Morphine-induced rotation (circling behavior) in rats and mice: species differences, persistence of withdrawal-induced rotation and antagonism by naloxone.
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In the present study, all the nystagmus reactions following the rotatory test are represented graphically after being split up into successive time intervals of 5 seconds each. The range of reactions is illustrated by comparing healthy subjects with patients with acute lesions of the vestibular system. It has been shown that during the rotatory test no signs of habituation were to be seen. The use of the parameter "fast phase velocity" (FPV) of the nystagmus to analyze the nystagmus reactions did not prove meaningful. In particular the findings in patients with acute vestibular lesions show that the nystagmus reactions following rotatory stimuli of appropriate intensity increase only to a limited extent. When interpreting the results, the influence of spontaneous nystagmus which usually underlies acute vestibular disease, is discussed in detail.
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