital duration and the age of the woman.

Adult↗

Health care providers' perceptions of the problems and causes of irrational use of drugs in two Middle East countries.

It is now evident that both developed and developing countries are experiencing many aspects of inappropriate use of drugs in their health care facilities. This is the first study in the region performed to examine the most common problems of irrational use of drugs and their causes in two Middle East countries--Jordan and Syria. Ninety senior participants from Jordan (50-15 physicians and 35 pharmacists) and Syria (40-12 physicians and 28 pharmacists) were enrolled in this study. The participants were asked to fill two questionnaires that deal with the problems and causes of irrational use of drugs in their country. Additionally, the participants were asked to perform a prescription analysis using WHO prescribing indicators on 40 prescriptions taken randomly from a comprehensive health centre in their country. The main drug use problems identified in the two countries were almost the same, but they vary in the percentage of occurrence and include excessive use of antibiotics and antidiarrhoeals, overprescribing of nonsteroidal anti-inflammatory drugs, prescribing by tradename, excessive use of antibiotics to treat minor upper respiratory infections and self-medication by the public. The main causes of irrational use of drugs were poor medical records, lack of patient education about illnesses and drugs, no family doctor system, lack of standard treatment guidelines and lack of continuing medical education for doctors and pharmacists. The results of this study are important for decision-makers to utilise when putting policies and strategies to improve the use of drugs in both countries.

Anti-Bacterial Agents↗

Comparison of patterns of use, beliefs, and attitudes related to waterpipe between beginning and established smokers.

BACKGROUND: To compare patterns of use, beliefs, and attitudes related to waterpipe smoking between university students (beginning smokers) and cafe customers (established smokers) in Aleppo Syria, in order to explore the evolution of this smoking method. METHODS: Two cross-sectional surveys were conducted among representative samples of university students (total 587, 48.4% men, mean age 22 years), and waterpipe users among cafe' customers (total 268, 60% men, mean age 30 years) in Aleppo, Syria. We used interviewer-administered questionnaire inquiring about pattern of waterpipe smoking (initiation, frequency), situational characteristics of use (partner, place, sharing), beliefs related to waterpipe smoking (harmful/addictive properties of waterpipe), attitudes related to waterpipe smoking (confidence in quitting, will to quit, motivation for quitting, past year quit attempt), and cigarette smoking. RESULTS: Daily and regular patterns of smoking become more prevalent with increased duration of smoking, but intermittent smoking remains the predominant pattern of waterpipe use. Women seem to be drawn later to the habit, which seem to escape the usual taboo against women's cigarette smoking. Patterns and context of waterpipe use tend to change with progress of the practice affecting frequency, setting, and sharing of waterpipe. Unlike beginners, established waterpipe smokers seem more smoking-method oriented, more hooked on the habit, less willing to quit, and less likely to foresee challenges to quitting. CONCLUSION: Use patterns and attitudes related to waterpipe smoking evolve to accommodate the change in dependence and life circumstances of the smoker. Most of use features, beliefs, attitudes, as well as time-course seem unique to this smoking method requiring novel approach to intervention.

Activities of Daily Living↗

[Jean-Charles Sournia, resident of Lyon Hospitals and Surgeons in Alep].

The article deals with the life and activity of J. Ch. Sournia from 1938 to 1966. Born in Bourges (France) in 1917, he studied at "l'Ecole du Service de Santé Militaire" in Lyon. In 1938 he became a non-resident student of Lyon Hospitals and a resident in 1943. Assistant of thoracic surgery by Professors Paul Santy and Marcel Bérard he underwent an advanced training course by Pr Crawford in Sweden. There he met his Swedish wife-to-be. Appointed professor of Surgery he taught Surgery in Alep and Anatomy in Beyrouth. In the same time he was interested in the History of Syria and its archeology during the Byzantine Centuries (from the IVth to the VIIth A. D.). While his wife was teaching literature at Rennes University he was appointed surgery professor at the Medical College in Rennes and wrote "the Middle-East of Primitive Christianity-History and Archaeology by Byzantine Syria" (Fayard 1966) in which he focused his study on monks who lived for long years on pillar top to be closer to God, like St Simeon.

France↗

Epidemiology of Spiroplasma citri in the Old World.

Epidemics of citrus stubborn disease (CSD) have been known in the Mediterranean citrus-growing areas as early as 1928. One such outbreak of stubborn disease occurred around 1980 in newly established citrus nurseries on the Syrian coast. Natural transmission of Spiroplasma citri could be shown to be involved. Enzyme-linked immunosorbent assay (ELISA) and culture of S. citri were used to detect the presence of S. citri in leafhoppers. Over 50 leafhopper species were submitted to these analyses, not only in Syria but also in Morocco and France (Corsica) from 1978 to 1985. Neoaliturus (Circulifer) haematoceps was the only species found to harbor the spiroplasma in Morocco, Syria and France (Corsica). Leafhoppers of this species were collected in Corsica, raised in Bordeaux and shown to be vectors of S. citri. The search for N. haematoceps in nature has revealed that Salsola kali (Chenopodiacae) is a favored host plant of this leafhopper. This plant has a wide geographical distribution. In Iran, for instance, it is well known, and grows close to sugar beet and citrus-growing areas. In such areas, sugar beet is known to be infected by curly top virus, and citrus by CSD. N. haematoceps is a vector of both of these diseases. N. tenellus, the vector of S. citri in the USA, is present in the Mediterranean area, but in view of its paucity it does not seem to be a major vector there. In Iran, even though less abundant than N. haematoceps, it could play a role in S. citri transmission.

Animals↗

Identification of two mutations for ataxia telangiectasia among the Druze community.

Ataxia telangiectasia (AT) is a rare autosomal recessive disease characterized by progressive cerebellar ataxia, immunodeficiency, susceptibility to lymphoreticular malignancies and cancer predisposition, hypersensitivity to ionic radiation and chromosomal instability. In this study, we report a founder effect of AT with two different mutations: 1339 C > T and 6672 del GG together with 6677 del TACG, found in four Israeli Druze clans originating from three different Druze centers in the Middle East (Lebanon, Syria and Jordan). The 1339 C > T mutation, which results in a stop codon at position 447 of the ATM protein, was observed in two unrelated clans originating from Lebanon and Jordan. The 6672 del GG/6677 del TACG mutation was observed in two unrelated clans originating from Syria and Lebanon. In the present study, simple and fast detection assays were developed for both mutations. The ability to identify AT carriers routinely provides a unique opportunity for prenatal diagnosis, genetic counseling as well as marriage guidance in the Druze community.

Adolescent↗

GluDy allele variations in Aegilops tauschii and Triticum aestivum: implications for the origins of hexaploid wheats.

To investigate the evolution and geographical origins of hexaploid wheat, we examined a 284 bp sequence from the promoter region of the GluDy locus, coding for the y subunit of high-molecular-weight glutenin. Fourteen different alleles were found in 100 accessions of Aegilops tauschii and 169 of Triticum aestivum. Two alleles were present in both species; the other 7 alleles from Ae. tauschii and 5 from T. aestivum were unique to their respective species. The two shared alleles differed at only one nucleotide position within the region sequenced, but their apparent association with the common haplotypes GluD1a and GluD1d, which have substantial differences within their GluDy coding regions, makes it unlikely that the alleles evolved independently in Ae. tauschii and T. aestivum. The results therefore support previous studies which suggest that there were at least two Ae. tauschii sources that contributed germplasm to the D genome of T. aestivum. The number of alleles present in T. aestivum, and the nucleotide diversity of these alleles, indicates that this region of the D genome has undergone relatively rapid change since polyploidisation. Ae. tauschii from Syria and Turkey had relatively high nucleotide diversity and possessed all the major GluDy alleles, indicating that these populations are probably ancient and not the result of adventive spread. The presence in the Turkish population of both of the shared alleles suggests that hexaploid wheat is likely to have originated in southeast Turkey or northern Syria, within the Fertile Crescent and near to the farming villages at which archaeological remains of hexaploid wheats are first found. A second, more recent, hexaploidisation probably occurred in Iran.

Alleles↗

Possible origin of the bluetongue epidemic in Cyprus, August 1977.

Possible origins of an epidemic of bluetongue in Cyprus in August 1977 have been analysed. First outbreaks occurred simultaneously in the south-east of the Famagusta district and on the north coast of the Kyrenia district respectively. Although the epidemic was due to type 4, which had been responsible for the previous outbreak in 1969, no evidence of persistance of virus could be found. Imports of domestic animals in the past year were not implicated since the imported cattle were introduced only to the southern part and not to the northern part of the island. Easterly, north-easterly and northerly winds during the period 11-14 August could have brought infected midges at a height of 0.5--1.5 km from Syria and Turkey, and such a movement would fit well the dates of the first outbreaks (20-25 August). Temperatures at a height of 1.5 km were 20-25 degrees C and at 0.5 km 30 35 degrees C, and with wind speeds 10-20 km h-1 the distance from Turkey and Syria would have been covered in 5-20 h. It follows that, in addition to surface winds, winds at all levels warm enough for flight should be taken into account when the possibility of disease spread by windborne midges is being assessed.

Animals↗

Comparison between restorations in the permanent dentition produced by hand and rotary instrumentation--survival after 3 years.

OBJECTIVES: In the early 1990s, the Ministry of Education in Syria introduced a school oral health programme based on preventive and educational activities only. A restorative component was missing at that time. A few years later, the Atraumatic Restorative Treatment (ART) approach was considered an option to complement the oral health programme but little was known about the longevity of ART restorations in permanent teeth. The null hypothesis which was researched in this trial was: there is no difference between the survival of restorations placed through the ART approach using glass ionomer and those produced through the traditional approach using amalgam (MTA) in permanent dentitions after 3 years. METHODS: Using a parallel group design, 679 grade 2 children, with a mean age of 7.5 years, participated. A total of 369 children were treated through the ART and 310 children through the MTA approach. Eight dentists produced a total of 1118 single- and multiple-surface restorations. RESULTS: The 3-year dropout of the single-surface restorations was 15.3%. Testing the null hypothesis for all single- and multiple-surface restorations revealed a statistically significant difference between the two approaches in favour of the ART approach (P = 0.04). The study showed a 3-year cumulative survival percentage of single-surface ART and MTA restorations of 82.1 (SE = 1.9%) and 76.9% (SE = 2.3%), respectively. The difference was not statistically significant. The number of 3-year surviving multiple-surface restorations was too low for further analyses. The main failure characteristics for both single-surface ART and MTA restorations were restoration missing and gross marginal defect. The 3-year survival percentage of both single-surface ART and MTA restorations varied widely among the eight operators resulting in an operator effect (P = 0.01). CONCLUSIONS: The null hypothesis was rejected in favour of the ART approach. It is recommended to select the ART approach to complement the educational and preventive activities of the school oral health programme in Syria.

Child↗

Genetic diversity of barley landrace accessions (Hordeum vulgare ssp. vulgare) conserved for different lengths of time in ex situ gene banks.

Large numbers of crop plant accessions from all over the world have been amassed in gene banks to secure a gene pool for future breeding programmes. Maintenance of accessions held as seed samples in cold stores involves frequent rejuvenation cycles to ensure the viability of seeds. The practice of rejuvenation by multiplication of a sample of each accession in small field plots has the potential to create population bottlenecks, leading to loss of genetic diversity and changes in gene frequencies every rejuvenation cycle. In order to determine whether these undesirable effects occur, genetic diversity levels were assessed for morphological and isozyme markers within gene bank accessions of two barley landraces from Syria that had been stored for 10, 40 and 72 years. These were compared with genetic diversity levels for the same markers in barley landraces collected recently at locations in Syria where they are still under cultivation. Average gene diversity (H), alleles per locus (A) and percentage polymorphic loci (P (0.01)) all showed very significant declines with length of time in storage, and genetic differentiation FST among accessions increased over time. If the observed differences in genetic diversity are caused by genetic drift in gene bank accessions rejuvenated every 5.3 years, it was estimated that the effective population size Ne of rejuvenation populations over their period in storage was only 4.7. Implications for gene bank management are discussed.

Base Sequence↗