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At least 217 records · Page 12Linked to original sources
PubMed1989

Clinical evaluation of magnetic stimulation in cervical spondylosis.

Conduction in central motor pathways and motor roots was assessed, using the new technique of magnetic stimulation, in 39 patients with cervical spondylosis. Recordings were taken from abductor digiti minimi in all patients and from biceps brachii and abductor hallucis in some. Findings were abnormal ipsilaterally in 27 out of 63 muscles examined in patients with myelopathy, and in 2 out of 38 muscles in patients with radiculopathy. No abnormality was found in 11 muscles examined in patients with negative radiology. There was some correlation between the degree of electrophysiological change and clinical disability. Abnormal conduction was found in some patients with cord compression at the C3/4 or C4/5 interspace but not in a small group with compression at the C5/6 interspace. It seems that magnetic stimulation will provide objective confirmation of upper motor neurone involvement and may provide some measure of its degree, but at present it does not appear to be superior to clinical methods in diagnosing its presence. It may also aid the selection of the correct level for surgical decompression.

Adult↗
PubMed1990

Pre- and postoperative motor conduction times, measured using magnetic stimulation, in patients with cervical spondylosis.

Motor conduction time (MCT) between head and neck in pathways to abductor digiti minimi was measured pre- and postoperatively in 15 patients. There was a significant improvement in MCTs in patients with myelopathy who improved clinically, but preoperative MCTs provided no clear, predictive information. Magnetic stimulation may be of value in quantifying motor function before and after surgery in patients with cervical spondylosis.

Adult↗
PubMed1977

Spondylosis in the whale--an anatomicoradiological study of an osteophyte.

This report describes a macroscopic and radiological study (on a dry specimen) of a whale vertebra having an osteophyte of spondylosis similar to those present in man and other mammalians. This osteophyte has a remodelled and dense structure different from that of the normal neighbouring bone of the vertebral body (which has the particular bone structure of a cetacean). The study of the osteophytes and the bridges of sponylosis in the marine mammalians offers particularly favourable conditions for a better dissociation of the pre-existing vertebral body and the extrinsic bone which was newly developed under the influence of mechanical factors.

Animals↗
PubMed1992

[Pharmacokinetics of oral alminoprofen (Minalfen) in elderly patients with rheumatoid arthritis and spondylosis deformans].

The pharmacokinetics of oral Alminoprofen, a nonsteroidal anti-inflammatory drug, were studied in five elderly patients with rheumatoid arthritis and spondylosis deformans after 200 mg (three times a day) repeated dose for 5 days. The pharmacokinetic parameters after oral administration of Alminoprofen were analyzed by the one-compartment open model method. The maximum plasma concentrations (Cmax) were 16.1 +/- 2.5 micrograms/ml, after dosing on day 1, 25.2 +/- 1.6 micrograms/ml on day 3 and 21.6 +/- 2.7 micrograms/ml on day 5. The maximum time (Tmax) were about 2 hours after the medication in al cases. The area under the curve in drug concentration in plasma versus time (AUC) were 58.5 +/- 6.3 micrograms hr/ml on day 1, 58.5 +/- 3.1 micrograms hr/ml on day 3 and 58.1 +/- 8.5 micrograms hr/ml on day 5. The biological half-lives (t1/2) were 2.45 +/- 0.35, 2.09 +/- 0.82 and 2.49 +/- 0.63 hours, after dosing on day 1, day 3 and day 5, respectively. The analysis of moment in pharmacokinetics revealed that the mean residence time (MRT) on day 1, day 3 and day 5 observed were 2.31 +/- 0.03, 2.15 +/- 0.09 and 2.15 +/- 0.07 hours, respectively. The variance residence times (VRT) observed were 0.95 +/- 0.05 hour2 on day 1, 0.88 +/- 0.09 hour2 on day 3 and 1.06 +/- 0.07 hour2 on day 5. The ratios of accumulation calculated were 1.16 +/- 0.05 in both the morning medication on day 3 day 5, and it therefore appears that the steady-state equilibrium is established within 3 days after commencement of dosage.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMed2002

Anterior decompression for cervical spondylosis associated with an early form of cervical ossification of the posterior longitudinal ligament.

OBJECT: The goal of this study was to determine the appropriate surgical strategy for cervical spondylosis associated with an early form of ossification of the posterior longitudinal ligament (EOPLL) of the cervical spine. METHODS: Patients with EOPLL-associated cervical spondyosis were selected for treatment. Medical records and radiographs were retrospectively reviewed. Specimens taken at the time of operation were histologically examined. There were 24 men and six women ranging in age from 39 to 74 years (mean 57.6 years). Symptoms consisted of myelopathy in 28 cases and radiculopathy in two cases. Anterior decompressive surgery was performed. The EOPLL, hypertrophy of the posterior longitudinal ligament (HPLL), and the disc-PLL complex were directly resected. The mean preoperative Japan Orthopaedic Association score was 12.6, and the mean postoperative score was 14.4. Histologically, EOPLL was consistent with foci of compact lamellar bone in the degenerative thickening of the PLL. CONCLUSIONS: Appropriate corpectomy should follow direct removal of EOPLL associated with HPLL compressing the spinal cord to achieve good outcomes.

Adult↗
PubMed2007

[A rabbit model of cervical spondylosis established by stimulation of wind, cold and dampness].

OBJECTIVE: To make an animal model of cervical spondylosis (arthralgia syndrome type) with stimulation of wind, cold, and dampness. METHODS: Twenty-four 8 months old male New Zealand white rabbits were randomly allocated into four groups: normal control group, light stimulation group, moderate stimulation group and severe stimulation group. The wind speed was 10.8-13.8 m/s, the temperature was (5+/-0.5)degrees centigrade, and the humidity was 100%. The rabbits of light, moderate, and severe stimulation groups were kept in the above-mentioned environments for 4 hours everyday, and for a total of 32, 64, and 128 hours, respectively. The intervertebral discs were stained with HE method, and observed with a light microscope. Prostaglandin E(2) (PGE(2)), 6-ketone-prostaglandin F1alpha (6-K-PGF(1alpha)) and thromboxane B(2) (TXB(2)) contents were measured by ELISA. Fas and Bcl-2 expressions were examined by immunohistochemical avidin-biotin peroxidose complex technique. Interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and transforming growth factor beta (TGF-beta) mRNA expressions were examined by reverse transcription-polymerase chain reaction. RESULTS: The nucleus pulposus of rabbits in the light and moderate stimulation groups shrunken, and in the severe stimulation group, the anulus fibrosus loosed or ruptured, and the cartilage end-plate became proliferated. Compared with rabbits in the normal control group, the PGE(2) content rose in the light stimulation group, the contents of PGE(2), 6-K-PGF(1alpha), and TXB(2) increased, the expressions of IL-1beta and TNF-alpha mRNAs and Fas were up-regulated, and the expressions of TGF-beta mRNA and Bcl-2 were down-regulated in the moderate and severe stimulation groups. The expression of Fas was up-regulated mostly and Bcl-2 was down-regulated mostly in the severe group. CONCLUSION: Moderate and severe stimulations of wind, cold and dampness can lead to degeneration of cervical intervertebral discs of rabbits. The model corresponds to the theory of traditional Chinese medicine about arthralgia syndrome caused by wind, cold and dampness.

Animals↗
PubMed1997

A case of spondylosis deformans in the defleshed skeleton of a wild coyote and its significance to osteopathologic interpretation.

The skeleton of a wild coyote (Canis latrans), collected in Alturas, California (USA), in 1940 and reported to have died of a blowfly infection, was analyzed. The axial components, primarily a series of fused and deformed vertebrae, had classic osteological indications of spondylosis deformans, a trauma-induced disorder. Severe crippling due to a crushing-type strain was identified as the primary pathological condition to which the coyote succumbed, with death hastened by vertebral degeneration and the complicating infection.

Animals↗
PubMed1976

[The antero-posterior diameter of the cervical spinal canal in cervical spondylosis. (Part 2) (author's transl)].

1. The antero-posterior diameter (APD) of the cervical spinal canals in 96 cases of cervical spondylosis with radiculopathy and radiculomyelopathy was measured for each vertebra by the method of Burrows, and the thecoperiosteal diameter (TPD) of the cervical spinal canals in the same cases was measured from myelograms by the method of Symon. 2. The APD in patients with myelopathy or positive Queckentedt's test was found to be significantly smaller than those of without them. The upper limit of APD at C4 to C6 vertebrae in patients with myelopathy or positive Queckenstedt's test was 15 mm, while the lower limit of APD in patients with radiculopathy or negative Queckenstedt's test was 13 mm. As based on these findings, the following conclusions were drawn: When the APD is smaller than 15 mm, there is always a chance to develop spondylotic myelopathy or spinal subarachnoid block though not absolute, but if the APD is smaller than 12 mm, the patient will have myelopathy and spinal subarachnoid block absolutely without exception. 3. The TPD in patients with myelopathy or positive Queckenstedt's test was also found to be more significantly smaller than those of without them. It could be seen that the smaller the TPD, the more chance to develop myelopathy and also spinal subarachnoid block. The upper limit of the TPD in myelopathy was 11 mm, and that in spinal arachnoid block was 10 mm. The smallest value in radiculopathy was 9 mm, so that it was suggested that a case which has the value smaller than 8 mm might develop myelopathy. 4. The hight of the inter-body spurs was measured from lateral myelograms in individual case. The value in case with myelopathy and positive Queckenstedt's test was much larger than that of radiculopathy or negative Queckenstedt's test. The lower limit of the hight of the inter-body spurs in case with myelopathy and spinal subarachnoid block was 3 mm.

Cervical Vertebrae↗
PubMed1999

Ossification of the yellow ligament and spondylosis and/or ossification of the posterior longitudinal ligament of the thoracic and lumbar spine.

Combinations of varying degrees of spondylosis and/or ossification of the posterior longitudinal ligament (OPLL), and ossification of the yellow ligament (OYL) contribute to thoracic and lumbar neural compression in North Americans. Preoperative magnetic resonance and computed tomography examinations dictated the surgical approaches used to address spondylosis/OPLL in 11 patients, OYL in 12 patients, and spondylosis/OPLL and OYL in 3 patients. Myelopathy (4 patients), radiculopathy (13 patients), and cauda equina dysfunction (11 patients) were observed, 2 patients showing combined deficits. Outcomes (Odom's criteria) after laminectomy (24 patients) and circumferential thoracic procedures (2 patients) were good to excellent in the 73% of patients with spondylosis/OPLL, in 83% with OYL, and excellent for all 3 with spondylosis/OPLL and OYL. Full recognition of thoracic or lumbar spondylosis/OPLL and OYL ensure optimal surgical planning and outcomes.

Adult↗
PubMed2002

[A case report of transverso-arthropediculectomy for thoracic spondylosis].

We report a case of a 23-year-old male with thoracic spondylosis at the T2/3 level. He complained of lumbago and gait disturbance (spastic paraparesis and sensory disturbance below the T4 level). Preoperative CT myelography showed a posterolateral spur at the left paramedian site which was compressing the spinal cord. We performed drilling of the spur using the posterolateral approach, and decompressed the spinal cord. After surgery, the motor weakness and sensory disturbance gradually improved and spasticity was reduced. Postoperative CT showed complete decompression of the spinal cord and no spur. In cases of upper thoracic lesions, there are various kinds of posterolateral approaches for decompression of the ventral side of the spinal cord. We adopted transverso-arthropediculectomy for this case, because this approach is minimally invasive of the costotransverse joint and the spinal cord. We discuss the other posterolateral approaches, in terms of merits and demerits for the vertebra and spinal cord.

Adult↗
PubMed2002

[Syringomyelobulbia associated with cervical spondylosis. Pathophysiology and therapeutic implications].

Spinal spondylosis is rarely implicated in syringomyelia. We report the case of a 70-year-old patient with a 10-year history of gait disturbance; constrictive pain of lower limbs and urinary incontinance. Physical examination disclosed spastic tetraparesis. In the upper limbs, deep tendon reflexes were abolished, with hyposthesia and hands amyotrophy. Brain and cervical MRI showed syringomyelobulbia with cervical spondylotic myelopathy. Extensive cervical laminectomy induced a mild clinical improvement. A second MRI performed 6 months after surgery depicted a complete disappearance of the bulbo-medullar cavitation with secondary atrophy. Extradural spondylotic compression of the spinal cord should be firmly considered as an etiology of syringomyelia. A purely extradural decompression could be sufficient to induce regression of the medullary cavitation.

Aged↗
PubMed2002

[Surgical treatment of intervertebral disk herniation and spondylosis in degenerative diseases of the thoracic vertebrae--basic approach. Review of the literature and a group of 12 patients].

Prolapse of an intervertebral disc and neurologically important spondylosis of the thoracic vertebrae are not a frequent finding--in the wide spectrum of surgical treatment of degenerative diseases of the spine the numbers of operations in the thoracic section account only for a few percent. The authors give an account of 12 patients treated surgically during the 5-year period 1997-2001 at the Neurosurgical Department of the First Medical Faculty Charles University and Institute for Postgraduate Training in Prague-Stresovice. They describe the establishment of the neurological finding from the differential diagnostic aspect, the algorithm of radiological examination and selected treatment. In the group of surgically treated patients were two with spinal and radicular symptoms, 8 patients had only spinal and 2 patients had only root symptoms. Laminectomy was performed in one female patient, in 9 patients discectomy was performed from a transpedicular approach and in two patients discectomy from costotransversectomy. Complete normalization of clinical complaints was recorded in 2 patients, in 8 the condition improved and 2 patients did not improve. In 2 patients a revision was made and extension of the approach on account of persisting clinical complaints, in one patient after revision complete normalization of the clinical finding occurred, the second patient did not improve after revision. Selection and results of the surgical approach--in all instances different types of posterior approach were involved--are discussed. In the discussion also a brief review, indications and illustrations of posterior approaches are given. The discussion deals also with the advantages and disadvantages of the method as compared with the anterior approach or endoscopic technique. The authors emphasize the advantages of the microsurgical technique--the open posterior approach still holds an irreplaceable place in the spectrum of surgical therapeutic methods despite the onset of endoscopic methods.

Adult↗
PubMed2002

[A case of thoracic spondylosis presented with an attack of abnormal sensation and hyperhydrosis on the upper back].

A 23-year-old man presented an attack of abnormal sensation and hyperhydrosis on his upper back when he was tense or took a bath. This presentation continued for a month after commencement of Judo practise. Neurological examination found hyperactivity of bilateral deep tendon reflex alone. Magnetic resonance image demonstrated that the anterior thoracic spinal cord at the Th 4/5, 5/6 and 7/8 level were compressed by a bony spur. In our case, limitation of exercise, and prescription of adenosine triphosphate disodium and vitamin B led to a favourable outcome. Thoracic spondylosis in a young person is rare and there have been no standard protocols for the treatment. Thus, further clinical investigations are warranted.

Adult↗
PubMed1992

[Neuron-specific enolase (NSE) and S-100b protein in cerebrospinal fluid of patients with cervical spondylosis--the relations with MRI findings and the changes of NSE and S-100b protein levels through Glisson's traction].

We have previously reported that NSE and S-100b protein (S-100) could be used as reliable markers to evaluate the damage of the spinal cord in cervical spondylosis (CS) and ossification of posterior longitudinal ligament (OPLL). In the present study we made MRI in 21 patients with CS. There was a positive correlation between the NSE level in CSF and the degree of the spinal cord compression shown by MRI. In 10 cases of CS we examined these specific protein levels in CSF before and after the Glisson's traction therapy for one month. In seven of them the NSE levels decreased with the clinical improvements. On the other hand, 2 cases showed the rise of NSE levels after the traction. One of them became clinically worse during the therapy, while in another case the NSE levels changed within the normal range. The level of NSE in the other case was unchanged. In 57-year-old patient with CS myelopathy we examined the NSE levels chronologically. The NSE level changed in parallel with his clinical features. We suggest that NSE level in CSF may be a useful marker to estimate the change of the degree of the spinal cord damage in CS.

Female↗
PubMed2004

[Analysis of vascular vertigo due to cervical spondylosis and vertebro-basilar insufficiency based on sex and age in clinical materials].

According to examination of 97 patients with vascular vertigo the dependence on vertigo to vertebral spondylosis and insufficiency vertebro-basilar artery was showed. Vertebral degeneration was noticed in 70.1%, basilar artery insufficiency in 42.3% of the patients. In 75.6% of the patients there was noticed both of above symptoms. Rotary test showed labyrinth asymmetry in 41.2% and in caloric test 50.5% of the patients.

Adult↗
PubMed1992

Vertebrobasilar insufficiency related to cervical spondylosis. A case report and review of the literature.

A 64-year-old man suffered from symptoms of vertebrobasilar insufficiency (VBI) while turning his head to the left. Roentgenograms of the cervical spines showed severe spondylosis. Cerebral angiography demonstrated compression of the left vertebral artery by osteophytes of the cervical spine when the patient turned his head to the left. He was treated surgically by fixation of the vertebral bodies with good relief of symptoms during one year of follow-up. VBI induced by spondylotic compression of the vertebral artery is uncommon. We therefore reviewed the literature and suggested a more simple method of operation.

Cervical Vertebrae↗
PubMed2004

[Therapeutic efficacy of peloid plasters in the treatment of osteoarthritis of the peripheral joints and spondylosis].

The objective of the study was to investigate the efficacy and tolerability of the peloid plasters in the group of 20 patients with osteoarthritis of peripheral joints (10 patients with gonarthrosis and 10 with omarthrosis) and 20 patients with spondylosis. This form of the pelotherapy decreased pain in joints after 10 days of the treatment. No allergic or other side effects were observed. Peloid plasters through the analgesic action improve the comfort of life and reduce the use of oral analgesic drugs.

Aged↗
PubMed2004

[Anterior spinal artery syndrome due to cervical spondylosis presenting as cervical angina].

A 54-year-old woman developed acute progressive paraparesis after repeated precordial pain. Neurological examination revealed bilateral four-limb weakness predominant in the distal part of the upper limbs, upper limbs brisk tendon reflexes, superficial sensory impairment below the C8 level, and atonic bladder. T2-weighted cervical MRI disclosed hyperintense lesion with disc herniation in gray matter of spinal cord between C5 and C7. No vertebral artery abnormalities were detected. We hypothesized that she developed anterior spinal artery syndrome after cervical angina caused by cervical spondylosis. We conclude that physicians need to be aware of patients who experience chest pain without evidence of cardiac disease and that they take into consideration spinal cord infarction.

Angina Pectoris↗