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At least 217 records · Page 12Linked to original sources
PubMed1997

Genetic and environmental influences on parent-son relationships: evidence for increasing genetic influence during adolescence.

Genetic and environmental influences on self-reported parent-child relationships were examined in a sample of 824 individual male twins and their parents. Cross-sectional comparisons of twin similarity at ages 11 and 17 were undertaken to identify developmental changes in the contribution of genetic and environmental factors to family relationships. Significant genetic influences were found on perceptions of parent-son conflict, regard, involvement, and overall support. Heritabilities were significantly higher in older twins, suggesting increased genetic influence with age. Age differences were present primarily in the father-son relationship. These results provide support for the proposal of S. Scarr and K. McCartney (1983) that the importance of active gene-environment correlations increases during adolescence. Older adolescents may have more choice and impact on the nature of the relationships they have with their parents.

Adolescent↗
PubMed1999

Chronic tolerance and sensitization to alcohol in sons of alcoholics: II. Replication and reanalysis.

Data from D. B. Newlin and J. B. Thomson (1991) were reanalyzed, and data from an independent replication study were analyzed, relative to tonic (baseline) and phasic (response to alcohol challenge) aspects of drinking alcohol administered at the same dose on several occasions. Among the high-risk men (sons of alcoholic fathers), linear trends across days for resting (predrinking) baselines were opposite to alcohol-evoked changes for finger pulse amplitude, finger temperature, and skin conductance in Study 1 and for pulse transit time and body sway (static ataxia) in Study 2. In contrast, the structure of the low-risk men's (sons of nonalcoholic parents) data was precisely the opposite. Results are discussed in terms of sensitization as a potential mechanism that relates vulnerability to final manifestation of addictive behavior.

Adult↗
PubMed1990

Alcohol challenge with sons of alcoholics: a critical review and analysis.

Studies are reviewed in which response to acute administration of alcohol was compared between individuals with and without family histories of alcoholism (FH+, FH-). This research represents a search for a psychobiological marker for alcoholism. A methodological critique of the procedures reported in this literature is then presented. Finally, a conceptual model is suggested in which differences in the response to alcohol between FH+ individuals and FH- individuals must be understood in relation to time after drinking alcohol. This Newtonian differentiator model proposes that sons of alcoholics exhibit acute sensitization as blood alcohol level rises and acute tolerance as blood alcohol level falls, compared with sons of nonalcoholics. Therefore, FH+ subjects find alcohol more rewarding because they accentuate the pleasurable, excitatory aspects of initial intoxication and attenuate the feelings of anxiety and depression that predominate as blood alcohol levels drop.

Acetaldehyde↗
PubMedDate not supplied

Mitochondrial DNA analysis on remains of a putative son of Louis XVI, King of France and Marie-Antoinette.

Carl Wilhelm Naundorff was buried in 1845 in Delft as Louis Charles, Duc de Normandie, 'Louis XVII'. However, the son of Louis XVI and Marie-Antoinette-Louis XVII--officially died in the Temple of Paris in 1795. In order to resolve the identity of Naundorff, mitochondrial DNA (mtDNA) D-loop sequences of his remains were compared with the sequences obtained from the hairs of two sisters of Marie-Antoinette, Marie-Antoinette herself, and with the sequences obtained from DNA samples of two living maternal relatives. The mtDNA sequence of a bone sample from Naundorff showed two nucleotide differences from the sequences of the three sisters and four differences from the sequences of living maternal relatives. Based on this evidence it becomes very unlikely that Naundroff is the son of Marie-Antoinette.

Base Sequence↗
PubMed1996

[Brain infections in father and son and their sequelae--a personal report].

The author (born 1943) shows which phases of "integration into the society" he has undergone since his brain fevers in 1994 and 1958. This paper continues his former paper [1], in which are referred the special relations between the author and his son (born 1984). As previously in his own case, after his son entered school, hardness of hearing was detected which had been caused by a brain infection. The paper shows similarities and differences in the pattern of symptoms and their social acceptance.

Brain Damage, Chronic↗
PubMed2002

Parents think their sons are brighter than their daughters: sex differences in parental self-estimations and estimations of their children's multiple intelligences.

In this study, 156 participants, predominantly White British adults (M age = 44.3 years) rated themselves on overall IQ and on H. Gardner's (1983) 7 intelligence subtypes. Parents (n = 120) also estimated the intelligence of their children. Men's self-estimates were significantly higher than women's (110.15 vs. 104.84). Participants thought their verbal, mathematical, and spatial intelligence scores were the best indicators of their own overall intelligence. Parents estimated that their sons had significantly higher IQs than their daughters (115.21 vs. 107.49). Self-estimates and estimates of children's multiple intelligences were higher for men and sons, significantly so for logical-mathematical and spatial intelligence. Parents rated 2nd-born daughters as having significantly higher verbal and musical intelligence than their male counterparts. Higher parental IQ self-estimates corresponded with higher IQ estimates for children. Results for 1st-born children were clearest and showed the most significant differences. The findings are interpreted in terms of sociocultural and familial influences and the possibility of actual sex differences in particular abilities.

Adolescent↗
PubMed2004

Mothers may transmit RSV infection more easily or severely to sons than daughters: community study from Guinea-Bissau.

Opposite gender transmission may increase the severity of certain infections. If infections transmitted from mother to son were more severe than from mother to daughter this might explain severe diseases among boys, particularly in small families with few individuals contributing to transmission. Among children from Guinea-Bissau, we tested whether mothers with recent respiratory syncytial virus exposure (positive IgM and IgA antibody responses) were more likely to have male than female children with respiratory syncytial virus antigen positive acute lower respiratory tract infection. Children with acute lower respiratory tract infection were identified at a paediatric clinic (n = 348), a health centre (n = 270), and in a community morbidity survey (n = 525), 14.2% (162/1143) having respiratory syncytial virus antigen. An equal number of boys and girls had acute lower respiratory tract infection, but boys were more likely to have respiratory syncytial virus detected (prevalence ratio = 1.36 (1.01-1.81)), this difference being particularly marked in the rainy season. With recent respiratory syncytial virus exposure of mother, boys were twice as likely to have respiratory syncytial virus detected (prevalence ratio = 2.04 (1.18-3.53)), the difference being marked in the rainy season. There was no gender difference in respiratory syncytial virus infection among children of RSV negative mothers. We conclude that mothers may transmit respiratory syncytial virus more easily or severely to sons.

Antibodies, Viral↗
PubMed2003

Missing girls and son preference in rural India: looking beyond popular myth.

Survival chances of girls in parts of South and East Asia have been adverse. Female foeticide, infanticide, abandonment, out-adoption, under-reporting of female births, and selective neglect of girls leading to higher death rates, have contributed to this adversity. Here, I reflect on an observed skewed sex ratio at birth in rural West Bengal, and discuss female foeticide, infanticide, son preference, and abortion. More boys were recorded at birth, and the majority of women desired sons. Trajectories of selective neglect of and discrimination against daughters have been researched extensively, but the related issues of female foeticide and infanticide have been less examined.

Abortion, Legal↗
PubMedDate not supplied

Connecting and disconnecting: bereavement experiences of six mothers whose sons died of AIDS.

The bereavement experiences of 6 mothers whose sons died of AIDS-related complications were identified. Interviews with these women provided data for grounded-theory analysis. Two basic social processes were identified: Connecting and Disconnecting. Connecting included support, rituals, transitions, and gathering mementos, and Disconnecting included accepting the death, performing death-related tasks, and letting go. Special considerations for mothers of sons who have died of AIDS are discussed.

Acquired Immunodeficiency Syndrome↗
PubMed2002

Identical mitochondrial DNA deletion in a woman with ocular myopathy and in her son with pearson syndrome.

Single deletions of mitochondrial DNA (mtDNA) are associated with three major clinical conditions: Kearns-Sayre syndrome, a multisystem disorder; Pearson syndrome (PS), a disorder of the hematopoietic system; and progressive external ophthalmoplegia (PEO), primarily affecting the ocular muscles. Typically, single mtDNA deletions are sporadic events, since the mothers, siblings, and offspring of affected individuals are unaffected. We studied a woman who presented with PEO, ptosis, and weakness of pharyngeal, facial, neck, and limb muscles. She had two unaffected children, but another of her children, an infant son, had sideroblastic anemia, was diagnosed with PS, and died at age 1 year. Morphological analysis of a muscle biopsy sample from the mother showed cytochrome c oxidase-negative ragged-red fibers-a typical pattern in patients with mtDNA deletions. Southern blot analysis using multiple restriction endonucleases and probed with multiple mtDNA fragments showed that both the mother and her infant son harbored an identical 5,355-bp single deletion in mtDNA, without flanking direct repeats. The deletion was the only abnormal species of mtDNA identified in both patients, and there was no evidence for duplications. We conclude that, although the vast majority of single large-scale deletions in mtDNA are sporadic, in rare cases, single deletions can be transmitted through the germline.

Adolescent↗
PubMed1992

Dual-site thyroid ectopy in a mother and son.

We found familial thyroid ectopy in a mother and son, each of whom had an anterior neck mass corresponding to a perihyoid ectopic thyroid. In addition, technetium scintigraphy revealed another focus of aberrant uptake at their tongue roots. Neither patient showed hypothyroid symptoms or abnormal biochemical data other than a mildly elevated TSH level in the son. No other member of the family had a thyroid disorder. To our knowledge this is the first documented instance of familial thyroid ectopy in multiple sites. The observed similarity in distribution of ectopic tissue suggests a hereditary pathogenic factor.

Adult↗
PubMed1985

Son-killer: a third extrachromosomal factor affecting the sex ratio in the parasitoid wasp, Nasonia (=Mormoniella) vitripennis.

An extrachromosomal factor, termed son-killer (sk), affects the sex ratio in a parasitoid wasp, Nasonia (=Mormoniella) vitripennis. The factor is maternally transmitted and alters the secondary sex ratio of an infected female through mortality of approximately 80% of the male embryos. No effect on the primary (zygotic) sex ratio is observed. Ninety-five percent of the daughters of an infected female inherit son-killer. The factor can also be transmitted contagiously when the progeny of infected and uninfected females develop simultaneously on a single host. In newly infected strains, the sex ratio effects are equivalent to those in the original.

Animals↗
PubMed1999

Parental age at child's birth and son's risk of prostate cancer. The Framingham Study.

The authors examined the relation of parental age at birth to the risk of prostate cancer among sons with the use of data from the Framingham Study. During 42 years of follow-up (1949-1993), 141 prostate cancer cases occurred in 2,164 men. All but six cases were confirmed by histologic report. The incidence rate of prostate cancer increased from 1.70 per 1,000 person-years among sons in the lowest quartile of paternal age (<27 years), to 2.00, 2.32, and 2.74 among those of each increased paternal age category (27-<32, 32-<38, and > or =38 years), respectively. After adjustment for age and other covariates, men in the second, third, and oldest quartiles of paternal age had 1.2, 1.3, and 1.7 times increased risk of prostate cancer compared with men in the youngest quartile (p for trend = 0.049). Further adjustment for maternal age did not change the relation materially. The association of older paternal age with risk of early-onset prostate cancer (<65 years) appeared stronger than that with late-onset disease (265 years). No increased risk of prostate cancer was observed among subjects in the older maternal age category. The effect of increased paternal age on prostate cancer risk may operate through increased germ cell mutation rate or by mechanisms not yet defined.

Adult↗
PubMed2001

Atrial fibrillation in father and son after ingestion of cold substances.

A man and his father each developed atrial fibrillation after the ingestion of a frozen sweet. In the son, atrial fibrillation recurred with the subsequent ingestion of cold beverages. Neither patient had documented episodes of atrial fibrillation at any other time. The son also had multiple other episodes of palpitation, suggesting brief episodes of atrial fibrillation, and these occurred only with the ingestion of cold substances. Possible mechanisms include direct cooling of the left atrium through the wall of the esophagus and autonomic stimulation by the cold substance.

Adult↗
PubMed2003

Early use of corrective lenses in Spanish colonies of the Americas including parts of the future United States: reference to Viceroy Luis de Velasco (the Son).

We discuss many aspects of a reproduction of a formal painting from the XVIth century. It is a portrait of Viceroy of New Spain Luis de Velasco, El Joven or Hijo (son-see text), found at the Museum of the Pecos National Monument (near Pecos and Santa Fe, New Mexico). A formal portrait of each Viceroy of New Spain was created, and this one was painted during de Velasco's first term as Viceroy (1590 to 1595 AD). In this depiction, he is seen wearing spectacles. To our knowledge, this is the first known reference suggesting the introduction of this form of visual correction in the Spanish Colonies in the Americas and in the future United States. There are three known portraits of Luis de Velasco (son): One painting, which included his father and significant others, hangs in the Colegiata (a small cathedral) de San Luis near Valladolid, Spain. In this portrayal, he was shown as a young man without a spectacle correction. And there are two viceregal portraits (Term 1, 1590 to 1595; Term 2, 1607 to 1611) in which he wears the same spectacle correction (these are located in Mexico City).

Eyeglasses↗
PubMed2001

Non-progressive mental retardation and peripheral neuropathy in a mother and her son.

The association of facial dysmorphism, moderate mental retardation and peripheral neuropathy was observed in a mother and her son. The son also has pyramidal tract involvement in the lower limbs. Although exactly the same association has not been described previously, it seems probable that it results from variable expression of a dominant gene defect.

Adolescent↗
PubMed2004

Effects of ethanol administration and induction of anxiety-related affective states on the acoustic startle reflex in sons of alcohol-dependent fathers.

BACKGROUND: The high rate of comorbidity between alcoholism and anxiety disorders suggests some causal link. This study used the startle reflex to investigate whether increased reactivity to stimuli inducing fear or related affective states might be one mechanism by which a family genetic risk promotes the development of alcohol use disorders. METHODS: Thirty-one sons of alcoholics (PH+) were recruited from the participants of a longitudinal epidemiologic survey representative of the Munich area population between 18 and 25 years. Thirty male low-risk participants without parental alcoholism (PH-) were matched for age and history of psychiatric disorders. The baseline acoustic startle reflex was elicited before and after subjects drank 0.6 g/kg ethanol or placebo in a randomized, double-blind, placebo-controlled crossover design. Thereafter, the startle response was investigated while the subjects' affective state was manipulated by announcement of aversive electric finger stimuli to induce fear potentiation and by presentation of photographic slides previously rated to be pleasant, unpleasant, or neutral in their emotional valence. RESULTS: Plain startle response was lower in PH+ than PH- participants and was equally dampened by alcohol in PH+ and PH- subjects. Threat of finger shocks increased the startle response to the same extent in both groups. This fear potentiation effect was significantly attenuated by alcohol given on the second experimental day but not if alcohol was administered first and placebo on the second day. Pleasant and unpleasant slides decreased and increased startle response, respectively, and this effect was influenced by neither risk group nor alcohol. CONCLUSIONS: The acoustic startle reflex seems to be reduced in sons of alcoholics. The nonsignificant results during startle modification do not support the concept of increased reactivity to anxiety-related environmental stimuli as a mechanism promoting alcohol use disorders in subjects at increased family genetic risk for alcoholism.

Acoustic Stimulation↗