Radiation detector probes for tumor localization using tumor-seeking radioactive tracers.
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The authors have injected Sr85 intravenously and studied its fixation in samples taken from the femoral head with a trephine in the course of reduction and fixation of fractures of the femoral neck. Thirty-eight cases were studied, of which ten developed secondary avascular necrosis of the femoral head. All the patients were followed up for more than three years. The standard technique is described in detail. The authors consider that this technique was valid. All the necroses were able to be predicted. The examination of the samples took about 15 minutes during the operation. The method makes it possible to choose between internal fixation and prosthetic replacement.
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For the investigation on the lymph drainage from the orbita 99mTc-microcolloid, 99mTc-albumin and 198Au-colloid have been injected into the retrobulbar space of 24 rabbits. Measurements of the activity's distribution have been made in vivo with an Anger type camera (pho-Gamma-IV Hp, Searle Nuclear Chicago) and in vitro after section with a sodium iodine crystal well counter (Clinimat-200, Picker). A significant concentration of the activity could be observed for the most part in the equilateral Lymphonoduli cervicales profundi and superficiales and for the less part also in the equilateral Lymphonoduli mandibulares and contralateral Lymphonoduli cervicales profoundi. Furthermore significant activities could be pointed out in the optic nerves as well as in the contralateral retrobulbar space. The data substantiate a lymph drainage from the orbita as well as a partly reverse "prelymphatic-lymphatic" flow and are of importance for discussions about lymphostatic ophthalmopathy and sympathetic ophthalmitis. For application on man 99mTc-microcolloid (Lymphoscint) shoud be preferred, because with this tracer 1. the lymph drainage can be measured quantitatively quite exactly by extern measurement with the Anger-camera, 2. the allowable radiation dosis for the lens is lying between 0.5-1.0 rad/mCi.
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