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Treatment of acute salpingitis with sulbactam/ampicillin.

The combination of sulbactam/ampicillin was compared to cefoxitin for the treatment of acute salpingitis in 40 women divided into two groups of 20 women each. There were 11 patients in each group who were given doxycycline because of evidence of chlamydial infection. All patients were diagnosed by laparoscopic examination and evaluated by the same procedure 7-12 weeks later. At the second laparoscopy, only 1 of the 20 patients (5%) treated with sulbactam/ampicillin had severe adhesions, while 6 of the 20 patients (40%) treated with cefoxitin had severe adhesions. Tubal patency was without obstruction in 14 patients (70%) given the combination treatment and in 12 patients (60%) given cefoxitin. Side effects were essentially absent in both groups.

Acute Disease↗

IUD and salpingitis: a prospective study of pathomorphological changes in the oviducts in IUD-users.

A prospective study on pathomorphological changes in the oviducts in 253 women who underwent voluntary sterilization via posterior colpotomy performed at the Catharina Ziekenhuis, Eindhoven, was performed in order to investigate the effect of the intrauterine device (IUD). Some form of salpingitis was found in 54% of the IUD-group and in only 6% of the control group (P less than 10(-6), four-fold table, chi-squared test.) Microbiological study in 51 patients did not explain the pathoanatomical changes. As the IUD-and control-groups were comparable in all investigated parameters, the inflammatory reaction must be caused by the method of contraception.

Adult↗

Actinomyces israelii-associated salpingitis.

Actinomyces israelii was identified in samples from the oviducts of 4/100 women with salpingitis diagnosed by laparoscopy. All four cases healed on 'routine' treatment. Possible pathogenic mechanisms for the development of actinomycosis are discussed.

Actinomyces↗

Salpingitis; aspects of diagnosis and etiology: a 4-year study from a Swedish capital hospital.

359 patients underwent laparoscopy to verify the diagnosis of salpingitis. Pelvic inflammatory disease (PID) was found in 187 (52%) cases. Laparoscopy revealed normal conditions in 136 (37%) cases. Other diseases were diagnosed in 36 (10%) cases. Bacteriological cultures from the fimbrial lumen were positive in 24% of the PID cases. Chlamydia trachomatis (CT) was detected in 12%, Bacteroides species (BS) in 5%, Actinomyces israelii (AI) in 3%, Gardnerella vaginalis (GV) in 2%, Neisseria gonorrhoeae (NG) in 1%, and Ureaplasma urealyticum (UU) in 1%. Cervical cultures were positive for NG and/or CT in 71% of the PID cases but only in 19% of the non-PID cases. From these no positive intra-abdominal cultures were detected. Serological tests for CT were carried out. A positive acute titre of greater than or equal to 1/64 was noted in 37%, a seroconversion (X4) 2-3 weeks later was found in 14%. Positive serology despite a negative culture was registered in 19%.

Adolescent↗

Chlamydia trachomatis in the fallopian tubes of women without laparoscopic evidence of salpingitis.

23 women with lower abdominal pain and Chlamydia trachomatis in the cervix, urethra, or both sites were studied. Laparoscopy was done with sampling of the endometrium and fallopian tubes for detection of C trachomatis. 11 women had laparoscopic evidence of pelvic inflammatory disease (PID); C trachomatis was detected in the upper genital tract of 8, but not in the upper tract of 5 who had laparoscopy again after treatment. The organism was also found in the upper genital tract of 9 of the 12 women without laparoscopic evidence of PID. Most of the women with abdominal pain or tenderness had tubal or endometrial C trachomatis infection, although only half had laparoscopic evidence of salpingitis. This finding suggests that antibiotic treatment should be given as soon as chlamydial infection is detected in the cervix and that pain does not necessarily point to C trachomatis in the upper genital tract. Laparoscopy may miss important pathogens in the upper genital tract, unless the procedure is complemented with detailed microbiological investigation.

Anti-Bacterial Agents↗

Microsurgical resection of nonocclusive salpingitis isthmica nodosa is beneficial.

OBJECTIVE: To determine the effect of microsurgical resection and tubocornual anastomosis (TCA) of nonocclusive salpingitis isthmica nodosa (SIN) on fertility and risk for ectopic pregnancy (EP). DESIGN: Prospective cohort. SETTING: University-affiliated tertiary fertility clinic. PATIENT(S): Infertile women with hysterosalpingography evidence of SIN in patent fallopian tubes. INTERVENTION(S): Microsurgical resection and TCA for nonocclusive SIN. MAIN OUTCOME MEASURE(S): Occurrence of IUP and EP after TCA; comparison of duration of infertility preceding TCA with time to intrauterine pregnancy (IUP) after TCA; and comparison of numbers of women who conceived an EP before and after TCA. RESULT(S): Twelve (46%) of the women had IUPs with a mean time to pregnancy of 10.5 months, which is significantly shorter than the preceding period of infertility. Three women experienced EPs after TCA, which is reduced compared with the number of women with an EP preceding the TCA. CONCLUSION(S): The significant decrease in time to conceive an IUP after surgery as compared with the duration of infertility before surgery and the apparent reduction in risk for EP after surgery demonstrate the benefit of TCA for resection of nonocclusive SIN.

Adult↗

Infertility after acute salpingitis with special reference to Chlamydia trachomatis.

Of 552 women with laparoscopically verified acute salpingitis (AS), 299 were reviewed 2.5 to 7.5 years later. Cervical secretions from these women had been cultured for the presence of Chlamydia trachomatis and Neisseria gonorrhoeae. For 49 of 82 women with visually normal pelvic organs, such cultures were also performed; these women served as control subjects. In women exposing themselves to pregnancy, 50 (23.3%) of 197 AS patients and 2 (6.7%) of 30 control women were infertile for at least 1 year (P less than 0.02). After one episode of AS, women harboring chlamydiae, gonococci, both, or neither of these microorganisms in the cervix on admission seemed to have the same fertility prognosis. Infertility was correlated with the number of AS episodes, the erythrocyte sedimentation rate (millimeters per hour) at admission, and the severity of the inflammatory reactions of the tubes. The use of oral contraceptives at admission was found to be a positive prognostic factor regarding fertility. Oral contraceptives might protect the patient from severe tubal inflammatory reactions.

Adolescent↗

Laparoscopy diagnosis of chlamydial salpingitis using a tubal cytobrush.

This is a report of our nontraumatic technique using a tubal cytobrush for epithelial tubal cell recovery during laparoscopy diagnosis of C. trachomatis salpingitis. We performed a three-way laparoscopy in 95 women and inserted a long flexible fallopian tube brush through one of the trocars. This technique showed that it is possible to reach the infection site avoiding vaginal contamination and that sufficient tubal cells can be obtained for isolation of intracellular pathogens. The technique also allowed rapid antigen detection directly on tubal cells by IFA and C. trachomatis isolation on cell culture. Tubal scraping did not cause bleeding or adhesions as later observed in a matched group of women who underwent further laparoscopy during GIFT.

Biopsy↗

Isthmic ectopic pregnancy and salpingitis isthmica nodosa.

Two hundred eighty-five charts were reviewed from patients who underwent surgery for ectopic pregnancy. Excluded were patients with previous tubal reparative surgery, linear salpingotomy, or failed sterilization. The incidence of isthmic ectopic pregnancy in the remaining 255 cases was 15.3%. The association of salpingitis isthmica nodosa (SIN) and isthmic ectopic pregnancy was determined by review of resected tubal segments. SIN was noted in 17 of 37 cases (45.9%) of isthmic ectopic pregnancy. SIN places the patient at risk for recurrent ectopic pregnancy or infertility. Recommended conservative management of isthmic ectopic pregnancy is segmental resection with postoperative emphasis on documentation of SIN when present. Postoperative hysterosalpingography is recommended with an abnormal contralateral tube or when SIN is noted in the resected tubal segment. Management options after an isthmic ectopic pregnancy when future fertility is desired are presented.

Fallopian Tubes↗

Perihepatitis and chlamydial salpingitis.

In 4 patients with acute salpingitis (3 of whom also had perihepatitis) the diagnoses were verified by laparoscopy or laparotomy and all 4 had cultural and serological evidence of current infection with Chlamydia trachomatis, whereas none had signs of gonococcal infection. 3 of the 4 had symptoms in the right upper abdomen, but the liver surface showed signs of perihepatitis in only 2. In the 4th patient, perihepatitis was diagnosed, although she denied symptoms in the hepatic region. Thus symptoms from the right upper abdomen in a young woman may be an indirect sign of a genital infection.

Abdomen, Acute↗

[Apropos of a case of Streptococcus pneumoniae salpingitis, epidemiology of female genital pneumococcal infections].

BACKGROUND: Pneumoccocci were sometimes isolated from female genital tract specimens, usually without any clinical signification. However few cases of female pneumococcal genital infections were previously reported. CASE REPORT: We describe an additional report of salpingitis, occurring in a 35-years old female early after installation of an intra-uterine device. DISCUSSION: Data collected by the National Reference Center for Pneumococci show that 0.9% of the strains documented in the past five years (1992 to 1996) were isolated from the female genitals tract. Most of these infections are caused by S. pneumoniae belonging to the serotypes 1 or 3. About 20% of the strains displayed a reduced sensitivity to penicillin. Although genital infections caused by S. pneumoniae and the neonatal colonisation with the maternal strain are rare, their potential occurrence should not be neglected. Thus, in order to limit the risks of such infections, an antibiotic treatment should immediately started following the detection of a pneumococcal genital carriage.

Adult↗

Unilateral salpingitis due to Enterobius vermicularis.

A case of perforated unilateral salpingitis in which Enterobius vermicularis ova were identified in the inflammatory process is reported. Arguments for considering the parasite to be of etiologic significance in the production of the pathologic changes and clinical symptoms are presented. The infrequent occurrence of symptoms associated with ectopic localization of Enterobius vermicularis is emphasized by a review of the literature.

Adult↗

Immunopathology and histopathology of experimental chlamydial salpingitis.

Experimental infection of fallopian tubes was produced in four sexually mature pig-tailed monkeys (Macaca nemestrina) by intratubal inoculation with serovar E or F Chlamydia trachomatis. Infection was confirmed by reisolation of the organism from both the endosalpinx and the endocervix. An antibody response to the infecting strain of C. trachomatis was demonstrated in monkey sera and in cervical secretions by the microimmunofluorescence test. A cellular immune response to C. trachomatis was shown by the in vitro lymphocyte transformation assay. Histopathologic examination of the endosalpinx following infection showed epithelial degeneration and deciliation of ciliated cells. Lymphocytic infiltration into both submucosa and mucosa was present at day 7 and approximated areas of epithelial cell degeneration. Two control monkeys remained unresponsive throughout the study. These results indicate that the pig-tailed macaque should be a suitable model for further studies of the pathogenesis of, immune responses to, and therapy for acute C. trachomatis salpingitis.

Animals↗

Experimental Chlamydia trachomatis salpingitis in mice: initial studies on the characterization of the leukocyte response to chlamydial infection.

The murine biovar (mouse pneumonitis) of Chlamydia trachomatis was inoculated into the left oviduct of female Swiss Webster mice to establish acute salpingitis. Chlamydial inclusions were observed in secretory epithelial cells by both transmission electron microscopy and light microscopy using immunoperoxidase staining of deparaffinized sections. By days 5-8 after infection, a mixed polymorphonuclear and mononuclear cellular infiltrate was observed in the submucosa and mucosa. Epithelial cell deterioration occurred in the endosalpinx in areas of heavy mononuclear cellular infiltration. During the acute phase of the disease a cellular infiltrate consisting mainly of T cells was identified by staining frozen tissue sections with monoclonal antibodies to mouse lymphocyte antigens. Occasionally B lymphocytes were observed. Widespread deciliation of the mucosa was observed by scanning electron microscopy. No histopathologic or immunopathologic responses were observed in the control oviducts. These observations suggest an immunologic basis for the structural abnormalities seen in the infected oviducts.

Acute Disease↗

An experimental model for salpingitis due to Chlamydia trachomatis and residual tubal infertility in the mouse.

A mouse model of salpingitis and subsequent tubal infertility induced by a human strain of Chlamydia trachomatis has been studied. C3H/He female mice were inoculated into the ovarian bursa. Some of the mice (six infected, five controls) were killed on days 15 and 23 and the remaining animals (10 infected, 10 controls) were mated on day 15. On day 15, the infection was maximal with intratubal inflammation, elevated antichlamydial antibody titre and positive cultures in 12 cases out of 16. After 19 weeks of housing with the male, the proportion of fertilized females was significantly lower in the infected group (20% versus 100% in the control group P less than 0.01). In the killed mice, hydrosalpinx and or tubal occlusion were noted at this time in nine cases out of 10, despite an apparent bacteriological healing.

Animals↗

Benign glandular inclusions in lymph nodes, endosalpingiosis, and salpingitis isthmica nodosa in a young girl with clear cell adenocarcinoma of the cervix.

A 12-year-old girl underwent radical surgery for clear cell adenocarcinoma of the endocervix. Bilaterally dilated fallopian tubes with hyperplastic mucosal folds and salpingitis isthmica nodosa were found in association with benign glandular inclusions in a para-aortic lymph node and in the serosa of pelvic organs. Changes in the müllerian-derived epithelium appear to be a common denominator of these unusual lesions in this young girl. A primary growth disturbance of the cells of the müllerian system, which was conditioned during embryonic development and manifested itself later in life in response to appropriate stimuli associated with menarche, is postulated as the underlying abnormality.

Adenocarcinoma↗

Pseudocarcinomatous hyperplasia of the fallopian tube associated with salpingitis. A report of 14 cases.

We describe 14 cases of pseudocarcinomatous changes in the fallopian tube characterized by florid epithelial hyperplasia and in half the cases mesothelial hyperplasia and associated with chronic salpingitis. The patients' ages ranged from 17 to 40 years. Seven had clinical evidence of pelvic inflammatory disease. Tubal enlargement or thickening were observed in 12 cases and pyosalpinx, tubo-ovarian abscesses, or hydrosalpinx, in six cases. All cases showed no gross evidence of tumor. The reactive atypical hyperplasia mimicked carcinoma microscopically because of a cribriform pattern, penetration of the tubal wall by hyperplastic epithelium, florid mesothelial hyperplasia, or a combination of these findings; epithelial papillae were present in the lymphatics in two cases. In five cases, an erroneous microscopic diagnosis of carcinoma had been made or seriously entertained initially, and one patient underwent a radical hysterectomy as a result. The typically young age of the patients, absence of a gross tumor, presence of severe chronic inflammation, lack of solid epithelial proliferation, mildness of nuclear atypia, and paucity of mitotic figures facilitated the differential diagnosis. Nine patients for whom follow-up information was available had no recurrence of tubal disease.

Adolescent↗